[an error occurred while processing this directive]

Journal of Chinese Integrative Medicine ›› 2010, Vol. 8 ›› Issue (7): 629-635.doi: 10.3736/jcim20100705

• Original Clinical Research • Previous Articles     Next Articles

Relationship between expressions of estrogen and progesterone receptors and syndrome types of gastric carcinoma

 Jun Shi,  Ye Lu,  Xuan Zhang,  Xiao-wei Wang, Min Ye, Jian-peng Jiao, Bei Pei,  Pin-kang Wei    

  1. Department of Traditional Chinese Medicine, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China
  • Received:2010-01-08 Online:2010-07-20 Published:2010-07-15
  • Contact: Pin-kang Wei E-mail:czzyk@smmu.edu.cn

RichHTML

2

PDF (PC)

102

Like

Objective

To explore the relationship between expressions of estrogen (ER) and progesterone (PR) receptors and syndromes of traditional Chinese medicine (TCM) in gastric carcinoma and to establish prognostic indicators for gastric carcinoma.
Methods

 A total of 72 patients with gastric carcinoma were divided into six groups according to TCM syndrome differentiation. Specimens were collected after operation and ER and PR protein expressions were detected by EnVision immunohistochemical method.
Results

The common syndromes in female patients with gastric carcinoma were disharmony between liver and stomach, yin impairment due to stomach heat, and insufficiency of both qi and blood; while in males, interior retention of stagnant toxin, interior retention of phlegm and dampness, and deficiency-cold in spleen and stomach were common. Different TCM syndromes were related with gender (P<0.01), pathology (P<0.01), cell differentiation (P<0.05), infiltration depth (P<0.01), lymphaden metastasis (P<0.05), distant metastasis (P<0.05), and TNM stage (P<0.01). Deficiency and excess syndromes were associated with gender (P<0.05), pathology (P<0.05), tumor location (P<0.01) and TNM stage (P<0.05). The deficiency syndromes were common in female patients. The total positive rates of ER and PR expressions were 8.33% and 37.5% respectively. There was a significant difference in PR expression among different TCM syndromes (P<0.01). PR expression was significantly higher in the syndrome of yin deficiency due to stomach heat than in the other syndromes. The PR expressions in deficiency syndromes were significantly higher than those in excess syndromes (P<0.01). No correlation was found between ER expression and different TCM syndromes.
Conclusion

There is a correlation between PR expression and different TCM syndromes in gastric carcinoma.

Key words: Gastric carcinoma, Syndrome, Estrogen receptors, Progesterone receptors

"

"

"

"

[1] Zhou XC, Wang SX, Xiong W . Expressions and clinical significance of estrogen and progesterone receptors in gastric cancer[J]. Henan Wai Ke Xue Za Zhi, 2005,11(1):2-3
doi: 10.3969/j.issn.1007-8991.2005.01.002
周新成, 王穗雄, 熊炜 . 胃癌中雌激素和孕激素受体的表达及其临床意义[J]. 河南外科学杂志, 2005,11(1):2-3
doi: 10.3969/j.issn.1007-8991.2005.01.002
[2] Sun DZ, Xu L, Jiang LD, Wei PK . Evaluation of the quality of clinical literatures of traditional Chinese medicine for gastric carcinoma[J]. Zhongguo Lin Chuang Yi Xue, 2003,10(6):833-835
doi: 10.3969/j.issn.1008-6358.2003.06.015
孙大志, 许玲, 姜林娣, 魏品康 . 中医药治疗胃癌临床研究文献质量的调查评价[J]. 中国临床医学, 2003,10(6):833-835
doi: 10.3969/j.issn.1008-6358.2003.06.015
[3] Xu L, Sun DZ, Shi J, Chen YL, Wei PK . Literature study on syndrome differentiation of traditional Chinese medicine for gastric cancer[J]. Shi Jie Hua Ren Xiao Hua Za Zhi, 2004,12(6):1457-1459
许玲, 孙大志, 施俊, 陈亚琳, 魏品康 . 胃癌中医证型分类的文献研究[J]. 世界华人消化杂志, 2004,12(6):1457-1459
[4] Chen RY, Guo Z, Wang CX, Wang PL, Yu WB . Correlation among differentiation, serum cholesterol, LDL and HDL in patients with gastric cancer[J]. Zhongguo Xian Dai Pu Tong Wai Ke Jin Zhan, 2009,12(8):683-685, 701
陈瑞云, 郭震, 王春祥, 王培林, 于文滨 . 胃癌患者血脂水平与肿瘤组织分化程度的相关性研究[J]. 中国现代普通外科进展, 2009,12(8):683-685, 701
[5] Tokunaga A, Kojima N, Andoh T, Matsukura N, Yoshiyasu M, Tanaka N, Ohkawa K, Shirota A, Asano G, Hayashi K . Hormone receptors in gastric cancer[J]. Eur J Cancer Clin Oncol, 1983,19(5):687-689
doi: 10.1016/0277-5379(83)90186-4 pmid: 6683640
[6] Liu Y, Wang SY, Wang GS . Relationship between gastric cancer and passageway of estrogen, estrogen receptor and estrogen-regulated protein[J]. Zhonghua Shi Yan Wai Ke Za Zhi, 2003,20(9):864
刘弋, 汪圣毅, 王光升 . 胃癌与雌激素-雌激素受体-雌激素调节蛋白信号传递系统的关系[J]. 中华实验外科杂志, 2003,20(9):864
[7] Wang WL, Wu YY, Miao LC . Expression and significance of estrogen receptor and progesterone receptor in gastric cancer[J]. Lin Chuang Xiao Hua Bing Za Zhi, 2000,12(1):25-26
doi: 10.3870/j.issn.1005-541X.2000.01.009
王卫理, 吴玉玉, 缪林川 . 胃癌雌激素受体和孕激素受体的检测及临床意义[J]. 临床消化病杂志, 2000,12(1):25-26
doi: 10.3870/j.issn.1005-541X.2000.01.009
[8] Fan ZY . Expression of estrogen receptor and progesterone receptor in 40 cases of gastric cancer[J]. Zhong Yuan Yi Kan, 2004,31(10):49-50
doi: 10.3760/cma.j.issn.1674-4756.2004.10.056
范支援 . 胃癌40例雌激素受体与孕激素受体的检测研究[J]. 中原医刊, 2004,31(10):49-50
doi: 10.3760/cma.j.issn.1674-4756.2004.10.056
[9] Agbessi AK, Cai D, Zhu HG, Zhang YL . Estrogen receptor expression in gastric cancer cells and the use of new generation anti-estrogenic drug in the treatment of gastric cancer[J]. Fudan Xue Bao Yi Xue Ban, 2002,29(5):379-382
Agbessi AK, 蔡端, 朱虹光, 张延龄.胃癌雌激素受体表达及新一代抗受体药物在胃癌治疗中的探讨[J]. 复旦学报医学版, 2002,29(5):379-382
[10] Kominea A, Konstantinopoulos PA, Kapranos N, Vandoros G, Gkermpesi M, Andricopoulos P, Artelaris S, Savva S, Varakis I, Sotiropoulou-Bonikou G, Papavassiliou AG . Androgen receptor(AR) expression is an independent unfavorable prognostic factor in gastric cancer[J]. J Cancer Res Clin Oncol, 2004,130(5):253-258
doi: 10.1007/s00432-003-0531-x
[11] Oshima CT, Wonraht DR, Catarino RM, Mattos D, Forones NM . Estrogen and progesterone receptors in gastric and colorectal cancer[J]. Hepatogastroenterology, 1999,46(30):3155-3158
[12] Zhao XH, Gu SZ, Liu SX, Pan BR . Expression of estrogen receptor and estrogen receptor messenger RNA in gastric carcinoma tissues[J]. World J Gastroenterol, 2003,9(4):665-669
doi: 10.1080/00365520310000753 pmid: 4611424
[13] Takano N, Lizuka N, Hazama S, Yoshino S, Tangoku A, Oka M . Expression of estrogen receptor-alpha and -beta mRNAs in human gastric cancer[J]. Cancer Lett, 2002,176(2):129-135
doi: 10.1016/S0304-3835(01)00739-X
[14] Zhao YF, Zhang YG, Tian XX, Du J, Zheng J . Aberrant methylation of multiple genes in gastric carcinomas[J]. Int J Surg Pathol, 2007,15(3):242-251
doi: 10.1177/1066896907302117 pmid: 17652530
[15] Wang M, Pan JY, Song GR, Chen HB, An LJ, Qu SX . Altered expression of estrogen receptor alpha and beta in advanced gastric adenocarcinoma: correlation with prothymosin alpha and clinicopathological parameters[J]. Eur J Surg Oncol, 2007,33(2):195-201
doi: 10.1016/j.ejso.2006.09.009
[16] Matsuyama S, Ohkura Y, Eguchi H, Kobayashi Y, Akagi K, Uchida K, Nakachi K, Gustafsson JA, Hayashi S . Estrogen receptor beta is expressed in human stomach adenocarcinoma[J]. J Cancer Res Clin Oncol, 2002,128(6):319-324
doi: 10.1007/s00432-002-0336-3 pmid: 12073050
[17] Shi J, Sun DZ, Xu L . Review of syndrome differentiation of traditional Chinese medicine for gastric cancer[J]. Nanjing Zhong Yi Yao Da Xue Xue Bao Zi Ran Ke Xue Ban, 2005,21(3):199-201
doi: 10.3969/j.issn.1000-5005.2005.03.028
施俊, 孙大志, 许玲 . 胃癌中医证型研究进展[J]. 南京中医药大学学报自然科学版, 2005,21(3):199-201
doi: 10.3969/j.issn.1000-5005.2005.03.028
[18] Yang Q, Bu P . Different expressions of IGF-1R, FAK and survivin in different TCM syndrome types among gastric carcinoma tissue[J]. Shanxi Zhong Yi, 2008,24(10):34-36
doi: 10.3969/j.issn.1000-7156.2008.10.026
杨勤, 卜平 . IGF-1R、FAK及survivin在不同证型胃癌组织中的表达参数[J]. 山西中医, 2008,24(10):34-36
doi: 10.3969/j.issn.1000-7156.2008.10.026
[19] Chen W, Ouyang XN, Lin QC . Relationship between CD44v6 and TCM syndrome types of gastric carcinoma[J]. Zhongguo Zhong Xi Yi Jie He Wai Ke Za Zhi, 2007,13(3):207-210
doi: 10.3969/j.issn.1007-6948.2007.03.001
陈文, 欧阳学农, 林求诚 . 胃癌不同中医证型的细胞粘附分子表达[J]. 中国中西医结合外科杂志, 2007,13(3):207-210
doi: 10.3969/j.issn.1007-6948.2007.03.001
[20] Liu L, Xu L, Sun DZ, Wei PK . Correlations of E-cadherin, matrix metalloproteinase-2 and intercellular adhesion molecule-1 expression with traditional Chinese medicine classifications of syndrome for gastric carcinoma[J]. Shi Jie Hua Ren Xiao Hua Za Zhi, 2006,14(36):3461-3465
doi: 10.3969/j.issn.1009-3079.2006.36.005
刘龙, 许玲, 孙大志, 魏品康 . E-钙黏素、MMP2和ICAM-1的表达与胃癌中医证型的关系[J]. 世界华人消化杂志, 2006,14(36):3461-3465
doi: 10.3969/j.issn.1009-3079.2006.36.005
[21] Shi J, Wei PK, Xu L, Sun DZ, He J . Relationship between gastric carcinoma traditional Chinese medicine classifications of syndrome and tumor proliferation[J]. Shi Jie Hua Ren Xiao Hua Za Zhi, 2006,14(5):470-475
doi: 10.3969/j.issn.1009-3079.2006.09.005
施俊, 魏品康, 许玲, 孙大志, 何金 . 胃癌证型与肿瘤增殖的关系[J]. 世界华人消化杂志, 2006,14(5):470-475
doi: 10.3969/j.issn.1009-3079.2006.09.005
[22] Li HG, Hua YL, Hu GB . Pathological analysis of 315 female cases of gastric cancer under endoscopy[J]. Zhongguo Zong He Lin Chuang, 2001,17(2):117-118
doi: 10.3760/cma.j.issn.1008-6315.2001.02.027
黎红光, 华永龙, 胡国斌 . 315例女性胃癌临床胃镜病理分析[J]. 中国综合临床, 2001,17(2):117-118
doi: 10.3760/cma.j.issn.1008-6315.2001.02.027
[23] Zhan C, Liu XB, Zeng M, Ding SG . Clinical and pathological analysis of 67 young female cases of gastric cancer[J]. Lin Chuang Zhong Liu Xue Za Zhi, 2003,8(3):176-177
doi: 10.3969/j.issn.1009-0460.2003.03.006
占城, 刘小北, 曾敏, 丁士刚 . 67例青年女性胃癌的临床病理分析[J]. 临床肿瘤学杂志, 2003,8(3):176-177
doi: 10.3969/j.issn.1009-0460.2003.03.006
[24] Zhou DS, Xiong X, He Y, Wang HB, Zhao K . Endoscopic and pathological characteristics of young gastric cancer of both sexes: a report of 67 cases[J]. Zunyi Yi Xue Yuan Xue Bao, 2003,26(1):33-34
doi: 10.3969/j.issn.1000-2715.2003.01.015
周稻菽, 熊弦, 何毅, 王海波, 赵逵 . 青年人胃癌两性的内镜及病理特点(附67例报告)[J]. 遵义医学院学报, 2003,26(1):33-34
doi: 10.3969/j.issn.1000-2715.2003.01.015
[25] Shi J, Xu L, Sun DZ . Gender differences of syndromes in 357 cases of gastric cancer[J]. Shandong Zhong Yi Yao Da Xue Xue Bao, 2004,28(6):429-430
施俊, 许玲, 孙大志 . 357例胃癌中医证型性别差异性分析[J]. 山东中医药大学学报, 2004,28(6):429-430
[26] Chandanos E, Rubio CA, Lindblad M, Jia C, Tsolakis AV, Warner M, Gustafsson JA, Lagergren J . Endogenous estrogen exposure in relation to distribution of histological type and estrogen receptors in gastric adenocarcinoma[J]. Gastric Cancer, 2008,11(3):168-174
doi: 10.1007/s10120-008-0475-6
[1] Qi-sheng Tang, Wen-jun Sun, Miao Qu, Dong-fang Guo. Analysis of syndrome discipline of generalized anxiety disorder using data mining techniques. Journal of Chinese Integrative Medicine, 2012, 10(9): 975-982.
[2] Lu Liu, Ying Gao. Study on the correlation between traditional Chinese medicine syndrome and short-term prognosis of ischemic stroke using logistic regression model and repeated-measures analysis of variance. Journal of Chinese Integrative Medicine, 2012, 10(9): 983-990.
[3] Yan Guan , Hui Zhang, Wei Zhang, Shi-bing Su . Analysis of differential gene expression profile in peripheral blood of patients with chronic hepatitis B and syndromes of dual deficiency of liver and kidney yin and accumulation of dampness heat. Journal of Chinese Integrative Medicine, 2012, 10(7): 751-756.
[4] Ying-fei Bi , Jing-yuan Mao , Xian-liang Wang , Ya-zhu Hou , Yi-zhu Lu , Shan Bin Soh , Bo-li Zhang. Clinical epidemiology survey of the traditional Chinese medicine etiology and syndrome differentiation of coronary artery disease: Study protocol of a multicenter trial. Journal of Chinese Integrative Medicine, 2012, 10(6): 619-627.
[5] Qing-bo Lang, Dong-xia Zhai , Feng Huang, Jian-guo Chen, Yong-hui Zhang, Qun Liu, Xiao-feng Zhai , Bai Li, Chang-quan Ling. Investigation on traditional Chinese medicine syndrome distribution of 4 618 hepatitis B virus infection subjects in Qidong of Jiangsu Province, China. Journal of Chinese Integrative Medicine, 2012, 10(5): 525-531.
[6] Jia-jia Wang , Tian-fang Wang , Xiu-yan WU , Yah Zhao , Xiao-lin Xue , Qing-guo Wang. Weighting coefficients of symptoms and signs in the diagnosis of corresponding TCM syndrome elements of ulcerative colitis based on expert questionnaire investigation. Journal of Chinese Integrative Medicine, 2012, 10(4): 398-405.
[7] Hu Xiao-Yu, Zhang Yang, Chen Guo, Zhong Sen, Fan Xin-Jian. A prospective cohort study on the influence of high doses of herbs for clearing heat and resolving stasis on survival rates in patients with hepatitis B-related acute-on-chronic liver failure. Journal of Chinese Integrative Medicine, 2012, 10(2): 176-185.
[8] Yu Zhao, Jing-hua Peng , Xue-mei Li , Qi-lin Fu, Tuan Cui , Qi Li, Ya-jun Tang , Qin Feng , Hua Zhang , Hua Zhou , Yi-yang Hu. Diagnostic value of clinical indices in syndrome differentiation of chronic hepatitis B: an exploration based on receiver operating characteristic curves and stepwise discriminant analysis. Journal of Chinese Integrative Medicine, 2012, 10(12): 1382-1387.
[9] Dong-tao Li, Jian Wang , Hong-yang Jiang , Feng-lei Shi , Fu-yu Li , Ji-hong Liu , Yong-mei Cheng , Nan Yan , Ai-hua Hu, Mei-zeng Zhang , Jie Li, Ling-bo Wei , Rong-qin Jiang. Quantitative evaluation of the degrees of traditional Chinese medicine qualitative syndromes of osteoporosis. Journal of Chinese Integrative Medicine, 2012, 10(11): 1254-1262.
[10] Jing Zhang , Long Liu , Xin Yan , Xiao-qiang Yue. Study of the syndromes of traditional Chinese medicine in terms of metabonomics technology: The current situation and considerations. Journal of Chinese Integrative Medicine, 2012, 10(10): 1069-1076.
[11] Gui-xiang Chu, Qing-guang Chen, Jia-tuo Xu , Bo Yu , Min Zhang , Long-tao Cui , Hong-jin Wu , Zhao-fu Fei. Analysis on pulse diagram characteristics of subjects with subhealth state. Journal of Chinese Integrative Medicine, 2012, 10(10): 1099-1105.
[12] Liu Yue, Xie Ming, Zhang Ye. Dynamic changes of laboratory parameters of rats with type 2 diabetes and insulin resistance: defining their role in development of traditional Chinese medicine syndrome. Journal of Chinese Integrative Medicine, 2012, 10(1): 100-108.
[13] Xing-jiang Xiong, Hai-xia Li . Experience on clinical application of Chinese herbal medicine Yi Guan Jian decoction. Journal of Chinese Integrative Medicine, 2011, 9(8): 920-923.
[14] Ji Sun, Sheng-liang Zhu, Shu-ying Ma, Xiao-su Wang, Jing Kong. Clinical characteristics of patients with reflux esophagitis exhibiting gallbladder heat attacking the stomach or stagnant heat of the liver and stomach syndrome. Journal of Chinese Integrative Medicine, 2011, 9(7): 732-736.
[15] Jun Shi, Pin-kang Wei. The phlegm theory of gastric cancer. Journal of Chinese Integrative Medicine, 2011, 9(6): 581-587.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
[1] Wei-xiong Liang. Problems-solving strategies in clinical treatment guideline for traditional Chinese medicine and integrative medicine. Journal of Chinese Integrative Medicine, 2008, 6(1): 1-4
[2] Zhao-guo Li. Discussion on English translation of commonly used sentences in traditional Chinese medicine: part one. Journal of Chinese Integrative Medicine, 2008, 6(1): 107-110
[3] Jun Hu, Jian-ping Liu. Non-invasive physical treatments for chronic/recurrent headache. Journal of Chinese Integrative Medicine, 2008, 6(1): 31
[4] Xue-mei Liu, Qi-fu Huang, Yun-ling Zhang, Jin-li Lou, Hong-sheng Liu, Hong Zheng. Effects of Tribulus terrestris L. saponion on apoptosis of cortical neurons induced by hypoxia-reoxygenation in rats. Journal of Chinese Integrative Medicine, 2008, 6(1): 45-50
[5] . Uniform requirements for manuscripts submitted to biomedical journals: Writing and editing for biomedical publication (Chinese version, part two). Journal of Chinese Integrative Medicine, 2010, 8(11): 1001-1005
[6] Daniel Weber, Janelle M Wheat, Geoffrey M Currie. Inflammation and cancer: Tumor initiation, progression and metastasis,and Chinese botanical medicines. Journal of Chinese Integrative Medicine, 2010, 8(11): 1006-1013
[7] Hong Liu , Guo-liang Zhang, Li Shen , Zhen Zeng, Bao-luo Zhou, Cheng-hai Liu, Guang Nie . Application and evaluation of a pseudotyped virus assay for screening herbs for anti-H5Nl avian influenza virus. Journal of Chinese Integrative Medicine, 2010, 8(11): 1036-1040
[8] Zhao-guo Li . A discussion of English translation of 1995 and 1997 Chinese National Standards of Traditional Chinese Medical Terminologies for Clinical Diagnosis and Treatment. Journal of Chinese Integrative Medicine, 2010, 8(11): 1090-1096
[9] Rui Jin, Bing Zhang. A complexity analysis of Chinese herbal property theory: the multiple formations of herbal property (Part 1). Journal of Chinese Integrative Medicine, 2012, 10(11): 1198-1205
[10] Hui-min Liu, Xian-bo Wang, Yu-juan Chang, Li-li Gu. Systematic review and meta-analysis of randomized controlled trials of integrative medicine therapy for treatment of chronic severe hepatitis. Journal of Chinese Integrative Medicine, 2012, 10(11): 1211-1228
[an error occurred while processing this directive]