Chinese herbal medicine Ginkgo biloba L. preparations for ischemic stroke: An overview of systematic reviews and meta-analyses

doi:10.1016/j.joim.2024.03.003

Journal of Integrative Medicine ›› 2024, Vol. 22 ›› Issue (2): 163-179.doi: 10.1016/j.joim.2024.03.003

• Systematic Review • Previous Articles Next Articles

Chinese herbal medicine Ginkgo biloba L. preparations for ischemic stroke: An overview of systematic reviews and meta-analyses

Tian-tian Meng^a,b, Ya-ping You^a, Min Li^c, Jian-bo Guo^d, Xin-bin Song^e, Jing-yi Ding^a, Xiao-long Xie^f, An-qi Li^a, Shang-jin Li^g, Xiang-jun Yin^h, Peng Wang^e, Zhe Wang^a, Bao-liang Wangⁱ, Qing-yong He^a

a. Department of Cardiology, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100032, China.
b. Department of Rehabilitation, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing 100071, China.
c. School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China
d. School of Chinese Medicine, the University of Hong Kong, Hong Kong, China.
e. Graduate School, Henan University of Chinese Medicine, Zhengzhou 450008, Henan Province, China.
f. Department of Acupuncture and Moxibustion, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100010, China
g. School of Integrated Traditional Chinese and Western Medicine, Southwest Medical University, Luzhou 646000, Sichuan Province, China
h. School of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, Zhejiang Province, China.
i. Department of Neurology, the First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450003, Henan Province, China.

Received:2023-07-07 Accepted:2024-01-25 Online:2024-03-31 Published:2024-03-20
Contact: Qing-yong He; Bao-liang Wang E-mail:heqingyongg@163.com; wang_baoliang@163.com.

Abstract

Background

Ginkgo biloba L. preparations (GBLPs) are a class of Chinese herbal medicine used in the adjuvant treatment of ischemic stroke (IS). Recently, several systematic reviews (SRs) and meta-analyses (MAs) of GBLPs for IS have been published.

Objective

This overview aims to assess the quality of related SRs and MAs.

Search strategy

PubMed, Embase, Cochrane Library, Web of Science, Chinese Biological Medicine, China National Knowledge Infrastructure, Wanfang, and Chinese Science and Technology Journals databases were searched from their inception to December 31, 2022.

Inclusion criteria

SRs and MAs of randomized controlled trials (RCTs) that explored the efficacy of GBLPs for patients with IS were included.

Data extraction and analysis

Two independent reviewers extracted data and assessed the methodological quality, risk of bias (ROB), reporting quality, and credibility of evidence of the included SRs and MAs using A Measurement Tool to Assess Systematic Reviews 2 (AMSTAR 2), Risk of Bias in Systematic Reviews (ROBIS), the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA), and the Grading of Recommendations Assessment, Development and Evaluation (GRADE), respectively. Additionally, descriptive analysis and data synthesis were conducted.

Results

Twenty-nine SRs/MAs involving 119 outcomes were included in this review. The overall methodological quality of all SRs/MAs was critically low based on AMSTAR 2, and 28 had a high ROB based on the ROBIS. According to the PRISMA statement, the reporting items of the included SRs/MAs are relatively complete. The results based on GRADE showed that of the 119 outcomes, 8 were rated as moderate quality, 24 as low quality, and 87 as very low quality. Based on the data synthesis, GBLPs used in conjunction with conventional treatment were superior to conventional treatment alone for decreasing neurological function scores.

Conclusion

GBLPs can be considered a beneficial supplemental therapy for IS. However, because of the low quality of the existing evidence, high-quality RCTs and SRs/MAs are warranted to further evaluate the benefits of GBLPs for treating IS.

Key words: Ginkgo biloba L. preparations, Ischemic stroke, Overview, Systematic review

Tian-tian Meng, Ya-ping You, Min Li, Jian-bo Guo, Xin-bin Song, Jing-yi Ding, Xiao-long Xie, An-qi Li, Shang-jin Li, Xiang-jun Yin, Peng Wang, Zhe Wang, Bao-liang Wang, Qing-yong He. Chinese herbal medicine Ginkgo biloba L. preparations for ischemic stroke: An overview of systematic reviews and meta-analyses. Journal of Integrative Medicine, 2024, 22(2): 163-179.

/ / Recommend

Add to citation manager EndNote| Reference Manager|ProCite|BibTeX|RefWorks

URL: http://www.jcimjournal.com/EN/10.1016/j.joim.2024.03.003

http://www.jcimjournal.com/EN/Y2024/V22/I2/163

Abstract

Cited

Shared

Discussed

Comments

Recommended 10

[1]	Ming-qing Wei , Jin-zhou Tian , Jing Shi , Fu-yun Ma , Ying-chun Miao , Yong-yan Wang. Effects of Chinese medicine for promoting blood circulation and removing blood stasis in treating patients with mild to moderate vascular dementia: a randomized, double-blind and parallel-controlled trial. Journal of Chinese Integrative Medicine, 2012, 10(11): 1240-1246
[2]	Chang-quan Ling. Cancerous toxin is the key pathogenic factor of malignant tumor. Journal of Chinese Integrative Medicine, 2008, 6(2): 111-114
[3]	Wu Hong-jin, Xu Jia-tuo, Lu Lu-ming, Chen Xiao, Tu Li-ping, Zhang Zhi-feng. Facial spectrum and color characteristics of five viscera reflecting on the face in sub-health status. Journal of Chinese Integrative Medicine, 2012, 10(1): 59-66
[4]	Kwan Leung Chia. Symptomatic Tarlov cyst and electroacupuncture: More studies required. Journal of Integrative Medicine, 2015, 13(1): 58-60
[5]	Arthur de Sá Ferreira, Antonio Guilherme Pacheco. SimTCM: A human patient simulator with application to diagnostic accuracy studies of Chinese medicine. Journal of Integrative Medicine, 2015, 13(1): 9-19
[6]	Jian-hong Zhou, Dong-feng Chen, Shao-hui Du, Hui Li, Yi-wei Li, Ru-dong Deng, Sai-xia Zhang. Effect of Niupo Zhibao Pellet on expression of neuronal nitric oxide synthase in brain of endotoxin-induced shock rats. Journal of Chinese Integrative Medicine, 2005, 3(2): 115-118
[7]	Oluwatosin Adaramoye, Bettina Erguen, Olubukola Oyebode, Bianca Nitzsche, Michael Höpfner, Klaus Jung, Anja Rabien. Antioxidant, antiangiogenic and antiproliferative activities of root methanol extract of Calliandra portoricensis in human prostate cancer cells. Journal of Integrative Medicine, 2015, 13(3): 185-193
[8]	Yong Tang, Hai-yan Yin, Fang Zeng, Shu-guang Yu. Pondering in-situ induction of endogenous neural stem cells in hippocampus of rats with Alzheimer disease by acupuncture. Journal of Chinese Integrative Medicine, 2005, 3(5): 351-354
[9]	Amal Bakr Shori. Screening of antidiabetic and antioxidant activities of medicinal plants. Journal of Integrative Medicine, 2015, 13(5): 297-305
[10]	Hui-jiao Liang , Zhen-jiao Liang , Xiao-ping Wang. Three-dimensional reconstruction of the Lung Meridian of Hand-Taiyin with continuous thin-section CT image. Journal of Chinese Integrative Medicine, 2012, 10(12): 1400-1404

Chinese herbal medicine Ginkgo biloba L. preparations for ischemic stroke: An overview of systematic reviews and meta-analyses

RichHTML

PDF (PC)

Like

Abstract

Cite this article

Share this article

TrendMD

References

Related Articles 6

Metrics

Comments

Recommended 10

[1]	Zhen-yu Ma, Shu-ping Yang, Ying Li, Tian-tian Xu, Ya-lin Yang, Hui-yong Yang, Heng-bing Li, Le-jin Zhou, Yong Diao, Su-yun Li. Associations between the use of red yeast rice preparations and adverse health outcomes: An umbrella review of meta-analyses of randomized controlled trials. Journal of Integrative Medicine, 2024, 22(2): 126-136.
[2]	Han Yang, Zhi-yong Xiao, Zi-han Yin, Zheng Yu, Jia-jia Liu, Yan-qun Xiao, Yao Zhou, Juan Li, Jie Yang, Fan-rong Liang. Efficacy and safety of acupuncture for polycystic ovary syndrome: An overview of systematic reviews. Journal of Integrative Medicine, 2023, 21(2): 136-148.
[3]	Han-ting Wu, Cong-hua Ji, Rong-chen Dai, Pei-jie Hei, Juan Liang, Xia-qiu Wu, Qiu-shuang Li, Jun-chao Yang, Wei Maob, Qing Guo. Traditional Chinese medicine treatment for COVID-19: An overview of systematic reviews and meta-analyses. Journal of Integrative Medicine, 2022, 20(5): 416-426.
[4]	Jun-peng Yao, Li-ping Chen, Xian-jun Xiao, Ting-hui Hou, Si-yuan Zhou, Ming-min Xu, Kai Wang, Yu-jun Hou, Lin Zhang, Ying Li. Effectiveness and safety of acupuncture for treating functional constipation: An overview of systematic reviews. Journal of Integrative Medicine, 2022, 20(1): 13-25.
[5]	Arthur Yin Fan, Sherman Gu, Sarah Faggert Alemi, Research Group for Evidence-based Chinese Medicine. Chinese herbal medicine for COVID-19: Current evidence with systematic review and meta-analysis. Journal of Integrative Medicine, 2020, 18(5): 385-394.
[6]	Heather Ann Hausenblas, Kacey Heekin, Heather Lee Mutchie, Stephen Antonb. A systematic review of randomized controlled trials examining the effectiveness of saffron (Crocus sativus L.) on psychological and behavioral outcomes. Journal of Integrative Medicine, 2015, 13(4): 231-240.