SUBSCRIBE
Search JIM Advanced Search

Journal of Chinese Integrative Medicine ›› 2006, Vol. 4 ›› Issue (1): 98-100.doi: 10.3736/jcim20060129

• Literature Review • Previous Articles     Next Articles

Progress in research on antitumor activity of saikosaponin and its mechanism

Yan-li Wang1, Shui-xiang He1, Jin-yan Luo2   

  1. 1. Department of Gastroenterology, First Hospital, Xi’an Jiaotong University, Xi’an, Shaanxi Province 710061, China
    2. Department of Gastroenterology, Second Hospital, Xi’an Jiaotong University, Xi’an, Shaanxi Province 710004, China 
  • Online:2006-01-20 Published:2006-01-15

RichHTML

4

PDF (PC)

113

Like

Key words: Saikosaponin, Antineoplastic drugs (TCD), Mechanisms of action, Review

CLC Number: 

  • R286.91
[1] Kumazawa Y, Kawakita T, Takimoto H , et al. Protective effect of saikosaponin A, saikosaponin D and saikogenin D against Pseudomonas aeruginosa infection in mice[J]. Int J Immunopharmacol, 1990,12(5):531-537
[2] Ushio Y, Abe H . The effects of saikosaponin on macrophage functions and lymphocyte proliferation[J]. Planta Med, 1991,57(6):511-514
doi: 10.1055/s-2006-960195 pmid: 1818339
[3] Ushio Y, Oda Y, Abe H . Effect of saikosaponin on the immune responses in mice[J]. Int J Immunopharmacol, 1991,13(5):501-508
doi: 10.1016/0192-0561(91)90069-J pmid: 1783462
[4] Kato M, Pu MY, Isobe K , et al. Characterization of the immunoregulatory action of saikosaponin-d[J]. Cell Immunol, 1994,159(1):15-25
doi: 10.1006/cimm.1994.1291 pmid: 7954839
[5] Motoo Y, Sawabu N . Antitumor effects of saikosaponins, baicalin and baicalein on human hepatoma cell lines[J]. Cancer Lett, 1994,86(1):91-95
doi: 10.1016/0304-3835(94)90184-8 pmid: 7954360
[6] Yano H, Mizoguchi A, Fukuda K , et al. The herbal medicine sho-saiko-to inhibits proliferation of cancer cell lines by inducing apoptosis and arrest at the G0/G1 phase[J]. Cancer Res, 1994,54(2):448-454
[7] 宋景贵, 肖正明, 李师鹏 , 等. 柴胡提取物对人肝癌细胞和小鼠S-180肉瘤的抑制作用[J]. 山东中医药大学学报, 2001,25(4):299-301
doi: 10.3969/j.issn.1007-659X.2001.04.032
[8] 陈静波, 夏薇, 崔清潭 . 柴胡皂苷d(SSd) 对HL60细胞增殖的抑制作用[J]. 北京大学学报(自然科学版), 2001,2(6):486-488
[9] 夏薇, 崔新羽, 崔清潭 . 柴胡皂苷d(SSd)对K562细胞增殖的抑制作用[J]. 北京大学学报(自然科学版), 2002,3(2):113-115
doi: 10.3969/j.issn.1009-4822.2002.02.007
[10] Hsu YL, Kuo PL, Chiang LC , et al. Involvement of p53, nuclear factor kappa B and Fas/Fas ligand in induction of apoptosis and cell cycle arrest by saikosaponin d in human hepatoma cell lines[J]. Cancer Lett, 2004,213(2):213-221
[11] Hsu YL, Kuo PL, Lin CC . The proliferative inhibition and apoptotic mechanism of Saikosaponin?D in human non-small cell lung cancer A549 cells[J]. Life Sci, 2004,75(10):1231-1242
[12] Zong Z, Fujikawa-Yamamoto K, Tanino M , et al. Saikosaponin b2-induced apoptosis of cultured B16 melanoma cell line through down-regulation of PKC activity[J]. Biochem Biophys Res Commun, 1996,219(2):480-485
[13] Chen JC, Chang NW, Chung JG , et al. Saikosaponin-A induces apoptotic mechanism in human breast MDA-MB-231 and MCF-7 cancer cells[J]. Am J Chin Med, 2003,31(3):363-377
doi: 10.1142/S0192415X03001065 pmid: 12943168
[14] Hsu MJ, Cheng JS, Huang HC . Effect of saikosaponin, a triterpene saponin, on apoptosis in lymphocytes:association with c-myc, p53, and bcl-2 mRNA[J]. Br J Pharmacol, 2000,131(7):1285-1293
[15] 步世忠, 许金廉, 孙继虎 , 等. 柴胡皂苷d上调HL-60细胞糖皮质激素受体mRNA并诱导细胞凋亡[J]. 中华血液学杂志, 1999,20(7):354-356
doi: 10.3760/j:issn:0253-2727.1999.07.005
[16] Chiang LC, Ng LT, Liu LT , et al. Cytotoxicity and anti-hepatitis B virus activities of saikosaponins from Bupleurum species[J]. Planta Med, 2003,69(8):705-709
doi: 10.1055/s-2003-42797 pmid: 14531019
[17] 张丰华, 黄秀深, 牛朝阳 , 等. 小柴胡汤对S180荷瘤小鼠肿瘤血管生成的影响[J]. 中医药学刊, 2004,22(2):269-270
[18] Bermejo-Benito P, Abad Martinez MJ, Sjlvan Sen AM , et al. In vivo and in vitro antiinflammatory activity of saikosaponins[J]. Life Sci, 1998,63(13):1147-1156
doi: 10.1016/S0024-3205(98)00376-2 pmid: 9763210
[19] Chang WC, Hsu FL . Inhibition of platelet activation and endothelial cell injury by flavan-3-ol and saikosaponin compounds[J]. Prostaglandins Leukot Essent Fatty Acids, 1991,44(1):51-56
[20] Kodama Y, Xiaochuan L, Tsuchiya C , et al. Dual effect of saikogenin D: in vitro inhibition of prostaglandin E2 production and elevation of intracellular free Ca2+ concentration in C6 rat glioma cells[J]. Planta Med, 2003,69(8):765-767
[21] Kyo R, Nakahata N, Kodama Y , et al. Antagonism of saikosaponin-induced prostaglandin E2 release by baicalein in C6 rat glioma cells[J]. Biol Pharm Bull, 1999,22(12):1385-1387
[22] 孙明瑜, 谢鸣 . 小柴胡汤诱发的间质性肺炎[J]. 中国中医药信息杂志, 2002,9(7):71-72
doi: 10.3969/j.issn.1005-5304.2002.07.049
[1] Ming-min Xu, Pei Guo, Qing-yu Ma, Xuan Zhou, Yu-long Wei, Lu Wang, Yue Chen, Yu Guo. Can acupuncture enhance therapeutic effectiveness of antidepressants and reduce adverse drug reactions in patients with depression? A systematic review and meta-analysis. Journal of Integrative Medicine, 2022, 20(4): 305-320.
[2] Ting-ting Lu, Cun-cun Lu, Mei-xuan Li, Li-xin Ke, Hui Cai, Ke-hu Yang. Reporting and methodological quality of meta-analyses of acupuncture for patients with migraine: A methodological investigation with evidence map. Journal of Integrative Medicine, 2022, 20(3): 213-220.
[3] Witoo Dilokthornsakul, Ramanya Kosiyaporn, Rattanamanee Wuttipongwaragon, Piyameth Dilokthornsakul. Potential effects of propolis and honey in COVID-19 prevention and treatment: A systematic review of in silico and clinical studies. Journal of Integrative Medicine, 2022, 20(2): 114-125.
[4] Jun-peng Yao, Li-ping Chen, Xian-jun Xiao, Ting-hui Hou, Si-yuan Zhou, Ming-min Xu, Kai Wang, Yu-jun Hou, Lin Zhang, Ying Li. Effectiveness and safety of acupuncture for treating functional constipation: An overview of systematic reviews. Journal of Integrative Medicine, 2022, 20(1): 13-25.
[5] Yi Yuan, Rui-Ting Wang, Jun Xia, Hui-Juan Cao. Interventions for preventing influenza: an overview of Cochrane systematic reviews and a Bayesian network meta-analysis. Journal of Integrative Medicine, 2021, 19(6): 503-514.
[6] Meng-zhu Zhao, Chen Zhao, Shuang-shuang Tu, Xu-xu Wei, Hong-cai Shang. Evaluating the methodology of studies conducted during the global COVID-19 pandemic: A systematic review of randomized controlled trials. Journal of Integrative Medicine, 2021, 19(4): 317-326.
[7] Liang Dai, Ka Kei Chan, Jian-chun Mao, Yu Tian, Jun-hua Gu, Jun Zhou, Linda L.D. Zhong. Modified Zhibai Dihuang pill, a traditional Chinese medicine formula, on steroid withdrawal in systemic lupus erythematosus: A systematic review and meta-analysis. Journal of Integrative Medicine, 2020, 18(6): 478-491.
[8] Arthur Yin Fan, Sherman Gu, Sarah Faggert Alemi, Research Group for Evidence-based Chinese Medicine. Chinese herbal medicine for COVID-19: Current evidence with systematic review and meta-analysis. Journal of Integrative Medicine, 2020, 18(5): 385-394.
[9] Xian-jun Xiao, Lei-xiao Zhang, Yun-zhou Shi, Jun-peng Yao, Wei Cao, Ying Liu, Zi-hao Zou, Si-yuan Zhou, Ming-ling Chen, Chun-xiao Li, Qian-hua Zheng, Ying Li. Cupping therapy for patients with chronic urticaria: A systematic review and meta-analysis. Journal of Integrative Medicine, 2020, 18(4): 303-312.
[10] Dong-dong Yu, Liang-zhen You, Wan-qiu Huang, Hui Cao, Fan-jing Wang, Xiu-qin Tang, Zhao-hui Fang, Guo-ming Shen, Yu-xiang Guan. Effects of traditional Chinese exercises on blood glucose and hemoglobin A1c levels in patients with prediabetes: A systematic review and meta-analysis. Journal of Integrative Medicine, 2020, 18(4): 292-302.
[11] Dona Nirmani Ann Wijewickrama Samarakoon, Deepthi Inoka Uluwaduge, Malith Aravinda Siriwardhene. Mechanisms of action of Sri Lankan herbal medicines used in the treatment of diabetes: A review. Journal of Integrative Medicine, 2020, 18(1): 13-20.
[12] Lena Grönblom Lundström, Ulrika Aasa, Yan Zhang, Tobias Sundberg. Health care in light of different theories of health—A proposed framework for integrating a social humanistic perspective into health care. Journal of Integrative Medicine, 2019, 17(5): 321-327.
[13] Jia Xu, Fu-qing Zhang, Jian Pei, Jun Ji . Acupuncture for migraine without aura: A systematic review and meta-analysis. Journal of Integrative Medicine, 2018, 16(5): 312-321.
[14] Wen-jie Xu, Ling-tai Wang, Zhi-ping Zhao, Li-ming Zhu, Liang-hua Zu, Qi Zhang, Dan-bo Dou. Prospects of a comprehensive evaluation system for traditional Chinese medicine services. Journal of Integrative Medicine, 2017, 15(6): 426-432.
[15] Naseem Akhtar Qureshi, Gazzaffi Ibrahim Ali, Tamer Shaban Abushanab, Ahmed Tawfik El-Olemy, Meshari Saleh Alqaed, Ibrahim S. El-Subai, Abdullah M.N. Al-Bedah. History of cupping (Hijama): A narrative review of literature. Journal of Integrative Medicine, 2017, 15(3): 172-181.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
[1] Dong Yang, Yong-ping Du, Qing Shen, Wei Chen, Yan Yu, Guang-lei Chen. Expression of alpha-smooth muscle actin in renal tubulointerstitium in patients with kidney collateral stasis. Journal of Chinese Integrative Medicine, 2008, 6(1): 41-44
[2] Hai-feng Wei, Bai-liu Ya, Ling Zhao, Cui-fei Ye, Li Zhang, Lin Li. Evaluation of tongue manifestation of blood stasis syndrome and its relationship with blood rheological disorder in a rat model of transient brain ischemia. Journal of Chinese Integrative Medicine, 2008, 6(1): 73-76
[3] Xi Lin, Jian-ping Liu. Herbal medicines for viral myocarditis. Journal of Chinese Integrative Medicine, 2008, 6(1): 76
[4] Liang-ping Hu, Hui Gao. Discrimination of errors in statistical analysis of medical papers published in the first issue of 2006 in Journal of Chinese Integrative Medicine. Journal of Chinese Integrative Medicine, 2008, 6(1): 98-106
[5] Yan-bo Zhu , Qi Wang, Cheng-yu Wu, Guo-ming Pang, Jian-xiong Zhao, Shi-lin Shen, Zhong-yuan Xia , Xue Yan . Logistic regression analysis on relationships between traditional Chinese medicine constitutional types and overweight or obesity. Journal of Chinese Integrative Medicine, 2010, 8(11): 1023-1035
[6] Wei Xu, Meng Shi, Jian-gang Liu, Cheng-long Wang . Collagen protein expressions in ischemic myocardium of rats with acute myocardial infarction and effects of qi-tonifying, yin-tonifying and blood-activating herbs and detoxifying and blood-activating herbs. Journal of Chinese Integrative Medicine, 2010, 8(11): 1041-1047
[7] Tao Wang , Feng Qin. Effects of Chinese herbal medicine Xiaoyao Powder on monoamine neurotransmitters in hippocampus of rats with postpartum depression. Journal of Chinese Integrative Medicine, 2010, 8(11): 1075-1079
[8] Ying Xu , Chang-chun Zeng , Xiu-yu Cai , Rong-ping Guo , Guang Nie , Ying Jin. Chromaticity and optical spectrum colorimetry of the tongue color in different syndromes of primary hepatic carcinoma. Journal of Chinese Integrative Medicine, 2012, 10(11): 1263-1271
[9] Xiang-ying Mao , Qin Bian , Zi-yin Shen. Analysis of the osteogenetic effects exerted on mesenchymal stem cell strain C3H10T1/2 by icariin via MAPK signaling pathway in vitro. Journal of Chinese Integrative Medicine, 2012, 10(11): 1272-1278
[10] Samadder Asmita, Das Jayeeta, Das Sreemanti, Biswas Raktim, Rahman Khuda-Bukhsh Anisur. Ameliorative potentials of Syzygium jambolanum extract against arsenic-induced stress in L6 cells in vitro. Journal of Chinese Integrative Medicine, 2012, 10(11): 1293-1302
Journal of Integrative Medicine, ISSN: 2095-4964 CN 31-2083/R
Copyright © Journal of Integrative Medicine
Powered by Beijing Magtech Co. Ltd
沪公网安备31010602003416号      沪ICP备18017633号-3