SUBSCRIBE
Search JIM Advanced Search

Journal of Chinese Integrative Medicine ›› 2007, Vol. 5 ›› Issue (5): 546-549.doi: 10.3736/jcim20070514

Special Issue: Acupuncture & Moxibustion

• Original Experimental Research • Previous Articles     Next Articles

Effect of electroacupuncture and diet adjusting on insulin resistance in rats with nutrition obesity

Hui Yang2, Yi Li2, Ling Cheng2, Jin-sen He2   

  1. 1.Department of Acupuncture,Huadong Hospital,Fudan University,Shanghai 200040,China
    2.College of Acupuncture and Tuina,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China
    3.Department of Acupuncture,Dongfang Hospital,Tongji University,Shanghai 200120,China
  • Online:2007-09-20 Published:2007-09-15

RichHTML

0

PDF (PC)

68

Cited

13

Like

Objective: To study the effects of electroacupuncture and diet adjusting on insulin resistance in rats with nutrition obesity, and the role of electroacupuncture and diet adjusting in the treatment of obesity.Methods: Obesity was induced in rats by high-fat diet. Rats with nutrition obesity were randomly divided into high-fat diet (HD) group, high-fat diet plus electroacupuncture (HA) group, normal diet (ND) group and normal diet plus electroacupuncture (NA) group, with another group of SD rats as normal control (NC). After 15 days, all the rats' body weight and length were measured, the Lee's index was calculated, and the levels of total cholesterol (TC), triglycerides (TG), free fatty acid (FFA), fasting plasma glucose (FPG), fasting insulin (FINS) and tumor necrosis factor-α (TNF-α) were detected.Results: Compared with the HD group, food intake, body weight and viscera fat weight of the rats with nutrition obesity in the HA group and the NA group were markedly reduced (P<0.05). The levels of blood serum TC, FFA and IR index in the NA group were obviously lower than those in the HD group (P<0.01). The levels of TNF-α and FINS in the NA group were lower than those in the HD group (P<0.05).Conclusion: Electroacupuncture plus diet adjusting can decrease the levels of serum TNF-α and FINS of the obesity rats, and improve the state of insulin resistance.

Key words: obesity, electroacupuncture, tumor necrosis factor-alpha, insulin, rats

CLC Number: 

  • R589.25

Table 1

Food intake in different groups (ヌ±S, g/d)"

GroupnFood intake
NC1025.52±2.36
HD1030.76±2.81
ND1025.65±1.79
HA1016.58±1.52*
NA1013.77±1.06*

Table 2

Obesity items in different groups (ヌ±S)"

GroupnBody weight (g)Body length (cm)Lee's indexViscera fat weight (g)
NC10502.4±39.5226.04±0.63305.14±6.3218.93±3.32
HD10626.2±28.2828.21±0.52303.27±5.7647.52±8.20
ND10611.6±32.2027.92±0.52304.00±6.2234.20±6.70*
HA10554.4±34.00*27.57±1.01298.11±9.1234.76±9.07*
NA10524.8±34.38*27.76±0.61290.61±10.11*27.48±7.84*

Table 3

Blood lipid levels in different groups (ヌ±S)"

GroupnTC （mmol/L）TG （mmol/L）FFA （μmol/L）
NC100.99±0.181.52±0.331 059.05±472.42
HD101.60±0.31**1.54±0.221 736.60±793.40**
ND101.37±0.291.52±0.731 357.97±457.64
HA101.43±0.411.55±0.111 002.54±204.27△△
NA101.18±0.30△△1.51±0.10966.67±516.69△△

Table 4

TNF-α level in different groups (ヌ±S, μg/L)"

GroupnTNF-α
NC1024.02±3.63
HD1028.34±5.48
ND1026.40±6.58
HA1026.88±6.05
NA1022.81±3.24*

Table 5

Insulin resistance in different groups (ヌ±S)"

groupnFPG （mmol/L）FINS （mU/L）IR index
NC106.25±0.9936.05±9.4510.45±2.87
HD108.68±0.67**59.32±6.32*23.19±2.81**
ND108.87±0.66**40.18±5.0615.95±2.12
HA107.69±2.0648.81±7.7416.18±2.89
NA107.91±0.7835.77±6.70△12.61±2.33△△
[1] 孙志, 张中成, 刘志诚.营养性肥胖动物模型的实验研究[J].中国药理学通报,2002,18(4):466-467
Sun Z, Zhang ZC, Liu ZC.Experiment study of nutritional obesity animal model[J].Zhongguo Yao Li Xue Tong Bao,2002,18(4):466-467
[2] 李忠仁. 实验针灸学[M].北京: 中国中医药出版社,2003327
Li ZR.Experimental acupuncture science[M].Beijing: China Press of Traditional Chinese Medicine,2003327
[3] Kieffer TJ, Habener JF.The adipoinsular axis: effects of leptin on pancreatic beta-cells[J].Am J Physiol Endocrinol Metab,2000,278(1):1-14
doi: 10.1046/j.1365-201X.2000.00638.x pmid: 10644531
[4] 李秀钧. 胰岛素抵抗综合征[M].北京: 人民卫生出版社,200117-26
Li XJ.Insulin resistance syndrome[M].Beijing: People's Medical Publishing House,200117-26
[5] 吴静, 张素华.肿瘤坏死因子-α与胰岛素抵抗[J].国外医学内分泌学分册,1999,19(5):220-222
Wu J, Zhang SH.Tumor necrosis factor α and insulin resistance[J].Guo Wai Yi Xue Nei Fen Mi Xue Fen Ce,1999,19(5):220-222
[1] Sonia Chew Wen Phang, Uma Devi Palanisamy, Khalid Abdul Kadir. Effects of geraniin (rambutan rind extract) on blood pressure and metabolic parameters in rats fed high-fat diet. Journal of Integrative Medicine, 2019, 17(2): 100-106.
[2] Mehranghiz Ebrahimi-Mameghani, Mohammad Asghari-Jafarabadi, Khatereh Rezazadeh. TCF7L2-rs7903146 polymorphism modulates the effect of artichoke leaf extract supplementation on insulin resistance in metabolic syndrome: A randomized, double-blind, placebo-controlled trial. Journal of Integrative Medicine, 2018, 16(5): 329-334.
[3] Morufu Eyitayo Balogun, Elizabeth Enohnyaket Besong, Jacinta Nkechi Obimma, Ogochukwu Sophia Mbamalu, Fankou Serges Athanase Djobissie. Protective roles of Vigna subterranea (Bambara nut) in rats with aspirin-induced gastric mucosal injury. Journal of Integrative Medicine, 2018, 16(5): 342-349.
[4] Lucky Legbosi Nwidu, Raphael Ellis Teme. Hot aqueous leaf extract of Lasianthera africana (Icacinaceae) attenuates rifampicin-isoniazid-induced hepatotoxicity. Journal of Integrative Medicine, 2018, 16(4): 263-272.
[5] Uduak Akpan Okon, Idorenyin Udo Umoren. Comparison of antioxidant activity of insulin, Ocimum gratissimum L., and Vernonia amygdalina L. in type 1 diabetic rat model. Journal of Integrative Medicine, 2017, 15(4): 302-309.
[6] Nazli Samadi, Hassan Mozaffari-Khosravi, Masoud Rahmanian, Mohsen Askarishahi. Effects of bee propolis supplementation on glycemic control, lipid profile and insulin resistance indices in patients with type 2 diabetes: A randomized, double-blind clinical trial. Journal of Integrative Medicine, 2017, 15(2): 124-134.
[7] Mahsa Jalili, Zahra Bazi, Azita Hekmatdoost. A novel treatment for weight reduction by the recombinant “Pichia pastoris” yeast expressing the hybrid protein of “irisin-furin-transferrin”. Journal of Integrative Medicine, 2016, 14(1): 1-4.
[8] Kylie Connolly, Douglas Jackson, Candice Pullen, Andrew Fenning. Alpha-adrenoceptor antagonism by Crassostrea gigas oyster extract inhibits noradrenaline-induced vascular contraction in Wistar rats. Journal of Integrative Medicine, 2015, 13(3): 194-200.
[9] Hussein O. B. Oloyede, Matthew C. Adaja, Taofeek O. Ajiboye, Musa O. Salawu. Anti-ulcerogenic activity of aqueous extract of Carica papaya seed on indomethacin-induced peptic ulcer in male albino rats. Journal of Integrative Medicine, 2015, 13(2): 105-114.
[10] Udhaya Lavinya Baskaran, Sherry Joseph Martin, Rasool Mahaboobkhan, Sabina Evan Prince. Protective role of Triphala, an Indian traditional herbal formulation, against the nephrotoxic effects of bromobenzene in Wistar albino rats. Journal of Integrative Medicine, 2015, 13(2): 115-121.
[11] Anirudha A. Lande, Shirishkumar D. Ambavade, Uma S. Swami, Prafulla P. Adkara Prashant D. Ambavade, Arun B. Waghamare. Saponins isolated from roots of Chlorophytum borivilianum reduce acute and chronic inflammation and histone deacetylase. Journal of Integrative Medicine, 2015, 13(1): 25-33.
[12] Elizabeth Abidemi Balogun, Sylvia Orume Malomo, Joseph Oluwatope Adebayo, Ahmed Adebayo Ishola, Ayodele Olufemi Soladoye, Lawrence Aderemi Olatunji, Olatunji Matthew Kolawole, Stephen Olubunmi Oguntoye, Abiola Samuel Babatunde, Oluwole Busayo Akinola . In vivo antimalarial activity and toxicological effects of methanolic extract of Cocos nucifera (Dwarf red variety) husk fibre. Journal of Integrative Medicine, 2014, 12(6): 504-511.
[13] Meng-yue Liu, Cheng-wei Wang, Zhou-peng Wu, Ning Li. Electroacupuncture for the prevention of postoperative gastrointestinal dysfunction in patients undergoing vascular surgery under general anesthesia: Study protocol for a prospective practical randomized controlled trial. Journal of Integrative Medicine, 2014, 12(6): 512-519.
[14] Xin-fang Zhang, Ji Zhu, Wen-ye Geng, Shu-jun Zhao, Chuan-wei Jiang, Sheng-rong Cai, Miao Cheng, Chuan-yun Zhou, Zi-bing Liu. Electroacupuncture at Feishu (BL13) and Zusanli (ST36) down-regulates the expression of orexins and their receptors in rats with chronic obstructive pulmonary disease. Journal of Integrative Medicine, 2014, 12(5): 417-424.
[15] Urmila Aswar, Mayuri Gurav, Ganesh More, Khaled Rashed, Manoj Aswar. Effect of aqueous extract of Solanum xanthocarpum Schrad. & Wendl. on postmenopausal syndrome in ovariectomized rats. Journal of Integrative Medicine, 2014, 12(5): 439-446.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
[1] Yi-ting He, Qing-lin Zha, Jian-ping Yu, Yong Tan, Cheng Lu, Ai-ping Lv. Principal factor analysis of symptoms of rheumatoid arthritis and their correlations with efficacy of traditional Chinese medicine and Western medicine. Journal of Chinese Integrative Medicine, 2008, 6(1): 32-36
[2] Jun Cai, Hua Wang, Sheng Zhou, Bin Wu, Hua-rong Song, Zheng-rong Xuan. Effect of Sijunzi Decoction and enteral nutrition on T-cell subsets and nutritional status in patients with gastric cancer after operation: A randomized controlled trial. Journal of Chinese Integrative Medicine, 2008, 6(1): 37-40
[3] Dong Yang, Yong-ping Du, Qing Shen, Wei Chen, Yan Yu, Guang-lei Chen. Expression of alpha-smooth muscle actin in renal tubulointerstitium in patients with kidney collateral stasis. Journal of Chinese Integrative Medicine, 2008, 6(1): 41-44
[4] A-gao Zhou, Yong Zhang, Gang Kui, De-Yun Kong, Hai-liang Ge, Qiu-hua Ren, Jia-rong Dong, Sheng Hong, Xu-ming Mao, Yin Wang, Hui-zheng Zhang, Shu-jun Wang. Influence of traditional Chinese compound recipes with different efficacy on body weight, tumor weight and immune function in H22 cancer-bearing mice. Journal of Chinese Integrative Medicine, 2008, 6(1): 77-82
[5] Xi Lin, Jian-ping Liu. Tai chi for treating rheumatoid arthritis. Journal of Chinese Integrative Medicine, 2008, 6(1): 82
[6] Guo-hong Yuan, Xiao-jing Pang, He-chao Ma. Synergic effects of Danggui Buxue Decoction in reducing toxicity of cytoxan in tumor-bearing mice. Journal of Chinese Integrative Medicine, 2008, 6(1): 83-88
[7] Ning-qun Wang, Liang-duo Jiang, Zong-xing Li. Research progress in asthma-related quality of life. Journal of Chinese Integrative Medicine, 2008, 6(1): 93-97
[8] Bo Wang , Wei Yan , Li-hui Hou, Xiao-ke Wu. Disorder of Tiangui (kidney essence) and reproductive dysfunction in patients with polycystic ovary syndrome. Journal of Chinese Integrative Medicine, 2010, 8(11): 1018-1022
[9] Bing Hu , Hong-mei An , Ke-ping Shen , Qin Du. Senescence-inducing effects of Chinese herbal medicine Tenglong Buzhong Decoction on human colon carcinoma LS-174-T cells and the mechanism. Journal of Chinese Integrative Medicine, 2010, 8(11): 1048-1052
[10] Jing-yuan Mao, Chang-xiao Liu, Heng-he Wang, Guang-li Wei , Zhen-peng Zhang, Jie Xing, Wang Xian liang , Ying-fei Bi . Effects of Shenmai Injection on serum concentration and pharmacokinetics of digoxin in dogs with heart failure. Journal of Chinese Integrative Medicine, 2010, 8(11): 1070-1074
Journal of Integrative Medicine, ISSN: 2095-4964 CN 31-2083/R
Copyright © Journal of Integrative Medicine
Powered by Beijing Magtech Co. Ltd
沪公网安备31010602003416号      沪ICP备18017633号-3