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Journal of Chinese Integrative Medicine ›› 2007, Vol. 5 ›› Issue (5): 546-549.doi: 10.3736/jcim20070514

Special Issue: Acupuncture & Moxibustion

• Original Experimental Research • Previous Articles     Next Articles

Effect of electroacupuncture and diet adjusting on insulin resistance in rats with nutrition obesity

Hui Yang2, Yi Li2, Ling Cheng2, Jin-sen He2   

  1. 1.Department of Acupuncture,Huadong Hospital,Fudan University,Shanghai 200040,China
    2.College of Acupuncture and Tuina,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China
    3.Department of Acupuncture,Dongfang Hospital,Tongji University,Shanghai 200120,China
  • Online:2007-09-20 Published:2007-09-15

Objective: To study the effects of electroacupuncture and diet adjusting on insulin resistance in rats with nutrition obesity, and the role of electroacupuncture and diet adjusting in the treatment of obesity.Methods: Obesity was induced in rats by high-fat diet. Rats with nutrition obesity were randomly divided into high-fat diet (HD) group, high-fat diet plus electroacupuncture (HA) group, normal diet (ND) group and normal diet plus electroacupuncture (NA) group, with another group of SD rats as normal control (NC). After 15 days, all the rats' body weight and length were measured, the Lee's index was calculated, and the levels of total cholesterol (TC), triglycerides (TG), free fatty acid (FFA), fasting plasma glucose (FPG), fasting insulin (FINS) and tumor necrosis factor-α (TNF-α) were detected.Results: Compared with the HD group, food intake, body weight and viscera fat weight of the rats with nutrition obesity in the HA group and the NA group were markedly reduced (P<0.05). The levels of blood serum TC, FFA and IR index in the NA group were obviously lower than those in the HD group (P<0.01). The levels of TNF-α and FINS in the NA group were lower than those in the HD group (P<0.05).Conclusion: Electroacupuncture plus diet adjusting can decrease the levels of serum TNF-α and FINS of the obesity rats, and improve the state of insulin resistance.

Key words: obesity, electroacupuncture, tumor necrosis factor-alpha, insulin, rats

CLC Number: 

  • R589.25

Table 1

Food intake in different groups (ヌ±S, g/d)"

GroupnFood intake
NC1025.52±2.36
HD1030.76±2.81
ND1025.65±1.79
HA1016.58±1.52*
NA1013.77±1.06*

Table 2

Obesity items in different groups (ヌ±S)"

GroupnBody weight (g)Body length (cm)Lee's indexViscera fat weight (g)
NC10502.4±39.5226.04±0.63305.14±6.3218.93±3.32
HD10626.2±28.2828.21±0.52303.27±5.7647.52±8.20
ND10611.6±32.2027.92±0.52304.00±6.2234.20±6.70*
HA10554.4±34.00*27.57±1.01298.11±9.1234.76±9.07*
NA10524.8±34.38*27.76±0.61290.61±10.11*27.48±7.84*

Table 3

Blood lipid levels in different groups (ヌ±S)"

GroupnTC (mmol/L)TG (mmol/L)FFA (μmol/L)
NC100.99±0.181.52±0.331 059.05±472.42
HD101.60±0.31**1.54±0.221 736.60±793.40**
ND101.37±0.291.52±0.731 357.97±457.64
HA101.43±0.411.55±0.111 002.54±204.27△△
NA101.18±0.30△△1.51±0.10966.67±516.69△△

Table 4

TNF-α level in different groups (ヌ±S, μg/L)"

GroupnTNF-α
NC1024.02±3.63
HD1028.34±5.48
ND1026.40±6.58
HA1026.88±6.05
NA1022.81±3.24*

Table 5

Insulin resistance in different groups (ヌ±S)"

groupnFPG (mmol/L)FINS (mU/L)IR index
NC106.25±0.9936.05±9.4510.45±2.87
HD108.68±0.67**59.32±6.32*23.19±2.81**
ND108.87±0.66**40.18±5.0615.95±2.12
HA107.69±2.0648.81±7.7416.18±2.89
NA107.91±0.7835.77±6.7012.61±2.33△△
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