重症肌无力患者报告结局指标量表的研制——计量心理学测评

doi:10.3736/jcim20100205

Abstract

Objective

To investigate the scientificity of patient-reported outcome (PRO) scale for myasthenia gravis (MG), which was used to evaluate the clinical effects of traditional Chinese and Western medicine treatment on MG patients. Psychometric performance of the MG-PRO scale was also expected to be evaluated in this study.
Methods:

A total of 100 MG patients and 100 healthy people were face-to-face interviewed by well-trained investigators, and the data of MG-PRO scale were collected. The classical theory test (CTT) and item response theory (IRT) methods were used to analyze the psychometric performance such as validity, reliability, person separation index (PSI) and differential item functioning (DIF) in the MG-PRO scale.
Results

The results of CTT analysis showed that the split-half reliabilities of the MG-PRO scale and each dimension were greater than 0.7. In the analysis of internal consistency of each dimension, the Cronbach's α was greater than 0.8. Each facet had greater correlation with its dimension than the other dimensions. Four principal components were extracted by exploratory factor analysis, which represented all dimensions of the scale, and the cumulative variance was 55.54%. The scores of each of the 8 facets between MG patients and healthy people were different (P<0.01). The results of IRT showed that the PSI of each model was greater than 0.8, and all items did not have uniform DIF and non-uniform DIF.
Conclusion

The MG-PRO scale reflects the definition and connotation of quality of life and contains special issues of MG patients as well, and shows good reliability (split-half reliability, Cronbach's α), validity (content validity, construct validity, discriminate validity) from the results of CTT, and good psychometric performance from the results of IRT.

Key words: Myasthenia gravis, PRO scale, Reliability and validity, Item response theory, Classical test theory

Xin-lin Chen, Feng-bin Liu, Li Guo, Xiao-bin Liu. Development of patient-reported outcome scale for myasthenia gravis: A psychometric test. Journal of Chinese Integrative Medicine, 2010, 8(2): 121-125.

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URL: http://www.jcimjournal.com/EN/10.3736/jcim20100205

http://www.jcimjournal.com/EN/Y2010/V8/I2/121

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References 12

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Facet	Dimension
Facet	PH	PS	SE	TR
Physical symptom	0.960	0.435	0.751	0.541
Physical functioning	0.898	0.429	0.664	0.603
Positive mood	0.371	0.930	0.503	0.463
Negative mood	0.473	0.825	0.663	0.534
Personal relationship	0.747	0.638	0.935	0.705
Social support	0.616	0.488	0.862	0.614
Side effects	0.470	0.495	0.630	0.951
Drug dependence	0.686	0.499	0.730	0.798

Facet	n	Mean score	t	P
Physical symptom
Healthy people	100	67.26±9.73	6.63	0.000
MG patients	100	62.20±11.64
Physical functioning
Healthy people	100	94.00±3.36	8.55	0.000
MG patients	100	78.13±18.26
Positive mood
Healthy people	100	11.20±2.60	3.87	0.000
MG patients	100	9.55±3.38
Negative mood
Healthy people	100	8.19±1.24	8.72	0.000
MG patients	100	5.99±2.20
Personal relationship
Healthy people	100	17.27±2.79	9.39	0.000
MG patients	100	12.75±3.92
Social support
Healthy people	100	11.60±2.22	9.72	0.000
MG patients	100	8.17±2.75
Side effects
Healthy people	100	7.73±1.73	4.15	0.000
MG patients	100	6.55±2.26
Drug dependence
Healthy people	100	4.96±0.24	20.00	0.000
MG patients	100	2.60±1.15

Development of patient-reported outcome scale for myasthenia gravis: A psychometric test

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