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Journal of Chinese Integrative Medicine ›› 2011, Vol. 9 ›› Issue (5): 487-490.doi: 10.3736/jcim20110504

• Methodology • Previous Articles     Next Articles

Statistical concepts related to negative clinical results

Wei Chen1, Guo-hua Zheng2, Jian-ping Liu2()   

  1. 1. Center for Evidence-based Medicine, Beijing University of Chinese Medicine, Beijing 100029, China
    2. Research Institute of Traditional Chinese and Western Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350108, Fujian Province, China
  • Received:2011-03-01 Accepted:2011-03-11 Online:2011-05-20 Published:2011-05-15
  • Contact: Liu Jian-ping E-mail:jianping_l@hotmail.com

It is a trend that clinical researchers overemphasize on hypothesis testing and the P value. However, P value has some limitations in the presentation of study results. Power is a tool for study design and results explanation, especially for negative results. Confidence interval contains more information for clinical results than P value. P value, power, and 95% confidence interval should be provided in the clinical reports to facilitate the interpretation of the results.

Key words: negative results, P value, power, confidence interval

Figure 1

Information provided by confidence interval in statistical inference"

[1] Hebert RS, Wright SM, Dittus RS, Elasy TA .Prominent medical journals often provide insufficient information to assess the validity of studies with negative results[J].J Negat Results Biomed, 2002, 1: 1
[2] Altman DG, Bland JM . Absence of evidence is not evidence of absence[J]. BMJ, 1995,311(7003):485
doi: 10.1136/bmj.311.7003.485
[3] Wu J . Placebo control and clinical trial of Chinese medicine[J]. J Chin Integr Med, 2010,8(10):906-910
doi: 10.3736/jcim20101001
吴静 . 安慰剂对照与中药临床试验[J]. 中西医结合学报, 2010,8(10):906-910
doi: 10.3736/jcim20101001
[4] Ludbrook J, Dudley H . Issues in biomedical statistics: statistical inference[J]. Aust N Z J Surg, 1994,64(9):630-636
doi: 10.1111/j.1445-2197.1994.tb02308.x pmid: 8085981
[5] Dimick JB, Diener-West M, Lipsett PA . Negative results of randomized clinical trials published in the surgical literature: equivalency or error?[J]. Arch Surg, 2001,136(7):796-800
doi: 10.1001/archsurg.136.7.796
[6] Liu JP . Methodological quality assessment of clinical trials in traditional Chinese medicine: the principles of evidence-based medicine[J]. J Chin Integr Med, 2006,4(1):1-6
刘建平 . 中医药临床试验的方法学问题与挑战: 循证医学的观点[J]. 中西医结合学报, 2006,4(1):1-6
[7] Shen J. TCM statistics[M]. Beijing: People’s Military Medical Press,2003:43-50, 61, 62
申杰 . 中医统计学[M]. 北京: 人民军医出版社,2003:43-50, 61, 62
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