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Journal of Chinese Integrative Medicine ›› 2011, Vol. 9 ›› Issue (11): 1185-1189.doi: 10.3736/jcim20111105

• Methodology • Previous Articles     Next Articles

Estimation of sample size and testing power (Part 2)

Liang-ping Hu(), Xiao-lei Bao, Li-xin Tao, Shi-guo Zhou, Xue Guan   

  1. Consulting Center of Biomedical Statistics, Academy of Military Medical Sciences, Beijing 100850, China
  • Received:2011-09-12 Accepted:2011-09-15 Online:2011-11-20 Published:2011-11-15

This article introduces definitions of three special tests, namely, non-inferiority test (to verify that the efficacy of the experimental drug is clinically not inferior to that of the positive control drug), equivalence test (to verify that the efficacy of the experimental drug is equivalent to that of the control drug) and superiority test (to verify that the efficacy of the experimental drug is superior to that of the control drug), and methods of sample size estimation under the three different conditions. By specific examples, the article introduces formulas of sample size estimation for the three special tests, and their SAS realization in detail.

Key words: statistics, medical, research design, sample size, testing power, parametric estimation

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