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Journal of Chinese Integrative Medicine ›› 2012, Vol. 10 ›› Issue (8): 925-931.doi: 10.3736/jcim20120814

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Analysis on content of serum monoamine neurotransmitters in macaques with anger-in-induced premenstrual syndrome and liver-qi depression syndrome

Sheng Wei(), Jin-liang Hou, Yu-bin Chao, Xi-yang Du, Shao-bo Zong#br#   

  1. Key Laboratory of Classics Theory of Traditional Chinese Medicine of the Ministry of Education of China, Shandong University of Traditional Chinese Medicine, Jinan 250355, Shandong Province, China
  • Received:2012-02-21 Accepted:2012-03-21 Online:2012-08-20 Published:2018-08-15
  • Contact: Sheng Wei

Objective: To observe the changes in content of monoamine neurotransmitters in the serum of rhesus macaques, and explore the role of serum monoamine neurotransmitters in premenstrual syndrome (PMS) and liver-qi depression induced by anger-in emotion.

Methods: Social level pressure was applied on 24 female macaques to induce the angry emotional reaction, and then nine of the low-status macaques with anger-in emotional reaction were screened out and were divided into anger-in emotion group, PMS and liver-qi depression group (model group) and Jingqianshu Granule group. Macaques in the last two groups were suffered extruding in a pack cage for inducing PMS liver-qi depression. After 5 d of extruding, experimental animals were evaluated according to the emotional evaluation scale, meanwhile, macaque serum of follicular phase and middle-late luteal phase was collected to analyze the content of serum norepinephrine, dopamine, and 5-hydroxytryptamine.

Results: Compared with the normal control group, the scores of depression of the model group and the anger-in emotion group evaluated with emotional evaluation scale were significantly increased (P<0.01, P<0.05); while the score of the model group was significantly higher than that of the anger-in emotion group (P<0.05), and it returned to normal after Jingqianshu Granule treatment. As compared to the normal control group, serum monoamine neurotransmitter levels of the model group and the anger-in emotion group were increased (P<0.05, P<0.01), and the serum monoamine neurotransmitter levels of the model group were significantly higher than those of the anger-in emotion group (P<0.05), while there was no significant difference when compared with the normal control group after the treatment.

Conclusion: Anger-in emotion can induce liver-qi depression syndrome which is related to the changes in monoamine neurotransmitters.

Key words: anger, premenstrual syndrome, biogenic monoamines, liver-qi depression, Macaca mulatta

Figure 1

Score of scale of macaques in different groupA: Comparison of anger scores in 4 groups; B: Comparison of depression scores in 4 groups. Data are represented as $\bar{x}$±s, n=3; *P<0.05, **P<0.01, vs normal control group;△P<0.05, vs anger-in group. PMS: premenstrual syndrome."

Figure 2

Serum neurotransmitter contents in follicular phase of macaque in different groups A: Comparison of serum NE content among different groups; B: Comparison of serum DA content among different groups; C: Comparison of serum 5-HT content among different groups. Data are represented as $\bar{x}$±s, n=3; *P<0.05, **P<0.01, vs normal control group; △P<0.05, vs anger-in group. NE: norepinephrine; DA: dopamine; 5-HT: 5-hydroxytrytamine; PMS: premenstrual syndrome."

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