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Journal of Integrative Medicine ›› 2021, Vol. 19 ›› Issue (6): 469-477.doi: 10.1016/j.joim.2021.08.004

• Review •     Next Articles

Traditional Chinese medicine for prevention and treatment of hepatocellular carcinoma: A focus on epithelial-mesenchymal transition

Jia-jia Li, Qing Liang, Guang-chun Sun   

  1. Department of Pharmacy, Shanghai Fifth People’s Hospital, Fudan University, 801 Heqing Road, Shanghai 200240, China
  • Received:2020-12-17 Accepted:2021-04-21 Online:2021-11-12 Published:2021-12-21
  • Contact: Guang-chun Sun E-mail:sunguangchun@5thhospital.com

Hepatocellular carcinoma (HCC) is one of the most prevalent malignant cancers worldwide. Epithelialmesenchymal transition (EMT), which endows epithelial cells with mesenchymal properties, plays an important role in the early stages of metastasis. Conventional cancer therapies have promising effects, but issues remain, such as high rates of metastasis and drug resistance. Thus, exploring and evaluating new therapies is an urgent need. Traditional Chinese medicines (TCMs) have been acknowledged for their multi-target and coordinated intervention effects against HCC. Accumulating evidence indicates that TCM can inhibit the malignancy of cells and the progression of EMT in HCC. However, studies on the effects of TCM on EMT in HCC are scarce. In this review, we summarized recent developments in anti-EMT TCMs and formulae, focusing on their underlying pharmacological mechanisms, to provide a foundation for further research on the exact mechanisms through which TCM affects EMT in HCC.

Key words: Traditional Chinese medicine, Chinese medicine formulae, Hepatocellular carcinoma, Epithelial-mesenchymal transition, Metastasis, Cancer therap

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