苦参碱联合丹参注射液治疗轻中度慢性乙型肝炎的临床疗效分析

doi:10.3736/jcim20060622

Abstract

CLC Number:

R512.6+2

Xia Hu, Yue-jin Zhou, Qing-rong Xie, Xiao-cai Sun, Yang Xiao. Clinical observation of sophocarpidine combined with Salviae miltiorrhizae injection in treating chronic hepatitis B. Journal of Chinese Integrative Medicine, 2006, 4(6): 648-649.

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[2]	余小虎, 朱金水, 朱祖明 , 等. 氧化苦参碱抗肝纤维化作用的病理学研究[J]. 胃肠病学和肝病学杂志, 2004,13(5):485-487 doi: 10.3969/j.issn.1006-5709.2004.05.010
[3]	王晓春, 刘立鹏, 龙苏 . 血清透明质酸、Ⅳ型胶原、层粘蛋白水平与慢性乙型肝炎肝纤维化的关系[J]. 中国医师杂志, 2002,4(4):369-371
[4]	Liu J, Zhu M, Shi R , et al. Radix Sophorae flavescentis for chronic hepatiis B: a systematic review of randomized trial[J]. Am J Chin Med, 2003,31(3):337-354 doi: 10.1142/S0192415X03001107 pmid: 12943166
[5]	洪阁, 刘培勋, 魏永燕 . 氧化苦参碱抗肝纤维化的研究[J]. 天津药学, 2005,17(3):48-50 doi: 10.3969/j.issn.1006-5687.2005.03.026
[6]	宋健, 王丽莉, 朱墚 , 等. 氧化苦参碱对肝纤维化胶原代谢及其基因的影响[J]. 中华肝脏病杂志, 2003,11(11):697-699 doi: 10.3760/j.issn:1007-3418.2003.11.025
[7]	叶维法, 钟振义 . 肝病治疗学(第1版)[M]. 天津: 天津科学技术出版社, 1990,( 第1版):231
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[9]	蔡雄, 王国俊, 翟瑶 , 等. 苦参素注射液治疗慢性乙型肝炎临床疗效分析[J]. 第二军医大学学报, 1997,18(1):47-49 doi: 10.1007/BF02951625

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组别	n	TBIL复常率	ALT复常率
治疗组
第1个疗程	42	83.3 (35/42)	66.6 (28/42)
第2个疗程	42	92.9 (39/42)	95.2 (40/42)*
对照组
第1个疗程	40	60.0 (24/40)^△	75.0 (30/40)
第2个疗程	40	87.5 (35/40)*	95.0 (38/40)*

组别	n	HA	IV-C	LN
治疗组
治疗前	42	356.91±191.78	117.05±43.78	103.49±39.95
治疗后	42	145.48±92.46*^△	75.76±19.09*^△	80.84±41.81*^△
对照组
治疗前	40	306.46±161.80	87.21±33.43	94.43±30.61
治疗后	40	274.16±141.22	99.13±31.13	98.42±39.95

Clinical observation of sophocarpidine combined with Salviae miltiorrhizae injection in treating chronic hepatitis B

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