793例脂肪肝患者证候分布规律

doi:10.3736/jcim20090503

Abstract

Objective

To study the distribution pattern of traditional Chinese medicine (TCM) syndromes in fatty liver disease.
Methods

A multicenter and large sample survey was carried out by adopting the model of "combining disease with syndrome". A TCM syndrome information database was established by EPidata 3.1 software. The distribution pattern of TCM syndromes in fatty liver was studied by factor analysis and cluster analysis methods with SPSS 13.0 software.
Results

The basic syndromes of fatty liver included insufficiency of liver and kidney, flaring fire due to yin deficiency, liver-qi stagnation and spleen deficiency, spleen deficiency, spleen deficiency and dampness stagnation, mild syndrome of internal accumulation of damp-heat, blood stasis, severe syndrome of internal accumulation of damp-heat, and internal stagnation of phlegm-dampness. Single syndrome and combination of two to four basic syndromes were common in fatty liver disease. The syndrome of spleen deficiency and dampness stagnation was the most frequent one when its pathogenesis was simple, while the syndrome of insufficiency of liver and kidney was most frequent one when the pathogenesis was complicated. A total of 108 patients (13.6%) had no obvious symptoms, 46 patients (5.8%) were classified into the pattern of non-categorization, and the other patients were classified into five syndromes including phlegm accumulating with stagnation due to spleen deficiency (11.5%, 91/793), yin deficiency of liver and kidney (18.5%, 147/793), retention of phlegmatic dampness due to spleen deficiency (32.0%, 254/793), internal accumulation of damp-heat due to spleen deficiency (10.2%, 81/793), and damp obstruction due to liver-qi stagnation and spleen deficiency (8.3%, 66/793).
Conclusion

Multi-element analysis reveals the distribution pattern of TCM syndromes in fatty liver disease, which is worthy of further study. The basic pathogenesis is spleen deficiency, and has a close correlation with the liver and kidney. The main pathogenesis factors are phlegm, dampness, blood stasis, heat and liver-qi stagnation. Yin deficiency of liver and kidney is a typical syndrome in fatty liver disease.

Key words: Fatty liver, Syndrome, Epidemiological method, Multivariate analysis

Hua-feng Wei, Tao Liu, Lian-jun Xing, Pei-yong Zheng, Guang Ji. Distribution pattern of traditional Chinese medicine syndromes in 793 patients with fatty liver disease. Journal of Chinese Integrative Medicine, 2009, 7(5): 411-417.

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URL: http://www.jcimjournal.com/EN/10.3736/jcim20090503

http://www.jcimjournal.com/EN/Y2009/V7/I5/411

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References 9

[1]	Wei HF, Ji G, Xing LJ . Rudimental investigation on fatty liver syndrome differentiation typing law[J]. Liaoning Zhong Yi Za Zhi, 2002,29(11):655-656
	魏华凤, 季光, 邢练军 . 脂肪肝辨证分型规律的初步研究[J]. 辽宁中医杂志, 2002,29(11):655-656
[2]	Feng MH, Du FB . Study progress and thinking about Chinese medicine for the treatment of fatty liver[J]. Hunan Zhong Yi Yao Dao Bao, 2004,10(5):61-63
	冯明辉, 杜发斌 . 脂肪肝中医药研究现状和思考[J]. 湖南中医药导报, 2004,10(5):61-63
[3]	Wang BX. Hepatobiliary diseases of traditional Chinese medicine[M]. Beijing: China Medical-Pharmaceutical Science and Technology Publishing House,1993: 438
	王伯祥 . 中医肝胆病学[M]. 北京: 中国医药科技出版社,1993: 438
[4]	Fatty Liver and Alcoholic Liver Committee of Chinese Society of Hepatology. Diagnostic criteria for non-alcoholic fatty liver[J]. Gan Zang, 2004,7(4):W002
	中华肝脏病学会脂肪肝和酒精性肝病学组. 非酒精性脂肪肝诊断标准[J]. 肝脏, 2004,7(4):W002
[5]	Wang JL. Clinical epidemiology(2nd ed)[M]. Shanghai: Shanghai Scientific and Technical Publishers, 2001,( 2nd ed):202
	王家良 . 临床流行病学(第2版)[M]. 上海: 上海科学技术出版社, 2001,( 第2版):202
[6]	Wang YY. Internal medicine of traditional Chinese medicine(2nd ed)[M]. Shanghai: Shanghai Scientific and Technical Publishers,1997,(2nd ed)
	王永炎 . 中医内科学(第2版)[M]. 上海: 上海科学技术出版社,1997,(第2版)
[7]	Deng TT. Diagnostics of traditional Chinese medicine[M]. Shanghai: Shanghai Scientific and Technical Publishers,1984
	邓铁涛 . 中医内科学[M]. 上海: 上海科学技术出版社,1984
[8]	Chen XY, Huang BQ, Zhu WF . Characteristics of syndrome factors in the diseases with energy deficiency[J]. Zhongguo Zhong Yi Yao Za Zhi, 2005,3(9):911-914
	陈新宇, 黄碧群, 朱文锋 . 正虚类病性证素的特征[J]. 中国中医药杂志, 2005,3(9):911-914
[9]	Wang YY, Zhang QM, Zhang ZB . The induction of syndrome factor and affecting target[J]. Shandong Zhong Yi Yao Da Xue Xue Bao, 2006,30(1):6-7
	王永炎, 张启明, 张志斌 . 证候要素及其靶位的提取[J]. 山东中医药大学学报, 2006,30(1):6-7

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Symptom	Component
Symptom	1	2	3	4	5	6	7	8	9	10
Afternoon fever		0.744
Hectic fever and tidal fever		0.851
Night sweats		0.577
Yellowish body and eyes								0.873
Tinnitus and deafness										0.678
Distending pain in hypochondrium					0.545
Dull pain of hypochondrium		0.420
Wandering pain			0.659
Fixed pain							0.909
Abdominal pain							0.880
Fullness of stomach and abdomen				0.475	0.568
Abdominal distension					0.623
Nausea and vomiting					0.642
Sour regurgitation			0.871
Belching			0.893
Anorexia					0.707
Tired of grease	0.434
Fatigue and weakness				0.459	0.520
Expectoration									0.823
Aching and weakness of waist and knees	0.729
Heel pain	0.732
Reddish swollen and painful eyes						0.885
Blurred vision	0.775
Dryness of eyes	0.762
Depression and sighing			0.695
Surprise and fear readily	0.616
Forgetfulness	0.715
Yellow urine								0.797
Frequent urination	0.585					0.404
Loose stools			0.436	0.441
Constipation								0.738
Halitosis						0.792
Pale-grayish complexion	0.538	0.534
Red face	0.570
Sallow complexion				0.740
Tongue with ecchymoses							0.865
Thin, whitish and greasy tongue fur					0.416				0.495
Thin, yellowish and greasy tongue fur						0.513		0.445
Yellow greasy fur							0.563
Scanty fur	0.517	0.600
Tongue with scanty fluid						0.401
Corpulent and tender tongue				0.836
Teeth-marked tongue				0.873
Prickled tongue						0.767
Thin tongue		0.668

Syndrome factor combination	Factor 1	Factor 2	Factor 3	Factor 4	Factor 5	Factor 6	Factor 7	Factor 8	Factor 9
One factor	16	12	8	19	37	6	18	8	12
Two factors	64	40	45	26	84	37	34	33	29
Three factors	83	65	68	29	75	53	29	40	44
Four factors	79	48	54	20	48	45	46	48	48
Five factors	20	19	18	3	13	18	16	7	11
Six factors	3	3	3	0	1	3	3	0	2
Total	265	187	196	97	258	162	146	136	146

Cluster	Regression factor score
Cluster	1	2	3	4	5
Regression factor score 1 for analysis 1	0.41	1.07	0.33	0.14	0.59
Regression factor score 2 for analysis 1	0.33	0.77	0.15	0.31	0.36
Regression factor score 3 for analysis 1	0.15	0.19	0.21	0.51	2.32
Regression factor score 4 for analysis 1	0.31	0.22	0.46	0.83	0.61
Regression factor score 5 for analysis 1	0.70	0.35	0.22	1.94	0.73
Regression factor score 6 for analysis 1	0.35	0.27	0.32	0.69	0.30
Regression factor score 7 for analysis 1	2.25	0.12	0.09	0.02	0.20
Regression factor score 8 for analysis 1	0.36	0.49	0.28	0.56	0.29
Regression factor score 9 for analysis 1	0.69	0.53	0.47	0.78	0.36
Regression factor score 10 for analysis 1	0.47	1.39	0.20	0.64	0.59

Distribution pattern of traditional Chinese medicine syndromes in 793 patients with fatty liver disease

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