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Journal of Chinese Integrative Medicine ›› 2010, Vol. 8 ›› Issue (10): 944-948.doi: 10.3736/jcim20101005

Special Issue: Traditional Chinese Medicine

• Original Clinical Research • Previous Articles     Next Articles

Application of voice signal collection and analysis in traditional Chinese medicine syndrome differentiation of deficiency and excess

 Chun-feng Chena, Yi-qinWanga, Jian-junYanb, YongShenb,Ling-yunChena   

  1. a College of Basic Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
    b School of Mechanical and Power Engineering, East China University of Science and Technology, Shanghai 200237, China
  • Received:2010-01-20 Accepted:2010-05-18 Online:2010-10-20 Published:2010-10-15


To provide more objective basis for traditional Chinese medicine (TCM) syndrome differentiation of deficiency and excess by collecting and analyzing voice signals and extracting characteristic parameters.

All of 308 samples including 150 samples of qi-deficiency, 52 yin-deficiency, 55 excess and 51 normal were collected by “Voice Collecting System of TCM” and analyzed by wavelet packet transform (WPT) combined with approximate entropy (ApEn). The characteristic parameters with remarkable differences were chosen as input vectors for support vector machine (SVM) classifier to obtain classification results.

Comparison between the normal and non-healthy showed that ApEn values of several nodes in 2 to 3 kHz, 3.5 to 4 kHz and 5 to 8 kHz frequencies were significantly different (P≤0.05); comparison between the deficiency and excess showed that ApEn values of several nodes in 0 to 2.5 kHz and 6 to 6.5 kHz frequencies were significantly different (P≤0.05); comparison between the qi-deficiency and yin-deficiency showed that ApEn values of node in 2 to 4 kHz frequency were significantly different(P≤0.05). The outputs of SVM showed that accuracies of samples in each group had good classification results by analyzing the ApEn values in different frequencies through WPT.

The methods of voice collection and analysis used in the auscultation of TCM can provide objective basis for syndrome differentiation of deficiency and excess.

Key words: Auscultation, Signal processing, Computer-assisted, Deficiency and excess

[1] State Bureau of Technical and Quality Supervision. Clinical terminology of traditional Chinese medical diagnosis and treatment — Syndromes[M]. Beijing: Standards Press of China,1997: 2-14
国家技术监督局. 中华人民共和国国家标准:中医临床诊疗术语证候部分[M]. 北京: 中国标准出版社,1997: 2-14
[2] Zhu WF. Diagnostics of traditional Chinese medicine[M]. Shanghai: Shanghai Scientific and Technnical Publishers,2006: 51-52
朱文锋 . 中医诊断学[M]. 上海: 上海科学技术出版社,2006: 51-52
[3] Hong B, Tang QY . ApEn and cross-ApEn: property, fast algorithm and preliminary application to the study of EEG and cognition[J]. Xin Hao Chu Li, 1999,15(2):100-108
doi: 10.1016/B978-008043005-8/50007-X
洪波, 唐庆玉 . 近似熵、互近似熵的性质、快速算法及其在脑电与认知研究中的初步应用[J]. 信号处理, 1999,15(2):100-108
doi: 10.1016/B978-008043005-8/50007-X
[4] Liu J, Guo L, Nie JX .Novel algorithm for designing classifier based on SVM[J].Ji Suan Ji Ying Yong Yan Jiu, 2006, 7: 181
doi: 10.3969/j.issn.1001-3695.2006.07.063
刘晶, 郭雷, 聂晶鑫 .基于SVM的一种新的分类器设计方法[J].计算机应用研究, 2006, 7: 181
doi: 10.3969/j.issn.1001-3695.2006.07.063
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