Search JIM Advanced Search

Journal of Chinese Integrative Medicine ›› 2006, Vol. 4 ›› Issue (2): 152-155.doi: 10.3736/jcim20060209

• Original Clinical Research • Previous Articles     Next Articles

Evaluation of therapeutic effects of Chinese materia medica by tongue image analysis software 1.0 based on tongue colors

Feng-lan Zhu1, Chao Gu1, Zhi-feng Zhang2, Chang-le Zhou3, Jia-tuo Xu2, Xiao-gu Liu2, Wen-shu Li4, Hui-qing Zhu1   

  1. 1. Department of Internal Medicine, Taicang First People’s Hospital, Taicang, Jiangsu Province 215400, China
    2. School of Basic Medical Science, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
    3. School of Computer and Information Engineering, Xiamen University, Xiamen, Fujian Province 361005, China
    4. School of Computer Science, Zhejiang University, Hangzhou, Zhejiang Province 310027, China
  • Online:2006-03-20 Published:2006-03-15

Objective

To evaluate the therapeutic effects of Chinese materia medica in treating patients with different syndromes by tongue image analysis software 1.0 based on tongue colors, and to discuss the feasibility of applying this computer science-based techniques into drug evaluation.

Methods

The tongue colors and the areas of tongue fur were examined and analyzed by the tongue image analysis software 1.0 in healthy persons and the patients with different syndromes before and after treatment. The parameters of tongue colors consisted of the followings: the hue (H), the lightness (L), the saturation (S), and the values of red (R), green (G) and blue (B).

Results

Obvious differences could be revealed in tongue color index between the healthy persons and the patients in five groups of different syndromes. There also existed some significant differences in those index between patients before and after treatment.

Conclusion

The tongue image analysis software 1.0 based on tongue colors is helpful to evaluate the therapeutic effects of Chinese materia medica.

Key words: Tongue color, Image processing, Computer-assisted, Chinese materia medica, Drug evaluation, Treatment outcome

CLC Number: 

  • R241.25

Table 1

Comparisons of tongue colors among normal control group and five groups of different syndromes before treatment (ヌ±S)"

Group n R G B H L S
Normal control 51 115.41±10.74 168.41±11.33 114.83±10.44 2.11±0.06 146.51±10.49 0.15±0.02
Syndrome of blood stasis 41 119.92±11.81 171.12±11.22 118.02±11.07 2.12±0.07 149.72±10.92 0.14±0.02
Syndrome of deficiency of both heart and spleen 22 109.53±10.64*△■ 164.11±12.83 116.03±18.49 2.21±0.30* 142.33±11.42 0.16±0.04*
Syndrome of deficiency of kidney-yin 20 109.52±9.93*△■ 168.79±9.50 105.41±10.03*△▲ 2.01±0.06 143.81±9.09△■ 0.18±0.03*△▲
Syndrome of excessive heat of stomach and intestine 20 100.63±13.88* 157.71±12.05* 102.72±13.24*△▲ 2.12±0.13 134.29±12.29*△▲ 0.18±0.03*△▲
Syndrome of deficiency of kidney-yang 22 115.54±10.52 167.13±13.27 115.81±8.93□■ 2.13±0.06 145.81±11.67 0.14±0.02□■

Table 2

Comparisons of tongue colors among five groups of different syndromes before and after treatment (ヌ±S)"

Group n R G B H L S
Syndrome of blood stasis
Before treatment 41 119.91±11.81 171.11±11.22 118.02±11.07 2.11±0.07 149.71±10.92 0.14±0.02
After 2 weeks of treatment 41 118.52±14.51 171.62±13.80 116.41±13.73 2.13±0.05 149.52±13.70 0.15±0.02
After 4 weeks of treatment 41 117.41±14.80 170.61±14.41 116.13±14.6 2.14±0.06 148.54±14.30 0.15±0.02
Syndrome of deficiency of both heart and spleen
Before treatment 22 109.52±10.64 164.12±12.83 116.04±18.49 2.23±0.30 142.31±11.42 0.16±0.04
After 2 weeks of treatment 22 106.72±9.02 162.02±9.70 109.02±9.91 2.12±0.08 139.42±9.00 0.16±0.02
After 4 weeks of treatment 22 103.64±11.20 160.01±11.13* 105.61±10.83 2.14±0.06 136.91±10.82 0.17±0.02
Syndrome of deficiency of kidney-yang
Before treatment 22 115.52±10.52 167.12±13.27 115.81±8.93 2.11±0.06 145.82±11.67 0.14±0.02
After 2 weeks of treatment 22 111.41±12.51 164.62±12.61 111.03±11.40 2.11±0.06 142.62±12.20 0.15±0.02
After 4 weeks of treatment 22 109.64±12.71 162.13±12.61 108.61±10.90* 2.11±0.06 140.31±12.20 0.15±0.02
Syndrome of deficiency of kidney-yin
Before treatment 20 109.50±9.93 168.81±9.50 105.41±10.03 2.01±0.06 143.82±9.09 0.18±0.03
After 2 weeks of treatment 20 117.11±12.60* 173.62±13.02 113.02±9.52* 2.02±0.07 149.81±12.31 0.16±0.02*
After 4 weeks of treatment 20 119.44±10.20* 176.31±11.23* 115.92±8.80* 2.01±0.07 152.44±10.32* 0.16±0.02*
Syndrome of excessive heat of stomach and intestine
Before treatment 20 100.62±13.88 157.71±12.05 102.72±13.24 2.12±0.13 134.32±12.29 0.18±0.03
After 2 weeks of treatment 20 110.73±15.52* 166.62±14.81* 109.02±16.41 2.11±0.08 143.34±14.91* 0.17±0.03

Table 3

Changes of tongue fur areas in syndrome of deficiency of kidney-yin group and syndrome of excessive heat of stom-ach and intestine group before and after treatment (ヌ±S)"

Group n Tongue fur area /
tongue area (%)
Syndrome of deficiency of kidney-yin
Before treatment 20 26.76±26.45
After 2 weeks of treatment 20 30.62±25.06
Syndrome of excessive heat of stomach and intestine
Before treatment 20 56.53±20.85
After 2 weeks of treatment 20 39.42±21.64**
[1] 阮秋琦 . 数字图像处理学(第1版)[M]. 北京: 电子工业出版社,2001,(第1版):
[2] 何斌, 马天予, 王运坚 , 等. Visual C++数字图像处理(第1版)[M]. 北京: 人民邮电出版社,2001,(第1版):
[1] Arthur de Sá Ferreira, Antonio Guilherme Pacheco. SimTCM: A human patient simulator with application to diagnostic accuracy studies of Chinese medicine. Journal of Integrative Medicine, 2015, 13(1): 9-19.
[2] Feng-bin Liu, Zheng-kun Hou, Yun-ying Yang, Pei-wu Li, Qian-wen Li, Nelson Xie, Jing-wei Li, Xiang-jing Zeng. Literature review and analysis of the application of health outcome assessment instruments in Chinese medicine. Journal of Chinese Integrative Medicine, 2013, 11(3): 157-167.
[3] Arthur de Sá Ferreira. Promoting integrative medicine by computerization of traditional Chinese medicine for scientific research and clinical practice: The SuiteTCM Project. Journal of Chinese Integrative Medicine, 2013, 11(2): 135-139.
[4] Jian-sheng Li, Ya Li, Su-yun Li, Yuan-yuan Wang, Li Deng, Yan-ge Tian, Su-li Jiang , Ying Wang. Long-term effects of Tiaobu Feishen therapies on systemic and local inflammation responses in rats with stable chronic obstructive pulmonary disease. Journal of Chinese Integrative Medicine, 2012, 10(9): 1039-1048.
[5] Zhao-lan Liu, Qing Li , Yu-jie Mu , Ying Gao, Jian-ping Liu. Using nested case-control study to appraise the effectiveness of Chinese medicines in the treatment of diabetic nephropathy. Journal of Chinese Integrative Medicine, 2012, 10(9): 991-996.
[6] Zhang-ling Zhou, Cheng-xin Li, Yue-bo Jiang, Cong Zuo, Yun Cai, Rui Wang. Correlation between facial nerve functional evaluation and efficacy evaluation of acupuncture treatment for Bell’s palsy. Journal of Chinese Integrative Medicine, 2012, 10(9): 997-1002.
[7] Wei-hua Xu, Ze-huai Wen, Wei-xiong Liang, Qi Wang. A review of research on the development of instruments for therapeutic efficacy evaluation of traditional Chinese medicine. Journal of Chinese Integrative Medicine, 2012, 10(7): 726-737.
[8] Li-xin Ma, Yu-yi Wang, Xin-xue Li, Jian-ping Liu . Systematic review on methodology of randomized controlled trials of post-marketing Chinese patent drugs for treatment of type 2 diabetes. Journal of Chinese Integrative Medicine, 2012, 10(3): 279-292.
[9] Yan-bo Zhu , Hideki Origasa, Xiao-xia Luo, Yang-yang Wang , Jie Di , Lin Lin. Responsiveness of three subjective report of outcome measures for chronic heart failure. Journal of Chinese Integrative Medicine, 2012, 10(12): 1375-1381.
[10] Ying Xu , Chang-chun Zeng , Xiu-yu Cai , Rong-ping Guo , Guang Nie , Ying Jin. Chromaticity and optical spectrum colorimetry of the tongue color in different syndromes of primary hepatic carcinoma. Journal of Chinese Integrative Medicine, 2012, 10(11): 1263-1271.
[11] Jie-ning Wang, Sheng Ye, Dong-hai Yu, Hui Zhao, Le-yi Du. Practice and exploration on clinical evaluations of hospital-made Chinese herbal formulas in the Pudong New Area of Shanghai. Journal of Chinese Integrative Medicine, 2012, 10(10): 1084-1087.
[12] Yan-ming Xie, Xing Liao, Yong-yan Wang. Introduce the idea of comparative effectiveness research to clinical research of Chinese medicine. Journal of Chinese Integrative Medicine, 2011, 9(8): 813-818.
[13] Meng Kong, Chang-chun Zeng, You-zhang Liu, Song-hao Liu . Quantitative analysis and classification of tongue inspection based on the visible reflection spectrum. Journal of Chinese Integrative Medicine, 2011, 9(1): 29-35.
[14] the Project Group for Demonstration Study of Syndrome Differentiation Protocol Effect Evaluation of Acute Ischemic Stroke, Yan Huang, Jian-wen Guo. Outcome and safety assessment of an herbal medicine treatment protocol for yin pattern of acute ischemic stroke. Journal of Chinese Integrative Medicine, 2010, 8(5): 417-426.
[15] Feng Tian , Yan-ming Xie. Real-world study: A potential new approach to effectiveness evaluation of traditional Chinese medicine interventions. Journal of Chinese Integrative Medicine, 2010, 8(4): 301-306.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
[1] Jin-zhou Tian, Jing Shi, Xin-qing Zhang, Qi Bi, Xin Ma, Zhi-liang Wang, Xiao-bin Li, Shu-li Shen, Lin Li, Zhen-yun Wu, Li-yan Fang, Xiao-dong Zhao, Ying-chun Miao, Peng-wen Wang, Ying Ren, Jun-xiang Yin, Yong-yan Wang, Beijing United Study Group on MCI of the Capital Foundation of Medical Developments. An explanation on "guiding principles of clinical research on mild cognitive impairment (protocol)". Journal of Chinese Integrative Medicine, 2008, 6(1): 15-21
[2] Li Zhou, Hong-xing Zhang, Ling-guang Liu, Wen-jun Wan. Effect of electro-acupuncture at Fenglong (GV 16) on nitric oxide and endothelin in rats with hyperlipidemia. Journal of Chinese Integrative Medicine, 2008, 6(1): 89-92
[3] Daniel Weber, Janelle M Wheat, Geoffrey M Currie. Inflammation and cancer: Tumor initiation, progression and metastasis,and Chinese botanical medicines. Journal of Chinese Integrative Medicine, 2010, 8(11): 1006-1013
[4] Tao Wang , Feng Qin. Effects of Chinese herbal medicine Xiaoyao Powder on monoamine neurotransmitters in hippocampus of rats with postpartum depression. Journal of Chinese Integrative Medicine, 2010, 8(11): 1075-1079
[5] Kishan Lal Tiwari, Shailesh Kumar Jadhav, Veenu Joshi. An updated review on medicinal herb genus Spilanthes. Journal of Chinese Integrative Medicine, 2011, 9(11): 1170-1178
[6] Li-ke Guo, Chao-xian Zhang, Xiao-feng Guo. Acupuncture combined with Chinese herbal medicine Plantain and Senna Granule in treatment of functional constipation: A randomized, controlled trial. Journal of Chinese Integrative Medicine, 2011, 9(11): 1206-1214
[7] Liang-ping Hu , Xiao-lei Bao, Qi Wang . Statistical inference and experimental design of univariate quantitative data of paired design. Journal of Chinese Integrative Medicine, 2010, 8(12): 1195-1198
[8] Mei-jun Lü, Hui-yong Zhang, Zhe Zhang, Guan-lin Yang. Measurement of health-related quality of life in coronary heart disease: A review. Journal of Chinese Integrative Medicine, 2011, 9(12): 1277-1285
[9] Shuo Zhang , Hong-cai Shang. Correlation between traditional Chinese medicine syndromes and omics: A literature review. Journal of Chinese Integrative Medicine, 2011, 9(12): 1286-1291
[10] Qin-hui Fu, Jian Pei, Jian-rong Hui, Yi Song . Studies on dynamic changes in traditional Chinese medicine syndrome patterns for stroke using data-driven and model-driven approaches: A review. Journal of Chinese Integrative Medicine, 2011, 9(12): 1292-1300