基于药性构成“三要素”数理分析模式的中药寒热药性生物学表征差异研究

doi:10.3736/jcim20110704

Abstract

Objective: The properties of Chinese materia medica are believed to be the summarization of the effects of biological performance on the various body states. Systemic discussion of chemical-factor elements, body-condition elements, biological-performance elements and their interrelationships is needed for research into the properties of Chinese materia medica. Following the practical characteristics of Chinese medicine, the three-element mathematical model was formed by introducing some mathematical concepts and methods and was used to study the cold or hot property of Chinese medicine, and to investigate the difference in biological performances of the two properties.
Methods: By using the concept of different functionality of Chinese medicine on abnormal states and the idea of interaction in mathematics, the effects of chemical-factor elements and body-condition elements were normalized to the amount of biological performance which was represented by some important indicators. The three-element mathematical model was formed with scatter plots through four steps, including effect separation, intensity calculation, frequency statistics and relevance analysis. A comparison pharmacology experiment of administration of hot property medicines, Fuzi (Radix Aconiti Lateralis Preparata) and Rougui (Cortex Cinnamomi), and cold property medicines, Huangbai (Cortex Phellodendri) and Zhizi (Fructus Gardeniae) on normal and glucocorticoid-induced yang-deficiency and yin-deficiency states was designed. The results were analyzed by the mathematical model. The scatter plots were the main output of model analysis. The expression of cold property and hot property was able to be quantified by frequency distribution of biological indexes of administrations on yang-deficiency and yin-deficiency states in the “efficacy zone” and “toxicity zone” of the plots and by the relevance analysis.
Results: The ratios of biological indicator frequency in the “efficacy zone” of administrations on yang-deficiency state and yin-deficiency state were 7∶3 for Fuzi, 3∶3 for Rougui, 4∶4 for Huangbai and 1∶5 for Zhizi. The sums of the biological indicator frequency in the “toxicity zone” of administration on the two states were 4 for Fuzi, 0 for Rougui, 2 for Huangbai and 4 for Zhizi. The relevance analysis showed that the order from Fuzi, Rougui, Huangbai to Zhizi was proportional to the change from “be true of yang-deficiency state” to “be true of yin-deficiency state”. The extent of the hot property decreased while that of the cold property increased in the order of Fuzi, Rougui, Huangbai and Zhizi. The stronger the efficacy of above medicines is, the more obvious the toxicity displayed.
Conclusion: The three-element mathematical model employed in this study is effectively capable of explaining the different biological expressions between hot property medicines and cold property medicines. This suggests that it may provide a mathematical tool and theoretical basis for the modern interpretation of cold property and hot property of Chinese medicine, and provide new ideas for further studing into the essence of Chinese medicine property theory.

Key words: cold (TCD), hot (TCD), four natures (TCD), models,theoretical, biological performance

Rui Jin, Bing Zhang, Xiao-qing Liu, Sen-mao Liu, Xin Liu, Lian-zhen Li, Qian Zhang, Chun-miao Xue. Study of biological performance of Chinese materia medica with either a cold or hot property based on the three-element mathematical analysis model. Journal of Chinese Integrative Medicine, 2011, 9(7): 715-724.

/ / Recommend

Add to citation manager EndNote| Reference Manager|ProCite|BibTeX|RefWorks

URL: http://www.jcimjournal.com/EN/10.3736/jcim20110704

http://www.jcimjournal.com/EN/Y2011/V9/I7/715

TrendMD

Figures/Tables 11

Table 1

Table 2

Table 3

Table 4

Figure 1

Figure 2

Figure 3

Figure 4

Table 7

References 15

[1]	Zhang B, Lin ZJ, Zhai HQ, Huang JM . Research of traditional Chinese medicine theory based on “three-element” hypojournal[J]. Zhongguo Zhong Yao Za Zhi, 2008,33(2):221-223
	张冰, 林志健, 翟华强, 黄建梅 . 基于“三要素”假说研究中药药性的设想[J]. 中国中药杂志, 2008,33(2):221-223
[2]	Liang MX, Fan Y . Research on “four properties” of Chinese herb: current status, problems and countermeasures[J]. Zhonghua Zhong Yi Yao Za Zhi, 2008,23(7):565-568
	梁茂新, 范颖 . 中药四性研究的现状、问题和对策[J]. 中华中医药杂志, 2008,23(7):565-568
[3]	Zhang B, Zhai HQ, Lin ZJ, Ni L . A discussion on formation of Chinese medicine property theory based on three-element idea[J]. Beijing Zhong Yi Yao Da Xue Xue Bao, 2007,30(10):656-657
	张冰, 翟华强, 林志健, 倪莉 . 从“三要素”理念探讨中药药性之核心构成[J]. 北京中医药大学学报, 2007,30(10):656-657
[4]	Gao XM. Science of Chinese materia medica(senior Chinese medicine books)[M]. Beijing: People’s Medical Publishing House,2000:46- 50, 801-805
	高学敏 .中药学( 中医药学高级丛书)[M]. 北京: 人民卫生出版社,2000:46- 50, 801-805
[5]	Zheng JS. Related historical process of development of Chinese medicine[M]. Guilin: Guangxi Normal University Press, 2007: 35
	郑金生 . 药林外史[M]. 桂林: 广西师范大学出版社, 2007: 35
[6]	Jin R, Lin Q, Liu SM, Zhao Q, Zhang Q, Zhang B . Mathematical analysis of the relationship between yang-deficiency syndrome in traditional Chinese medicine and its objective indicators in clinical literature[J]. J Chin Integr Med, 2010,8(7):678-683 doi: 10.3736/jcim20100712
	金锐, 林茜, 刘森茂, 赵茜, 张倩, 张冰 . 基于数学方法的中医“阳虚证”与临床文献中客观指标的关联分析[J]. 中西医结合学报, 2010,8(7):678-683 doi: 10.3736/jcim20100712
[7]	Jin R, Zhang B, Liu SM, Ni L, Li M, Li LZ . Mathematical analysis of characteristics of glucocorticoid-induced yang deficiency or yin deficiency syndrome in animal models based on information entropy theory[J]. J Chin Integr Med, 2011,9(1):15-21
	金锐, 张冰, 刘森茂, 倪莉, 李敏, 李连珍 . 基于数据信息熵探讨糖皮质激素诱导的阳虚或阴虚证候动物模型的状态特征[J]. 中西医结合学报, 2011,9(1):15-21
[8]	Zheng Y, Wen GY. Mathematical models[M]. Harbin: Northeast Forestry University Press,2006: 1-8
	郑煜, 温广玉 . 数学模型[M]. 哈尔滨: 东北林业大学出版社,2006: 1-8
[9]	Kimura M. Translated by Cui Z.Pharmacology of Chinese prescription[M]. Beijing: China Medical Science and Technology Press, 2006: 15-19
	木村正康 . 崔征 , 译.汉方药理学[M]. 北京: 中国医药科技出版社, 2006: 15-19
[10]	Spiegel MR, Stephens LJ. Statistics.3rd ed . [M]. Translated by Yang JL, Du XL, Yao Y, Zhao YY, Liang ZB. Beijing: Science Press, 2002: 275-277
	Spiegel MR, Stephens LJ. 统计学.第 3 版.杨纪龙, 杜秀丽,姚奕,赵媛媛,梁志彬,译.北京:科学出版社. 2002: 275-277.
[11]	Wu JR, Zhang B, Zhang GM . Development of pharmacology research for Cortex Phellodendri Chinsis[J]. Ya Tai Chuan Tong Yi Yao, 2009,5(11):160-162
	吴嘉瑞, 张冰, 张光敏 . 黄柏药理作用研究进展[J]. 亚太传统医药, 2009,5(11):160-162
[12]	Yang HJ, Fu MH, Wu ZL, Liang RX, Huang LQ, Fang J, Li G, Cao Y . Experimental studies on hepatotoxicity of rats induced by Fructus Gardeniae[J]. Zhongguo Zhong Yao Za Zhi, 2006,31(13):1091-1093 doi: 10.3321/j.issn:1001-5302.2006.13.017
	杨洪军, 付梅红, 吴子伦, 梁日欣, 黄璐琦, 方婧, 李耿, 曹莹 . 栀子对大鼠肝毒性的实验研究[J]. 中国中药杂志, 2006,31(13):1091-1093 doi: 10.3321/j.issn:1001-5302.2006.13.017
[13]	Li DF. Guide of statistical software: SAS system and S language[M]. Beijing: People’s Posts & Telecommunications Publishing House, 2006: 155-156
	李东风 . 统计软件教程: SAS系统与S语言[M]. 北京: 人民邮电出版社, 2006: 155-156
[14]	Wang XH. Basic theory of traditional Chinese medicine(senior Chinese medicine books)[M]. Beijing: People’s Medical Publishing House, 2001: 91-97
	王新华 . 中医基础理论(中医药学高级丛书)[M]. 北京: 人民卫生出版社, 2001: 91-97
[15]	Kuang HX, Cheng W . Studies on the capability of properties and flavors of Chinese medicine to be split and combined[J]. Shi Jie Ke Xue Ji Shu Zhong Yi Yao Xian Dai Hua, 2009,11(6):768-770
	匡海学, 程伟 . 中药性味的可拆分性、可组合性研究[J]. 世界科学技术——中医药现代化, 2009,11(6):768-770

Metrics

Viewed

Full text

Abstract

Cited

Shared

Discussed

Comments

Recommended 10

[1]	Wei-xiong Liang. Problems-solving strategies in clinical treatment guideline for traditional Chinese medicine and integrative medicine. Journal of Chinese Integrative Medicine, 2008, 6(1): 1-4
[2]	Zhao-guo Li. Discussion on English translation of commonly used sentences in traditional Chinese medicine: part one. Journal of Chinese Integrative Medicine, 2008, 6(1): 107-110
[3]	Jun Hu, Jian-ping Liu. Non-invasive physical treatments for chronic/recurrent headache. Journal of Chinese Integrative Medicine, 2008, 6(1): 31
[4]	Xue-mei Liu, Qi-fu Huang, Yun-ling Zhang, Jin-li Lou, Hong-sheng Liu, Hong Zheng. Effects of Tribulus terrestris L. saponion on apoptosis of cortical neurons induced by hypoxia-reoxygenation in rats. Journal of Chinese Integrative Medicine, 2008, 6(1): 45-50
[5]	. Uniform requirements for manuscripts submitted to biomedical journals: Writing and editing for biomedical publication (Chinese version, part two). Journal of Chinese Integrative Medicine, 2010, 8(11): 1001-1005
[6]	Daniel Weber, Janelle M Wheat, Geoffrey M Currie. Inflammation and cancer: Tumor initiation, progression and metastasis,and Chinese botanical medicines. Journal of Chinese Integrative Medicine, 2010, 8(11): 1006-1013
[7]	Hong Liu , Guo-liang Zhang, Li Shen , Zhen Zeng, Bao-luo Zhou, Cheng-hai Liu, Guang Nie . Application and evaluation of a pseudotyped virus assay for screening herbs for anti-H5Nl avian influenza virus. Journal of Chinese Integrative Medicine, 2010, 8(11): 1036-1040
[8]	Zhao-guo Li . A discussion of English translation of 1995 and 1997 Chinese National Standards of Traditional Chinese Medical Terminologies for Clinical Diagnosis and Treatment. Journal of Chinese Integrative Medicine, 2010, 8(11): 1090-1096
[9]	Rui Jin, Bing Zhang. A complexity analysis of Chinese herbal property theory: the multiple formations of herbal property (Part 1). Journal of Chinese Integrative Medicine, 2012, 10(11): 1198-1205
[10]	Hui-min Liu, Xian-bo Wang, Yu-juan Chang, Li-li Gu. Systematic review and meta-analysis of randomized controlled trials of integrative medicine therapy for treatment of chronic severe hepatitis. Journal of Chinese Integrative Medicine, 2012, 10(11): 1211-1228

Chemical-factor		Body-condition
	Yang-deficiency	Normal	Yin-deficiency
Control	√	√	√
A	√	√	√
B	√	√	√
C	√	√	√
D	√	√	√

Group	Mean value	Standard deviation	Number of animals
Normal	x₁	s₁	n
Normal+A	x₂	s₂	n
Yang-deficiency	x₃	s₃	n
Yang-deficiency+A	x₄	s₄	n
Yin-deficiency	x₅	s₅	n
Yin-deficiency+A	x₆	s₆	n

Group	n	Administration method
Group	n	1-21 days	15-21 days
Normal group
Administration 1	10	—	Radix Aconiti Lateralis Preparata water decoction (12.0 g/kg body weight)
Administration 2	10	—	Cortex Cinnamomi Cassiae water decoction (30.0 g/kg body weight)
Administration 3	10	—	Cortex Phellodendri Amurensis water decoction (5.0 g/kg body weight)
Administration 4	10	—	Fructus Gardeniae water decoction (2.0 g/kg body weight)
Yang-deficiency group
Administration 5	10	Hydrocortisone sodium succinate (20.0 mg/kg body weight)	Radix Aconiti Lateralis Preparata water decoction (12.0 g/kg body weight)
Administration 6	10	Hydrocortisone sodium succinate (20.0 mg/kg body weight)	Cortex Cinnamomi Cassiae water decoction (30.0 g/kg body weight)
Administration 7	10	Hydrocortisone sodium succinate (20.0 mg/kg body weight)	Cortex Phellodendri Amurensis water decoction (5.0 g/ kg body weight)
Administration 8	10	Hydrocortisone sodium succinate (20.0 mg/kg body weight)	Fructus Gardeniae water decoction (2.0 g/kg body weight)
Yin-deficiency group
Administration 9	10	Dexamethasone acetate (0.35 mg/kg body weight)	Radix Aconiti Lateralis Preparata water decoction (12.0 g/kg body weight)
Administration 10	10	Dexamethasone acetate (0.35 mg/kg body weight)	Cortex Cinnamomi Cassiae water decoction (30.0 g/kg body weight)
Administration 11	10	Dexamethasone acetate (0.35 mg/kg body weight)	Cortex Phellodendri Amurensis water decoction (5.0 g/kg body weight)
Administration 12	10	Dexamethasone acetate (0.35 mg/kg body weight)	Fructus Gardeniae water decoction (2.0 g/kg body weight)

Drug	Number of “*” in efficacy zone	Number of “△” in toxicity zone	Number of “*” in toxicity zone	Number of “△” in efficacy zone
Radix AconitiLateralis Preparata	7	1	3	3
Cortex Cinnamomi Cassiae	3	0	0	3
Cortex Phellodendri Amurensis	4	1	1	4
Fructus Gardeniae	1	3	1	5

Study of biological performance of Chinese materia medica with either a cold or hot property based on the three-element mathematical analysis model

RichHTML

PDF (PC)

Like

Abstract

Cite this article

Share this article