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Journal of Integrative Medicine ›› 2022, Vol. 20 ›› Issue (2): 135-144.doi: 10.1016/j.joim.2021.12.001

• Original Chinical Research • Previous Articles     Next Articles

Stress reduction via neuro-emotional technique to achieve the simultaneous resolution of chronic low back pain with multiple inflammatory and biobehavioural indicators: A randomized, double-blinded, placebo-controlled trial

Peter Bablisa, Henry Pollardb, Anthony L. Rosnerc   

  1. a. Universal Health, New South Wales 2028, Australia
    b. School of Medical and Applied Sciences, University of Central Queensland, Brisbane, New South Wales 4000, Australia
    c. Medical Information Services, MA 02479-4149, United States
  • Received:2021-02-22 Accepted:2021-10-27 Online:2022-03-25 Published:2022-03-30
  • About author:Anthony L. Rosner


Beginning with the concepts of stress developed by Selye, an approach to stress and pain management, known as neuro-emotional technique (NET), has been developed. It is a treatment approach based on the principle that the stressor effects of dormant and/or current unresolved issues or trauma are what determine one’s bodily responses. These responses are relatively personalized to the conditioned, experiential and emotional reality of the individual.


To determine the effect of NET on patients with chronic low back pain (CLBP) over time. 

Design, setting, participants, and interventions

In a randomized, double-blinded, placebo-controlled study conducted in a single clinic, NET or control treatments were given twice weekly for 4 weeks in a population of 112 patients. 

Main outcome measures

Outcome measures, including Oswestry Disability Index, Quadruple Visual Analogue Scale, the psychoneuroimmunology markers of blood serum levels of C-reactive protein, tumour necrosis factor-α, interleukin-1 (IL-1), IL-6, and IL-10, and 10 dimensions of the Short Form Health Survey scale, were assessed at baseline and at 1, 3 and 6 months following the intervention period.


Compared to placebo, NET produced clinical and statistical significance (P < 0.001) via declines of virtually all physiological, pain and disability markers, accompanied by gains in quality-of-life indicators at 0 (baseline), 1, 3 and 6 months. Reductions of the percentages of patients whose 5 biomarkers lay outside the normative range were achieved at 1, 3 and 6 months by NET but not control interventions. 


A randomized, controlled trial of CLBP patients indicated that 8 NET interventions, compared to placebo, produced clinically and statistically significant reductions in pain, disability and inflammatory biomarkers, and improvements in quality-of-life measures.

Trial Registration

The trial was registered with the Australian and New Zealand Clinical Trials Registry (No. ACTRN12608000002381).

Key words: Neuro-emotional technique, Biopsychosocial model, Emotion, Mind-body therapies, Inflammation, Biomarker

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