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Journal of Chinese Integrative Medicine ›› 2012, Vol. 10 ›› Issue (6): 635-640.doi: 10.3736/jcim20120606

• Original Clinical Research • Previous Articles     Next Articles

Influence of Chinese herbal medicine Feitai Capsule on completion or delay of chemotherapy in patients with stage ⅢB/Ⅳ non-small-cell lung cancer: a Randomized controlled trial

Shui-qiu Deng1, Xue-nong Ouyang2, Zong-yang Yu2, Xi-hu Dai 2, Xi Chen 2, Fang-zheng Fang2, Wen-wu Wang2, Zhi-zhen Liu2   

  1. 1. Department of Disease Prevention, Fuzhou General Hospital of Nanjing Military Region, Fuzhou 350025, Fujian Province, China
    2. Department of Oncology, Fuzhou General Hospital of Nanjing Military Region, Fuzhou 350025, Fujian Province, China
  • Received:2011-09-27 Accepted:2011-12-18 Online:2012-06-20 Published:2018-06-15
  • Contact: Xue-nong Ouyang

Background: Chemotherapy completion rate can reflect the tolerance and compliance of patients to chemotherapy. Poor tolerance may result in delay or suspension of the comprehensive treatment plan, thus affect the efficacy of cancer treatment. Evaluating methods to improve the completion rate of chemotherapy and reduce the occurrence of delayed chemotherapy has gained increasing attention and is the significant area of study in the field of cancer treatment. Studies have shown that Chinese medicine combined with chemotherapy could improve the quality of life in patients with stage ⅢB/Ⅳ non-small-cell lung cancer (NSCLC).
Objective: To observe the effects of Feitai Capsule, a Chinese patent herbal drug, combined with chemotherapy in patients with stage ⅢB/Ⅳ NSCLC.DESIGN, SETTING, PARTICIPANTS AND INTERVENTIONS: A total of 60 diagnosed stage IIIB/IV NSCLC patients from the Department of Oncology, Fuzhou General Hosipital of Najing Military Region were randomly divided into treatment group (30 cases) and control group (30 cases). Patients in the treatment group were treated with chemotherapy plus Feitai Capsule and patients in the control group only received chemotherapy. Both groups of patients were treated for 4 therapeutic cycles.MAIN OUTCOME MEASURES: The chemotherapy completion rate and the chemotherapy delay rate were observed in each cycle of treatment. The therapeutic efficacy was evaluated after 4 cycles.
Results: The chemotherapy completion rate was 96.42% in the treatment group, while that of the control group was 74.07%. The chemotherapy delay rate was 3.57% in the treatment group, while that of the control group was 14.8% (P=0.007 0). The disease control rate was 78.6% in the treatment group, while that of the control group was 59.3% (P=0.173 9).
Conclusion: Feitai Capsule can increase the chemotherapy completion rate in patients with stage ⅢB/Ⅳ NSCLC.

Key words: carcinoma, non-small-cell lung, drugs, Chinese herbal, antineoplastic combined chemotherapy protocols, randomized controlled trial

Table 1

Comparison of general information in patients between the two groups"

Item Total patients (N=55) Control group (n=27) Treatment group (n=28) χ2 Pvalue
Male (n, %) 47 24 (51.06%) 23 (48.94%) 0.503 0.705
Female 8 3 (37.5%) 5 (62.5%)
Age (Median (Q25, Q75), years) 60 55.7 (29, 72) 59.5 (36~74)
Smoking 31 15 (48.39%) 16 (51.61%) 0.014 1
Non-smoking 24 12 (50.0%) 12 (50.0%)
NSCLC stage
ⅢB 16 7 (43.75%) 9 (56.25%) 0.258 0.768
39 20 (51.28%) 19 (65.52%)
Karnofsky
80 to 90 36 18 (50.0%) 18 (50.0%) 0.034
90 to 100 19 9 (47.37%) 10 (52.63%)

Figure 1

Flow diagram of this randomized trial"

Table 2

Chemotherapy completion rate and chemotherapy delay rate of the two groups (n, %)"

Group Chemotherapy completion rate Chemotherapy delay rate
Cycle 1 Cycle 2 Cycle 3 Cycle 4 Cycle 1 Cycle 2 Cycle 3 Cycle 4
Treatment 100 (28/28) 100 (28/28) 96.42 (27/28) 96.42 (27/28) 0 (0/28) 0 (0/28) 3.57 (1/28) 3.57 (1/28)
Control 100 (27/27) 96.29 (26/27) 88.88 (24/27) 74.07 (20/27) 0 (0/27) 0 (0/27) 7.4 (2/27) 14.8 (3/27)
[1] American Cancer Society . Cancer facts and figures 2006[M]. Atlanta: American Cancer Society, 2006: 13-14
[2] Jemal A, Tiwari RC, Murray T, Ghafoor A, Samuels A, Ward E, Feuer EJ , Thun MJ. American Cancer Society. Cancer statistics[J]. 2004; CA Cancer J Clin, 2004,54(1):8-29
[3] Lin LZ, Zhou DH, Zheng XT . Effect of traditional Chinese medicine in improving quality of life of patients with non-small cell lung cancer in late stage[J]. Zhongguo Zhong Xi Yi Jie He Za Zhi, 2006,26(5):389-393
林丽珠, 周岱翰, 郑心婷 . 中医药提高晚期非小细胞肺癌患者生存质量的临床观察[J]. 中国中西医结合杂志, 2006,26(5):389-393
[4] Zhou YM, Piao BK, Hou W, Lin HS, Hua BJ, Xiong L, Zheng HG . Clinical observation of Feiliuping ointment on immune state and prognosis in patients with non-small-cell lung cancer[J]. Zhongguo Zhong Yi Yao Xin Xi Za Zhi, 2008,15(5):78-79
doi: 10.3969/j.issn.1005-5304.2008.05.040
周雍明, 朴炳奎, 侯炜, 林洪生, 花宝金, 熊露, 郑红刚 . 肺瘤平膏改善非小细胞肺癌患者免疫状态及预后的临床观察[J]. 中国中医药信息杂志, 2008,15(5):78-79
doi: 10.3969/j.issn.1005-5304.2008.05.040
[5] Liu JX . Effect of Chinese medicine in maintaining quality of life of cancer patients[J]. Zhonghua Zhong Liu Za Zhi, 2002,24(3):309-310
doi: 10.3760/j.issn:0253-3766.2002.03.032
刘嘉湘 . 中医药维护癌症患者生存质量的作用[J]. 中华肿瘤杂志, 2002,24(3):309-310
doi: 10.3760/j.issn:0253-3766.2002.03.032
[6] Ye L, Ouyang XN, Dai XH, Yu ZY, Liu ZZ . Clinical effect of Feitai Capsule in the treatment for 60 cases with advanced non-small cell lung cancer with the syndrome of deficiency of vital energy and phlegm blood-stasis[J]. Zhongguo Zhong Liu, 2010,19(12):828-832
叶磊, 欧阳学农, 戴西湖, 余宗阳, 刘志臻 . 肺泰胶囊对晚期非小细胞肺癌“气虚痰瘀互结证”患者疗效评价[J]. 中国肿瘤, 2010,19(12):828-832
[7] Liu ZZ, Yu ZY, Ouyang XN, Dai XH, Chen X, Zhao ZQ, Wang WW, Li J, Tu H, Ye L, Yan Y . Effect of maintenance therapy with Feitai capsules in patients with advanced non-small cell lung cancer[J]. Lin Chuang Zhong Liu Xue Za Zhi, 2009,14(4):344-346
doi: 10.3969/j.issn.1009-0460.2009.04.014
刘志臻, 余宗阳, 欧阳学农, 戴西湖, 陈曦, 赵忠全, 王文武, 李捷, 涂华, 叶磊, 颜艳 . 中药复方肺泰胶囊维持治疗对中晚期非小细胞肺癌无进展生存期的影响[J]. 临床肿瘤学杂志, 2009,14(4):344-346
doi: 10.3969/j.issn.1009-0460.2009.04.014
[8] Han R. Cancer chemoprevention and drug treatment[M]. Beijing: Peking Union Medical College Press, 1995: 353-356
韩锐 . 肿瘤化学预防及药物治疗[M]. 北京: 中国协和医科大学出版社, 1995: 353-356
[9] DeVita VT, IIellman S Jr, Rosenberg SA. 癌——肿瘤学原理和实践. 徐从高, 张茂宏, 杨兴季主译.第5版[M]. 济南: 山东科学技术出版社, 2002: 355
DeVita VT, IIellman S Jr, Rosenberg SA . Cancer — Principles and practice of oncology. Translated by Xu CG, Zhang MH, Yang XJ.5th ed[M]. Jinan: Shandong Science and Technology Press, 2002: 355
[10] Goldie JH, Goldman AJ . A mathematical model for relating the drug sensitivity of tumors to their spontaneous mutation rate[J]. Cancer Treat Rep, 1979,63(11-12):1727-1733
[11] Wang RT, Shan BE, Li QX, Tang JF, Qiao F, Du XN, Li H, Ye J . Extracorporeal experimental study on immuno-modulatory activity of Astragalus membranaceus extract[J]. Zhongguo Zhong Xi Yi Jie He Za Zhi, 2002,22(6):453-456
王润田, 单保恩, 李巧霞, 唐建发, 乔芳, 杜肖娜, 李宏, 叶静 . 黄芪提取物免疫调节活性的体外实验研究[J]. 中国中西医结合杂志, 2002,22(6):453-456
[12] Zhang S, Mou XY, Wang HM, Jiang SJ . Enhancement of the cytotoxic effect of cytokine induced killers by dendritic cells pulsed with Astragalus polysaccharides[J]. Zhongguo Mian Yi Xue Za Zhi, 2009,25(2):140-142
张嵩, 牟晓燕, 王红梅, 姜淑娟 . 黄芪多糖诱导的树突状细胞增强CIK细胞的杀伤作用[J]. 中国免疫学杂志, 2009,25(2):140-142
[13] Hong G, Dai YH, Liu PX, Shen X, Wei YY, Li G . Advances in research on chemical constituents and pharmacological activities of Agrimonia pilosa[J]. Yao Xue Fu Wu Yu Yan Jiu, 2008,8(5):362-363
洪阁, 戴永红, 刘培勋, 沈秀, 魏永燕, 李根 . 仙鹤草化学成分和药理作用研究进展[J]. 药学服务与研究, 2008,8(5):362-363
[14] Ma LP, Zhao PR, Wang LX, Zhang SH . Inhibitory effects of Agrimonia pilosa Ledeb. water extract on Eca109 cells in vitro[J]. Zhengzhou Da Xue Xue Bao Yi Xue Ban, 2007,42(1):149-151
doi: 10.3969/j.issn.1671-6825.2007.01.057
马丽萍, 赵培荣, 王留兴, 张书红 . 仙鹤草水提液对食管癌Eca109细胞生长的抑制作用[J]. 郑州大学学报(医学版), 2007,42(1):149-151
doi: 10.3969/j.issn.1671-6825.2007.01.057
[15] Wen Y, Bi L, Zhang YB, Chen WP . Inhibitory effects of Agrimonia pilosa Ledeb. water extract on lung cancer A549 cells in vitro[J]. Zhong Yi Yao Xin Xi, 2009,26(5):33-35
doi: 10.3969/j.issn.1002-2406.2009.05.013
温雅, 毕蕾, 张义彪, 陈卫平 . 仙鹤草水提液对肺癌A549细胞增殖的抑制作用[J]. 中医药信息, 2009,26(5):33-35
doi: 10.3969/j.issn.1002-2406.2009.05.013
[16] Wang F, Yuan ST, Zhu DN . Active components of antitumor fraction from Sarcandra glabra[J]. Zhongguo Tian Ran Yao Wu, 2007,5(3):174-178
王菲, 袁胜涛, 朱丹妮 . 肿节风抗肿瘤活性部位的化学成分[J]. 中国天然药物, 2007,5(3):174-178
[17] Kang M, Tang AZ, Liang G, Yi X, Liu J . A study on the inhibition of Sarcandrea extracts on proliferation of nasopharyngeal carcinoma cell[J]. Guangxi Yi Ke Da Xue Xue Bao, 2008,25(3):347-349
康敏, 唐安洲, 梁钢, 易翔, 刘津 . 肿节风提取物抑制鼻咽癌细胞增殖的实验研究[J]. 广西医科大学学报, 2008,25(3):347-349
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