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Journal of Chinese Integrative Medicine ›› 2012, Vol. 10 ›› Issue (6): 628-634.doi: 10.3736/jcim20120605

• Original Clinical Research • Previous Articles     Next Articles

Effects of Ginkgo biloba extract in improving episodic memory of patients with mild cognitive impairment: A randomized controlled trial

Ming-xing Zhao, Zhen-hua Dong, Zhong-hai Yu, Shi-yuan Xiao,Ya-ming Li()   

  1. Department of Traditional Chinese Medicine, Huadong Hospital, Fudan University, Shanghai 200040, China
  • Received:2011-10-09 Accepted:2011-12-06 Online:2012-06-20 Published:2018-06-15
  • Contact: Ya-ming Li E-mail:lymys@yahoo.cn

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BACKGROUND: Mild cognitive impairment is a transitional stage between normal aging and dementia. It is important in terms of recognizing memory loss in older people as well as identifying a group of individuals at high risk of developing dementia and who may benefit from preventive strategies. Ginkgo biloba extract has been shown to possess polyvalent properties, such as anti-oxidation, anti-apoptosis and anti-inflammation. Ginkgo bilobaextract appears to have a neuroprotective effect against neurodegenerative diseases.
OBJECTIVE: To observe the efficacy of Ginkgo biloba leaf tablet in improving episodic memory of mild cognitive impairment.DESIGN, SETTING, PARTICIPANTS AND INTERVENTIONS: This is a multicenter, randomized, controlled trial. The authors enrolled generally healthy, ambulatory or ambulatory-aided amnestic subjects with MCI, 60 to 85 years old, who expressed a memory complaint from Huadong Hospital, seven Community Health Centers in Shanghai, and Shanghai First Welfare Institution. A total of 120 MCI patients were randomly assigned to the Ginkgo biloba leaf tablet group (treatment group, 60 cases) and control group (60 cases). The patients in the treatment group took Ginkgo biloba leaf tablets 3 times a day, 19.2 mg each dose. The control group did not receive any intelligence-promoting or vasodilator reflex treatment except some health care.MAIN OUTCOME MEASURES: The patients were tested with nonsense picture recognition of the clinical memory scale and the logical memory test based on the Wechsler memory scale before and after treatment.
RESULTS: After 6 months of treatment, the scores of the logical memory test and nonsense picture recognition were increased significantly in the treatment group (P<0.01, P<0.05), while the scores of the two tests from the control group had no statistically significant difference (P>0.05). After treatment, the positive rate of nonsense picture recognition was 55.17% in the treatment group, which was significantly higher than that of the control group at 32.73% (P<0.05). The efficacy rate of logical memory was 58.62% in the treatment group, also higher than 38.18% in the control group (P<0.05).
CONCLUSION: Ginkgo biloba leaf tablet showed good efficacy in promoting episodic memory function in MCI patients.

Key words: Ginkgo biloba leaf, mild cognitive impairment, Chinese traditional treatment, clinical study, randomized controlled trials

Table 1

Baseline data of the two groups"

Item Treatment group (n=58) Control group (n=55) Statistic value P value
Gender (n, %)
Male 17 (29.31) 23 (41.82) χ2=1.93 0.165
Female 41 (70.69) 32 (58.18)
Education level (n, %)
Senior school and above 21 (36.21) 13 (23.64) χ2=2.97 0.397
Junior middle school 12 (20.69) 10 (18.18)
Primary school 19 (32.76) 23 (41.82)
Illiteracy 6 (10.34) 9 (16.36)
Age (x±s, years) 72.78±5.03 73.53±5.97 t=0.72 0.472

Figure 1

Flow diagram of this randomized trial"

Table 2

Score of nonsense picture recognition before and after treatment (x±s)"

Group n Score of nonsense picture recognition
Before treatment After treatment Difference
Treatment 58 14.71±8.97 20.17±8.48 5.47±10.22*
Control 55 19.13±9.98 19.49±9.37 0.36±11.99

Table 3

Clinical curative effects of nonsense picture recognition"

Group n Obviously effective (n, %) Effective (n, %) Invalid (n, %) Effective rate (%)
Treatment 58 18 (31.03) 14 (24.14) 26 (44.83) 55.17*
Control 55 8 (14.55) 10 (18.18) 37 (67.27) 32.73

Table 4

Score of logical memory of the Wechsler memory scale before and after treatment (x±s)"

Group n Score of Wechsler memory scale
Before treatment After treatment Difference
Treatment 58 7.33±2.84 9.93±3.11 2.60±2.44*
Control 55 6.86±2.73 8.36±3.47 1.50±2.79

Table 5

Clinical curative effect of logical memory of the Wechsler memory scale"

Group n Obviously effective (n, %) Effective (n, %) Invalid (n, %) Effective rate (%)
Treatment 58 16 (27.59) 18 (31.03) 24 (41.38) 58.62*
Control 55 9 (16.36) 12 (21.82) 34 (61.82) 38.18
[1] Petersen RC, Doody R, Kurz A, Mohs RC, Morris JC, Rabins PV, Ritchie K, Rossor M, Thal L, Winblad B . Current concepts in mild cognitive impairment[J]. Arch Neurol, 2001,58(12):1985-1992
doi: 10.1001/archneur.58.12.1985 pmid: 11735772
[2] Wen HB, Zhou HB . Changes in cerebral blood flow in patients with mild cognitive impairment[J]. Zhongguo Lin Chuang Kang Fu, 2005,9(37):6-7
doi: 10.3321/j.issn:1673-8225.2005.37.005
闻红斌, 周宏斌 . 轻度认知障碍患者的脑血流变化[J]. 中国临床康复, 2005,9(37):6-7
doi: 10.3321/j.issn:1673-8225.2005.37.005
[3] Xiao SY, Zhang CY, Li JY, Liu YF, Zhao MX, Dong ZH, Li YM . Clinical study on effect of Ginkgo-leaf tablet(Sitailong) in treating mild cognitive impairment[J]. Zhong Cheng Yao, 2011,33(5):751-754
肖世源, 张春燕, 李践一, 刘吟枫, 赵明星, 董振华, 李亚明 . 银杏叶片G(斯泰隆)治疗轻度认知障碍的临床研究[J]. 中成药, 2011,33(5):751-754
[4] American Psychiatric Association . Diagnostic and statistical manual of mental disorders (DSM-Ⅳ).4th ed[M]. Washington: American Psychiatric Association, 1994,: 143-147
[5] Petersen RC, Smith GE, Waring RC, Ivnik RJ, Tangalos EG, Kokmen E . Mild cognitive impairment: clinical characterization and outcome[J]. Arch Neurol, 1999,56(3):303-308
doi: 10.1001/archneur.56.3.303
[6] Reisberg B , Ferris SH, de Leon MJ, Crook T . The Global Deterioration Scale for the assessment of primary degenerative dementia[J]. Am J Psychiatry, 1982,139(9):1136-1139
doi: 10.1176/ajp.139.9.1136
[7] Hughes CP, Berg L, Danziger WL, Coben LA, Martin RL . A new clinical scale for the staging of dementia[J]. Br J Psychiatry, 1982,140:566-572
doi: 10.1192/bjp.140.6.566
[8] The Cooperation Group for the Construction of “the Clinical Memory Test”. The construction of “the clinical memory test”[J]. Xin Li Xue Bao, 1986,( 1):100-108
“临床记忆量表”协作组. “临床记忆量表”的编制[J]. 心理学报, 1986,( 1):100-108
[9] Yu H, Guo QH, Hong Z, Lü CZ . Detecting of logical memory impairment in mild Alzheimer’s disease[J]. Shen Jing Ji Bing Yu Jing Shen Wei Sheng, 2005,5(2):89-91
doi: 10.3969/j.issn.1009-6574.2005.02.003
于欢, 郭起浩, 洪震, 吕传真 . 逻辑记忆在早期识别阿尔茨海默病患者中的作用[J]. 神经疾病与精神卫生, 2005,5(2):89-91
doi: 10.3969/j.issn.1009-6574.2005.02.003
[10] Panza F, Capurso C , D’Introno A, Colacicco AM, Capurso A, Solfrizzi V, Bennett . Mild cognitive impairment: risk of Alzheimer disease and rate of cognitive decline[J]. Neurology, 2007,68(12):964-965
doi: 10.1212/01.wnl.0000259691.26674.d3
[11] Li BR, Bi GN, Qiu YD, Shi SL . Clinical study on cognition of mild cognitive impairment[J]. Guangxi Yi Xue, 2007,29(5):627-628
doi: 10.3969/j.issn.0253-4304.2007.05.003
黎彬如, 毕桂南, 邱燕东, 石胜良 . 轻度认知障碍患者认知功能的临床研究[J]. 广西医学, 2007,29(5):627-628
doi: 10.3969/j.issn.0253-4304.2007.05.003
[12] Kandel ER, Kupfermann L, Iversen S. Learning and Memory. In: Kandel ER, Schwartz JH, Jessell TM. Principles of neural science.4th ed[M]. Columbia: McGraw-Hill Companies Inc, 2000,: 1231-1233
[13] Wang W, Wang LN, Xie HG, Zhang XH . A follow-up study on the memorial function of the patients with mild cognitive impairment[J]. Jie Fang Jun Yi Xue Za Zhi, 2006,31(5):379-381
王炜, 王鲁宁, 解恒革, 张晓红 . 轻度认知损伤患者记忆功能的随访研究[J]. 解放军医学杂志, 2006,31(5):379-381
[14] Celsis P . Age-related cognitive decline, mild cognitive impairment or preclinical Alzheimer’s disease? Ann Med. 2000; 32(1): 6-14.
doi: 10.3109/07853890008995904 pmid: 10711572
[15] Wolf H, Grunwald M, Kruggel F, Riedel-Heller SG , Angerhofer S, Hojjatoleslami A, Hensel A, Arendt T, Gertz H .Hippocampal volume discriminates between normal cognition; questionable and mild dementia in the elderly[J]. Neurobiol Aging, 2001,22(2):177-186
doi: 10.1016/S0197-4580(00)00238-4
[16] Gao P, Qin SS, Liu YH, Cai XJ, Yu ZG, Han LJ . Study on the correlation between cognitive functions and regional blood flow in Alzheimer disease and mild cognitive impairment[J]. Zhongguo Shen Jing Mian Yi Xue He Shen Jing Bing Xue Za Zhi, 2006,13(4):205-208
高平, 秦绍森, 刘银红, 蔡晓杰, 于治国, 韩丽君 . Alzheimer病和轻度认知功能障碍患者认知功能与局部脑血流灌注的相关性研究[J]. 中国神经免疫学和神经病学杂志, 2006,13(4):205-208
[17] Xu JP, Li L, Sun LS . Effects of ginkgolide on cerebral blood flow in dogs[J]. J Chin Integr Med, 2005,3(1):50-53
徐江平, 李琳, 孙莉莎 . 银杏内酯对犬脑血流量的影响[J]. 中西医结合学报, 2005,3(1):50-53
[18] Bao YM, Liu AH, Zhang ZX, Li Y, Wang XY . Effects of Ginkgo biloba extract 50 preconditioning on contents of inflammation-related cytokines in myocardium of rats with ischemia reperfusion injury[J]. J Chin Integr Med, 2010,8(4):373-378
包怡敏, 刘爱华, 张志雄, 李云, 王星禹 . 银杏酮酯预处理对心肌缺血再灌注大鼠心肌组织炎症相关细胞因子含量的影响[J]. 中西医结合学报, 2010,8(4):373-378
[19] Erbil G, Ozbal S, Sonmez U, Pekcetin C, Tugyan K, Bagriyanik A, Ozogul C . Neuroprotective effects of selenium and Ginkgo biloba extract(EGb761) against ischemia and reperfusion injury in rat brain[J]. Neurosciences (Riyadh), 2008,13(3):233-238
[20] Shen J, Lee W, Gu Y, Tong Y, Fung PC, Tong L . Ginkgo biloba extract(EGb761) inhibits mitochondria-dependent caspase pathway and prevents apoptosis in hypoxia-reoxygenated cardiomyocytes[J]. Chin Med, 2011,6:8
doi: 10.1186/1749-8546-6-8
[21] Shi C, Yao Z, Xu J, Yew DT . Effects of Gingko extract(EGb761) on oxidative damage under different conditions of serum supply[J]. J Bioenerg Biomembr, 2009,41(1):61-69
doi: 10.1007/s10863-009-9197-7
[22] Barnes PM, Bloom B, Nahin RL . Complementary and alternative medicine use among adults and children: United States, 2007[J]. Natl Health Stat Report, 2008,12:1-23
[23] Zhu ZF, Ji K, Han BJ, Feng DH . Clinical study on effect of Aricept combined with Ginkgo biloba in treating vascular cognitive impairment[J]. Lin Chuang Xin Shen Ji Bing Za Zhi, 2007,13(6):549-550
朱祖福, 季凯, 韩伯军, 冯东华 . 安理申联合银杏叶治疗血管性认知障碍[J]. 临床心身疾病杂志, 2007,13(6):549-550
[24] Feng YQ, Wang JH, Zhao DW, Qi YC, Gao JS, Li ZL, Liu GF . Donepezil alone vs Donepezil combined with Gingko biloba extract in treatment of Alzheimer disease[J]. Zhongguo Xin Yao Yu Lin Chuang Za Zhi, 2004,11(11):792-795
doi: 10.3969/j.issn.1007-7669.2004.11.019
冯亚青, 王建华, 赵大卫, 齐亚超, 高俊书, 李志立, 刘桂芳 . 多奈哌齐与多奈哌齐加银杏叶提取物合用治疗阿尔采未病的疗效比较[J]. 中国新药与临床杂志, 2004,11(11):792-795
doi: 10.3969/j.issn.1007-7669.2004.11.019
[25] Yan L, Wang SS, Yang XT, Wang H . Effect of Gingko biloba Tablet in improving early postoperative cognitive function in patients with senile dementia[J]. Zhongguo Lao Nian Xue Za Zhi, 2002,22(3):175-177
严镭, 王树声, 杨绣塔, 王红 . 银杏叶制剂对老年痴呆病人早期认知功能的影响[J]. 中国老年学杂志, 2002,22(3):175-177
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