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Journal of Integrative Medicine ›› 2025, Vol. 23 ›› Issue (5): 462-470.

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Salvia miltiorrhiza components and gut microbiota interactions in Helicobacter pylori infection

Shao-jian Li a 1,  Jin-xin Miao b 1, Fei Wang a, Hao-yu Wang d, Yao-wu Ma c, Ying Jiang c, Xia Xue d   

  1. a. Institute of Plant Protection, Henan Academy of Agricultural Sciences, Zhengzhou 450002, Henan Province, China b. Academy of Chinese Medicine Science, Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-yao, Henan University of Chinese Medicine, Zhengzhou 450000, Henan Province, China c. College of Resources and Environment, Henan Agricultural University, Zhengzhou 450046, Henan Province, China d. Henan Key Laboratory of Helicobacter pylori & Microbiota and Gastrointestinal Cancer, Marshall Medical Research Center, the Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, Henan Province, China
  • Received:2024-06-06 Accepted:2025-03-17 Online:2025-09-15 Published:2025-09-15
  • Contact: Ying Jiang, Xia Xue E-mail:jy27486@163.com; summerxuexia@zzu.edu.cn

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Salvia miltiorrhiza (Danshen) is a traditional Chinese herb that is commonly known for its cardiovascular and hepatoprotective benefits. Recent studies have confirmed that Danshen and its bioactive components can influence gut microbial homeostasis, thereby affecting Helicobacter pylori (HP) colonization in the human stomach. HP is a bacterial pathogen associated with various gastrointestinal diseases. Current HP treatments mainly involve antibiotics and proton pump inhibitors. However, their efficacy is strongly compromised by the rapid emergence of antibiotic resistance in HP and genetic heterogeneity among patients. The interaction between Danshen and gut microbial status provides a novel perspective for HP treatment. Understanding the medical properties of Danshen in altering gut microbiota and eliminating HP, as well as the underlying mechanisms, is important for improving human gastrointestinal healthcare. This review investigates the interaction between Danshen and gut microbiota and its impact on HP infection using databases including Web of Science, PubMed, and Google Scholar. We explored the unconventional intersection between Danshen, gut microbiota, and HP infection, shedding light on their intricate interplay and potential therapeutic implications. A comprehensive understanding of this interaction provides valuable insights into developing novel therapeutic strategies that target the gut microbiota to mitigate HP-associated gastrointestinal disorders.

Please cite this article as: Li SJ, Miao JX, Wang F, Wang HY, Ma YW, Jiang Y, Xue X. Salvia miltiorrhiza components and gut microbiota interactions in Helicobacter pylori infection. J Integr Med. 2025; 23(5):462–470.

Key words: Helicobacter pylori, Salvia miltiorrhiza, Gastrointestinal microbiota, Gut microbiome, Interplay, Modulation

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