Background

Resistin level is high in patients with severe acute pancreatitis (SAP), and resistin is expected to be a new marker for evaluating the severity of acute pancreatitis.
Objective

To explore the influence of integrated traditional Chinese and Western medicine therapy on serum resistin levels in SAP patients.Design, setting, participants and interventions: Twenty-eight SAP patients meeting inclusion criteria from Department of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University were included, and the patients were randomly divided into treatment group and placebo group. There were 13 patients in the treatment group and 15 patients in the placebo group. Patients in the treatment group were given traditional Chinese herbal medicine in addition to the conventional treatment. Patients in the placebo group were given placebo in addition to the conventional treatment.Main outcome measures: The serum resistin levels on admission, and days 1, 3, 5, and 7 after the admission were detected.
Results

The serum resistin levels on admission in all the patients were higher than normal level, and there was no significant difference between the two groups (P>0.05). On days 1, 3, 5, and 7 after admission, the resistin levels in the treatment group were (3.29±1.66) μg/L, (3.71±1.05) μg/L, (3.08±1.47) μg/L and (3.62±1.67) μg/L, and in the control group (5.16±1.93) μg/L, (5.07±1.53) μg/L, (4.88±1.47) μg/L and (5.12±1.48) μg/L, respectively. The resistin levels were lower in the treatment group than in the control group (P<0.05).
Conclusion

Serum resistin level in SAP patients can be decreased by integrated traditional Chinese medicine and Western medicine therapy.

Key words: Severe acute pancreatitis, Resistin, Integrated traditional Chinese and Western medicine, Placebo, Prospective studies, Randomized controlled trial