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Journal of Chinese Integrative Medicine ›› 2010, Vol. 8 ›› Issue (1): 30-34.doi: 10.3736/jcim20100106

• Original Clinical Research • Previous Articles     Next Articles

Relationship between quality of life and basic syndromes of traditional Chinese medicine in patients with posthepatitic cirrhosis

 Qin Zhanga, Lei Wanga, Ping Liub   

  1. a Department of Liver Diseases, Shanghai Public Clinical Health Center, Fudan University, Shanghai 201508, China
    b Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
  • Received:2009-07-27 Accepted:2009-10-15 Online:2010-01-20 Published:2010-01-15
  • Contact: Ping Liu


To investigate the main factors influencing the quality of life and the relationship between quality of life and basic syndromes of traditional Chinese medicine (TCM) in patients with posthepatitic cirrhosis.

The outcomes of revised Short Form-36 Health Survey (SF-36) Questionnaire in 108 patients with posthepatitic cirrhosis and the normal control population were assessed, and the related clinical information including gender, age, body mass index (BMI), course of disease, basic syndromes of disease and main laboratory parameters were collected. The data were analyzed by t-test, analysis of variance (ANOVA) and stepwise regression analysis.

The Cronbach’s α coefficient of the revised SF-36 questionnaire was 0.773, indicating good consistency within the items. The outcomes of revised SF-36 and the scores of physical function, role physical, bodily pain, mental health, and social function in the patients with posthepatitic cirrhosis were significantly lower than those in the normal control population (P<0.01). Correlation analysis showed that there was a correlation between basic TCM syndromes and scores of physical function, mental health, role emotion, vitality, and general health. Stepwise regression analysis indicated that basic TCM syndromes, aspartate aminotransferase, total billirubin, albumin, and prothrombin time played major role in the quality of life in the patients with posthepatitic cirrhosis, and the values of regression coefficient were 0.262, –0.297 8, –0.483 9, –0.483 9, –0.512 3, –0.571 9 respectively.

The quality of life in the patients with posthepatitic cirrhosis is significantly decreased. The revised SF-36 with basic TCM syndrome items is more objective and has certain clinical practical value on measurement of quality of life in patients with posthepatitic cirrhosis.

Key words: Hepatitis, Liver cirrhosis, Quality of life, Syndrome, Traditional Chinese medicine

Table 1

Values of quality of life in normal control population and patients with posthepatitic cirrhosis ($\bar{x}$±s)"

Evaluation item Normal control (n=100) Posthepatitic cirrhosis (n=108)
Physical function 83.32±9.61 71.53±10.24**
Role physical 90.62±8.91 62.72±20.34**
Bodily pain 70.30±11.23 69.72±9.09**
General health 71.25±10.63 55.18±9.35**
Vitality 50.12±30.29 49.04±9.25
Social function 80.12±11.11 51.18±9.45**
Role emotion 69.36±21.30 68.93±11.50
Mental health 76.13±16.21 50.96±7.87**
Factors of TCM syndrome 80.10±22.43 45.66±13.68**
SF-36 77.49±8.76 60.41±9.29**

Table 2

Correlation analysis of the items of SF-36 in patients with posthepatitic cirrhosis"

Evaluation items Physical
Vitality Bodily
Factors of
TCM syndrome
Physical function 1
Role physical 0.231 4 1
Bodily pain 0.325 6 0.102 2 1
General health 0.224 3 0.438 7 0.374 5 1
Vitality 0.252 3 0.375 6 0.268 9 0.297 4 1
Social function 0.563 4 0.391 5 0.684 2 0.512 1 0.396 8 1
Role emotion 0.238 9 0.192 8 0.402 3 0.287 9 0.201 3 0.445 2 1
Mental health 0.513 9 0.321 5 0.381 3 0.331 1 0.321 4 0.506 6 0.236 5 1
Factors of TCM syndrome 0.631 1 0.453 2 0.697 8 0.603 1 0.521 4 0.711 3 0.451 3 0.692 7 1

Table 3

Main factors influencing quality of life in patients with posthepatitic cirrhosis"

Screened factor Regression coefficient Standard error F P
Factors of TCM syndrome 0.256 2 0.054 3 4.820 0.024 7
AST –0.297 8 0.235 9 3.931 0.022 3
TB –0.483 9 0.127 6 2.865 0.031 1
Alb –0.512 3 0.049 7 2.636 0.036 0
PT –0.5719 0.215 3 2.043 0.045 1
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