Search JIM Advanced Search

Journal of Chinese Integrative Medicine ›› 2004, Vol. 2 ›› Issue (3): 172-174.doi: 10.3736/jcim20040305

• Youth Forum • Previous Articles     Next Articles

Relationship between glucocorticoid receptor and deficiency-syndrome and the regulation of traditional Chinese medicine

Yong Li   

  1. Department of Traditional Chinese Medicine, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
  • Online:2004-06-20 Published:2018-10-25

The glucocorticoid receptor (GR) is a ligand-dependent transcription factor belonging to the nuclear hormone receptor superfamily. Due to its almost ubiquitous expression, GR plays an important role in many physiological and pathological processes. These include regulation of homeostasis, adaptation to stress, and modulation of central nervous system. In addition, GR is a major modulator of the immune system due to its proficient anti-inflammatory and immunosuppressive activity; and its function is important for proper regulation of many physiological processes. The exploration on the regulation of traditional Chinese medicine on GR has established a modern physiological and pathological foundation for research of traditional Chinese medicine.

Key words: glucocorticoid receptors, traditional Chinese medicine, deficiency syndrome, targetings

CLC Number: 

  • R392.11
[1] 徐克川, 张善徵 . 甲亢类阴虚大鼠肝胞液糖皮质激素受体的实验研究[J]. 广州中医学院学报, 1990,7(3):145-149
[2] 凌昌全, 李敏, 朱德增 , 等. 阴阳虚证与糖皮质激素受体关系的临床与实验研究[J]. 浙江中西医结合杂志, 2001,11(9):532-533
[3] 凌昌全, 陈喆, 俞超芹 , 等. 52例阴虚阳虚患者外周血混合白细胞糖皮质激素受体的实验观察[J]. 中医杂志, 1998,39(10):619-620
[4] 刘福春, 翟美芙 . 老年及老年虚证病人周围血白细胞糖皮质激素受体的研究[J]. 中医杂志, 1989,30(7):40-42
[5] 张广宇, 谢竹藩 . 虚寒及虚热证患者血浆皮质醇及其受体观察[J]. 中西医结合杂志, 1991,11(11):664-665
[6] 凌昌全, 李敏, 谭金兴 , 等. 中药对糖皮质激素受体保护作用的实验研究[J]. 中国中西医结合杂志, 1999,19(5):302-303
doi: 10.7661/CJIM.1999.5.302
[7] 张家庆, 刘志民 . 阳虚患者单个核及多形核白细胞糖皮质激素受体改变[J]. 中西医结合杂志, 1990,10(4):215-216
doi: 10.7661/CJIM.1990.4.215
[8] 姚连初 . 肾气丸对原发肾病综合征患者外周血糖皮质激素受体水平的影响[J]. 中成药, 2000,22(10):704-705
doi: 10.3969/j.issn.1001-1528.2000.10.014
[9] 马以泉 . 六味地黄丸对肾病综合征患儿外周血糖皮质激素受体水平的影响[J]. 浙江中医学院学报, 2000,24(3):49
[10] 李曙光, 杨柳松, 王浩丹 , 等. 小柴胡汤治疗肾病综合征机理的探讨[J]. 山东医科大学学报, 1998,36(4):286-288
[11] 张玲娟, 沈自尹, 王文健 , 等. 补肾益气法对淋巴细胞糖皮质激素受体老年性改变的影响[J]. 中西医结合杂志, 1990,10(10):583-585
[12] 凌昌全, 李敏, 苏永华 , 等. 人参茎叶皂苷对失血性休克大鼠糖皮质激素受体的影响[J]. 中草药, 2003,34(5):433-436
[13] 李敏, 凌昌全, 沈志雷 , 等. 人参茎叶皂苷对热损伤大鼠糖皮质激素受体的影响[J]. 第二军医大学学报, 2003,24(8):S16-F3
[14] 奚蓓莉, 吴敦序 , 包照日格图, 等.补肾定喘汤对哮喘大鼠肺组织糖皮质激素受体的影响[J]. 标记免疫分析与临床, 1997,4(4):217-220
[15] 赵伟康, 金国琴, 王润平 , 等. 固真方对老年大鼠下丘脑-垂体-甲状腺-胸腺轴作用的研究[J]. 中医杂志, 1997,38(6):363-365
[16] 王光利 . 小青龙汤治疗哮喘药理机制探讨[J]. 临床急诊杂志, 2001,2(2):56-58
[17] 包照日格图, 吴敦序, 陈淑俊 , 等. 龟芪散对哮喘大鼠糖皮质激素受体及皮质酮的影响[J]. 中成药, 1998,20(2):25-28
[18] 杨霞, 王浩丹, 侯桂华 , 等. 小柴胡汤对糖皮质激素受体及其mRNA的调节作用[J]. 中国病理生理杂志, 2000,16(12):1304-1306
[19] 刘毅, 叶松柏, 金彰红 . 雷公藤多苷对糖皮质激素受体的影响[J]. 川北医学院学报, 2000,15(2):4-6
[20] Chung E, Lee KY, Lee YJ , et al. Ginsenoside Rg1 down-regulates glucocorticoid receptor and displays synergistic effects with cAMP[J]. Steroids, 1998,63(7-8):421-424
[21] 步世忠, 许金廉, 孙继虎 , 等. 柴胡皂苷d上调HL-60细胞糖皮质激素受体mRNA并诱导细胞凋亡[J]. 中华血液学杂志, 1999,20(7):354-356
[22] 赵晓山, 罗仁 . 肾虚证相关基因的研究[J]. 中西医结合学报, 2003,1(1):18-20
Zhao XS, Luo R . Study of genes related with kidney deficiency syndrome[J]. Zhong Xi Yi Jie He Xue Bao, 2003,1(1):18-20
[1] Sherman Gu, Arthur Yin Fan. Controversial conclusions from two randomized controlled trials for acupuncture's effects on polycystic ovary syndrome or in vitro fertilization support. Journal of Integrative Medicine, 2020, 18(2): 89-91.
[2] Xue-qing Yu, Shu-guang Yang, Yang Xie, Jian-sheng Li. Traditional Chinese medicine in the treatment of idiopathic pulmonary fibrosis based on syndrome differentiation: Study protocol of exploratory trial. Journal of Integrative Medicine, 2020, 18(2): 163-168.
[3] Chang-quan Ling. Traditional Chinese medicine is a resource for drug discovery against 2019 novel coronavirus (SARS-CoV-2). Journal of Integrative Medicine, 2020, 18(2): 87-88.
[4] Wen Qiang Lee, Jeremy Teoh, Pei Zheng Kenneth Lee, Zhi Xiong Gerard Low, Xueling Sim, Foong Fong Mary Chong, Norbert Ludwig Wagner. Factors influencing communication of traditional Chinese medicine use between patients and doctors: a multisite cross-sectional study. Journal of Integrative Medicine, 2019, 17(6): 396-403.
[5] Mikhail Teppone. Medicine has always been “Modern” and “Scientific” from ancient times to the present day. Journal of Integrative Medicine, 2019, 17(4): 229-237.
[6] Charles Dalcanale Tesser, Ari Ojeda Ocampo Moré, Melissa Costa Santos, Emiliana Domingues Cunha da Silva, Fátima Terezinha Pelachini Farias, Lúcio José Botelho. Auriculotherapy in primary health care: A large-scale educational experience in Brazil. Journal of Integrative Medicine, 2019, 17(4): 302-309.
[7] Rachael Farrington, Ian F.Musgrave, Roger W.Byard. Evidence for the efficacy and safety of herbal weight loss preparations. Journal of Integrative Medicine, 2019, 17(2): 87-92.
[8] Fung-Kei Cheng. An overview of the contribution of acupuncture to thyroid disorders. Journal of Integrative Medicine, 2018, 16(6): 375-383.
[9] Chang-quan Ling, Jia Fan, Hong-sheng Lin, Feng Shen, Zhen-ye Xu, Li-zhu Lin, Shu-kui Qin, Wei-ping Zhou, Xiao-feng Zhai, Bai Li, Qing-hui Zhou, on behalf of the Chinese Integrative Therapy of Primary Liver Cancer Working Group. Clinical practice guidelines for the treatment of primary liver cancer with integrative traditional Chinese and Western medicine. Journal of Integrative Medicine, 2018, 16(4): 236-248.
[10] Qing Ji, Yun-quan Luo, Wen-hai Wang, Xuan Liu, Qi Li, Shi-bing Su. Research advances in traditional Chinese medicine syndromes in cancer patients. Journal of Integrative Medicine, 2016, 14(1): 12-21.
[11] Bing He, Ge Zhang, Ai-ping Lu. Integrative network analysis: Bridging the gap between Western medicine and traditional Chinese medicine. Journal of Integrative Medicine, 2015, 13(3): 133-135.
[12] Zhao-guo Li, Xi-ru Liu. Comparative study on WHO Western Pacific Region and World Federation of Chinese Medicine Societies international standard terminologies on traditional medicine: Diseases of Paediatrics (Part 3). Journal of Integrative Medicine, 2015, 13(3): 201-204.
[13] Xiao Ye, Jing Wang. On English translation of infant Tuina points in traditional Chinese medicine. Journal of Integrative Medicine, 2015, 13(3): 205-207.
[14] Zhao-guo Li. Comparative study on WHO Western Pacific Region and World Federation of Chinese Medicine Societies international standard terminologies on traditional medicine: Diseases of Paediatrics (Part 2). Journal of Integrative Medicine, 2015, 13(2): 129-132.
[15] Zhao-guo Li . Comparative study on WHO Western Pacific Region and World Federation of Chinese Medicine Societies international standard terminologies on traditional medicine: Diseases of Paediatrics (Part 1). Journal of Integrative Medicine, 2015, 13(1): 61-64.
Full text



[1] Jun Hu, Jian-ping Liu. Non-invasive physical treatments for chronic/recurrent headache. Journal of Chinese Integrative Medicine, 2008, 6(1): 31
[2] Min Cheng, Qiong Feng, Shu-wen Qian, Hui Gao, Cui-qing Zhu. Preliminary assay of p-amyloid binding elements in heart-beneficial recipe. Journal of Chinese Integrative Medicine, 2008, 6(1): 68-72
[3] Jin-zhou Tian, Jing Shi, Xin-qing Zhang, Qi Bi, Xin Ma, Zhi-liang Wang, Xiao-bin Li, Shu-li Shen, Lin Li, Zhen-yun Wu, Li-yan Fang, Xiao-dong Zhao, Ying-chun Miao, Peng-wen Wang, Ying Ren, Jun-xiang Yin, Yong-yan Wang, Beijing United Study Group on MCI of the Capital Foundation of Medical Developments. Guiding principles of clinical research on mild cognitive impairment (protocol). Journal of Chinese Integrative Medicine, 2008, 6(1): 9-14
[4] . Uniform requirements for manuscripts submitted to biomedical journals: Writing and editing for biomedical publication (Chinese version, part two). Journal of Chinese Integrative Medicine, 2010, 8(11): 1001-1005
[5] Bo Wang , Wei Yan , Li-hui Hou, Xiao-ke Wu. Disorder of Tiangui (kidney essence) and reproductive dysfunction in patients with polycystic ovary syndrome. Journal of Chinese Integrative Medicine, 2010, 8(11): 1018-1022
[6] Hong Liu , Guo-liang Zhang, Li Shen , Zhen Zeng, Bao-luo Zhou, Cheng-hai Liu, Guang Nie . Application and evaluation of a pseudotyped virus assay for screening herbs for anti-H5Nl avian influenza virus. Journal of Chinese Integrative Medicine, 2010, 8(11): 1036-1040
[7] Bing Hu , Hong-mei An , Ke-ping Shen , Qin Du. Senescence-inducing effects of Chinese herbal medicine Tenglong Buzhong Decoction on human colon carcinoma LS-174-T cells and the mechanism. Journal of Chinese Integrative Medicine, 2010, 8(11): 1048-1052
[8] Ya-bing Zhou, Jian-er Yu, Jie Wu, Li Bai, Li-li Huo, Xin-guang Zhang, Li-qing Li . Effects of Chinese herbal medicine Bushen Gubiao Recipe on toll-like receptor 4 and CD4 +CD25 +foxp3 +regulatory T cells in mice with recurrent respiratory tract infections. Journal of Chinese Integrative Medicine, 2010, 8(11): 1053-1059
[9] Zhi-mei Wang, Bin Zhang. A study on translation of ellipses in Huangdi Neijing from perspective of hermeneutic theory. Journal of Chinese Integrative Medicine, 2010, 8(11): 1097-1100
[10] Samadder Asmita, Das Jayeeta, Das Sreemanti, Biswas Raktim, Rahman Khuda-Bukhsh Anisur. Ameliorative potentials of Syzygium jambolanum extract against arsenic-induced stress in L6 cells in vitro. Journal of Chinese Integrative Medicine, 2012, 10(11): 1293-1302