Integration of traditional Chinese medicine and Western medicine in the era of precision medicine

doi:10.1016/S2095-4964(17)60314-5

Abstract

Precision medicine has received growing recognition from clinicians, health systems, and the pharmaceutical industry, as well as patients and policymakers, which will leave a major impact on the practice of medicine. Interestingly, traditional Chinese medicine (TCM) provides personalized medical treatment based on the theory of TCM characterized by holistic concept and pattern differentiation. This, to some extent, is similar to the personalized medical treatment of precision medicine. In China, TCM as well as Western medicine (WM) plays an important role in healthcare. In this article, the authors summarized the influence of precision medicine on current medical directions, the advantages of TCM in disease treatment, further development of precision medicine and the strategies for integration of TCM and WM under this new treatment approach. In addition, the authors discuss the perspective of precise medical diagnosis and treatment, precise prevention, and the complementary advantages of the integration of TCM and WM. Finally, the authors give their perspectives on the challenges and opportunities presented by precision medicine, in the context of further research toward the integration of TCM and WM.

Key words: Precision medicine, Medicine,Chinese traditional, Western medicine, Integrative medicine

Wen-jian Wang, Teng Zhang. Integration of traditional Chinese medicine and Western medicine in the era of precision medicine. Journal of Integrative Medicine, 2017, 15(1): 1-7.

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References

1 Mei T, Zhang Y, Hu S, Yang HM, Zhou Y.Construction of precision medicine system and its challenges. Zhongguo Shu Zi Yi Xue.2016; 11(1): 44-48. Chinese with abstract in English.
2 Yang JF, Noffsinger A, Sreenarasimhaiah J, Yang Q.Mo1683 colorectal cancers with/without DNA mismatch repair defi ciency and tumor distribution patterns from 5 088 patients. Gastroenterology.2016; 150(4): S750-S750.
3 Yan W, Zhang A, Powell MJ.Genetic alteration and mutation profiling of circulating cell-free tumor DNA (cfDNA) for diagnosis and targeted therapy of gastrointestinal stromal tumors. Chin J Cancer.2016; 35(1): 68.
4 Liontos M, Anastasiou I, Bamias A, Dimopoulos MA.DN A damage, tumor mutational load and their impact on immune responses against cancer. Ann Transl Med. 2016; 4(14): 264.
5 Baek JH, Sun JM, Min YJ, Cho EK, Cho BC, Kim JH, Ahn MJ, Park K.Efficacy of EGFR tyrosine kinase inhibitors in patients with EG FR-mutated non-small cell lung cancer except both exon 19 deletion and exon 21 L858R: a retrospective analysis in Korea. Lung Cancer.2015; 87(2): 148-154.
6 Jang SH.Long te rm therapeutic plan for patients with nonsmall cell lung cancer harboring EGFR mutation. Tuberc Respir Dis (Seoul).2014; 76(1): 8-14.
7 Anderson WF, Rosenberg PS, Katki HA.Tr acking and evaluating molecular tumor markers with cancer registry data: HER2 and breast cancer. J Natl Cancer Inst.2014; 106(5): pii: dju093.
8 Wong IO, Schooling CM, Cowling BJ, Leung GM.Br east cancer incidence and mortality in a transitioning Chinese population: current and future trends. Br J Cancer.2015; 112(1): 167-170.
9 Recondo G Jr, de la Vega M, Galanternik F, Díaz-Cantón E, Leone BA, Leone JP. Nove l approaches to target HER2- positive breast cancer: trastuzumab emtansine.Cancer Manag Res. 2016; 8: 57-65.
10 Meers C, Keskin H, Storici F.DNA repair by RNA: templated, or not templated, that is the question. DNA Repair (Amst).2016; 44: 17-21.
11 Marshall E.Huma n genome 10th anniversary. Waiting for the revolution.Science. 2011; 331(6017): 526-529.
12 Editorial. Best is yet to come.Nature. 2011; 470(7333): 140.
13 Check Hayden E.Huma n genome at ten: life is complicated. Nature.2010; 464(7289): 664-667.
14 National Research Council.Toward precision medicine: building a knowledge network for biomedical research and a new taxonomy of disease. Washington DC: National Academies Press. 2011.
15 Wu JR.Precision medicine based on systems biology. Sheng Ming Ke Xue.2015; 27(5): 558-563. Chinese with abstract in English.
16 16 Luo CS, Liu XJ. The problems we faced in development of precision medicine. (2015-06-10) [2016-08-10]. . The problems we faced in development of precision medicine. (2015-06-10) [2016-08-10]. http:// h.wokeji.com/jbsj/bb/201506/t20150610_1268749.shtml.
17 Yang GZ, Su XH, Wu XF, Dai XJ, Yang LY, Pan CZ.Association of single nucleotide polymorphisms in the proximal promoter region of the adiponectin gene with TCM syndromes in patients with type 2 diabetes. Guo Ji Zhong Yi Zhong Yao Za Zhi.2016; 38(3): 204-208. Chinese with abstract in English.
18 Liu Q, Ling JY, Li XD, Zhang CZ, Song QL, Tan J, Huang J, Peng XM, Wang JP, Wu JH.Associations of rs3820998 polymorphism in TANK gene with syndrome types of TCM of hepatitis B related cirrhosis. Zhong Xi Yi Jie He Gan Bing Za Zhi.2013; 23(4): 241-244. Chinese with abstract in English.
19 Shen ZY, Huang JH, Chen WH. Comparison of gene expression profiles between rats of Shen deficiency syndrome and Shen-yang defi ciency syndrome differentiated according to therapeutic effi cacy of drugs used. Zhongguo Zhong Xi Yi Jie He Za Zhi.2007; 27(2): 135-137. Chinese with abstract in English.
20 Fan X, Shi M, Wang Y, Liang Q, Luo G.Tran scriptional profi ling analysis of HMP-treated rats with experimentally induced myocardial infarction. J Ethnopharmacol.2011; 137(1): 199-204.
21 Zhu H, Luo XP, Wang LJ, Li Y, Shi HM, Fan WH, Dai HR.Evaluation on clinical effect of long-term Shexiang Baoxin pill administration for treatment of coronary heart disease. Zhongguo Zhong Xi Yi Jie He Za Zhi.2010; 30(5): 474-477. Chinese with abstract in English.
22 Luo XP, Li Y, Fan WJ, Zhang GF, Zhang J, Shi HM, Wang CP, Wang SY, Dai RH.Experimental study on reducing effect of Shexiang Baoxin pill from damage of arterial wall caused by hyperlipemia. Zhongguo Zhong Xi Yi Jie He Za Zhi.1998; 18(8): 486-489. Chinese with abstract in English.
23 Zhang RX, Liu HJ. Treatment of unstable angina pectoris with Shexiang Baoxin pills combined with clopidogrel. Zhong Xi Yi Jie He Xin Nao Xue Guan Bing Za Zhi. 2009; 7(9):1114-1115. Chinese.
24 Gan L, Ling YJ, Zhu LP.Experience of the treatment of mild hypertension with increased low-density lipoprotein cholesterol. Zhong Cheng Yao.2005; 27(5): 635-637. Chinese.
25 Song KY, Wei YJ, Li LT.Effects of Shexiang Baoxin pills on coronary flow reserve in patients with slow coronary flow. Changchun Zhong Yi Yao Da Xue Xue Bao.2011; 27(5): 720-722. Chinese.
26 Shen W, Fan WH, Shi HM, Li Y, Luo XP, Zhang XL, Zhu J, Jin B, Li J, Pan JJ. Effects of Shexiang Baoxin pill on angiogenesis in atherosclerosis plaque and ischemic myocardium. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2010; 30(12):1284-1287. Chinese with abstract in English.
27 Chen Y, Fu DY, Chen Y, He YM, Fu XD, Xu YQ, Liu Y, Feng XT, Zhang T, Wang WJ.Effe cts of Chinese herbal medicine Yiqi Huaju Formula on hypertensive patients with metabolic syndrome: a randomized, placebo-controlled trial. J Integr Med. 2013; 11(3): 184-194.
28 Wang TZ, Chen Y, He YM, Fu XD, Wang Y, Xu YQ, Yang HJ, Xue HL, Liu Y, Feng XT, Zhang T, Wang WJ.Effe cts of Chinese herbal medicine Yiqi Huaju Qingli Formula in metabolic syndrome patients with microalbuminuria: a randomized placebo-controlled trial. J Integr Med. 2013; 11(3): 175-183.
29 Zhang Z, Xue HL, Liu Y, Wang WJ.Yi-Qi-Zeng-Min-Tang, a Ch inese medicine, ameliorates insulin resistance in type 2 diabetic rats. World J Gastroenterol.2011; 17(8): 987-995.
30 Feng XT, Wang TZ, Leng J, Chen Y, Liu JB, Liu Y, Wang WJ.Palm itate contributes to insulin resistance through down-regulation of the Src-mediated phosphorylation of Akt in C2C12 myotubes. Biosci Biotechnol Biochem.2012; 76(7): 1356-1361.
31 Feng X, Wang W, Liu J, Liu Y.β-Arrestins: multi functional signaling adaptors in type 2 diabetes. Mol Biol Rep.2011; 38(4): 2517-2528.
32 Ya ng Q, Jia C, Wang P, Xiong M, Cui J, Li L, Wang W, Wu Q, Chen Y, Zhang T. MicroR NA-505 identified from patients with essential hypertension impairs endothelial cell migration and tube formation.Int J Cardiol. 2014; 177(3): 925-934.
33 Ga o S, Wang P, Hua Y, Xi H, Meng Z, Liu T, Chen Z, Liu L. ROR fu nctions as a ceRNA to regulate Nanog expression by sponging miR-145 and predicts poor prognosis in pancreatic cancer.Oncotarget. 2016; 7(2): 1608-1618.
34 Hu J, Qiu M, Jiang F, Zhang S, Yang X, Wang J, Xu L, Yin R.MiR-14 5 regulates cancer stem-like properties and epithelial-to-mesenchymal transition in lung adenocarcinoma-initiating cells. Tumour Biol.2014; 35(9): 8953-8961.
35 Yi JH, Shi WD, Liu LM.The recipe of Qingyi Huaji in treating advanced pancreatic cancer against expression of MMP-2. Zhong Yi Lin Chuang Yan Jiu.2014; 6(7): 30-32. Chinese with abstract in English.
36 Zhang JJ, Chen Z, Shi WD, Zhu XY, Liu LM.Effect of Qingyi Huaji Formula on serum immunosuppressive factors and immune function of splenic lymphocytes in mice with pancreatic cancer. Zhongguo Shi Yan Fang Ji Xue Za Zhi.2008; 14(6): 49-51. Chinese with abstract in English.

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