Search JIM Advanced Search

Journal of Chinese Integrative Medicine ›› 2011, Vol. 9 ›› Issue (11): 1206-1214.doi: 10.3736/jcim20111108

• Original Clinical Research • Previous Articles     Next Articles

Acupuncture combined with Chinese herbal medicine Plantain and Senna Granule in treatment of functional constipation: A randomized, controlled trial

Li-ke Guo1, Chao-xian Zhang2(), Xiao-feng Guo3   

  1. 1. Department of Stomatology, the First Affiliated Hospital of Xinxiang Medical College, Weihui 453100, Henan Province, China
    2. Department of Gastroenterology, the First Affiliated Hospital of Xinxiang Medical College, Weihui 453100, Henan Province, China
    3. Department of Hepatology, the Sixth People's Hospital of Hangzhou, Hangzhou 310014, Zhejiang Province, China
  • Received:2011-05-30 Accepted:2011-07-25 Online:2011-11-20 Published:2011-11-15

Background: Functional constipation is one of the most common gastrointestinal diseases. Currently, there is no effective Western medical therapy for functional constipation and it significantly impacts the quality of life of the patients. Integrated traditional Chinese and Western medicine therapies were reported to have better therapeutic effects than routine Western medicine therapies.
Objective: To explore the efficacy of acupuncture combined with Chinese herbal medicine Plantain and Senna Granule in the treatment of functional constipation.
Design, setting, participants and interventions: A total of 390 patients with confirmed functional constipation enrolled from the Department of Gastroenterology, the First Affiliated Hospital of Xinxiang Medical College in China from February 2008 to January 2010 were randomly divided into three groups, with 130 cases in each group. Acupuncture group was treated with puncture of point Tianshu (ST25), Shangjuxu (ST37), Zusanli (ST36), Dachangyu (BL25) and Zhigou (SJ6) twice daily for four weeks, while Plantain and Senna Granule group was treated with 5 g of Plantain and Senna Granule once daily, and the combination group was given above-mentioned acupuncture and Plantain and Senna Granule.
Main outcome measures: The defecation cycle, stool property, constipation symptom, accompanying symptoms, gastrointestinal transit time, including total gastrointestinal transit time, mouth-intestine transit time, colonic transit time, right colonic transit time, left colonic transit time and rectosigmoid colonic transit time, and adverse reactions of the three groups were evaluated before treatment, at the end of treatment and 64 weeks after treatment, respectively.
Results: Compared with before treatment, the scores of defecation cycle, stool property, constipation symptoms and accompanying symptoms, and gastrointestinal transit time all decreased significantly at the end of treatment in each group (P<0.01), and the combination group showed better results than the other groups (P<0.05). Compared with the end of treatment, the above-mentioned indexes recurred insignificantly in the combination group and acupuncture group after 64 weeks of follow-up (P>0.05), but all recurred significantly in the Plantain and Senna Granule group (P>0.05). Both short- and long-term total response rates of the combination group showed significant differences compared with those of the other two groups (P<0.05 or P<0.01). No serious adverse reactions occurred in all the three groups.
Conclusion: Acupuncture plus Plantain and Senna Granule can significantly decrease gastrointestinal transit time and defecation cycle in patients with functional constipation; it can also change stool property and alleviate constipation symptom and accompanying symptoms, with good security and tolerance.

Key words: acupuncture, Chinese patent medicine, functional constipation, defecation cycle, stool property, constipation symptom, accompanying symptom, gastrointestinal transit time

Figure 1

Flow diagram of this randomized trial PSG: Plantain and Senna Granule."

Table 1

General characteristics of patients of the three groups"


Item

Acupuncture group (n=125)

PSG group (n=125)

Combination group (n=128)

Gender (Male/female)

62/63

64/61

65/63

Age (x±s, years)

49.7±10.5

51.7±10.3

50.4±12.6

Course of disease (x±s, years)

20.71±5.56

20.67±3.41

20.74±4.81

Degree of disease (n, %)

Mild

36 (28.8)

36 (28.8)

35 (27.3)

Medium

56 (44.8)

55 (44.0)

58 (45.3)

Severe

33 (26.4)

34 (27.2)

35 (27.3)

Table 2

Grades of defecation cycle, stool property, constipation symptom and accompanying symptom of the three groups (x±s, score)"


Group

n

Defecation cycle

Stool property

Constipation
symptom

Accompanying
symptom

Total symptom

Combination

128

Before treatment

2.67±0.52

2.59±0.24

3.84±0.31

7.18±2.54

16.28±4.51

After treatment

0.92±0.26**

0.85±0.44**

1.26±0.24**

3.28±1.74**

7.31±2.39**

64 weeks after treatment

0.93±0.47□■■

0.85±0.53□■■

1.27±0.76□■■

3.31±0.52□■■

7.36±1.25□■■

Acupuncture

125

Before treatment

2.66±1.24

2.60±0.29

3.85±0.64

7.18±4.51

16.29±3.26

After treatment

1.44±0.65**

1.37±0.39**

1.79±0.28**

4.51±1.53**

9.11±2.42**

64 weeks after treatment

1.45±0.37

1.37±0.32

1.80±0.18

4.53±2.07

9.15±2.57

PSG

125

Before treatment

2.66±0.34

2.61±1.32

3.84±0.76

7.18±2.08

16.29±5.54

After treatment

1.45±0.68**

1.38±0.46**

1.79±0.29**

4.48±1.26**

9.10±2.73**

64 weeks after treatment

2.08±0.1

1.92±1.91

2.51±0.43

5.82±3.05

12.33±5.58

Table 3

Results of gastrointestinal transit time of the three groups (x±s)"


Group

n

50% TGITT

50% M-ITT

50% CTT

50% RCTT

50% LCTT

50% RSTT

Combination

128

Before treatment

81.8±2.3

21.5±0.4

60.3±1.4

21.5±0.8

12.8±1.7

26.0±2.6

After treatment

21.0±1.6**

8.1±1.2**

12.9±1.5**

6.1±2.1**

2.8±0.3**

4.0±0.4**

64 weeks after treatment

22.5±1.4□■■

8.5±1.7□■■

14.0±0.9▲□■■

6.7±0.3□■■

3.0±1.5□■■

4.3±0.9□■■

Acupuncture

125

Before treatment

81.7±1.5

21.3±0.6

60.4±1.4

21.4±0.8

12.8±0.8

26.2±1.2

After treatment

33.0±2.3**

11.9±1.4**

21.1±1.3**

9.1±1.9**

5.4±2.4**

6.6±0.7**

64 weeks after treatment

37.5±1.3

13.8±2.4

23.7±0.9

10.0±0.3

6.3±1.5

7.4±1.9

PSG

125

Before treatment

81.9±2.4

21.4±0.9

60.5±1.7

21.5±1.5

12.7±2.2

26.3±1.3

After treatment

33.1±1.8**

12.0±2.2**

21.1±0.6**

9.2±1.2**

5.6±2.4**

6.3±0.8**

64 weeks after treatment

57.2±1.5

20.9±0.6

36.3±0.9

15.2±1.8

9.7±1.2

11.4±1.8

Table 4

Results of motolin and residual rate of radiopaque markers of the three groups (x±s)"


Group

n

Motolin (mg/L)

Residual rate of radiopaque markers (%)

Combination

128

Before treatment

326.82±52.73

73.45±8.94

After treatment

504.65±72.64**

25.61±4.82**

64 weeks after treatment

497.95±61.39□■■

27.03±5.74□■■

Acupuncture

125

Before treatment

325.87±41.57

73.43±9.76

After treatment

418.20±26.83**

37.76±5.43**

64 weeks after treatment

413.51±56.17

39.85±10.34

PSG

125

Before treatment

327.02±62.44

73.46±4.91

After treatment

420.50±51.43**

38.50±5.12**

64 weeks after treatment

368.52±41.36

52.93±7.36

Table 5

Response rates of the three groups (n, %)"


Group

n

Obviously effective

Effective

Improvement

Ineffective

Total response rate

Combination

128

After treatment

62 (48.44)

39 (30.47)

24 (18.75)

3 (2.34)

125 (97.66)

64 weeks after treatment

60 (46.87)

39 (30.47)

25 (19.53)

4 (3.13)

124 (96.87)△□■■

Acupuncture

125

After treatment

39 (31.20)

29 (23.20)

33 (26.40)

24 (19.20)

101 (80.80)

64 weeks after treatment

38 (30.40)

29 (23.20)

32 (25.60)

26 (20.80)

99 (79.20)

PSG

125

After treatment

40 (32.00)

28 (22.40)

32 (25.60)

25 (20.00)

100 (80.00)

64 weeks after treatment

31 (24.80)

24 (19.20)

24 (19.20)

46 (36.80)

79 (63.20)△▲
[1] Longstreth GF, Thompson WG, Chey WD, Houghton LA, Mearin F, Spiller RC . Functional bowel disorders. Gastroenterology. 2006; 130(5):1480-1491.
doi: 10.1053/j.gastro.2005.11.061
[2] Guo J, Zhang RM, Huang ZW, Wang L, Liu SS, Diao JC, Hu SY, Lin BH . Yunchang Capsule in treatment of functional constipation : a randomized, double-blinded controlled, multicenter trial. J Chin Integr Med. 2009 ; 7(12) : 1123-1129. Chinese with abstract in English.
郭佳, 张瑞明, 黄宗文, 王蕾, 刘松山, 刁军成, 胡思源, 林炳辉 . 运肠胶囊治疗功能性便秘的多中心随机、 双盲、阳性药对照n期临床研究.中西医结合学报. 2009; 7(12) : 1123-1129.
[3] Zhang LY, Yao YZ, Wang T, Fei J, Shen Y, Chen YH, Zong ZW . Efficacy of polyethylene glycol 4000 on constipation of posttraumatic bedridden patients. [J] Chin Traumatol. 2010; 13(3):182-187.
doi: 10.3760/cma.j.issn.1008-1275.2010.03.010 pmid: 20515598
[4] Jiang SL, Fan HL . Double-blind and randomized controlled trial of mosapride in the treatment of functional constipations. Zhongguo She Qu Yi Shi Yi Xue Zhuan Ye. 2008; 10(19): 31. Chinese.
姜绍连, 范红丽 . 莫沙必利治疗功能性便秘的随机双盲对照研究.中国社区医师:医学专业. 2008; 10(19):31.
[5] Wang CW, Li N, He HB, Lu JQ, Liu ZS . Effect of electroacupuncture of Tianshu ( ST25) on the rational symptoms of functional constipation patients and evaluation on its efficacy satisfaction: a single-center, prospective, practical and randomized control trial. Zhen Ci Yan Jiu. 2010 ; 35 (5): 375-379. Chinese with abstract in English.
王成伟, 李宁, 何洪波, 吕建琴, 刘志顺 . 电针双侧天枢穴对功能性便秘患者自觉症状的影响及疗效满意度评价:一项单中心、前瞻性随机对照临床试验.针刺研究. 2010; 35(5):375-379.
[6] Cheng CW, Bian ZX, Zhu LX, Wu JC, Sung JJ . Efficacy of a Chinese herbal proprietary medicine( Hemp Seed Pill) for functional constipation. Am J Gastroenterol. 2011; 106(1) : 120-129.
doi: 10.1038/ajg.2010.305 pmid: 21045817
[7] Bharucha AE, Wald A, Enck P, Rao S . Functional anorectal disorders. Gastroenterology. 2006; 130(5):1510-1518.
doi: 10.1053/j.gastro.2005.11.064
[8] Thompson WG, Longstreth GF, Drossman DA, Heaton KW, Irvine EJ, Müller-Lissner SA . Functional bowel disorders and functional abdominal pain. Gut. 1999; 45 Suppl 2: H43-H47.
doi: 10.1136/gut.45.2008.ii43 pmid: 1766683
[9] Liu BH. Diagnosis and treatment of constipation. Beijing: Military Medical Science Press. 2002: 168. Chinese.
刘宝华 . 便秘的诊断及治疗.北京: 军事医学科学出版社. 2002: 168.
[10] Yang M, Wang BX, Feng Z, Zhao G, Zhong RL, Yang FZ, Li P, Wang MG . Total gastrointestinal transit time of children with functional constipation. Di Si Jun Yi Da Xue Xue Bao. 2003; 24(10): 942-943. Chinese with abstract in English.
杨敏, 王宝西, 冯哲, 赵刚, 钟汝玲, 杨辅直, 李萍, 王茂贵 . 功能性便秘患儿胃肠传输时间的测定.第四军医大学学报. 2003; 24(10):942-943.
[11] Wald A, Sigurdsson L . Quality of life in children and adults with constipation. Best Pract Res Clin Gastroenterol. 2011; 25(1) : 19-27.
doi: 10.1016/j.bpg.2010.12.004 pmid: 21382576
[12] Gong M, Li Y . The treatment status of functional constipation. Zhongguo Dang Dai Yi Yao. 2009 ; 16(16): 199-200. Chinese.
贡鸣, 李岩 . 功能性便秘的治疗现状.中国当代医药. 2009; 16(16) : 199-200 .
[13] Guest JF, Clegg JP, Helter MT . Cost-effectiveness of macrogol 4000 compared to lactulose in the treatment of chronic functional constipation in the UK. Curr Med Res Opin. 2008; 24(7):1841-1852.
doi: 10.1185/03007990802102349
[14] Liu Z, Sakakibara R, Odaka T, Uchiyama T, Uchiyama T, Yamamoto T, Ito T, IAsahina M, IYamaguchi K, IYamaguchi T, IHattori T . Mosapride citrate, a novel 5- HT4 agonist and partial 5-HT3 antagonist, ameliorates constipation in parkinsonian patients. Mov Disord. 2005; 20(6) : 680-686.
doi: 10.1002/(ISSN)1531-8257
[15] Ji SW, Park HJ, Cho JS, Lim JH, Lee SI . Investigation into the effects of mosapride on motility of Guinea pig stomach, ileum, and colon. Yonsei Med J. 2003; 44(4) : 653-664.
doi: 10.3349/ymj.2003.44.4.653 pmid: 12950122
[16] Wang LY, Yang SY . Observation on functionary coprostasis in diabetes mellitus treated by the methods of nourishing qi and yin and activating blood circulation. Zhong Yi Yao Tong Bao. 2006; 5(2) : 45-47. Chinese.
doi: 10.3969/j.issn.1671-2749.2006.02.015
王丽英, 杨叔禹 . 益气养阴活血法治疗2型糖尿病功能性便秘的疗效观察.中医药通报. 2006; 5(2):45-47.
doi: 10.3969/j.issn.1671-2749.2006.02.015
[17] Qiu XP, Liu YC . Therapeutic effect of reinforcing qi and lubricant laxation in treating aged patients with chronic slow-transit constipation. Zhong Yi Yao Lin Chuang Za Zhi. 2006; 19(4): 379-380. Chinese.
doi: 10.3969/j.issn.1672-7134.2007.04.039
邱新平, 刘远成 . 益气润肠法治疗老年慢传输型便秘疗效观察.中医药临床杂志. 2006; 19(4):379-380.
doi: 10.3969/j.issn.1672-7134.2007.04.039
[18] Yu Y, Kang XZ, Shan TL, Liao Q, Chen H, Xiao GH . Effect of Tongbian capsule on gastrointestinal hormones of slow transit constipation in rats. Zhongguo Zhong Xi Yi Jie He Xiao Hua Za Zhi. 2010; 18(4): 244-246. Chinese with abstract in English.
doi: 10.3969/j.issn.1671-038X.2010.04.010
喻玉, 康晓征, 单铁莲, 廖琴, 陈辉, 肖国辉 . 通便胶囊对慢传输型便秘模型大鼠胃肠激素影响的研究.中国中西医结合消化杂志. 2010; 18(4):244-246.
doi: 10.3969/j.issn.1671-038X.2010.04.010
[19] Ding SQ, Ding YJ, Ji XT, Han DM, Sun MM, Huo WY, Huang SL, Geng JX . Effect of acupuncture on PGP9.5 expression in rats with experimental constipation. Shi Jie Hua Ren Xiao Hua Za Zhi. 2009; 17(21): 2184-2187. Chinese with abstract in English.
doi: 10.3969/j.issn.1009-3079.2009.21.012
丁曙晴, 丁义江, 季新涛, 韩惦梅, 孙明明, 霍维宇, 黄书亮, 耿建祥 . 针刺对便秘模型大鼠PGP9.5表达的影响.世界华人消化杂志. 2009; 17(21):2184-2187.
doi: 10.3969/j.issn.1009-3079.2009.21.012
[20] Yang YP, An BQ, Tan QW . Comparison and observation about the immediate effect of postoperative distension of the abdomen with electroacupuncting Zusanli and Shangjuxu Points. Zhejiang Zhong Yi Yao Da Xue Xue Bao. 2009 ; 33(2): 256-257. Chinese with abstract in English.
doi: 10.3969/j.issn.1005-5509.2009.02.066
杨玉平, 安宝泉, 谭奇纹 . 电针足三里、上巨虚治疗术后腹胀临床疗效对比观察.浙江中医药大学学报.2009; 33(2) : 256-257.
doi: 10.3969/j.issn.1005-5509.2009.02.066
[21] Zhou HF, Wang LL, Yi YL, Yu Z, Ju CH, Ma FX . Effects of acupuncture, cisapride and combined acupuncture and cisapride on colonic electromyography in rats with slow transit constipation. Shi Jie Hua Ren Xiao Hua Za Zhi. 2009; 17(33): 3402-3407. Chinese with abstract in English.
doi: 10.3969/j.issn.1009-3079.2009.33.005
周惠芬, 王玲玲, 衣运玲, 余芝, 鞠传慧, 马飞翔 . 针刺结合西沙必利对慢传输便秘大鼠结肠肌电的影响. 世界华人消化杂志. 2009; 17(33):3402-3407.
doi: 10.3969/j.issn.1009-3079.2009.33.005
[22] Zhang FL, Lin HS, He QY . Effect of electro-acupuncture in treating morphine sulfate caused constipation in tumor patients. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2009 ; 29(10) : 922-925. Chinese with abstract in English.
doi: 10.3321/j.issn:1003-5370.2009.10.015
张锋利, 林洪生, 何庆勇 . 电针治疗肿瘤患者口服硫酸吗啡控释片所致便秘的临床研究.中国中西医结合杂志. 2009; 29(10):922-925.
doi: 10.3321/j.issn:1003-5370.2009.10.015
[23] Lu DW, Liu LY . Theoretical analysis of deep acupuncture at Tianshu point in treatment of colon slow-transit constipation. Zhen Jiu Lin Chuang Za Zhi. 2008; 24 (12): 39-40. Chinese.
doi: 10.3969/j.issn.1005-0779.2008.12.025
卢岱魏, 刘兰英 . 天枢穴深刺治疗结肠慢转运性便秘的理论浅析.针灸临床杂志. 2008; 24(12):39-40.
doi: 10.3969/j.issn.1005-0779.2008.12.025
[1] Chiung-Hui Huang, Mei-Ling Yeh, Fang-Pey Chen, Daphne Wu. Low-level laser acupuncture reduces postoperative pain and morphine consumption in older patients with total knee arthroplasty: A randomized placebo-controlled trial. Journal of Integrative Medicine, 2022, 20(4): 321-328.
[2] Ming-min Xu, Pei Guo, Qing-yu Ma, Xuan Zhou, Yu-long Wei, Lu Wang, Yue Chen, Yu Guo. Can acupuncture enhance therapeutic effectiveness of antidepressants and reduce adverse drug reactions in patients with depression? A systematic review and meta-analysis. Journal of Integrative Medicine, 2022, 20(4): 305-320.
[3] Yen-Lin Chao, Yi-Ai Rau, Hong-Sheng Shiue, Jiun-Lin Yan, Yuan-Yun Tang, Shao-Wen Yu, Bo-Yan Yeh, Yen-Lung Chen, Tsung-Hsien Yang, Shu-Chen Cheng, Yi-Wen Hsieh, Hsin-Chia Huang, Fu-Kuang Tsai, Yu-Sheng Chen, Geng-Hao Liu. Using a consensus acupoints regimen to explore the relationship between acupuncture sensation and lumbar spinal postoperative analgesia: A retrospective analysis of prospective clinical cooperation. Journal of Integrative Medicine, 2022, 20(4): 329-337.
[4] Sergey Filist, Riad Taha Al-Kasasbeh, Olga Shatalova, Nikolay Korenevskiy, Ashraf Shaqadan, Zeinab Protasova, Maksim Ilyash, Mikhail Lukashov. Biotechnical system based on fuzzy logic prediction for surgical risk classification using analysis of current-voltage characteristics of acupuncture points. Journal of Integrative Medicine, 2022, 20(3): 252-264.
[5] Ting-ting Lu, Cun-cun Lu, Mei-xuan Li, Li-xin Ke, Hui Cai, Ke-hu Yang. Reporting and methodological quality of meta-analyses of acupuncture for patients with migraine: A methodological investigation with evidence map. Journal of Integrative Medicine, 2022, 20(3): 213-220.
[6] Xiang-yu Wei, Shi-lei Luo, HuiChen, Shan-shan Liu, Zhi-gang Gong, Song-huaZhan. Functional connectivity changes during migraine treatment with electroacupuncture at Shuaigu (GB8). Journal of Integrative Medicine, 2022, 20(3): 237-243.
[7] Samwel Sylvester Msigwa, Yan Li, Xiang-lin Cheng, Fen Cao. Combining electroacupuncture and transcranial direct current stimulation as an adjuvant therapy enhances spontaneous conversation and naming in subacute vascular aphasia: A retrospective analysis. Journal of Integrative Medicine, 2022, 20(3): 244-251.
[8] Xiao Ye, Yu-lan Ren, Yun-hui Chen, Ji Chen, Xiao-jiao Tang, Zong-ming Zhang. A "4D" systemic view on meridian essence: Substantial, functional, chronological and cultural attributes. Journal of Integrative Medicine, 2022, 20(2): 96-103.
[9] Bin Zhao, Yong Chen, Shi-min Liao, Jian-ying Zheng, Shi-hua Yan, Dong-shu Zhang. Successfully treated recalcitrant atopic eczema with acupoint autohemotherapy: A case report and hypothesized mechanism of the therapy. Journal of Integrative Medicine, 2022, 20(2): 182-186.
[10] Jun-peng Yao, Li-ping Chen, Xian-jun Xiao, Ting-hui Hou, Si-yuan Zhou, Ming-min Xu, Kai Wang, Yu-jun Hou, Lin Zhang, Ying Li. Effectiveness and safety of acupuncture for treating functional constipation: An overview of systematic reviews. Journal of Integrative Medicine, 2022, 20(1): 13-25.
[11] Xin Yin, Shu-bin Cai, Lan-ting Tao, Lu-ming Chen, Zhong-de Zhang, Su-hong Xiao, Arthur Yin Fan, Xu Zou. Recovery of a patient with severe COVID-19 by acupuncture and Chinese herbal medicine adjuvant to standard care. Journal of Integrative Medicine, 2021, 19(5): 460-466.
[12] Thomas Efferth, An-long Xu, Roxana Damiescu, Mita Banerjee, Norbert W. Paul, David Y.W. Lee. Can eastern wisdom resolve western epidemics? Traditional chinese medicine therapies and the opioid crisis. Journal of Integrative Medicine, 2021, 19(4): 295-299.
[13] Qiu-yu Tong, Ran Liu, Kun Zhang, Yuan Gao, Guang-wei Cui, Wei-dong Shen. Can acupuncture therapy reduce preoperative anxiety? A systematic review and meta-analysis. Journal of Integrative Medicine, 2021, 19(1): 20-28.
[14] Xian-jun Xiao, Lei-xiao Zhang, Yun-zhou Shi, Jun-peng Yao, Wei Cao, Ying Liu, Zi-hao Zou, Si-yuan Zhou, Ming-ling Chen, Chun-xiao Li, Qian-hua Zheng, Ying Li. Cupping therapy for patients with chronic urticaria: A systematic review and meta-analysis. Journal of Integrative Medicine, 2020, 18(4): 303-312.
[15] Luciana Aikawa, Alexandre Massao Yoshizumi, Mirian Matsura Shirassu, Marcia Kiyomi Koike. Rapid acupuncture for musculoskeletal pain in the emergency room of the Hospital Servidor Publico Estadual, Brazil: A quasi-experimental study. Journal of Integrative Medicine, 2020, 18(4): 313-318.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
[1] Jin-rong Fu. Establishment of multivariate diagnosis and treatment system of modern gynecology of traditional Chinese medicine. Journal of Chinese Integrative Medicine, 2008, 6(1): 22-24
[2] Hao Li, Ming-jiang Yao, Wen-ming Zhao, Jie Guan, Lin-lin Cai, Ling Cui. A randomized, controlled, double-blind trial of Huannao Yicong capsule in senile patients with mild cognitive impairment. Journal of Chinese Integrative Medicine, 2008, 6(1): 25-31
[3] Zhi-chun Jin. Problems in establishing clinical guideline for integrated traditional Chinese and Western medicine. Journal of Chinese Integrative Medicine, 2008, 6(1): 5-8
[4] SUN Ming-yu, ZUO Jian, DUAN Ji-feng, HAN Jun, FAN Shi-ming, ZHANG Wei, ZHU Li-fang, YAO Ming-hui. Antitumor activities of kushen flavonoids in vivo and in vitro. Journal of Chinese Integrative Medicine, 2008, 6(1): 51-59
[5] Min Cheng, Qiong Feng, Shu-wen Qian, Hui Gao, Cui-qing Zhu. Preliminary assay of p-amyloid binding elements in heart-beneficial recipe. Journal of Chinese Integrative Medicine, 2008, 6(1): 68-72
[6] Ning-qun Wang, Liang-duo Jiang, Zong-xing Li. Research progress in asthma-related quality of life. Journal of Chinese Integrative Medicine, 2008, 6(1): 93-97
[7] Jing-yuan Mao, Chang-xiao Liu, Heng-he Wang, Guang-li Wei , Zhen-peng Zhang, Jie Xing, Wang Xian liang , Ying-fei Bi . Effects of Shenmai Injection on serum concentration and pharmacokinetics of digoxin in dogs with heart failure. Journal of Chinese Integrative Medicine, 2010, 8(11): 1070-1074
[8] Zhi-mei Wang, Bin Zhang. A study on translation of ellipses in Huangdi Neijing from perspective of hermeneutic theory. Journal of Chinese Integrative Medicine, 2010, 8(11): 1097-1100
[9] Gui Yu, Jie Wang. Thinking on building the network cardiovasology of Chinese medicine. Journal of Chinese Integrative Medicine, 2012, 10(11): 1206-1210
[10] Pedro Saganha João, Doenitz Christoph, Greten Tobias, Efferth Thomas, J. Greten Henry. Qigong therapy for physiotherapists suffering from burnout: a preliminary study. Journal of Chinese Integrative Medicine, 2012, 10(11): 1233-1239