Search JIM Advanced Search

Journal of Chinese Integrative Medicine ›› 2003, Vol. 1 ›› Issue (3): 195-198.doi: 10.3736/jcim20030315

Previous Articles     Next Articles

Prognostic analysis of advanced non small cell lung cancer treated by sequential chemo-radiation therapy combined with traditional Chinese medicine: A report of 54 cases

Ming-quan Han(), Jin-mei Su, Hai-yin Huang, Wei-hong Long, Li-ping Qin, Ping Qin, Wei Liu, Zhao-ying Sheng   

  1. Department of Integrated Traditional Chinese and Western Medicine,Pulmonary Disease Hospital of Shanghai, Shanghai 200433, China
  • Received:2003-07-21 Online:2003-09-20 Published:2003-09-20

Objective

To evaluate the influence of fewer courses and prolonged intervals of chemotherapy on survival rate of advanced non small cell lung cancer (NSCLC) patients treated by sequential chemo-radiation therapy combined with traditional Chinese medicine (TCM).


Methods

From Jan.2000 to Dec.2001, 54 untreated advanced NSCLC patients (2 stage Ⅲa, 18 stage Ⅲb, 34 stage Ⅳ) were treated by sequential chemo-radiation therapy combined with TCM. The courses of chemotherapy were reduced and the intervals of chemotherapy were longer than that of the standard regimen. The efficacy and survival rate were documented and the prognostic factors were analyzed.


Results

Complete remission (CR) was observed in 1 case and partial remission (PR) in 20 cases. The overall objective response rate was 40.4%. Median survival was 15.3 months, 1-, 2- and 3- year survival rate were 53.7%, 28.9% and 9.6% respectively. The median survival of stage Ⅲ and Ⅳ were 21.8 months and 12.5 months respectively. The 1-, 2-, and 3- year survival rates of stage Ⅲ were 65.0%,49.5%, 24.7% and that of stage Ⅳ were 47.0%, 23.3%, 0%, respectively. The quality of life was improved in most of the patients. Cox's proportional hazards regression showed that improved quality of life and treatment of TCM were the significant prognostic factors of overall survival.


Conclusion

Chemotherapy and radiotherapy combined with TCM is beneficial to extending the interval of chemotherapy, improving the quality of life, and increasing the survival rate of advanced NSCLC patients.

Key words: advanced NSCLC, prognostic factor, survival time, quality of life, chemotherapy, radiotherapy, drugs, Chinese herbal

CLC Number: 

  • R734.2

"

患者类别 n 1年生存率(%) 2年生存率(%) 3年生存率(%) 中位生存期(月)
Ⅲ期 20 65.0 49.5 24.7 21.8
Ⅳ期 34 47.0 23.3 0 12.5
全部患者 54 53.7 28.9 9.6 15.3

"

变量 回归系数(β) 标准误(Sx P 相对危险度[Exp(β)]
性别 -0.458 0.371 0.217 0.632
年龄 0.554 0.317 0.080 1.740
病理类型 0.028 0.210 0.893 1.029
TNM分期 0.734 0.361 0.042 2.084
近期疗效 0.741 0.289 0.010 2.098
Karnofsky评分 -1.182 0.217 0.000 0.307
化疗疗程 -0.469 0.182 0.010 0.626
化疗间隔时间 -0.538 0.172 0.002 0.584
放疗 -0.407 0.277 0.142 0.666
中药治疗 -1.120 0.340 0.001 0.326

"

变量 回归系数(β) 标准误(Sx P 相对危险度[Exp(β)]
性别 -0.074 0.537 0.890 0.928
年龄 -0.038 0.483 0.938 0.963
病理类型 0.509 0.290 0.079 1.663
TNM分期 0.455 0.448 0.310 1.576
近期疗效 0.339 0.362 0.349 1.404
Karnofsky评分 -1.282 0.329 0.000 0.277
化疗疗程 -0.445 0.301 0.139 0.641
化疗间隔时间 -0.341 0.275 0.215 0.711
放疗 -0.231 0.387 0.550 0.794
中药治疗 -1.321 0.511 0.010 0.267
[1] 吴一龙 . 非小细胞肺癌的治疗——2001年ASCO会议综述之三[J]. 癌症, 2001,20(11):1317-1318
[2] Le Chevalier T, Arriagada R, Tarayre M , et al. Significant effect of adjuvant chemotherapy on survival in locally advanced non-small cell lung carcinoma[J]. J Natl Cancer Inst, 1992,84(1):58-63
doi: 10.1093/jnci/84.1.58
[3] Sause WT, Scott C, Taylor S , et al. Radiation Therapy Oncology Group(RTOG) 88-08 and Eastern Cooperative Oncology Group(ECOG) 4588: preliminary results of a phase Ⅲ trial in regionally advanced, unresectable non-small-cell lung cancer[J]. J Natl Cancer Inst, 1995,87(3):198-205
doi: 10.1093/jnci/87.3.198
[4] 刘嘉湘, 施志明, 李和根 , 等. 益肺抗瘤饮治疗271例非小细胞肺癌临床观察[J]. 上海中医药杂志, 2001,35(2):4-6
[5] 李邦华, 曾纪权, 袁国庆 . 益气养阴散结加化疗治疗Ⅲ期非小细胞肺癌临床观察[J]. 江西中医药, 2001,32(1):21-22
[6] Dillman RO, Herndon J, Seagren SL , et al. Improved survival in stage Ⅲ non-small-cell lung cancer: seven-year follow-up of cancer and leukemia group B(CALGB) 8433 trial[J]. J Natl Cancer Inst, 1996,88(17):1210-1215
doi: 10.1093/jnci/88.17.1210
[7] Chu DT, Zhang XR, Li JL , et al. The treatment of advanced non-small-cell lung cancer(NSCLC) --overseas updated and local experiences[J]. Gan To Kagaku Ryoho, 2002,29(Suppl 1):117-124
[8] Millward MJ, Boyer MJ, Lehnert M , et al. Docetaxel and carboplatin is an active regimen in advanced non-small-cell lung cancer: a phase Ⅱ study in Caucasian and Asian patients[J]. Ann Oncol, 2003,14(3):449-454
doi: 10.1093/annonc/mdg118
[9] Cardenal F, Domine M, Massuti B , et al. Three-week schedule of irinotecan and cisplatin in advanced non-small-cell lung cancer: a multicenter phase Ⅱ study[J]. Lung Cancer, 2003,39(2):201-207
doi: 10.1016/S0169-5002(02)00512-3
[10] Zaniboni A, Ardizzoni A, De Marinis F , et al. Phase Ⅱ study of Taxol combined with ifosfamide and carboplatin in the treatment of stage ⅢB-Ⅳ non-small-cell lung cancer[J]. Am J Clin Oncol, 2003,26(1):84-88
doi: 10.1097/00000421-200302000-00016
[11] Montazeri A, Milroy R, Hole D , et al. Quality of life in lung cancer patients as an important prognostic factor[J]. Lung Cancer, 2001,31(2-3):223-240
doi: 10.1016/S0169-5002(00)00179-3 pmid: 11165402
[1] Shu-yi Chen, Qun-wei Chen, Liu-mei Shou, Hong Pan, Shan-ming Ruan, Zhe-hao Liang, Qi-jin Shu. Stevens-Johnson syndrome/toxic epidermal necrolysis successfully treated with Chinese herbal medicine Pi-Yan-Ning: A case report. Journal of Integrative Medicine, 2021, 19(6): 555-560.
[2] Xin Yin, Shu-bin Cai, Lan-ting Tao, Lu-ming Chen, Zhong-de Zhang, Su-hong Xiao, Arthur Yin Fan, Xu Zou. Recovery of a patient with severe COVID-19 by acupuncture and Chinese herbal medicine adjuvant to standard care. Journal of Integrative Medicine, 2021, 19(5): 460-466.
[3] Bing-rong Li, Shi-yun Shao, Long Yuan, Ru Jia, Jian Sun, Qing Ji, Hua Sui, Li-hong Zhou, Yi Zhang, Hui Liu, Qi Li, Yan Wang, Bi-meng Zhang. Effects of mild moxibustion on intestinal microbiome and NLRP3 inflammasome in rats with 5-fluorouracil-induced intestinal mucositis. Journal of Integrative Medicine, 2021, 19(2): 144-157.
[4] Qing-lan Wang, Yan-yan Tao, Hong-dong Xie, Cheng-hai Liu, Ping Liu. Fuzheng Huayu recipe, a traditional Chinese compound herbal medicine, attenuates renal interstitial fibrosis via targeting the miR-21/PTEN/AKT axis. Journal of Integrative Medicine, 2020, 18(6): 505-513.
[5] Ming-sheng Lyu, De-ying Li, Shao-zhong Zhou, Cheng-jun Ban, Jun Yan. Adult-onset Still's disease successfully treated with Chinese herbal medicine: A case report with 15-month follow-up. Journal of Integrative Medicine, 2020, 18(6): 530-534.
[6] Arthur Yin Fan, Sherman Gu, Sarah Faggert Alemi, Research Group for Evidence-based Chinese Medicine. Chinese herbal medicine for COVID-19: Current evidence with systematic review and meta-analysis. Journal of Integrative Medicine, 2020, 18(5): 385-394.
[7] Bin Lan, Jin-wen Ge, Shao-wu Cheng, Xi-long Zheng, Jun Liao, Chao He, Zheng-qing Rao, Guo-zuo Wang. Extract of Naotaifang, a compound Chinese herbal medicine, protects neuron ferroptosis induced by acute cerebral ischemia in rats. Journal of Integrative Medicine, 2020, 18(4): 344-350.
[8] Fatemeh Sadat Hasheminas, Seyed Mehdi Hashemi, Azizallah Dehghan, Fariba Sharififar, Mohammad Setayesh, Pegah Sasanpour, Mojtaba Tasbandi, Mahboobeh Raeiszadeh. Effects of a Plantago ovata-based herbal compound in prevention and treatment of oral mucositis in patients with breast cancer receiving chemotherapy: A double-blind, randomized, controlled crossover trial. Journal of Integrative Medicine, 2020, 18(3): 214-221.
[9] Deng-hai Zhang, Kun-lun Wu, Xue Zhang, Sheng-qiong Deng, Bin Peng. In silico screening of Chinese herbal medicines with the potential to directly inhibit 2019 novel coronavirus. Journal of Integrative Medicine, 2020, 18(2): 152-158.
[10] Gerli E.G. Herr, Fábio Goulart da Silva, Francisco José Cidral-Filho, Fabricia Petronilho, Lucinéia Gainski Danielski, Mariana Pereira de Souza Goldim, Afonso Shiguemi Inoue Salgado, Franciane Bobinski, Daniel Fernandes Martins, Eliane R. Winkelmann. Effects of the use of bioceramic wraps in patients with lower limb venous ulcers: A randomized double-blind placebo-controlled trial. Journal of Integrative Medicine, 2020, 18(1): 27-.
[11] Goulnar Kasymjanova, Anh-Thi Tran, Victor Cohen, Carmela Pepe, Lama Sakr, David Small, Jason Scott Agulnik, Robert Thomas Jagoe. The use of a standardized Chinese herbal formula in patients with advanced lung cancer: A feasibility study. Journal of Integrative Medicine, 2018, 16(6): 390-395.
[12] Carola Analía Torres, Cristina Marisel Pérez Zamora, María Beatriz Nuñez, Ana María Gonzalez. In vitro antioxidant, antilipoxygenase and antimicrobial activities of extracts from seven climbing plants belonging to the Bignoniaceae. Journal of Integrative Medicine, 2018, 16(4): 255-262.
[13] Ching-Feng Su. Home care with acupuncture increased the quality of life in a patient with advanced cancer with neuropathic pain induced by bone metastasis: A case report. Journal of Integrative Medicine, 2018, 16(3): 208-210.
[14] Hidetoshi Mori, Hiroshi Kuge, Shunji Sakaguchi, Tim Hideaki Tanaka, Junji Miyazaki. Determination of symptoms associated with hiesho among young females using hie rating surveys. Journal of Integrative Medicine, 2018, 16(1): 34-38.
[15] Shui-jie Shen, Yong-hong Zhang, Xiao-xia Gu, Shui-ju Jiang, Ling-jun Xu. Yangfei Kongliu Formula, a compound Chinese herbal medicine, combined with cisplatin, inhibits growth of lung cancer cells through transforming growth factor-β1 signaling pathway. Journal of Integrative Medicine, 2017, 15(3): 242-251.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
[1] Wei-xiong Liang. Problems-solving strategies in clinical treatment guideline for traditional Chinese medicine and integrative medicine. Journal of Chinese Integrative Medicine, 2008, 6(1): 1-4
[2] Zhao-guo Li. Discussion on English translation of commonly used sentences in traditional Chinese medicine: part one. Journal of Chinese Integrative Medicine, 2008, 6(1): 107-110
[3] Jun Hu, Jian-ping Liu. Non-invasive physical treatments for chronic/recurrent headache. Journal of Chinese Integrative Medicine, 2008, 6(1): 31
[4] Xue-mei Liu, Qi-fu Huang, Yun-ling Zhang, Jin-li Lou, Hong-sheng Liu, Hong Zheng. Effects of Tribulus terrestris L. saponion on apoptosis of cortical neurons induced by hypoxia-reoxygenation in rats. Journal of Chinese Integrative Medicine, 2008, 6(1): 45-50
[5] . Uniform requirements for manuscripts submitted to biomedical journals: Writing and editing for biomedical publication (Chinese version, part two). Journal of Chinese Integrative Medicine, 2010, 8(11): 1001-1005
[6] Daniel Weber, Janelle M Wheat, Geoffrey M Currie. Inflammation and cancer: Tumor initiation, progression and metastasis,and Chinese botanical medicines. Journal of Chinese Integrative Medicine, 2010, 8(11): 1006-1013
[7] Hong Liu , Guo-liang Zhang, Li Shen , Zhen Zeng, Bao-luo Zhou, Cheng-hai Liu, Guang Nie . Application and evaluation of a pseudotyped virus assay for screening herbs for anti-H5Nl avian influenza virus. Journal of Chinese Integrative Medicine, 2010, 8(11): 1036-1040
[8] Zhao-guo Li . A discussion of English translation of 1995 and 1997 Chinese National Standards of Traditional Chinese Medical Terminologies for Clinical Diagnosis and Treatment. Journal of Chinese Integrative Medicine, 2010, 8(11): 1090-1096
[9] Rui Jin, Bing Zhang. A complexity analysis of Chinese herbal property theory: the multiple formations of herbal property (Part 1). Journal of Chinese Integrative Medicine, 2012, 10(11): 1198-1205
[10] Hui-min Liu, Xian-bo Wang, Yu-juan Chang, Li-li Gu. Systematic review and meta-analysis of randomized controlled trials of integrative medicine therapy for treatment of chronic severe hepatitis. Journal of Chinese Integrative Medicine, 2012, 10(11): 1211-1228