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Journal of Chinese Integrative Medicine ›› 2008, Vol. 6 ›› Issue (8): 856-859.doi: 10.3736/jcim20080816

• Original Experimental Research • Previous Articles     Next Articles

Effects of different Chinese herbal medicines on biochemical parameters in guinea-pig with pigment gallstones

Jing-zhe Zhang1(), Xue-lin Zhang1, Xiao-qiang Liang2, Hong-gang Gu1, Pei-ting Zhu1   

  1. 1. Department of Hepatobiliary Surgery, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China
    2. Institute of Chinese Traditional Surgery, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China
  • Received:2008-02-14 Online:2008-08-20 Published:2008-08-15

Objective: To observe the effects of Qingdan Capsule (QDC) and Yanggan Lidan Granule (YGLDG), two kinds of compound traditional Chinese herbal medicines, on biochemical parameters in guinea-pigs with pigment gallstones.
Methods: An animal model of pigment gallstones was established in male guinea-pigs by hypodermic injection of lincomycin. The guinea-pigs were randomly divided into blank control group, untreated group, QDC group and YGLDG group. There were 8 guinea-pigs in each group. After ten-day treatment, animals were sacrificed and sampled to calculate the rate of stone formation, total bilirubin (TB), unconjugated bilirubin (UCB) and Ca2+ density in bile of the four groups.
Results: In comparison with the untreated group, the rates of stone formation in the QDC and YGLDG groups were significantly decreased (P<0.01). TBIL, UCB and Ca2+ content of bile in both QDC and YGLD groups was also significantly decreased (P<0.05, P<0.01).
Conclusion: QDC and YGLD have good effects on biochemical changes of animal model of pigment gallstone in reversing the lithogenesity of bile by reducing the content of TB, UCB and Ca2+, hence resulting in clinical treatment and prevention of pigment gallstone disease.

Key words: choleretics, bile pigments, cholelithiasis, guinea-pigs

CLC Number: 

  • R575.623

Table 1

Levels of total bilirubin, unconjugated bilirubin and Ca2 in four groups (x±s)"

Group n Total bilirubin (μmol/L) Unconjugated bilirubin (μmol/L) Ca2+ (mmol/L)
Blank control 8 7.43±5.36** 2.43±5.44** 0.60±0.40**
Untreated 8 34.59±4.29 22.62±3.61 1.30±0.19
Qingdan Capsule 8 29.62±6.12 15.61±6.26* 0.51±0.29**
Yanggan Lidan Granule 8 22.60±4.42* 9.94±4.24* 0.61±0.19**
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