不同中药对豚鼠胆色素结石模型的生化学影响

doi:10.3736/jcim20080816

Abstract

Objective: To observe the effects of Qingdan Capsule (QDC) and Yanggan Lidan Granule (YGLDG), two kinds of compound traditional Chinese herbal medicines, on biochemical parameters in guinea-pigs with pigment gallstones.
Methods: An animal model of pigment gallstones was established in male guinea-pigs by hypodermic injection of lincomycin. The guinea-pigs were randomly divided into blank control group, untreated group, QDC group and YGLDG group. There were 8 guinea-pigs in each group. After ten-day treatment, animals were sacrificed and sampled to calculate the rate of stone formation, total bilirubin (TB), unconjugated bilirubin (UCB) and Ca2+ density in bile of the four groups.
Results: In comparison with the untreated group, the rates of stone formation in the QDC and YGLDG groups were significantly decreased (P<0.01). TBIL, UCB and Ca2+ content of bile in both QDC and YGLD groups was also significantly decreased (P<0.05, P<0.01).
Conclusion: QDC and YGLD have good effects on biochemical changes of animal model of pigment gallstone in reversing the lithogenesity of bile by reducing the content of TB, UCB and Ca2+, hence resulting in clinical treatment and prevention of pigment gallstone disease.

Key words: choleretics, bile pigments, cholelithiasis, guinea-pigs

CLC Number:

R575.623

Jing-zhe Zhang, Xue-lin Zhang, Xiao-qiang Liang, Hong-gang Gu, Pei-ting Zhu. Effects of different Chinese herbal medicines on biochemical parameters in guinea-pig with pigment gallstones. Journal of Chinese Integrative Medicine, 2008, 6(8): 856-859.

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URL: http://www.jcimjournal.com/EN/10.3736/jcim20080816

http://www.jcimjournal.com/EN/Y2008/V6/I8/856

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Group	n	Total bilirubin (μmol/L)	Unconjugated bilirubin (μmol/L)	Ca²⁺ (mmol/L)
Blank control	8	7.43±5.36**	2.43±5.44**	0.60±0.40**
Untreated	8	34.59±4.29	22.62±3.61	1.30±0.19
Qingdan Capsule	8	29.62±6.12	15.61±6.26*	0.51±0.29**
Yanggan Lidan Granule	8	22.60±4.42*	9.94±4.24*	0.61±0.19**

Effects of different Chinese herbal medicines on biochemical parameters in guinea-pig with pigment gallstones

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