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Journal of Chinese Integrative Medicine ›› 2004, Vol. 2 ›› Issue (2): 100-102.doi: 10.3736/jcim20040207

• Original Clinical Research • Previous Articles     Next Articles

Effects of granules for nourishing kidney and strengthening brain on main symptoms of kidney-yin deficiency and blood stasis syndrome and hemorrheological characteristics of brain atrophy

Shen Zhou, Wei-hua Yang, You-sheng Li, Fang Liu, Da-hua Wu, Li Yang   

  1. Hunan Provincial Academy of Trditional Chinese Medicine and Chinese Materia Medica, Changsha, Hunan Province 410006, China
  • Online:2004-03-20 Published:2018-10-25

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Objective: To explore the influence of granules for nourishing kidney and strengthening brain (GNKSB) on main symptoms of kidney-yin deficiency and blood stasis syndrome and the hemorrheological characteristics of brain atrophy patients.Methods: Ninety patients of brain atrophy with kidney-yin deficiency and blood stasis syndrome were randomly divided into two groups. Sixty cases in treatment group were treated with GNKSB, and the 30 cases in control group were treated with piracetam for 8 weeks.Results: The effective rate of treatment group was 73.3%, with significant difference as compared with 46.6% of the control group (P<0.01). The scores of symptom-assessment of the two groups were also significantly different (P<0.01). The mini-mental state examination of treatment group was obviously improved, and was significantly different as compared with the control group (P<0.01). The scores of Hasegawa's dementia scale and activities of daily living were increased, but without significant difference as compared with the control group. The platelet aggregation rate was improved, with significant difference as compared with the control group (P<0.05). The whole blood viscosity was also improved obviously, but without significant difference as compared with the control group.Conclusion: GNKSB is effective for kidney-yin deficiency and blood stasis syndrome of brain atrophy patients and can improve their mental state and the hemorrheological indexes.

Key words: brain atrophy, kidney-yin deficiency syndrome, blood stasis syndrome, hemorrheology, nourishing kidney and strengthening brain

CLC Number: 

  • R742.8

Tab 1

Results of MMSE, HDS and ADL in 2 groups（Scores）"

Group n MMSE HDS ADL
Treatment group
Before treatment 60 20.61±7.11 18.70±7.04 23.65±7.55
After treatment 60 25.90±4.03**△△ 25.22±5.44** 20.48±5.75**
Control group
Before treatment 30 18.93±5.90 20.25±6.88 21.06±6.04
After treatment 30 21.96±4.91** 24.98±5.49** 19.33±5.20**

Tab 2

Hemorrheological indexes tested in 2 groups (ヌ±S)"

Group n Whole blood viscosity (mPa·s) Platelet aggregation rate (%)
At high shear rate At low shear rate
Treatment group
Before treatment 40 5.41±0.72 12.27±1.80 57.80±15.71
After treatment 40 4.51±0.50* 10.07±2.02* 48.50±14.56*△
Control group
Before treatment 20 5.39±0.37 13.41±3.33 59.37±5.59
After treatment 20 4.31±0.66* 10.95±2.87 57.25±5.75*
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