Search JIM Advanced Search

Journal of Chinese Integrative Medicine ›› 2004, Vol. 2 ›› Issue (2): 100-102.doi: 10.3736/jcim20040207

• Original Clinical Research • Previous Articles     Next Articles

Effects of granules for nourishing kidney and strengthening brain on main symptoms of kidney-yin deficiency and blood stasis syndrome and hemorrheological characteristics of brain atrophy

Shen Zhou, Wei-hua Yang, You-sheng Li, Fang Liu, Da-hua Wu, Li Yang   

  1. Hunan Provincial Academy of Trditional Chinese Medicine and Chinese Materia Medica, Changsha, Hunan Province 410006, China
  • Online:2004-03-20 Published:2018-10-25

Objective: To explore the influence of granules for nourishing kidney and strengthening brain (GNKSB) on main symptoms of kidney-yin deficiency and blood stasis syndrome and the hemorrheological characteristics of brain atrophy patients.Methods: Ninety patients of brain atrophy with kidney-yin deficiency and blood stasis syndrome were randomly divided into two groups. Sixty cases in treatment group were treated with GNKSB, and the 30 cases in control group were treated with piracetam for 8 weeks.Results: The effective rate of treatment group was 73.3%, with significant difference as compared with 46.6% of the control group (P<0.01). The scores of symptom-assessment of the two groups were also significantly different (P<0.01). The mini-mental state examination of treatment group was obviously improved, and was significantly different as compared with the control group (P<0.01). The scores of Hasegawa's dementia scale and activities of daily living were increased, but without significant difference as compared with the control group. The platelet aggregation rate was improved, with significant difference as compared with the control group (P<0.05). The whole blood viscosity was also improved obviously, but without significant difference as compared with the control group.Conclusion: GNKSB is effective for kidney-yin deficiency and blood stasis syndrome of brain atrophy patients and can improve their mental state and the hemorrheological indexes.

Key words: brain atrophy, kidney-yin deficiency syndrome, blood stasis syndrome, hemorrheology, nourishing kidney and strengthening brain

CLC Number: 

  • R742.8

Tab 1

Results of MMSE, HDS and ADL in 2 groups(Scores)"

Treatment group
Before treatment 60 20.61±7.11 18.70±7.04 23.65±7.55
After treatment 60 25.90±4.03**△△ 25.22±5.44** 20.48±5.75**
Control group
Before treatment 30 18.93±5.90 20.25±6.88 21.06±6.04
After treatment 30 21.96±4.91** 24.98±5.49** 19.33±5.20**

Tab 2

Hemorrheological indexes tested in 2 groups (ヌ±S)"

Group n Whole blood viscosity (mPa·s) Platelet aggregation rate (%)
At high shear rate At low shear rate
Treatment group
Before treatment 40 5.41±0.72 12.27±1.80 57.80±15.71
After treatment 40 4.51±0.50* 10.07±2.02* 48.50±14.56*
Control group
Before treatment 20 5.39±0.37 13.41±3.33 59.37±5.59
After treatment 20 4.31±0.66* 10.95±2.87 57.25±5.75*
[1] 中国中医研究院广安门医院. 实用中医脑病学(第1版)[M]. 北京: 学苑出版社, 1993,( 第1版):791-794
[2] 张明园 . 精神科评定量表手册(第1版)[M]. 长沙: 湖南科学技术出版社, 1998,( 第1版):166-188
[1] Pi-qi Zhou, Lin Shen, Yan-ping Yang, Jing Xie. Clinical observation of puerarin in treating patients with vertebral artery insufficiency due to cervical spondylosis: A report of 123 cases. Journal of Chinese Integrative Medicine, 2006, 4(1): 80-81.
[2] Jian Wang, Xin Liu. Effects of Naoluo Xintong Recipe on expression of HSP70 and bFGF in focal ischemia-reperfusion rats. Journal of Chinese Integrative Medicine, 2004, 2(4): 271-273.
[3] Jie Wang, Jian-Sheng Li, Kui-Wu Yao, Yong-Xia Wang, Jing-bai Zhong. Research on quantified diagnosis and combining diseases with syndrome of blood stasis. Journal of Chinese Integrative Medicine, 2003, 1(1): 21-24.
Full text



[1] Dong Yang, Yong-ping Du, Qing Shen, Wei Chen, Yan Yu, Guang-lei Chen. Expression of alpha-smooth muscle actin in renal tubulointerstitium in patients with kidney collateral stasis. Journal of Chinese Integrative Medicine, 2008, 6(1): 41-44
[2] Hai-feng Wei, Bai-liu Ya, Ling Zhao, Cui-fei Ye, Li Zhang, Lin Li. Evaluation of tongue manifestation of blood stasis syndrome and its relationship with blood rheological disorder in a rat model of transient brain ischemia. Journal of Chinese Integrative Medicine, 2008, 6(1): 73-76
[3] Xi Lin, Jian-ping Liu. Herbal medicines for viral myocarditis. Journal of Chinese Integrative Medicine, 2008, 6(1): 76
[4] Liang-ping Hu, Hui Gao. Discrimination of errors in statistical analysis of medical papers published in the first issue of 2006 in Journal of Chinese Integrative Medicine. Journal of Chinese Integrative Medicine, 2008, 6(1): 98-106
[5] Yan-bo Zhu , Qi Wang, Cheng-yu Wu, Guo-ming Pang, Jian-xiong Zhao, Shi-lin Shen, Zhong-yuan Xia , Xue Yan . Logistic regression analysis on relationships between traditional Chinese medicine constitutional types and overweight or obesity. Journal of Chinese Integrative Medicine, 2010, 8(11): 1023-1035
[6] Wei Xu, Meng Shi, Jian-gang Liu, Cheng-long Wang . Collagen protein expressions in ischemic myocardium of rats with acute myocardial infarction and effects of qi-tonifying, yin-tonifying and blood-activating herbs and detoxifying and blood-activating herbs. Journal of Chinese Integrative Medicine, 2010, 8(11): 1041-1047
[7] Tao Wang , Feng Qin. Effects of Chinese herbal medicine Xiaoyao Powder on monoamine neurotransmitters in hippocampus of rats with postpartum depression. Journal of Chinese Integrative Medicine, 2010, 8(11): 1075-1079
[8] Ying Xu , Chang-chun Zeng , Xiu-yu Cai , Rong-ping Guo , Guang Nie , Ying Jin. Chromaticity and optical spectrum colorimetry of the tongue color in different syndromes of primary hepatic carcinoma. Journal of Chinese Integrative Medicine, 2012, 10(11): 1263-1271
[9] Xiang-ying Mao , Qin Bian , Zi-yin Shen. Analysis of the osteogenetic effects exerted on mesenchymal stem cell strain C3H10T1/2 by icariin via MAPK signaling pathway in vitro. Journal of Chinese Integrative Medicine, 2012, 10(11): 1272-1278
[10] Samadder Asmita, Das Jayeeta, Das Sreemanti, Biswas Raktim, Rahman Khuda-Bukhsh Anisur. Ameliorative potentials of Syzygium jambolanum extract against arsenic-induced stress in L6 cells in vitro. Journal of Chinese Integrative Medicine, 2012, 10(11): 1293-1302