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Journal of Chinese Integrative Medicine ›› 2003, Vol. 1 ›› Issue (1): 21-24.doi: 10.3736/jcim20030110

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Research on quantified diagnosis and combining diseases with syndrome of blood stasis

Jie Wang1(), Jian-sheng Li2, Kui-wu Yao1, Yong-xia Wang2, Jing-bai Zhong1   

  1. 1. Xiyuan Hospital, China Academy of Traditional Chinese Medicine, Beijing 100091, China
    2. Department of Geriatrics, Henan College of Traditional Chinese Medicine, Zhengzhou, Henan Province 450003, China
  • Received:2003-03-15 Online:2003-03-20 Published:2018-10-19

Objective

To explore the way of quantified diagnosis of blood stasis syndrome (BSS) and the essence of BSS.


Methods

Using t-test and logistic regression to analyze the symptoms, signs, and objective indexes of BSS in clinical test.


Results

(1) The levels of endothelin, nitric oxide, and t-PA between 182 patients with BSS and non-BSS had notable difference. (2) The stepwise regression analysis about hemoglobin, triglyceride, total cholesterol, endothelin, nitric oxide, and t-PA in 170 patients with BSS or non-BSS revealed that the order of these indexes considering their importance was: endothelin, hemoglobin, t-PA, nitric oxide. However, the triglyceride and total cholesterol could not enter the regression equations. (3) The stepwise regression analysis about 40 symptoms and signs in 601 patients with BSS or non-BSS revealed that the 18 items had the very contribution to diagnose the BSS when the F value was 6, and so a regression equation was available. The total coincidence ratio was 94.24% when the other quantified data about BSS were tested in the equation.


Conclusion

The standardized TCM syndrome, which accorded with the criteria of combining diseases with syndrome,was made up of symptoms, signs, and objective indexes.The standard could be obtained by multi-center, prospective, random and controlled clinical epidemiological survey and clinical test.

Key words: blood stasis syndrome, quantified diagnosis, multivariate regression

CLC Number: 

  • R203

"

指 标 例数 ($\bar{x}$±s P
纤溶酶原激活物
(μg/L)
血瘀型 98 34.00 ± 16.53 <0.05
非血瘀型 84 29.19 ± 14.37
一氧化氮
(μmol/L)
血瘀型 98 40.34 ± 30.50 <0.05
非血瘀型 84 53.22 ± 41.16
内皮素
(ng/L)
血瘀型 98 170.47 ± 115.85 <0.01
非血瘀型 84 127.20 ± 48.53

"

F 入选因子 复相关系数 显著性
F=2 内皮素、纤溶酶原激活物、血红蛋
白、一氧化氮
0.431 <0.01
F=4 内皮素、血红蛋白 0.368 <0.01
F=8 内皮素 0.242 <0.01

"

入选因素 标准化系数
内皮素 -0.229
血红蛋白 0.236
纤溶酶原激活物 -0.184
一氧化氮 0.151

"

F 入选因素 复相关系数 显著性
F=2 舌下静脉曲张, 腭粘膜症, 脉涩, 舌体瘀斑, 口唇暗红, 舌质青紫, 人流史, 肢体偏瘫,
齿龈暗红, 脉结代, 少腹抵抗, 神志异常,腹壁静脉曲张, 外伤史, 肢体麻木, 细络, 眼
周暗黑, 疼痛程度,月经色黑,面部暗黑,少腹压痛,人流次数,民族,年龄
0.895 <0.01
F=6 舌下静脉曲张, 腭粘膜症, 脉涩, 舌体瘀斑, 口唇暗红, 舌质青紫, 人流史, 肢体偏瘫,
齿龈暗红, 脉结代, 少腹抵抗, 神志异常, 腹壁静脉曲张, 外伤史, 肢体麻木, 细络, 眼
周暗黑, 疼痛程度
0.890 <0.01
F=8 舌下静脉曲张, 腭粘膜症, 脉涩, 舌体瘀斑, 口唇暗红, 舌质青紫, 人流史, 肢体偏瘫,
齿龈暗红, 脉结代, 少腹抵抗, 神志异常, 腹壁静脉曲张, 外伤史, 肢体麻木
0.885 <0.01
F=10 舌下静脉曲张, 腭粘膜症, 脉涩, 舌体瘀斑, 口唇暗红, 舌质青紫, 人流史, 肢体偏瘫,
齿龈暗红, 脉结代, 少腹抵抗, 神志异常, 腹壁静脉曲张, 外伤史
0.883 <0.01

"

入选因素 标准化系数 入选因素 标准化系数 入选因素 标准化系数
舌下静脉曲张 -0.472 人流史 -0.098 腹壁静脉曲张 0.081
腭粘膜征 0.255 肢体偏瘫 0.078 外伤史 -0.063
脉涩 -0.229 齿龈暗红 -0.108 肢体麻木 -0.073
舌体瘀斑 -0.171 脉结代 -0.099 细络 0.084
口唇暗红 -0.075 少腹抵抗 0.072 眼周暗黑 -0.070
舌质青紫 -0.115 神志异常 -0.071 疼痛程度 -0.054

"

本试验 血瘀证诊断标准 合 计
血瘀证 非血瘀证
血瘀证 真阳性(a) 假阳性(b) (a+b)
272 22 294
非血瘀证 假阴性(c) 真阴性(d) (c+d)
13 294 307
合 计 (a+c) (b+d) N
285 316 601
[1] 林果为 . 诊断试验的研究与评价[A]. 见: 陈灏珠. 实用内科学[M]. 北京: 人民卫生出版社, 2001. 173.
[2] 王阶, 陈可冀, 翁维良 , 等. 血瘀证诊断标准的研究[J]. 中西医结合杂志, 1988,8(10):585-587, 589
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