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Journal of Chinese Integrative Medicine ›› 2003, Vol. 1 ›› Issue (3): 199-201.doi: 10.3736/jcim20030316

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Correlation between TXB2, 6-Keto-PGF1α and liver metastasis in rats model with blood stasis

Zhen Chen(), Lu-ming Liu, Yi-bei He   

  1. Department of Traditional Chinese Medicine, Cancer Hospital, Fudan University, Shanghai 200032, China
  • Received:2003-05-26 Online:2003-09-20 Published:2003-09-20


To observe the correlation between serum level of TXB2, 6-Keto-PGF and liver metastasis.


The metastatic model was made by injection of W256 carcinosarcoma. Rats were randomly divided into two groups: rats with blood stasis group and control group. Rats in control group were given normal saline via abdominal cavity once a day. Rats in blood stasis group were injected adrenalin in the fourteenth day. Tumor size and liver metastasis were observed. Serum TXB2 and 6-Keto-PGFwere tested by radioimmunoassay.


Tumor size in rats with blood stasis was significantly smaller than that of the control group (P<0.01). Occurrence of liver metastasis in rats with blood stasis was significantly lower than that of the control group (P<0.01). The values of 6-Keto-PGF, TXB2, and TXB2/6-Keto-PGF were higher in the group with blood stasis.


In the status of blood stasis, W256 carcinosarcoma grows slowly, and liver metastasis increases insignificantly, with the elevations of 6-Keto-PGF, TXB2 and TXB2/6-Keto-PGF1α.

Key words: liver neoplasms, neoplasm metastasis, blood stasis, TXB2, 6-Keto-PGF1α

CLC Number: 

  • R73-37


组别 n 脾脏瘤重(g) 肝转移灶数
对照组 10 0.514±0.118 2.6±2.12
血瘀证组 10 0.240±0.121** 2.0±1.33*


组别 n TXB2 6-Keto-PGF
对照组 10 943.60±108.98 285.73±102.10
血瘀证组 10 2118.08±460.21** 402.28±61.31**
[1] 刘明章, 黄贻穗, 肖伟琪 . 丹参酮Ⅱ-A磺酸钠对Lewis癌无促进生长与转移作用[J]. 中国药理学报, 1991,12(6):534-537
[2] Khan O, Hensby CN, Williams G , et al. Prostacyclin in prostatic cancer:a better marker than bone scan or serum acid phosphatase[J]. Br J Urol, 1982,54(1):26-31
doi: 10.1111/j.1464-410X.1982.tb13506.x pmid: 7037104
[3] 陈卫国, 李自成, 袁先厚 . 脑肿瘤患者血浆前列环素和血栓素A2水平的探讨[J]. 中国肿瘤临床, 1992,19(6):425-427
[4] 周端, 顾仁樾, 曹卫 , 等. 血清血栓烷B2含量与高血压病淤血证的关系[J]. 湖北中医杂志, 1990,12(3):38-39
doi: 10.3969/j.issn.1671-3141.2014.27.147
[5] 马治中, 杨明, 和岚 , 等. 血瘀病理模型探索(三)——模拟阴虚火旺复制慢性血瘀模型[J]. 北京医科大学学报, 1991,23(4):287-289
[6] 汤钊猷 . 现代肿瘤学(第1版)[M]. 上海: 上海医科大学出版社, 1993,( 第1版):104-106
[7] 关海蓉 . 肺癌患者肺泡巨噬细胞与PGI2、TXA2的关系[J]. 山东医药, 1992,32(5):22-23
[8] 朱菊人, 朱忆, 陆伟君 , 等. 原发性肝癌患者血浆PGE2、TXB2、6-Keto-PGF1α含量变化及其临床意义[J]. 山东医药, 1997,37(6):3-4
[9] Aitokallio-Tallberg A, Karkkainen J, Pantzar P , et al. Prostacyclin and thromboxane in breast cancer:re1ationship between steroid receptor status and medroxyprogesterone acetate[J]. Br J Cancer, 1985,51(5):671-674
doi: 10.1038/bjc.1985.101
[10] Slotman GJ . P1asma thromboxane A2 and prostacyclin concentrations in squamous cell carcinoma of the head and neck[J]. J Surg Oncol, 1988,38(1):33-37
doi: 10.1002/(ISSN)1096-9098
[11] 韩俊庆, 陈延条, 满运艳 , 等. 复春片合并放射治疗鼻咽癌临床研究[J]. 中国中西医结合杂志, 1995,15(12):710-712
doi: 10.7661/CJIM.1995.12.710
[12] 李学汤, 王永泉, 傅乃武 . 几种活血化瘀药物对小鼠肝癌细胞形成肺转移影响的初步实验观察[J]. 中医杂志, 1980,21(8):75-77
[13] 傅乃武 . 丹参对实验肿瘤生长和转移的影响及其作用原理的初步探讨[J]. 中华肿瘤杂志, 1981,3(2):165-170
[14] Honn KV . Cancer invasion and metastasis [A].In:Nieolson GL. Biologic and therapeutic aspects[M]. London: Williams & Wilkins, 1984. 361-383.
[15] Mehta P . Potential role of platelets in the pathogenesis of tumor metastasis[J]. Blood, 1984,63(1):55-63
doi: 10.1046/j.1537-2995.1983.23684074284.x pmid: 6360248
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