血瘀证模型大鼠血栓烷B2、6-酮-前列腺素F1α与肿瘤肝转移的关系

doi:10.3736/jcim20030316

Abstract

Objective

To observe the correlation between serum level of TXB₂, 6-Keto-PGF_1α and liver metastasis.

Methods

The metastatic model was made by injection of W256 carcinosarcoma. Rats were randomly divided into two groups: rats with blood stasis group and control group. Rats in control group were given normal saline via abdominal cavity once a day. Rats in blood stasis group were injected adrenalin in the fourteenth day. Tumor size and liver metastasis were observed. Serum TXB₂ and 6-Keto-PGF_1αwere tested by radioimmunoassay.

Results

Tumor size in rats with blood stasis was significantly smaller than that of the control group (P<0.01). Occurrence of liver metastasis in rats with blood stasis was significantly lower than that of the control group (P<0.01). The values of 6-Keto-PGF_1α, TXB₂, and TXB₂/6-Keto-PGF_1α were higher in the group with blood stasis.

Conclusion

In the status of blood stasis, W256 carcinosarcoma grows slowly, and liver metastasis increases insignificantly, with the elevations of 6-Keto-PGF_1α, TXB₂and TXB₂/6-Keto-PGF_1α.

Key words: liver neoplasms, neoplasm metastasis, blood stasis, TXB2, 6-Keto-PGF1α

CLC Number:

R73-37

Zhen Chen, Lu-ming Liu, Yi-bei He. Correlation between TXB2, 6-Keto-PGF1α and liver metastasis in rats model with blood stasis. Journal of Chinese Integrative Medicine, 2003, 1(3): 199-201.

/ / Recommend

Add to citation manager EndNote| Reference Manager|ProCite|BibTeX|RefWorks

URL: http://www.jcimjournal.com/EN/10.3736/jcim20030316

http://www.jcimjournal.com/EN/Y2003/V1/I3/199

[1]	刘明章, 黄贻穗, 肖伟琪 . 丹参酮Ⅱ-A磺酸钠对Lewis癌无促进生长与转移作用[J]. 中国药理学报, 1991,12(6):534-537
[2]	Khan O, Hensby CN, Williams G , et al. Prostacyclin in prostatic cancer:a better marker than bone scan or serum acid phosphatase[J]. Br J Urol, 1982,54(1):26-31 doi: 10.1111/j.1464-410X.1982.tb13506.x pmid: 7037104
[3]	陈卫国, 李自成, 袁先厚 . 脑肿瘤患者血浆前列环素和血栓素A2水平的探讨[J]. 中国肿瘤临床, 1992,19(6):425-427
[4]	周端, 顾仁樾, 曹卫 , 等. 血清血栓烷B2含量与高血压病淤血证的关系[J]. 湖北中医杂志, 1990,12(3):38-39 doi: 10.3969/j.issn.1671-3141.2014.27.147
[5]	马治中, 杨明, 和岚 , 等. 血瘀病理模型探索(三)——模拟阴虚火旺复制慢性血瘀模型[J]. 北京医科大学学报, 1991,23(4):287-289
[6]	汤钊猷 . 现代肿瘤学(第1版)[M]. 上海: 上海医科大学出版社, 1993,( 第1版):104-106
[7]	关海蓉 . 肺癌患者肺泡巨噬细胞与PGI2、TXA2的关系[J]. 山东医药, 1992,32(5):22-23
[8]	朱菊人, 朱忆, 陆伟君 , 等. 原发性肝癌患者血浆PGE2、TXB2、6-Keto-PGF1α含量变化及其临床意义[J]. 山东医药, 1997,37(6):3-4
[9]	Aitokallio-Tallberg A, Karkkainen J, Pantzar P , et al. Prostacyclin and thromboxane in breast cancer:re1ationship between steroid receptor status and medroxyprogesterone acetate[J]. Br J Cancer, 1985,51(5):671-674 doi: 10.1038/bjc.1985.101
[10]	Slotman GJ . P1asma thromboxane A2 and prostacyclin concentrations in squamous cell carcinoma of the head and neck[J]. J Surg Oncol, 1988,38(1):33-37 doi: 10.1002/(ISSN)1096-9098
[11]	韩俊庆, 陈延条, 满运艳 , 等. 复春片合并放射治疗鼻咽癌临床研究[J]. 中国中西医结合杂志, 1995,15(12):710-712 doi: 10.7661/CJIM.1995.12.710
[12]	李学汤, 王永泉, 傅乃武 . 几种活血化瘀药物对小鼠肝癌细胞形成肺转移影响的初步实验观察[J]. 中医杂志, 1980,21(8):75-77
[13]	傅乃武 . 丹参对实验肿瘤生长和转移的影响及其作用原理的初步探讨[J]. 中华肿瘤杂志, 1981,3(2):165-170
[14]	Honn KV . Cancer invasion and metastasis [A].In:Nieolson GL. Biologic and therapeutic aspects[M]. London: Williams & Wilkins, 1984. 361-383.
[15]	Mehta P . Potential role of platelets in the pathogenesis of tumor metastasis[J]. Blood, 1984,63(1):55-63 doi: 10.1046/j.1537-2995.1983.23684074284.x pmid: 6360248

Related Articles 15

[1]	Xuanbin Wang, Ning Wang, Fan Cheung, Lixing Lao, Charlie Li, Yibin Feng. Chinese medicines for prevention and treatment of human hepatocellular carcinoma: Current progress on pharmacological actions and mechanisms. Journal of Integrative Medicine, 2015, 13(3): 142-164.
[2]	Ze-long Dai, Hui Chen, Xiao-ying Wu . Relationship between cytochrome P450 2C19*17 genotype distribution platelet aggregation and bleeding risk in patients with blood stasis syndrome of coronary artery disease treated with clopidogrel. Journal of Chinese Integrative Medicine, 2012, 10(6): 647-654.
[3]	Chun Li, Yong Wang, Yu-lin Ouyang , Wen-jing Chuo , Qi Qiu , Shu-zhen Guo, Wei Wang. Effects of a compound Chinese herbal medicine Yixin Jiedu Formula on haemodynamic in rats with heart failure of qi-deficiency and blood stasis syndrome. Journal of Chinese Integrative Medicine, 2012, 10(5): 577-583.
[4]	Qing-bo Lang, Dong-xia Zhai , Feng Huang, Jian-guo Chen, Yong-hui Zhang, Qun Liu, Xiao-feng Zhai , Bai Li, Chang-quan Ling. Investigation on traditional Chinese medicine syndrome distribution of 4 618 hepatitis B virus infection subjects in Qidong of Jiangsu Province, China. Journal of Chinese Integrative Medicine, 2012, 10(5): 525-531.
[5]	Gang Guo, Jian-hua Xu, Jian-hong Han, Fang Liang, Yong Zhang, Qiang Zhang, Jue Sun, Zhong-ze Fan . Chinese herbal decoction Shiquan Dabu Tang inhibits tumor growth and angiogenesis of metastasis after primary tumor surgical removal in mice. Journal of Chinese Integrative Medicine, 2012, 10(4): 436-447.
[6]	Li Weng, Juan Du, Wen-ring He, Chang-quan Ling. Characteristic genomics of peripheral blood mononuclear cells of hepatocellular carcinoma patients with liver-kidney yin deficiency syndrome. Journal of Chinese Integrative Medicine, 2012, 10(4): 406-415.
[7]	Ying Xu , Chang-chun Zeng , Xiu-yu Cai , Rong-ping Guo , Guang Nie , Ying Jin. Chromaticity and optical spectrum colorimetry of the tongue color in different syndromes of primary hepatic carcinoma. Journal of Chinese Integrative Medicine, 2012, 10(11): 1263-1271.
[8]	Yong Wang, Shu-zhen Guo, Chun Li, Jian-xin Chen, Wen-jing Chuo, Fang Dong, Wei Wang, Ying-feng Wang. Analysis of plasma metabonomics of mini-swines with qi deficiency and blood stasis syndrome due to chronic myocardial ischemia. Journal of Chinese Integrative Medicine, 2011, 9(2): 158-164.
[9]	Jian-peng Du, Da-zhuo Shi , Tian-chang Li, Hao Xu, Hao Chen. Correlation between blood stasis syndrome and pathological characteristics of coronary artery in patients with coronary heart disease. Journal of Chinese Integrative Medicine, 2010, 8(9): 848-852.
[10]	Xuan Liu , Qing-qi Wang. Professor Wang Qingqi's experience in treating senile diseases based on the theory of blood stasis. Journal of Chinese Integrative Medicine, 2010, 8(5): 486-488.
[11]	Hui Han, Li-min Wu, Wen-ming Yang, Mei-xia Wang, Jing-jing Tang, Han Wang, Zhi-xiu Liu, Rong-zhi Liu, Ting Dong, Juan Zhang , Bo Yang, Ming-xiang Han. Characteristics of traditional Chinese medicine syndromes in post-stroke depression. Journal of Chinese Integrative Medicine, 2010, 8(5): 427-431.
[12]	Xiao-bing Li, Xiao-juan He, Biao Liu, Li Xu, Da-hong Ju, Miao Jiang, Ai-ping Lu. Immunoregulatory function of Radix Glycyrrhizae polysaccharide in tumor-bearing mice. Journal of Chinese Integrative Medicine, 2010, 8(4): 363-367.
[13]	Rui Wu , Wen-wen Xiong, Yi-ping Jiang, Guo-xian Li. Changes of eye signs in chronic hepatitis B patients with blood stasis syndrome. Journal of Chinese Integrative Medicine, 2010, 8(1): 46-48.
[14]	Yan Wang , Li-wu Lin, Zhi-kui Chen, En-sheng Xue, Xiao-dong Lin, Li-yun Yu, Zhen-hu Lin. Effects of intratumoral injection of microspheres containing cobra venom cytotoxin on transplanted human hepatoma in nude mice. Journal of Chinese Integrative Medicine, 2009, 7(9): 836-841.
[15]	Bin Li , Rong Xu, Fu-lun Li, Ke-qin Zhao, Ming Zhang, Zheng-cheng Xu. Study of syndrome differentiation factor of gouty arthritis with blood stasis syndrome based on connection number. Journal of Chinese Integrative Medicine, 2009, 7(8): 724-727.

Metrics

Viewed

Full text

Abstract

Cited

Shared

Discussed

Comments

Recommended 10

[1]	Wei-xiong Liang. Problems-solving strategies in clinical treatment guideline for traditional Chinese medicine and integrative medicine. Journal of Chinese Integrative Medicine, 2008, 6(1): 1-4
[2]	Zhao-guo Li. Discussion on English translation of commonly used sentences in traditional Chinese medicine: part one. Journal of Chinese Integrative Medicine, 2008, 6(1): 107-110
[3]	Jun Hu, Jian-ping Liu. Non-invasive physical treatments for chronic/recurrent headache. Journal of Chinese Integrative Medicine, 2008, 6(1): 31
[4]	Xue-mei Liu, Qi-fu Huang, Yun-ling Zhang, Jin-li Lou, Hong-sheng Liu, Hong Zheng. Effects of Tribulus terrestris L. saponion on apoptosis of cortical neurons induced by hypoxia-reoxygenation in rats. Journal of Chinese Integrative Medicine, 2008, 6(1): 45-50
[5]	. Uniform requirements for manuscripts submitted to biomedical journals: Writing and editing for biomedical publication (Chinese version, part two). Journal of Chinese Integrative Medicine, 2010, 8(11): 1001-1005
[6]	Daniel Weber, Janelle M Wheat, Geoffrey M Currie. Inflammation and cancer: Tumor initiation, progression and metastasis,and Chinese botanical medicines. Journal of Chinese Integrative Medicine, 2010, 8(11): 1006-1013
[7]	Hong Liu , Guo-liang Zhang, Li Shen , Zhen Zeng, Bao-luo Zhou, Cheng-hai Liu, Guang Nie . Application and evaluation of a pseudotyped virus assay for screening herbs for anti-H5Nl avian influenza virus. Journal of Chinese Integrative Medicine, 2010, 8(11): 1036-1040
[8]	Zhao-guo Li . A discussion of English translation of 1995 and 1997 Chinese National Standards of Traditional Chinese Medical Terminologies for Clinical Diagnosis and Treatment. Journal of Chinese Integrative Medicine, 2010, 8(11): 1090-1096
[9]	Rui Jin, Bing Zhang. A complexity analysis of Chinese herbal property theory: the multiple formations of herbal property (Part 1). Journal of Chinese Integrative Medicine, 2012, 10(11): 1198-1205
[10]	Hui-min Liu, Xian-bo Wang, Yu-juan Chang, Li-li Gu. Systematic review and meta-analysis of randomized controlled trials of integrative medicine therapy for treatment of chronic severe hepatitis. Journal of Chinese Integrative Medicine, 2012, 10(11): 1211-1228

组别	n	脾脏瘤重(g)	肝转移灶数
对照组	10	0.514±0.118	2.6±2.12
血瘀证组	10	0.240±0.121**	2.0±1.33*

组别	n	TXB₂	6-Keto-PGF_1α
对照组	10	943.60±108.98	285.73±102.10
血瘀证组	10	2118.08±460.21**	402.28±61.31**

Correlation between TXB2, 6-Keto-PGF1α and liver metastasis in rats model with blood stasis

RichHTML

PDF (PC)

Like

Abstract

Cite this article

Share this article

TrendMD

Figures/Tables 2

References 15

Related Articles 15

Metrics

Comments

Recommended 10