[an error occurred while processing this directive]

Journal of Chinese Integrative Medicine ›› 2005, Vol. 3 ›› Issue (1): 39-42.doi: 10.3736/jcim20050112

• Original Experimental Research • Previous Articles     Next Articles

Effects of Yangyin Shengjin Decoction on hemorheological parameters and coagulation factors in model rabbits with syndrome of excessive heat consuming body fluid and blood stasis

Hong Ma,Jin Yang,Shu-ling Nan,Jie-ning Gong,Xue-feng Liu   

  1. College of Basic Medical Sciences, Nanjing University of Traditional Chinese Medicine, Nanjing, Jiangsu Province 210029, China
  • Received:2004-06-16 Online:2005-01-20 Published:2005-01-20
  • Contact: Jin Yang E-mail:jyang@njutcm.edu.cn

RichHTML

1

PDF (PC)

698

Like

Objective

To investigate the effects of Yangyin Shengjin Decoction (YYSJD) on hemorheological parameters and coagulation factors in model rabbits with syndrome of excessive heat consuming body fluid and blood stasis.

Methods

Rabbit model with syndrome of excessive heat consuming body fluid and blood stasis was produced. The effects of YYSJD on the blood viscosity, erythrocyte sedimentation rate (ESR), hematocrit, platelet aggregation rate, prothrombin time (PT), thrombin time (TT), kaolin partial thromboplastin time (KPTT), fibrinogen (Fg), thromboxane B2 (TXB2), and 6-keto-prostaglandin F1α (6-keto-PGF1α) in the model rabbits were observed.

Results

YYSJD decreased the whole blood viscosity and hematocrit, inhibited the platelet aggregation, prolonged PT, TT and KPTT, and reduced the content of Fg. It also regulated the balance between TXB2 and 6-keto-PGF1α.

Conclusion

YYSJD can promote the blood circulation, adjust the blood agglutinating function, and decrease the formation of thrombus. This is one of the pharmacological mechanisms of the therapeutic method of "nourishing yin to promote blood circulation" in the theory of traditional Chinese medicine for seasonal febrile diseases.

Key words: Yangyin Shengjin Decoction, Hemorheology, Coagulation factors, Science for epidemic febrile diseases, Therapy in TCM

CLC Number: 

  • R242

Tab 1

Comparison of whole blood viscosity and plasma viscosity among 3 groups ($\bar{x}$±smPa·s)"

Group n Whole blood viscosity Plasma viscosity
200/s 60/s 5/s 1/s
Normal control group 6 2.96±0.36 3.57±0.37 7.92±0.99 18.94±3.96 1.43±0.07
Model group 6 3.40±0.24* 4.11±0.21* 9.66±1.15* 24.91±4.77* 1.62±0.09**
YYSJD-treated group 6 2.87±0.13△△ 3.42±0.18△△ 7.06±0.33△△ 16.33±0.84△△ 1.51±0.06△

Tab 2

Comparison of ESR and hematocrit among 3 groups ($\bar{x}$±s)"

Group n ESR (mm/h) Hematocrit (%)
Normal control group 6 0.48±0.43 33.58±2.73
Model group 6 10.17±14.83 42.67±3.56**
YYSJD-treated group 6 2.58±1.74 31.50±1.05△△

Tab 3

Comparison of ADP-induced platelet aggregation rate among 3 groups ($\bar{x}$±s)"

Group n Platelet aggregation rate （％） Platelet aggregation time （s）
1 min Maximum 5 min
Normal control group 6 10.48±5.66 15.75±9.02 6.23±3.56 180.00±85.02
Model group 6 25.72±10.75* 32.13±14.66* 15.50±7.72* 85.00±17.96*
YYSJD-treated group 6 7.25±4.12△△ 9.33±4.81△△ 3.23±1.02△△ 144.33±59.36△

Tab 4

Comparison of PT, TT, KPTT and Fg in plasma among 3 groups ($\bar{x}$±s)"

Group n PT （s） TT （s） KPTT （s） Fg （g/L）
Normal control group 6 21.83±0.98 102.17±5.78 99.67±9.20 3.27±0.55
Model group 6 18.67±1.03** 89.83±9.87* 81.33±10.29** 5.20±0.65**
YYSJD-treated group 6 20.50±1.38△ 105.00±4.94△△ 103.17±5.74△△ 3.27±0.49△△

Tab 5

Comparison of TXB2 and 6-keto-PGF1α among 3 groups ($\bar{x}$±s)"

Group n TXB2 (ng/L) 6-keto-PGF1α (ng/L) TXB2/6-keto-PGF1α
Normal control group 6 168.75±52.97 939.41±189.48 0.18
Model group 6 254.65±62.39* 382.12±171.50** 0.64
YYSJD-treated group 6 141.89±26.19△△ 831.62±285.30△△ 0.17
[1] 翁维良, 廖福龙, 吴云鹏 , 等. 血液流变学研究方法及其应用(第1版)[M]. 北京: 科学出版社, 1989,( 第1版):64
[2] 王秋 . 家兔“温病阴虚热盛证”动物模型的实验研究[J]. 辽宁中医杂志, 1995,22(9):427-429
[3] 陈文杰 . 血液流变学(第1版)[M]. 天津: 天津科学技术出版社, 1987,( 第1版):43
[4] 李家增, 王鸿利, 韩忠朝 . 血液实验学(第1版)[M]. 上海: 上海科学技术出版社, 1997,( 第1版):343
[1] Tao Liu , Li-li Yang , Li Zhang, Hai-yan Song , Dong-fei Li , Guang li. Comparative study on the effects of different therapeutic methods in preventing and treating nonalcoholic fatty liver in rats. Journal of Chinese Integrative Medicine, 2012, 10(10): 1120-1126.
[2] Jun Shi, Pin-kang Wei. The phlegm theory of gastric cancer. Journal of Chinese Integrative Medicine, 2011, 9(6): 581-587.
[3] Chia-Chun Hung, Pin-Kuei Fu, Hsyn-Yi Wang, Chin-Hong Chan, Tsuo-Hung Lan. Treatment effects of traditional Chinese medicines Suoquan Pill and Wuling Powder on clozapine-induced hypersalivation in patients with schizophrenia: Study protocol of a randomized, placebo-controlled trial. Journal of Chinese Integrative Medicine, 2011, 9(5): 495-502.
[4] Jun-zhang Lu, Li Zhao, Jian-ping Ren, Xiu-tang Cao, Hai-xia Li, Hong Zhao. Preventive and therapeutic effects of Chinese herbal medicine Compound Zhuye Shigao Granule in rats with radiation-induced esophagitis. Journal of Chinese Integrative Medicine, 2011, 9(4): 435-441.
[5] Jin Zheng, Ji Li, Lin-yi Song, Shuang Ni, Ying-chao Chen, Shan-di Huang. Comprehensive traditional Chinese medicine intervention for perimenopausal syndrome in women: a community study. Journal of Chinese Integrative Medicine, 2011, 9(3): 287-291.
[6] Jun Shi, Pin-kang Wei. Eight therapies of resolving phlegm and dispersing nodules in treatment of gastric cancer: Experience from Professor Wei Pin-kang. Journal of Chinese Integrative Medicine, 2011, 9(10): 1066-1069.
[7] Yu Wang, Yan-ting Wang, Ya-hua Lin, Zhong-dong Zou. Effects of Xuesaitong Injection on coagulation function of gastric cancer patients undergoing laparoscopic surgery: A randomized controlled trial. Journal of Chinese Integrative Medicine, 2009, 7(6): 514-517.
[8] Mei Xue, Ke-Ji Chen, Xiao-juan Ma, Jian-gang Liu, Yue-rong Jiang, Yu Miao, Hui-jun Yin. Effects of Xuefu Zhuyu Oral Liquid on hemorheology in patients with blood-stasis syndrome due to coronary disease and their relationship with human platelet antigen-3 polymorphism. Journal of Chinese Integrative Medicine, 2008, 6(11): 1129-1135.
[9] Hai-feng Wei, Bai-liu Ya, Ling Zhao, Cui-fei Ye, Li Zhang, Lin Li. Evaluation of tongue manifestation of blood stasis syndrome and its relationship with blood rheological disorder in a rat model of transient brain ischemia. Journal of Chinese Integrative Medicine, 2008, 6(1): 73-76.
[10] A-gao Zhou, Yong Zhang, Gang Kui, De-Yun Kong, Hai-liang Ge, Qiu-hua Ren, Jia-rong Dong, Sheng Hong, Xu-ming Mao, Yin Wang, Hui-zheng Zhang, Shu-jun Wang. Influence of traditional Chinese compound recipes with different efficacy on body weight, tumor weight and immune function in H22 cancer-bearing mice. Journal of Chinese Integrative Medicine, 2008, 6(1): 77-82.
[11] De-gang Zhang​, Ying Zhao​, Pei-jin Xia​, Xiao-qun Huang​, Zhi-min ​Liu, Hui Zhou. Effects of Tongluo Recipe on experimental diabetic peripheral neuropathy in rats. Journal of Chinese Integrative Medicine, 2006, 4(6): 601-605.
[12] Pi-qi Zhou, Lin Shen, Yan-ping Yang, Jing Xie. Clinical observation of puerarin in treating patients with vertebral artery insufficiency due to cervical spondylosis: A report of 123 cases. Journal of Chinese Integrative Medicine, 2006, 4(1): 80-81.
[13] Yu-hua Shen, Xiang-hua Yin, Zhao-ling You, Ling-mei Fu, Zhao-yang Tan. Effects of Sanqi Qiancao Recipe on hemorheological parameters of rabbits with copper intrauterine device. Journal of Chinese Integrative Medicine, 2005, 3(6): 473-475.
[14] Qing Liu, Yan-bo Zhang, Chuan-hong Ma, Xiao-qiang Yue, Chang-quan Ling. Analysis of literature on therapeutic methods and medicines of traditional Chinese medicine for primary liver cancer. Journal of Chinese Integrative Medicine, 2005, 3(4): 260-262.
[15] Xing-gang Han. A brief introduction to Shengjiang Powder, a traditional Chinese recipe. Journal of Chinese Integrative Medicine, 2004, 2(6): 455-455.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
[1] Wei-xiong Liang. Problems-solving strategies in clinical treatment guideline for traditional Chinese medicine and integrative medicine. Journal of Chinese Integrative Medicine, 2008, 6(1): 1-4
[2] Zhao-guo Li. Discussion on English translation of commonly used sentences in traditional Chinese medicine: part one. Journal of Chinese Integrative Medicine, 2008, 6(1): 107-110
[3] Jun Hu, Jian-ping Liu. Non-invasive physical treatments for chronic/recurrent headache. Journal of Chinese Integrative Medicine, 2008, 6(1): 31
[4] Xue-mei Liu, Qi-fu Huang, Yun-ling Zhang, Jin-li Lou, Hong-sheng Liu, Hong Zheng. Effects of Tribulus terrestris L. saponion on apoptosis of cortical neurons induced by hypoxia-reoxygenation in rats. Journal of Chinese Integrative Medicine, 2008, 6(1): 45-50
[5] . Uniform requirements for manuscripts submitted to biomedical journals: Writing and editing for biomedical publication (Chinese version, part two). Journal of Chinese Integrative Medicine, 2010, 8(11): 1001-1005
[6] Daniel Weber, Janelle M Wheat, Geoffrey M Currie. Inflammation and cancer: Tumor initiation, progression and metastasis,and Chinese botanical medicines. Journal of Chinese Integrative Medicine, 2010, 8(11): 1006-1013
[7] Hong Liu , Guo-liang Zhang, Li Shen , Zhen Zeng, Bao-luo Zhou, Cheng-hai Liu, Guang Nie . Application and evaluation of a pseudotyped virus assay for screening herbs for anti-H5Nl avian influenza virus. Journal of Chinese Integrative Medicine, 2010, 8(11): 1036-1040
[8] Zhao-guo Li . A discussion of English translation of 1995 and 1997 Chinese National Standards of Traditional Chinese Medical Terminologies for Clinical Diagnosis and Treatment. Journal of Chinese Integrative Medicine, 2010, 8(11): 1090-1096
[9] Rui Jin, Bing Zhang. A complexity analysis of Chinese herbal property theory: the multiple formations of herbal property (Part 1). Journal of Chinese Integrative Medicine, 2012, 10(11): 1198-1205
[10] Hui-min Liu, Xian-bo Wang, Yu-juan Chang, Li-li Gu. Systematic review and meta-analysis of randomized controlled trials of integrative medicine therapy for treatment of chronic severe hepatitis. Journal of Chinese Integrative Medicine, 2012, 10(11): 1211-1228
[an error occurred while processing this directive]