血塞通注射液对腹腔镜胃癌手术患者凝血功能影响的随机对照研究

doi:10.3736/jcim20090604

Abstract

Objective

To study the effects of Xuesaitong Injection, an extract from a Chinese herbal medicine, on coagulation function of gastric cancer patients undergoing laparoscopic surgery.
Methods

Fifty patients undergoing laparoscopic surgery for gastric cancer were randomly divided into control group and Xuesaitong group, with 25 patients in each group. Conventional anti-infection and transfusion treatment was given to the patients in the control group, and intravenous drip infusion of 400 mg Xuesaitong Injection added into 250 mL 5% glucose injection was administered once daily to the patients in the Xuesaitong group for 6 days from the first day after laparoscopic operation besides the conventional anti-infection and transfusion treatment. The values of prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen (FIB) and international normalized ratio (INR) were detected by using blood coagulation method, and the values of D-dimer (D-D) before operation, instantly and 3, 5, 7 days after operation were detected by using enzyme-linked immunosorbent assay in the two groups. Furthermore, the development of deep vein thrombosis on the day 7 after operation was observed by vein angiography.
Results

There were no significant differences in the values of PT, APTT, INR, FIB and D-D between the two groups before operation, and there were no significant changes in APTT and INR after operation in the two groups. The values of PT decreased in the two groups on day 3 after operation, while there was no significant difference between the two groups. The value of PT in the control group decreased gradually with the extension of postoperation time (P<0.05), while the PT value in the Xuesaitong group did not change significantly, and there was significant difference between the two groups (P<0.05). The values of FIB and D-D increased instantly after operation in the two groups as compared with those before operation (P<0.05), while there was no significant difference between the two groups. With the extension of postoperation time, the values of FIB and D-D increased gradually in the control group (P<0.05); the D-D value on day 3 after operation increased, but the D-D values on day 5 and day 7 after operation decreased gradually in the Xuesaitong group (P<0.05). The occurrence rate of deep vein thrombosis on day 7 after operation in the Xuesaitog group was lower than that in the control group.
Conclusion

Laparoscopic surgery for gastric cancer may cause high agglutination condition, which will increase the risk of deep vein thrombosis, and Xuesaitong Injection can improve this state.

Key words: Laparoscopic surgical procedures, Gastric cancer, Xuesaitong Injection, Coagulation factors, Randomized controlled trial

Yu Wang, Yan-ting Wang, Ya-hua Lin, Zhong-dong Zou. Effects of Xuesaitong Injection on coagulation function of gastric cancer patients undergoing laparoscopic surgery: A randomized controlled trial. Journal of Chinese Integrative Medicine, 2009, 7(6): 514-517.

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URL: http://www.jcimjournal.com/EN/10.3736/jcim20090604

http://www.jcimjournal.com/EN/Y2009/V7/I6/514

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Group	n	Coagulation indexes			Fibrolysis indexes
Group	n	PT (s)	APTT (s)	INR	FIB (g/L)	D-D (mg/L)
Control
Before operation	25	12.84±0.68	29.42±4.76	1.04±0.12	2.82±0.51	0.18±0.07
Instantly after operation	25	12.51±0.62	29.21±4.74	1.04±0.11	3.66±0.72*	0.33±0.12*
Three days after operation	25	11.43±0.69*^△	28.96±4.83	0.96±0.11	4.12±0.76*^△	0.56±0.14*^△
Five days after operation	25	11.26±0.68*	29.13±5.08	0.95±0.13	4.37±0.69*^▲	0.72±0.15*^▲
Seven days after operation	25	10.63±0.64*^□	29.34±5.18	0.95±0.13	4.62±0.71*^□	1.17±0.18*^□
Xuesaitong
Before operation	25	12.79±0.71	29.64±4.81	1.04±0.15	2.79±0.53	0.17±0.08
Instantly after operation	25	12.56±0.71	29.44±4.57	0.98±0.11	3.46±0.68*	0.34±0.13*
Three days after operation	25	11.47±0.63*^△	29.04±5.22	0.96±0.13	3.68±0.71*^△■	0.37±0.12*^■■
Five days after operation	25	11.44±0.60*	28.76±5.11	0.91±0.12	3.84±0.58*^■	0.29±0.12*^▲■
Seven days after operation	25	11.46±0.66*^■	29.06±5.02	0.95±0.15	3.37±0.56*^□■	0.23±0.10*^□■■

Effects of Xuesaitong Injection on coagulation function of gastric cancer patients undergoing laparoscopic surgery: A randomized controlled trial

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