血塞通注射液对腹腔镜胃癌手术患者凝血功能影响的随机对照研究

doi:10.3736/jcim20090604

Abstract

Objective

To study the effects of Xuesaitong Injection, an extract from a Chinese herbal medicine, on coagulation function of gastric cancer patients undergoing laparoscopic surgery.
Methods

Fifty patients undergoing laparoscopic surgery for gastric cancer were randomly divided into control group and Xuesaitong group, with 25 patients in each group. Conventional anti-infection and transfusion treatment was given to the patients in the control group, and intravenous drip infusion of 400 mg Xuesaitong Injection added into 250 mL 5% glucose injection was administered once daily to the patients in the Xuesaitong group for 6 days from the first day after laparoscopic operation besides the conventional anti-infection and transfusion treatment. The values of prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen (FIB) and international normalized ratio (INR) were detected by using blood coagulation method, and the values of D-dimer (D-D) before operation, instantly and 3, 5, 7 days after operation were detected by using enzyme-linked immunosorbent assay in the two groups. Furthermore, the development of deep vein thrombosis on the day 7 after operation was observed by vein angiography.
Results

There were no significant differences in the values of PT, APTT, INR, FIB and D-D between the two groups before operation, and there were no significant changes in APTT and INR after operation in the two groups. The values of PT decreased in the two groups on day 3 after operation, while there was no significant difference between the two groups. The value of PT in the control group decreased gradually with the extension of postoperation time (P<0.05), while the PT value in the Xuesaitong group did not change significantly, and there was significant difference between the two groups (P<0.05). The values of FIB and D-D increased instantly after operation in the two groups as compared with those before operation (P<0.05), while there was no significant difference between the two groups. With the extension of postoperation time, the values of FIB and D-D increased gradually in the control group (P<0.05); the D-D value on day 3 after operation increased, but the D-D values on day 5 and day 7 after operation decreased gradually in the Xuesaitong group (P<0.05). The occurrence rate of deep vein thrombosis on day 7 after operation in the Xuesaitog group was lower than that in the control group.
Conclusion

Laparoscopic surgery for gastric cancer may cause high agglutination condition, which will increase the risk of deep vein thrombosis, and Xuesaitong Injection can improve this state.

Key words: Laparoscopic surgical procedures, Gastric cancer, Xuesaitong Injection, Coagulation factors, Randomized controlled trial

Yu Wang, Yan-ting Wang, Ya-hua Lin, Zhong-dong Zou. Effects of Xuesaitong Injection on coagulation function of gastric cancer patients undergoing laparoscopic surgery: A randomized controlled trial. Journal of Chinese Integrative Medicine, 2009, 7(6): 514-517.

/ / Recommend

Add to citation manager EndNote| Reference Manager|ProCite|BibTeX|RefWorks

URL: http://www.jcimjournal.com/EN/10.3736/jcim20090604

http://www.jcimjournal.com/EN/Y2009/V7/I6/514

[1]	Japanese Gastric Cancer Association . Guidelines for the treatment of gastric cancer(2nd ed)[M]. Tokyo: Kanehara, 2004,( 2nd ed):12
[2]	Holzheimer RG . Laparoscopic procedures as a risk factor of deep venous thrombosis, superficial ascending thrombophlebitis and pulmonary embolism — case report and review of the literature[J]. Eur J Med Res, 2004,9(9):417-422
[3]	Schaepkens Van Riempst JT, Van Hee RH, Weyler JJ . Deep venous thrombosis after laparoscopic cholecystectomy and prevention with nadroparin[J]. Surg Endosc, 2002,16(1):184-187 doi: 10.1007/s004640090048
[4]	Kuroiwa M, Arai M, Kinoshita S, Takenaka T, Okamoto H, Hoka S . Clinical characteristics of perioperative pulmonary thromboembolism: analysis of 18 patients in Kitasato University Hospital[J]. Masui, 2002,51(9):977-982
[5]	Kinoshita H, Hara M, Maruyama Y, Matsuo H, Kawahara R, Nishimura K, Kodama T, Odo M, Shirouzu K, Aoyaqi S . A case of pulmonary embolism after abdominal angiography[J]. Kurume Med J, 2004,51(1):95-98 doi: 10.2739/kurumemedj.51.95
[6]	Liu BB . Experimental study on anticoagulation function of Sanqi Tablets in rabbits[J]. Zhongguo Zhong Yi Yao Ke Ji, 2005,12(5):296
	刘炳波 . 三七片对家兔凝血作用的实验研究[J]. 中国中医药科技, 2005,12(5):296
[7]	Lensing AW, Buller HR, Prandoni P, Batchelor D, Molenaar AH, Coqo M, Huisman PM, Ten Cate JW . Contrast venography, the gold standard for the diagnosis of deep-vein thrombosis: improvement in observer agreement[J]. Thromb Haemost, 1992,67(1):8-12 doi: 10.1055/s-0038-1648130
[8]	Wang MT, Yao XP, Li Q . Risk factor analysis of hospitalized patients with pulmonary thromboembolism and deep venous thrombosis[J]. Di Er Jun Yi Da Xue Xue Bao, 2004,25(7):740-742
	王美堂, 姚小鹏, 李强 . 肺血栓栓塞症和深静脉血栓形成住院患者相关危险因素的分析[J]. 第二军医大学学报, 2004,25(7):740-742
[9]	Zhang BG, Xue GH . Causes and risk factors of deep venous thrombosis[J]. Zhongguo Shi Yong Wai Ke Za Zhi, 2003,23(4):197-198
	张柏根, 薛冠华 . 深静脉血栓形成的病因及高危因素[J]. 中国实用外科杂志, 2003,23(4):197-198
[10]	Chen YH, Zhang SF, Sun JN, Wu JY, Jia ZH . Effect of Xuesaitong drop pills on experimerntal thrombosis and thrombolysis in rats[J]. Zhongguo Zhong Yao Za Zhi, 2007,32(3):253-256
	陈云华, 张硕峰, 孙建宁, 吴金英, 贾占红 . 血塞通滴丸抗大鼠血栓形成及溶栓作用的实验研究[J]. 中国中药杂志, 2007,32(3):253-256

Related Articles 15

[1]	Chiung-Hui Huang, Mei-Ling Yeh, Fang-Pey Chen, Daphne Wu. Low-level laser acupuncture reduces postoperative pain and morphine consumption in older patients with total knee arthroplasty: A randomized placebo-controlled trial. Journal of Integrative Medicine, 2022, 20(4): 321-328.
[2]	Shang-jin Song, Xuan Liu, Qing Ji, Da-zhi Sun, Li-juan Xiu, Jing-yu Xu, Xiao-qiang Yue. Ziyin Huatan Recipe, a Chinese herbal compound, inhibits migration and invasion of gastric cancer by upregulating RUNX3 expression. Journal of Integrative Medicine, 2022, 20(4): 355-364.
[3]	Maryam Azimi, Hanieh Niayesh, Mahboobeh Raeiszadeh, Sedigheh Khodabandeh-shahraki. Efficacy of the herbal formula of Foeniculum vulgare and Rosa damascena on elderly patients with functional constipation: A double-blind randomized controlled tria. Journal of Integrative Medicine, 2022, 20(3): 230-236.
[4]	Ubiratan Cardinalli Adler, Maristela Schiabel Adler, Ana Elisa Madureira Padula, Livia Mitchiguian Hotta, Amarilysde Toledo Cesar, José Nelson Martins Diniz, Helen de Freitas Santos, Edson Zangiacomi Martinez. Homeopathy for COVID-19 in primary care: A randomized, double-blind, placebo-controlled trial (COVID-Simile study). Journal of Integrative Medicine, 2022, 20(3): 221-229.
[5]	Xin Wang, Wen-juan Song, Yi Ruan, Bing-chu Li, Can Lü, Nian Huang, Fan-fu Fang, Wei Gu. Core muscle functional strength training for reducing the risk of low-back pain in military recruits: An open-label randomized controlled trial. Journal of Integrative Medicine, 2022, 20(2): 145-152.
[6]	Meng-zhu Zhao, Chen Zhao, Shuang-shuang Tu, Xu-xu Wei, Hong-cai Shang. Evaluating the methodology of studies conducted during the global COVID-19 pandemic: A systematic review of randomized controlled trials. Journal of Integrative Medicine, 2021, 19(4): 317-326.
[7]	Si-chun Gu, Jie Zhou, Qing Ye, Can-xing Yuan. Pingchan granule for depressive symptoms in Parkinson’s disease: A randomized, double-blind, placebo-controlled trial. Journal of Integrative Medicine, 2021, 19(2): 120-128.
[8]	Jie Wu, Shu-wei Duan, Hong-tao Yang, Yue-yi Deng, Wei Li, Ya-ni He, Zhao-hui Ni, Yong-li Zhan, Shan Lin, Zhi-yong Guo, Jun Zhu, Jing-ai Fang, Xu-sheng Liu, Li-hua Wang, Rong Wang, Nian-song Wang, Xiao-hong Cheng, Li-qun He, Ping Luo, Shi-ren Sun s, Ji-feng Sun, Ai-ping Yin, Geng-ru Jiang, Hong-yu Chen, Wen-hu Liu, Hong-li Lin, Meng Liang, Lu Ma, Ming Chen, Li-qun Song, Jian Chen, Qing Zhu, Chang-ying Xing, Yun Li, Ji-ning Gao, Rong-shan Li, Ying Li, Hao Zhang, Ying Lu, Qiao-ling Zhou, Jun-zhou Fu, Qiang He, Guang-yan Cai, Xiang-mei Chen. Efficacy and safety of Shenyankangfu Tablet, a Chinese patent medicine, for primary glomerulonephritis: A multicenter randomized controlled trial. Journal of Integrative Medicine, 2021, 19(2): 111-119.
[9]	Xian Wang, Xuan Yin, Xiu-tian Guo, Yan Wang, Wen-qi Jin, Ai-jun Mao, Lixing Lao, Zhang-jin Zhang, Jie Zhang, Shi-fen Xu. Effects of the pestle needle therapy, a type of acupoint stimulation, on post-hemorrhoidectomy pain: A randomized controlled trial. Journal of Integrative Medicine, 2020, 18(6): 492-498.
[10]	Sherman Gu, Arthur Yin Fan. Controversial conclusions from two randomized controlled trials for acupuncture's effects on polycystic ovary syndrome or in vitro fertilization support. Journal of Integrative Medicine, 2020, 18(2): 89-91.
[11]	Gerli E.G. Herr, Fábio Goulart da Silva, Francisco José Cidral-Filho, Fabricia Petronilho, Lucinéia Gainski Danielski, Mariana Pereira de Souza Goldim, Afonso Shiguemi Inoue Salgado, Franciane Bobinski, Daniel Fernandes Martins, Eliane R. Winkelmann. Effects of the use of bioceramic wraps in patients with lower limb venous ulcers: A randomized double-blind placebo-controlled trial. Journal of Integrative Medicine, 2020, 18(1): 27-.
[12]	Xin-yu Yue, Zhuo-qi Feng, Xi-yi Yu, Jia-min Hu, Xiao-Jing He, Shi Shu. Fire-needle acupuncture for upper limb spastic paralysis after stroke: Study protocol for a randomized controlled trial. Journal of Integrative Medicine, 2019, 17(3): 167-172.
[13]	Pádraic J.Dunne, Julie Lynch, Lucia Prihodova, Caoimhe O'Leary, Atiyeh Ghoreyshi, Sharee A. Basdeo, Donal J.Cox, Rachel Breen, Ali Sheikhi, Áine Carroll, Cathal Walsh, Geraldine McMahon, Barry White. Burnout in the emergency department: Randomized controlled trial of an attention-based training program. Journal of Integrative Medicine, 2019, 17(3): 173-180.
[14]	Ya-ru Huangfu, Wei Peng, Bao-jun Guo, Zhi-fu Shen, Li Li, Shi-wei, Liu, Hui Zheng, You-ping Hu. Effects of acupuncture in treating insomnia due to spleen-stomach disharmony syndrome and its influence on intestinal microbiome: Study protocol for a randomized controlled trial. Journal of Integrative Medicine, 2019, 17(3): 161-167.
[15]	J.M. Oliver-Baxter, H.S. Whitford, D.A. Turnbull, M.J. Bond. Effects of vitamin supplementation on inflammatory markers and psychological wellbeing among distressed women: A randomized controlled trial. Journal of Integrative Medicine, 2018, 16(5): 322-328.

Metrics

Viewed

Full text

Abstract

Cited

Shared

Discussed

Comments

Recommended 10

[1]	Jin-rong Fu. Establishment of multivariate diagnosis and treatment system of modern gynecology of traditional Chinese medicine. Journal of Chinese Integrative Medicine, 2008, 6(1): 22-24
[2]	Hao Li, Ming-jiang Yao, Wen-ming Zhao, Jie Guan, Lin-lin Cai, Ling Cui. A randomized, controlled, double-blind trial of Huannao Yicong capsule in senile patients with mild cognitive impairment. Journal of Chinese Integrative Medicine, 2008, 6(1): 25-31
[3]	Zhi-chun Jin. Problems in establishing clinical guideline for integrated traditional Chinese and Western medicine. Journal of Chinese Integrative Medicine, 2008, 6(1): 5-8
[4]	SUN Ming-yu, ZUO Jian, DUAN Ji-feng, HAN Jun, FAN Shi-ming, ZHANG Wei, ZHU Li-fang, YAO Ming-hui. Antitumor activities of kushen flavonoids in vivo and in vitro. Journal of Chinese Integrative Medicine, 2008, 6(1): 51-59
[5]	Min Cheng, Qiong Feng, Shu-wen Qian, Hui Gao, Cui-qing Zhu. Preliminary assay of p-amyloid binding elements in heart-beneficial recipe. Journal of Chinese Integrative Medicine, 2008, 6(1): 68-72
[6]	Ning-qun Wang, Liang-duo Jiang, Zong-xing Li. Research progress in asthma-related quality of life. Journal of Chinese Integrative Medicine, 2008, 6(1): 93-97
[7]	Jing-yuan Mao, Chang-xiao Liu, Heng-he Wang, Guang-li Wei , Zhen-peng Zhang, Jie Xing, Wang Xian liang , Ying-fei Bi . Effects of Shenmai Injection on serum concentration and pharmacokinetics of digoxin in dogs with heart failure. Journal of Chinese Integrative Medicine, 2010, 8(11): 1070-1074
[8]	Zhi-mei Wang, Bin Zhang. A study on translation of ellipses in Huangdi Neijing from perspective of hermeneutic theory. Journal of Chinese Integrative Medicine, 2010, 8(11): 1097-1100
[9]	Gui Yu, Jie Wang. Thinking on building the network cardiovasology of Chinese medicine. Journal of Chinese Integrative Medicine, 2012, 10(11): 1206-1210
[10]	Pedro Saganha João, Doenitz Christoph, Greten Tobias, Efferth Thomas, J. Greten Henry. Qigong therapy for physiotherapists suffering from burnout: a preliminary study. Journal of Chinese Integrative Medicine, 2012, 10(11): 1233-1239

Group	n	Coagulation indexes			Fibrolysis indexes
Group	n	PT (s)	APTT (s)	INR	FIB (g/L)	D-D (mg/L)
Control
Before operation	25	12.84±0.68	29.42±4.76	1.04±0.12	2.82±0.51	0.18±0.07
Instantly after operation	25	12.51±0.62	29.21±4.74	1.04±0.11	3.66±0.72*	0.33±0.12*
Three days after operation	25	11.43±0.69*^△	28.96±4.83	0.96±0.11	4.12±0.76*^△	0.56±0.14*^△
Five days after operation	25	11.26±0.68*	29.13±5.08	0.95±0.13	4.37±0.69*^▲	0.72±0.15*^▲
Seven days after operation	25	10.63±0.64*^□	29.34±5.18	0.95±0.13	4.62±0.71*^□	1.17±0.18*^□
Xuesaitong
Before operation	25	12.79±0.71	29.64±4.81	1.04±0.15	2.79±0.53	0.17±0.08
Instantly after operation	25	12.56±0.71	29.44±4.57	0.98±0.11	3.46±0.68*	0.34±0.13*
Three days after operation	25	11.47±0.63*^△	29.04±5.22	0.96±0.13	3.68±0.71*^△■	0.37±0.12*^■■
Five days after operation	25	11.44±0.60*	28.76±5.11	0.91±0.12	3.84±0.58*^■	0.29±0.12*^▲■
Seven days after operation	25	11.46±0.66*^■	29.06±5.02	0.95±0.15	3.37±0.56*^□■	0.23±0.10*^□■■

Effects of Xuesaitong Injection on coagulation function of gastric cancer patients undergoing laparoscopic surgery: A randomized controlled trial

RichHTML

PDF (PC)

Cited

Like

Abstract

Cite this article

Share this article

TrendMD

Figures/Tables 1

References 10

Related Articles 15

Metrics

Comments

Recommended 10