养阴生津方对热盛津伤瘀滞证模型家兔血液流变性和凝血因子的影响

doi:10.3736/jcim20050112

Abstract

Objective

To investigate the effects of Yangyin Shengjin Decoction (YYSJD) on hemorheological parameters and coagulation factors in model rabbits with syndrome of excessive heat consuming body fluid and blood stasis.

Methods

Rabbit model with syndrome of excessive heat consuming body fluid and blood stasis was produced. The effects of YYSJD on the blood viscosity, erythrocyte sedimentation rate (ESR), hematocrit, platelet aggregation rate, prothrombin time (PT), thrombin time (TT), kaolin partial thromboplastin time (KPTT), fibrinogen (Fg), thromboxane B₂ (TXB₂), and 6-keto-prostaglandin F_1α (6-keto-PGF_1α) in the model rabbits were observed.

Results

YYSJD decreased the whole blood viscosity and hematocrit, inhibited the platelet aggregation, prolonged PT, TT and KPTT, and reduced the content of Fg. It also regulated the balance between TXB₂ and 6-keto-PGF_1α.

Conclusion

YYSJD can promote the blood circulation, adjust the blood agglutinating function, and decrease the formation of thrombus. This is one of the pharmacological mechanisms of the therapeutic method of "nourishing yin to promote blood circulation" in the theory of traditional Chinese medicine for seasonal febrile diseases.

Key words: Yangyin Shengjin Decoction, Hemorheology, Coagulation factors, Science for epidemic febrile diseases, Therapy in TCM

CLC Number:

R242

Hong Ma, Jin Yang, Shu-ling Nan, Jie-ning Gong, Xue-feng Liu. Effects of Yangyin Shengjin Decoction on hemorheological parameters and coagulation factors in model rabbits with syndrome of excessive heat consuming body fluid and blood stasis. Journal of Chinese Integrative Medicine, 2005, 3(1): 39-42.

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URL: http://www.jcimjournal.com/EN/10.3736/jcim20050112

http://www.jcimjournal.com/EN/Y2005/V3/I1/39

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References 4

[1]	翁维良, 廖福龙, 吴云鹏 , 等. 血液流变学研究方法及其应用(第1版)[M]. 北京: 科学出版社, 1989,( 第1版):64
[2]	王秋 . 家兔“温病阴虚热盛证”动物模型的实验研究[J]. 辽宁中医杂志, 1995,22(9):427-429
[3]	陈文杰 . 血液流变学(第1版)[M]. 天津: 天津科学技术出版社, 1987,( 第1版):43
[4]	李家增, 王鸿利, 韩忠朝 . 血液实验学(第1版)[M]. 上海: 上海科学技术出版社, 1997,( 第1版):343

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Group	n	Whole blood viscosity				Plasma viscosity
Group	n	200/s	60/s	5/s	1/s	Plasma viscosity
Normal control group	6	2.96±0.36	3.57±0.37	7.92±0.99	18.94±3.96	1.43±0.07
Model group	6	3.40±0.24*	4.11±0.21*	9.66±1.15*	24.91±4.77*	1.62±0.09**
YYSJD-treated group	6	2.87±0.13^△△	3.42±0.18^△△	7.06±0.33^△△	16.33±0.84^△△	1.51±0.06^△

Group	n	ESR (mm/h)	Hematocrit (%)
Normal control group	6	0.48±0.43	33.58±2.73
Model group	6	10.17±14.83	42.67±3.56**
YYSJD-treated group	6	2.58±1.74	31.50±1.05^△△

Group	n	Platelet aggregation rate （％）			Platelet aggregation time （s）
Group	n	1 min	Maximum	5 min	Platelet aggregation time （s）
Normal control group	6	10.48±5.66	15.75±9.02	6.23±3.56	180.00±85.02
Model group	6	25.72±10.75*	32.13±14.66*	15.50±7.72*	85.00±17.96*
YYSJD-treated group	6	7.25±4.12^△△	9.33±4.81^△△	3.23±1.02^△△	144.33±59.36^△

Group	n	PT （s）	TT （s）	KPTT （s）	Fg （g/L）
Normal control group	6	21.83±0.98	102.17±5.78	99.67±9.20	3.27±0.55
Model group	6	18.67±1.03**	89.83±9.87*	81.33±10.29**	5.20±0.65**
YYSJD-treated group	6	20.50±1.38^△	105.00±4.94^△△	103.17±5.74^△△	3.27±0.49^△△

Group	n	TXB₂ (ng/L)	6-keto-PGF_1α (ng/L)	TXB₂/6-keto-PGF_1α
Normal control group	6	168.75±52.97	939.41±189.48	0.18
Model group	6	254.65±62.39*	382.12±171.50**	0.64
YYSJD-treated group	6	141.89±26.19^△△	831.62±285.30^△△	0.17

Effects of Yangyin Shengjin Decoction on hemorheological parameters and coagulation factors in model rabbits with syndrome of excessive heat consuming body fluid and blood stasis

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