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Journal of Chinese Integrative Medicine ›› 2005, Vol. 3 ›› Issue (1): 39-42.doi: 10.3736/jcim20050112

• Original Experimental Research • Previous Articles     Next Articles

Effects of Yangyin Shengjin Decoction on hemorheological parameters and coagulation factors in model rabbits with syndrome of excessive heat consuming body fluid and blood stasis

Hong Ma,Jin Yang,Shu-ling Nan,Jie-ning Gong,Xue-feng Liu   

  1. College of Basic Medical Sciences, Nanjing University of Traditional Chinese Medicine, Nanjing, Jiangsu Province 210029, China
  • Received:2004-06-16 Online:2005-01-20 Published:2005-01-20
  • Contact: Jin Yang


To investigate the effects of Yangyin Shengjin Decoction (YYSJD) on hemorheological parameters and coagulation factors in model rabbits with syndrome of excessive heat consuming body fluid and blood stasis.


Rabbit model with syndrome of excessive heat consuming body fluid and blood stasis was produced. The effects of YYSJD on the blood viscosity, erythrocyte sedimentation rate (ESR), hematocrit, platelet aggregation rate, prothrombin time (PT), thrombin time (TT), kaolin partial thromboplastin time (KPTT), fibrinogen (Fg), thromboxane B2 (TXB2), and 6-keto-prostaglandin F (6-keto-PGF) in the model rabbits were observed.


YYSJD decreased the whole blood viscosity and hematocrit, inhibited the platelet aggregation, prolonged PT, TT and KPTT, and reduced the content of Fg. It also regulated the balance between TXB2 and 6-keto-PGF.


YYSJD can promote the blood circulation, adjust the blood agglutinating function, and decrease the formation of thrombus. This is one of the pharmacological mechanisms of the therapeutic method of "nourishing yin to promote blood circulation" in the theory of traditional Chinese medicine for seasonal febrile diseases.

Key words: Yangyin Shengjin Decoction, Hemorheology, Coagulation factors, Science for epidemic febrile diseases, Therapy in TCM

CLC Number: 

  • R242

Tab 1

Comparison of whole blood viscosity and plasma viscosity among 3 groups ($\bar{x}$±smPa·s)"

Group n Whole blood viscosity Plasma viscosity
200/s 60/s 5/s 1/s
Normal control group 6 2.96±0.36 3.57±0.37 7.92±0.99 18.94±3.96 1.43±0.07
Model group 6 3.40±0.24* 4.11±0.21* 9.66±1.15* 24.91±4.77* 1.62±0.09**
YYSJD-treated group 6 2.87±0.13△△ 3.42±0.18△△ 7.06±0.33△△ 16.33±0.84△△ 1.51±0.06

Tab 2

Comparison of ESR and hematocrit among 3 groups ($\bar{x}$±s)"

Group n ESR (mm/h) Hematocrit (%)
Normal control group 6 0.48±0.43 33.58±2.73
Model group 6 10.17±14.83 42.67±3.56**
YYSJD-treated group 6 2.58±1.74 31.50±1.05△△

Tab 3

Comparison of ADP-induced platelet aggregation rate among 3 groups ($\bar{x}$±s)"

Group n Platelet aggregation rate (%) Platelet aggregation time (s)
1 min Maximum 5 min
Normal control group 6 10.48±5.66 15.75±9.02 6.23±3.56 180.00±85.02
Model group 6 25.72±10.75* 32.13±14.66* 15.50±7.72* 85.00±17.96*
YYSJD-treated group 6 7.25±4.12△△ 9.33±4.81△△ 3.23±1.02△△ 144.33±59.36

Tab 4

Comparison of PT, TT, KPTT and Fg in plasma among 3 groups ($\bar{x}$±s)"

Group n PT (s) TT (s) KPTT (s) Fg (g/L)
Normal control group 6 21.83±0.98 102.17±5.78 99.67±9.20 3.27±0.55
Model group 6 18.67±1.03** 89.83±9.87* 81.33±10.29** 5.20±0.65**
YYSJD-treated group 6 20.50±1.38 105.00±4.94△△ 103.17±5.74△△ 3.27±0.49△△

Tab 5

Comparison of TXB2 and 6-keto-PGF1α among 3 groups ($\bar{x}$±s)"

Group n TXB2 (ng/L) 6-keto-PGF (ng/L) TXB2/6-keto-PGF
Normal control group 6 168.75±52.97 939.41±189.48 0.18
Model group 6 254.65±62.39* 382.12±171.50** 0.64
YYSJD-treated group 6 141.89±26.19△△ 831.62±285.30△△ 0.17
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