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Journal of Chinese Integrative Medicine ›› 2005, Vol. 3 ›› Issue (4): 270-273.doi: 10.3736/jcim20050407

• Original Clinical Research • Previous Articles     Next Articles

Clinical study of chronic renal failure with syndrome of dampness-heat due to spleen deficiency treated with Jianpi Qinghua Recipe

Li-qun He1,Gan Cai2   

  1. 1. Department of Nephrology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200021, China
    2. Department of Digestion, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200021, China
  • Received:2005-02-17 Online:2005-07-20 Published:2005-07-20
  • Contact: Li-qun He E-mail:heliqun59@yahoo.com.cn

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Objective

To evaluate the effects of Jianpi Qinghua Recipe (JPQHR) on chronic renal failure with syndrome of dampness-heat due to spleen deficiency and its mechanism.

Methods

One hundred and six patients were randomly divided into two groups: control group (53 patients treated with routine therapy) and JPQHR-treated group (53 patients treated with routine therapy and JPQHR).

Results

Routine therapy combined with JPQHR could improve symptoms. The serum creatinine, blood urea nitrogen, triglyceride and low density lipoprotein decreased significantly in the JPQHR-treated group as compared with those in the control group (P<0.05), while the number of erythrocyte rosette-forming cells increased significantly in the JPQHR-treated group as compared with those in the control group (P<0.05).

Conclusion

Routine therapy combined with JPQHR can significantly decrease blood lipid level and strengthen cellular immune system, so it can lower the urine protein in the early and middle stages of chronic renal failure and improve renal function.

Key words: Jianpi Qinghua Recipe, Syndrome of dampness-heat due to spleen deficiency, Kidney failure, Chronic

CLC Number: 

  • R692.5

Tab 1

Comparison of SCr and BUN of two groups （$\bar{x}$±s）"

Group n SCr (μmol/L) BUN (mmol/L)
JPQHR-treated group
Before treatment 53 236.98±115.22 11.52±5.06
After treatment 53 200.56±97.51* 10.51±4.73*
Control group
Before treatment 53 245.32±117.86 13.15±6.20
After treatment 53 243.44±122.63 13.00±5.87

Tab 2

Comparison of Ccr, 24 h Upr of two groups （$\bar{x}$±s）"

Group n Ccr (ml/min) Upr (g/24 h)
JPQHR-treated group
Before treatment 50 37.30±19.11 1.31±1.49
After treatment 50 40.34±18.47 1.12±1.22*
Control group
Before treatment 49 35.43±18.30 0.93±0.75
After treatment 49 33.91±18.80 0.85±0.76

Tab 3

Comparison of CH, TG, HDL and LDL of two groups （$\bar{x}$±s, mmol/L）"

Group n CH TG HDL LDL
JPQHR-treated group
Before treatment 39 4.87±1.01 2.52±1.29 1.15±0.28 2.85±1.05
After treatment 39 4.58±1.04 1.81±1.32*△ 1.21±0.28△△ 2.17±0.93**△△
Control group
Before treatment 39 4.44±0.75 2.04±0.92 1.14±0.29 2.04±0.92
After treatment 39 4.47±1.04 2.59±1.65 1.13±0.26 2.59±1.65

Tab 4

Comparison of EtRFC and IgG of two groups （$\bar{x}$±s, g/L）"

Group n EtRFC IgG
JPQHR-treated group
Before treatment 35 74.85±10.79 12.25±3.39
After treatment 35 79.81±9.01*△ 11.77±3.31
Control group
Before treatment 35 73.22±9.64 11.99±2.93
After treatment 35 74.51±8.79 11.39±2.61
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