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Journal of Chinese Integrative Medicine ›› 2005, Vol. 3 ›› Issue (4): 274-277.doi: 10.3736/jcim20050408

• Original Clinical Research • Previous Articles     Next Articles

Significance of serum vascular endothelial growth factor test before radiotherapy in patients with nasopharyngeal carcinoma

Guo-qi Zhao,Yi Xu,Qiang Wang   

  1. Department of Radiology, Shanghai First People’s Hospital, Shanghai Jiao Tong University, Shanghai 200080, China
  • Received:2005-03-18 Online:2005-07-20 Published:2005-07-20
  • Contact: Guo-qi Zhao


To study the changes of serum vascular endothelial growth factor (VEGF) and beta 2-microglobulin levels before and after radiotherapy in 58 patients with nasopharyngeal carcinoma (NPC), and to elucidate the clinical significance of VEGF and beta 2-microglobulin test before radiotherapy.


Serum VEGF level was measured by sandwich ELISA in 58 patients with NPC and 24 healthy individuals, and the serum beta 2-microglobulin was assayed with time-resolved fluoroimmunoassay.


The serum VEGF level in patients with NPC was (174.0±130.0) ng/L, higher than (134.1±66.6) ng/L of the healthy subjects, but the difference was not significant (P>0.05). The serum VEGF level was higher in T4 and Ⅳ a patients with NPC. No significant differences in the levels of serum VEGF were found among various N classifications in the patients with NPC. Patients with the serum VEGF level higher than 267.3 ng/L (mean+2 s of the serum VEGF level in the healthy individuals) had a shorter metastasis-free survival time (P<0.05). Although the patients with high beta 2-microglobulin level had a shorter survival time, the difference was not significant.


The NPC patients with high serum VEGF level have a poor prognosis.

Key words: Nasopharyngeal carcinoma, Radiotherapy, Vascular endothelial growth factor, Beta 2-microglobulin

CLC Number: 

  • R739.63

Tab 1

Serum VEGF level in patients with NPC before and after treatment ($\bar{x}$±s, ng/L)"

Group n Serum VEGF
Healthy control 24 134.1±66.6
Before treatment 58 174.0±130.0
After treatment 54 140.5±85.2*

Tab 2

Relation of Serum VEGF level and TNM staging in patients with NPC ($\bar{x}$±s, ng/L)"

Stage n VEGF level before treatment
T1 6 136.2±30.4
T2 16 182.1±123.3
T3 29 153.1±119.1
T4 7 274.5±200.0
N0 1 232.1
N1 33 163.4±122.6
N2 21 171.0±111.0
N3 3 291.0±305.9
12 152.8±93.6
37 150.7±92.2
9 297.7±222.9

Tab 3

Results of Cox analysis in 58 patients with NPC"

Factor β value S$\bar{x}$ value χ2 value P
T categories 0.687 0.540 1.618 0.203
N classification 0.262 0.502 0.273 0.601
VEGF level 1.125 0.553 4.139 0.042

Fig 1

Non-metastasis survival curves according to VEGF levels in patients with NPC"

Tab 4

Relation of serum beta 2-microglobulin level and TNM staging in patients with NPC ($\bar{x}$±s, mg/L)"

Stage n Beta 2-microglobulin level
N0-1 34 1.96±0.52
N2 21 1.79±0.39
N3 3 4.36±4.23
12 2.00±0.66
37 1.79±0.33
9 3.02±2.39
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