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Journal of Chinese Integrative Medicine ›› 2005, Vol. 3 ›› Issue (4): 266-269.doi: 10.3736/jcim20050406

• Original Clinical Research • Previous Articles     Next Articles

Clinical research of intraperitoneal chemotherapy plus Shenmai Injection in treating advanced colorectal cancer

Wei-rong Zhu1,Lan Zheng1,Yuan-biao Guo1,Jian-ming Yuan2,Xiao-heng Shen1   

  1. 1. Department of Traditional Chinese Medicine, Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025, China
    2. Department of Surgery, Ruijin Hospital Luwan Branch, Shanghai Second Medical University, Shanghai 200020, China
  • Received:2005-04-13 Online:2005-07-20 Published:2005-07-20
  • Contact: Xiao-heng Shen E-mail:meilixl@51277.com

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Objective

To study the effects of intraperitoneal chemotherapy (IPC) plus Shenmai Injection (SMI) in treating advanced colorectal cancer following radical resections.

Methods

Fifty-eight cases of colorectal cancer in stage B2 and C following radical resections were divided into two groups: SMI+IPC group (36 cases) and IPC group (22 cases). In the SMI+IPC group, IPC (5-fluorouracil combined with cisplatin) plus SMI was administered, while in the IPC group, only IPC was administered. Clinical symptoms, quality of life (Karnofsky score), white blood cell counts, natural killer cells and CD4/CD8 were observed, and disease-free survival (DFS) rate was also evaluated.

Results

The total short-term response rate was 83.33% in the SMI+IPC group, significantly higher than 63.64% in the IPC group (P<0.05). The data of clinical symptoms, quality of life, white blood cell counts, natural killer cells and CD4/CD8 in the SMI+IPC group were also significantly improved as compared with those in the IPC group (P<0.05 or P<0.01). In the SMI+IPC group, 1-, 3- and 5-year DFS rates were 91.7% (33/36), 77.8% (28/36) and 72.2% (26/36) respectively, and those in the IPC group were 90.9% (20/22), 72.7% (16/22) and 45.5% (10/22) respectively. The 5-year DFS rate was significantly improved in the SMI+IPC group as compared with that in the IPC group (P<0.05), while the 1-year and 3-year DFS rates had no significant difference between these two groups.

Conclusion

IPC plus SMI is effective in treating post-operative patients with advanced colorectal cancer.

Key words: Shenmai Injection, Intraperitoneal chemotherapy, Colorectal cancer, Clinical research

CLC Number: 

  • R273

Tab 1

Comparison of clinical symptomatic integrals in 2 groups ($\bar{x}$±s)"

Group n Clinical symptomatic integral
Before treatment After treatment Difference value
SMI+IPC group 36 15.7±3.16 11.4±1.91** 4.3±2.46△△
IPC group 22 15.5±2.51 14.3±2.73* 1.18±2.59

Tab 2

Comparison of life quality in 2 groups ($\bar{x}$±s)"

Group n Clinical symptomatic integral
Before treatment After treatment Difference value
SMI+IPC group 36 69.7±12.72 80.9±13.16** 11.2±9.26△△
IPC group 22 70.6±13.25 70.8±13.82 0.20±6.19

Tab 3

Comparison of white blood cell counts in 2 groups ($\bar{x}$±s, ×109/L)"

Group n White blood cell count
1st month 2nd month 3rd month 4th month 5th month 6th month
SMI+IPC group
Before treatment 36 5.48±2.27 5.43±2.04 5.37±2.32 5.28±1.71 5.21±1.66* 4.82±1.39*
After treatment 36 5.12±1.56 5.06±1.78 5.08±1.83 5.03±1.58** 4.97±1.34** 4.65±1.23**
IPC group
Before treatment 22 5.62±2.20 5.17±1.76 5.04±1.65 4.73±1.48 4.24±1.37 4.05±1.14
After treatment 22 4.77±1.52 4.63±1.55 4.41±1.59 3.82±1.11 3.69±1.25 3.55±1.20

Tab 4

Comparison of NK cells in 2 groups ($\bar{x}$±s, %)"

Group n NKcell
Before treatment After treatment Difference value
SMI+IPC group 36 14.76±2.87 16.98±3.14** 2.22±2.35△△
IPC group 22 14.81±3.14 15.16±3.43 0.35±0.95

Tab 5

Comparison of CD4/CD8 in 2 groups ($\bar{x}$±s)"

Group n CD4/CD8
Before treatment After treatment Difference value
SMI+IPC group 36 1.52±0.16 1.57±0.17** 0.05±0.09△△
IPC group 22 1.50±0.17 1.48±0.18 0.02±0.11

Tab 6

Comparison of DFS rates in 2 groups ($\bar{x}$±s, %)"

Group n Disease-Free Survival rate
1-year 3-year 5-year
SMI+IPC group 36 91.7 (33/36) 77.8 (28/36) 72.2 (26/36)*
IPC group 22 90.9 (20/22) 72.7 (16/22) 45.5 (10/22)
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