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Journal of Chinese Integrative Medicine ›› 2007, Vol. 5 ›› Issue (3): 263-267.doi: 10.3736/jcim20070307

• Original Clinical Research • Previous Articles     Next Articles

Clinical research of Yiqi Sanju Formula in treating central obese men at high risk of metabolic syndrome

Chun-yan He1, Wen-jian Wang1, Bin Li2, De-sheng Xu1, Wei-hua Chen1, Jiang Ying1, Yan-ming He1   

  1. 1. Institute of Chinese Integrative Medicine, Fudan University, Shanghai 200040, China
    2. Department of Internal Medicine, Fengcheng People's Hospital, Fengxian District, Shanghai 201411, China
  • Online:2007-05-31 Published:2007-05-15

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Objective: To observe the therapeutic effects of Yiqi Sanju Formula (YQSJF), a compound Chinese herbal medicine, on central obese men at high risk of metabolic syndrome (MS).

Methods: Compared with 30 healthy male volunteers, 45 central obese men were separated randomly into two groups and received the interventions with YQSJF and placebo respectively for 10 weeks. Baseline characteristics, insulin resistance, inflammation cytokines and plasminogen activator inhibitor-1 (PAI-1) and tissue plasminogen activator (t-PA) were evaluated before and after treatment. 

Result: The score of homeostatic model assessment for insulin resistance (HOMA-IR) and the levels of C reactive protein (CRP), free fatty acid (FFA) and PAI-1 in obese men were higher than those in the control group, while t-PA was lower. After treatment, compared with placebo group, body mass index, waist, and waist-to-hip ratio were decreased significantly in subjects who received YQSJF (P＜0.01). The score of HOMA-IR and the levels of CRP, FFA and PAI-1 were decreased significantly, and the level of t-PA was increased significantly (P＜0.01). 

Conclusion: YQSJF can reduce obesity and insulin resistance in central obese men at high risk of MS and improve inflammation and fibrinolysis, which indicates that it can reduce the risk of atherosclerosis.

Key words: metabolic syndrome, obesity, insulin, traditional Chinese medicine

CLC Number: 

  • R589

Table 1

Common state before and after treatment （ヌ±S）"

GroupnAge (year)BMI (kg/m2)Waist (cm)WHR
Control3043.4±7.6023.40±2.1080.70±6.850.85±0.05
TCM
Before treatment2246.04±5.7627.50±2.22**96.26±5.93**0.93±0.04**
After treatment2246.04±5.7626.70±2.81△△▲▲92.74±5.30△△▲▲0.91±0.02△△▲▲
Placebo
Before treatment2345.68±6.3926.98±2.81**97.41±6.73**0.94±0.03**
After treatment2345.68±6.3927.00±2.8496.69±6.730.94±0.04

Table 2

Changes of FBG, TG and HOMA-IR before and after treatment （ヌ±S）"

GroupnFBG (mmol/L)TG (mmol/L)HOMA-IR
Control304.95±0.481.12±0.331.62±1.44
TCM
Before treatment225.03±0.391.30±0.332.68±0.85**
After treatment225.16±0.361.39±0.411.76±0.64△△▲▲
Placebo
Before treatment235.09±0.341.26±0.332.66±0.92**
After treatment235.27±0.441.36±0.422.89±1.41

Table 3

Changes of CRP, FFA, PAI-1 and t-PA before and after treatment （ヌ±S）"

GroupnCRP (mg/L)FFA (mmol/L)PAI-1 (μg/L)t-PA (μg/L)
Control302.76±2.180.48±0.2623.70±9.1021.83±9.07
TCM
Before treatment224.79±2.69*0.65±0.33**35.28±11.52**16.26±4.89*
After treatment222.89±1.40△△▲▲0.42±0.20△△▲22.74±5.30△▲24.14±8.85△△▲▲
Placebo
Before treatment235.18±3.70*0.65±0.27**31.01±10.09*14.27±6.23**
After treatment235.48±2.660.61±0.2231.05±10.2414.01±6.80
[1] 顾东风, Reynolds K, 杨文杰, 等.中国成年人代谢综合征的患病率.中国糖尿病杂志,2005,13(3):181-185
Gu DF, Reynolds K, Yang WJ, et al.The prevalence of metabolic syndrome in the general adult population aged 35-74 years in China.Zhongguo Tang Niao Bing Za Zhi,2005,13(3):181-185
[2] Temelkova-Kurktschiev T, Siegert G, Bergmann S, et al.Subclinical inflammation is strongly related to insulin resistance but not to impaired insulin secretion in a high risk population for diabetes.Metabolism,2002,51(6):743-749
[3] Florez H, Castillo-Florez S, Mendez A, et al.C-reactive protein is elevated in obese patients with the metabolic syndrome.Diabetes Res Clin,2006,71(1):92-100
doi: 10.1016/j.diabres.2005.05.003 pmid: 16002176
[4] Bastard JP, Maachi M, Lagathu C, et al.Recent advances in the relationship between obesity, inflammation, and insulin resistance.Eur Cytokine Netw,2006,17(1):4-12
doi: 10.1104/pp.92.4.891 pmid: 16613757
[5] Mertens I, Ballaux D, Funahashi T, et al.Inverse relationship between plasminogen activator inhibitor-I activity and adiponectin in overweight and obese women. Interrelationship with visceral adipose tissue, insulin resistance, HDL-chol and inflammation.Thromb Haemost,2005,94(6):1190-1195
[6] Alessi MC, Juhan-Vague I.PAI-1 and the metabolic syndrome: links, causes, and consequences.Arterioscler Thromb Vasc Biol,2006,26(10):2200-2207
doi: 10.1161/01.ATV.0000242905.41404.68 pmid: 16931789
[7] 王文健. 聚证学说的建立和应用.中西医结合学报,2007,5(2):111-114
Wang WJ.Foundation and application of aggregation theory in traditional Chinese medicine.Zhong Xi Yi Jie He Xue Bao,2007,5(2):111-114
[8] 王树海, 王文健, 汪雪峰, 等.黄芪多糖和小檗碱对3T3-L1脂肪细胞糖代谢及细胞分化的影响.中国中西医结合杂志,2004,24(10):926-928
Wang SH, Wang WJ, Wang XF, et al.Effect of astragalus polysaccharides and berberine on carbohydrate metabolism and cell differentiation in 3T3-L1 adipocytes.Zhongguo Zhong Xi Yi Jie He Za Zhi,2004,24(10):926-928
[9] 何燕铭, 王文健, 陈伟华, 等.蒲黄总黄酮对3T3-L1脂肪细胞糖脂代谢的影响.中西医结合学报,2006,4(6):593-595
He YM, Wang WJ, Chen WH, et al.Effects of Pollen Typhae total flavone on glucose and lipid metabolism in 3T3-L1 adipocytes.Zhong Xi Yi Jie He Xue Bao,2006,4(6):593-595
[10] Kahn SE, Zinman B, Haffner SM, et al.Obesity is a major determinant of the association of C-reactive protein levels and the metabolic syndrome in type 2 diabetes.Diabetes Res Clin Pract,2006,71(1):92-100
[11] Kahn SE, Zinman B, Haffner SM, et al.Obesity is a major determinant of the association of C-reactive protein levels and the metabolic syndrome in type 2 diabetes.Diabetes,2006,55(8):2357-2364
[12] Bo S, Gambino R, Uberti B, et al.Does C-reactive protein identify a subclinical metabolic disease in healthy subjects.Eur J Clin Invest,2005,35(4):265-270
doi: 10.1111/j.1365-2362.2005.01490.x pmid: 15816996
[13] Boden G.Fatty acid-induced inflammation and insulin resistance in skeletal muscle and liver.Curr Diab Rep,2006,6(3):177-181
doi: 10.1007/s11892-006-0031-x pmid: 16898568
[14] Nieuwdorp M, Stroes ES, Meijers JC, et al.Hypercoagulability in the metabolic syndrome.Curr Opin Pharmacol,2005,5(2):155-159
doi: 10.1016/j.coph.2004.10.003 pmid: 15780824
[15] Umpaichitra V, Hussain MM, Castells S.Plasminogen activator inhibitor-1 and tissue-plasminogen activator in minority adolescents with type 2 diabetes and obesity.Pediatr Res,2005,58(3):483-487
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