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Journal of Chinese Integrative Medicine ›› 2008, Vol. 6 ›› Issue (2): 163-165.doi: 10.3736/jcim20080211

• Original Experimental Research • Previous Articles     Next Articles

Matrine and anti-tumor drugs in inhibiting the growth of human lung cancer cell line

Mu-yun Zhu(), Zheng-hua Jiang, Yuan-wen Lu, Yuan Guo, Jun-ji Gan   

  1. Department of Respiratory Diseases, Clinical Medical College, Yangzhou University, Yangzhou, Jiangsu Province 225001, China
  • Received:2007-05-16 Online:2008-02-20 Published:2008-02-15
  • Contact: ZHU Mu-yun E-mail:yzszmy@163.com

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objective: To study the activities of matrine and anti-tumor drugs on SPCA/Ⅰ human lung adenocarcinoma cell line.

Methods: Suppression effects of different concentrations of matrine and matrine combined with anti-tumor drugs on lung cancer cells were measured by methyl thiazolyl tetrazolium (MTT) colorimetric assay.

Results: Different concentrations of matrine could inhibit the growth of SPCA/Ⅰ human lung adenocarcinoma cells and there was a positive correlation between the inhibition rate and the drug concentration. Different concentrations of matrine combined with anti-tumor drugs had higher growth inhibition rate than anti-tumor drugs alone.

Conclusion: Matrine has direct growth suppression effect on SPCA/Ⅰ human lung adenocarcinoma cells and matrine conbined with anti-tumor drugs shows a significant synergistic effect on tumor cells.

Key words: matrine, combination chemotherapy, lung cancer

CLC Number: 

  • R734.2

Table 1

Growth inhibitory rate of anti-tumor drugs alone and matrine combined with anti-tumor drugs ($\bar{x}$±s, %)"

Group Growth inhibitory rate
1 PPC HCPT-treated 55.88±5.93
1 PPC HCPT plus 0.1 PPC matrine-treated 84.01±2.92**
1 PPC HCPT plus 1 PPC matrine-treated 88.81±4.11**
1 PPC VP-16-treated 66.10±1.29
1 PPC VP-16 plus 0.1 PPC matrine-treated 80.06±4.76△
1 PPC VP-16 plus 1 PPC matrine-treated 87.37±3.07△△
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