Search JIM Advanced Search

Journal of Chinese Integrative Medicine ›› 2008, Vol. 6 ›› Issue (8): 827-829.doi: 10.3736/jcim20080811

• Original Experimental Research • Previous Articles     Next Articles

Effects of Feiji Formula on lung cancer metastasis in mice

Jian-hui Tian1(), Zhi-ming Shi1, Zhi-yi Zhou1, Yun-sheng Huang2, Lin Wang3   

  1. 1. Department of Oncology, Shanghai Municipal Clinical Medicine Center for Chinese Traditional Oncology, Longhua Hospi¬tal, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China;
    2. Department of Internal Medicine, Central Hospital of Nanhui District, Shanghai 201300, China
    3. Department of Internal Medicine,Longhua hospital, Shanghai University of Traditional Chinese Medicine,Shanghai 200032, China
  • Received:2007-11-13 Online:2008-08-20 Published:2008-08-15

Objective: To observe the effects of Feiji Formula, a compound traditional Chinese herbal medicine, on lung cancer metastasis in mice.
Methods: The lung cancer metastasis model of mice was established in this experiment study. Twenty-four mice were randomly divided into three groups: untreated group, cisplatin group and Feiji Formula group. Mice in the Feiji Formula group were treated with Feiji Formula decoction; in cisplatin group, with cisplatin by intraperitoneal injection; and in the untreated group, with normal saline (NS). After twenty-day treatment, the body and tumor weights as well as the number of metastatic tumors in both lungs of each mouse were measured.
Results: The body weight of mice in cisplatin group was significantly less than that of Feiji Formula group and untreated group (P<0.01); the tumor weight of mice in cisplatin group and Feiji Formula group was markedly lower than that of untreated group (P<0.01); and the number of metastatic tumors in cisplatin group and Feiji Formula group was markedly lower than that of the untreated group (P<0.01), no significant difference between the Feiji Formula group and cisplatin group in terms of the weights and the numbers of metastatic tumors in bilateral lungs.
Conclusion: Feiji Formula can suppress tumor growth and decrease the number of lung metastatic tnmors in the mice, and maintain the body weight of the mice.

Key words: lung cancer, metastasis, traditional Chinese medicine, Feiji Formula, mice

CLC Number: 

  • R730.52

Table 1

Weights of body, solid tumor and lung and number of lung metastatic tumors in three groups(x±s)"

Group n Body weight (g) Solid tumor weight (g) Lung weight (mg) Number of lung metastatic tumors
Untreated 8 22.92±1.22 3.54±1.21 170±2 28.37±10.87
Cisplatin 8 18.92±2.67** 1.94±1.71** 150±2 12.63±6.58**
Feiji Formula 8 23.65±1.65△△ 2.11±0.99** 150±3 19.13±8.47**

Figure 1

Solid tumor size after Feiji Formula treatment A: Cisplatin group; B: Untreaed group; C: Feiji Formula group."

Figure 2

Metastatic tumor located at periphery part of the lung"

[1] You J, Shi ZM . Study on the relationship among the international scales for quality of life evaluation in patients with lung cancer, the east cooperative oncology group status and lung cancer symptoms lists of traditional Chinese medicine[J]. Zhongguo Zhong Xi Yi Jie He Za Zhi, 2005,25(7):595-598
doi: 10.7661/CJIM.2005.7.595
游捷, 施志明 . 肺癌国际生存质量量表与体能状态评定指标及中医症状量表的关系[J]. 中国中西医结合杂志, 2005,25(7):595-598
doi: 10.7661/CJIM.2005.7.595
[2] You J, Shi ZM . Clinical evaluation of "Feiji Decoction" in treating non-small cell lung cancer in 61 cases[J]. Shanghai Zhong Yi Yao Za Zhi, 2005,39(6):17-20
doi: 10.3969/j.issn.1007-1334.2005.06.007
游捷, 施志明 . 肺积方治疗非小细胞肺癌61例临床疗效评价[J]. 上海中医药杂志, 2005,39(6):17-20
doi: 10.3969/j.issn.1007-1334.2005.06.007
[3] Huang YS, Shi ZM . Intervention effect of Feiji Recipe on immune escape of lung cancer[J]. Zhongguo Zhong Xi Yi Jie He Za ZhYi Jie He Za Zhi, 2007,27(6):501-504
doi: 10.3321/j.issn:1003-5370.2007.06.006
黄云胜, 施志明 . 肺积方对肺癌免疫逃逸干预作用的临床研究[J]. 中国中西医结合杂志, 2007,27(6):501-504
doi: 10.3321/j.issn:1003-5370.2007.06.006
[4] Chen Q. Methodology on Chinese medicinal pharmacology[M]. Beijing: People's Medical Publishing House,1997: 1103-1104
陈奇 . 中药药理研究方法学[M]. 北京: 人民卫生出版社,1997: 1103-1104
[5] Gao J, Zhang JB. Preclinical and clinical cancer invasion and metastasis[M]. Beijing: Science Press,2003: 78
高进, 章静波 . 癌的侵袭与转移基础医学与临床[M]. 北京: 科学出版社,2003: 78
[6] Li LY . Lung cancer[J]. Ai Zheng Jin Zhan, 2005,3(2):114
李龙芸 . 肺癌[J]. 癌症进展, 2005,3(2):114
[7] Liu JX . Analysis of therapeutic effect of syndrome differentiation treatment of 310 patients with lung cancer[J]. Shanghai Zhong Yi Yao Za Zhi, 1985,10(10):3-6
刘嘉湘 . 辨证治疗原发性肺癌310例疗效分析[J]. 上海中医药杂志, 1985,10(10):3-6
[8] Shi ZM . The relationship between differentiation by Chinese medicine and clinical stage as well as carcinoma type[J]. Zhongguo Ai Zheng Za Zhi, 1998,8(4):317-318
施志明 . 原发性肺癌中医辨证分型与西医分期及细胞类型关系[J]. 中国癌症杂志, 1998,8(4):317-318
[9] Li YJ . Experimental study on Qi-replenishing and Yin-nourishing in inhibiting tumor metastasis[J]. Zhong Xi Yi Jie He Xue Bao, 2004,2(1):49-52
doi: 10.3969/j.issn.1672-397X.2001.01.006
李涌健 . 益气养阴法防治癌转移的实验研究[J]. 中西医结合学报, 2004,2(1):49-52
doi: 10.3969/j.issn.1672-397X.2001.01.006
[1] Sherman Gu, Arthur Yin Fan. Controversial conclusions from two randomized controlled trials for acupuncture's effects on polycystic ovary syndrome or in vitro fertilization support. Journal of Integrative Medicine, 2020, 18(2): 89-91.
[2] Xue-qing Yu, Shu-guang Yang, Yang Xie, Jian-sheng Li. Traditional Chinese medicine in the treatment of idiopathic pulmonary fibrosis based on syndrome differentiation: Study protocol of exploratory trial. Journal of Integrative Medicine, 2020, 18(2): 163-168.
[3] Chang-quan Ling. Traditional Chinese medicine is a resource for drug discovery against 2019 novel coronavirus (SARS-CoV-2). Journal of Integrative Medicine, 2020, 18(2): 87-88.
[4] Yi Ran Hu, San Li Xing, Chuan Chen, Ding Zhu Shen, Jiu Lin Chen. Tiaoxin Recipe, a Chinese herbal formula, inhibits microRNA-34a expression in the APPswe/PS1ΔE9 mouse model of Alzheimer's disease. Journal of Integrative Medicine, 2019, 17(6): 404-409.
[5] Wen Qiang Lee, Jeremy Teoh, Pei Zheng Kenneth Lee, Zhi Xiong Gerard Low, Xueling Sim, Foong Fong Mary Chong, Norbert Ludwig Wagner. Factors influencing communication of traditional Chinese medicine use between patients and doctors: a multisite cross-sectional study. Journal of Integrative Medicine, 2019, 17(6): 396-403.
[6] Charles Dalcanale Tesser, Ari Ojeda Ocampo Moré, Melissa Costa Santos, Emiliana Domingues Cunha da Silva, Fátima Terezinha Pelachini Farias, Lúcio José Botelho. Auriculotherapy in primary health care: A large-scale educational experience in Brazil. Journal of Integrative Medicine, 2019, 17(4): 302-309.
[7] Mikhail Teppone. Medicine has always been “Modern” and “Scientific” from ancient times to the present day. Journal of Integrative Medicine, 2019, 17(4): 229-237.
[8] Rachael Farrington, Ian F.Musgrave, Roger W.Byard. Evidence for the efficacy and safety of herbal weight loss preparations. Journal of Integrative Medicine, 2019, 17(2): 87-92.
[9] Fung-Kei Cheng. An overview of the contribution of acupuncture to thyroid disorders. Journal of Integrative Medicine, 2018, 16(6): 375-383.
[10] Goulnar Kasymjanova, Anh-Thi Tran, Victor Cohen, Carmela Pepe, Lama Sakr, David Small, Jason Scott Agulnik, Robert Thomas Jagoe. The use of a standardized Chinese herbal formula in patients with advanced lung cancer: A feasibility study. Journal of Integrative Medicine, 2018, 16(6): 390-395.
[11] Chang-quan Ling, Jia Fan, Hong-sheng Lin, Feng Shen, Zhen-ye Xu, Li-zhu Lin, Shu-kui Qin, Wei-ping Zhou, Xiao-feng Zhai, Bai Li, Qing-hui Zhou, on behalf of the Chinese Integrative Therapy of Primary Liver Cancer Working Group. Clinical practice guidelines for the treatment of primary liver cancer with integrative traditional Chinese and Western medicine. Journal of Integrative Medicine, 2018, 16(4): 236-248.
[12] Shui-jie Shen, Yong-hong Zhang, Xiao-xia Gu, Shui-ju Jiang, Ling-jun Xu. Yangfei Kongliu Formula, a compound Chinese herbal medicine, combined with cisplatin, inhibits growth of lung cancer cells through transforming growth factor-β1 signaling pathway. Journal of Integrative Medicine, 2017, 15(3): 242-251.
[13] Bhesh Raj Sharma, Dong Wook Kim, Dong Young Rhyu. Korean Chungtaejeon tea extract attenuates weight gain in C57BL/6J-Lep ob/ob mice and regulates adipogenesis and lipolysis in 3T3-L1 adipocytes. Journal of Integrative Medicine, 2017, 15(1): 56-63.
[14] Qing Ji, Yun-quan Luo, Wen-hai Wang, Xuan Liu, Qi Li, Shi-bing Su. Research advances in traditional Chinese medicine syndromes in cancer patients. Journal of Integrative Medicine, 2016, 14(1): 12-21.
[15] Shi-li Jiang, Xu-dong Hu, Ping Liu. Immunomodulation and liver protection of Yinchenhao decoction against concanavalin A-induced chronic liver injury in mice. Journal of Integrative Medicine, 2015, 13(4): 262-268.
Full text



[1] Jun Cai, Hua Wang, Sheng Zhou, Bin Wu, Hua-rong Song, Zheng-rong Xuan. Effect of Sijunzi Decoction and enteral nutrition on T-cell subsets and nutritional status in patients with gastric cancer after operation: A randomized controlled trial. Journal of Chinese Integrative Medicine, 2008, 6(1): 37-40
[2] Min Cheng, Qiong Feng, Shu-wen Qian, Hui Gao, Cui-qing Zhu. Preliminary assay of p-amyloid binding elements in heart-beneficial recipe. Journal of Chinese Integrative Medicine, 2008, 6(1): 68-72
[3] Hai-feng Wei, Bai-liu Ya, Ling Zhao, Cui-fei Ye, Li Zhang, Lin Li. Evaluation of tongue manifestation of blood stasis syndrome and its relationship with blood rheological disorder in a rat model of transient brain ischemia. Journal of Chinese Integrative Medicine, 2008, 6(1): 73-76
[4] Guo-hong Yuan, Xiao-jing Pang, He-chao Ma. Synergic effects of Danggui Buxue Decoction in reducing toxicity of cytoxan in tumor-bearing mice. Journal of Chinese Integrative Medicine, 2008, 6(1): 83-88
[5] Jin-zhou Tian, Jing Shi, Xin-qing Zhang, Qi Bi, Xin Ma, Zhi-liang Wang, Xiao-bin Li, Shu-li Shen, Lin Li, Zhen-yun Wu, Li-yan Fang, Xiao-dong Zhao, Ying-chun Miao, Peng-wen Wang, Ying Ren, Jun-xiang Yin, Yong-yan Wang, Beijing United Study Group on MCI of the Capital Foundation of Medical Developments. Guiding principles of clinical research on mild cognitive impairment (protocol). Journal of Chinese Integrative Medicine, 2008, 6(1): 9-14
[6] Bo Wang , Wei Yan , Li-hui Hou, Xiao-ke Wu. Disorder of Tiangui (kidney essence) and reproductive dysfunction in patients with polycystic ovary syndrome. Journal of Chinese Integrative Medicine, 2010, 8(11): 1018-1022
[7] Yan-bo Zhu , Qi Wang, Cheng-yu Wu, Guo-ming Pang, Jian-xiong Zhao, Shi-lin Shen, Zhong-yuan Xia , Xue Yan . Logistic regression analysis on relationships between traditional Chinese medicine constitutional types and overweight or obesity. Journal of Chinese Integrative Medicine, 2010, 8(11): 1023-1035
[8] Hong Liu , Guo-liang Zhang, Li Shen , Zhen Zeng, Bao-luo Zhou, Cheng-hai Liu, Guang Nie . Application and evaluation of a pseudotyped virus assay for screening herbs for anti-H5Nl avian influenza virus. Journal of Chinese Integrative Medicine, 2010, 8(11): 1036-1040
[9] Bing Hu , Hong-mei An , Ke-ping Shen , Qin Du. Senescence-inducing effects of Chinese herbal medicine Tenglong Buzhong Decoction on human colon carcinoma LS-174-T cells and the mechanism. Journal of Chinese Integrative Medicine, 2010, 8(11): 1048-1052
[10] Zhi-mei Wang, Bin Zhang. A study on translation of ellipses in Huangdi Neijing from perspective of hermeneutic theory. Journal of Chinese Integrative Medicine, 2010, 8(11): 1097-1100