[an error occurred while processing this directive]

Journal of Chinese Integrative Medicine ›› 2009, Vol. 7 ›› Issue (5): 478-481.doi: 10.3736/jcim20090515

Special Issue: Acupuncture & Moxibustion

• Medical Statistice • Previous Articles     Next Articles

Fuzzy cluster analysis of therapeutic effects of electro-acupuncture at different parameters

Le Kuaia,Ru-feng Jinb,Ming Gaoa,Hua-yuan Yanga   

  1. a Department of Traditional Chinese Engineering, College of Acupuncture-Moxibustion and Tuina, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
    b Department of Preventive Medicine,College of Basic Medical Sciences,Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
  • Received:2008-12-29 Accepted:2009-02-11 Online:2009-05-20 Published:2018-10-15

RichHTML

3

PDF (PC)

132

Cited

10

Like

Objective

To probe into the application of fuzzy cluster in analysis of therapeutic effects of electroacupuncture at different parameters on adjuvant-induced arthritis (AA) in rats.
Methods

One hundred Wistar rats were randomly divided into ten groups： normal control group, untreated group and eight electro-acupuncture groups at different parameters. There were ten rats in each group. AA rats were treated by electro-acupuncture at different frequencies (2 Hz or 100 Hz), waveforms (successive wave or intermittent wave) and current intensities (0.1 mA or 0.2 mA). Firstly, the anti-inflammatory and analgesic effects of electro-acupuncture at different parameters were compared with orthogonal experiment, and then with the application of fuzzy mathematics, the data of joint swelling, pain threshold and the contents of (3-endorphin ((3-EP) and interleukin-ip (IL-1(3) after the treatment in all groups were standardized by the method of data range normalization. Programming and solution were done by MATLAB. The methods of fuzzy similar matrix and the transitive closure were used in similarity evaluation of therapeutic effects of electroacupuncture at different parameters.
Results

Based on index determination and variance analysis, both the normal control group and untreated group were clustered to one category as A equaled to 0. 72. Electro-acupuncture at 100 Hz, successive wave, 0. 2 mA, electro-acupuncture at 100 Hz, intermittent wave, 0. 1 mA and electro-acupuncture at 100 Hz, intermittent wave, 0. 2 mA were clustered to one category and had similar good anti-inflammatory and analgesic effects. The therapeutic effects of the remaining electro-acupuncture types were similar.
Conclusion

Fuzzy cluster analysis provides a better method for evaluating the overall therapeutic effects of electro-acupuncture with multiple factors.

Key words: Fuzzy mathematics, Cluster analysis, Electroacupuncture, Treatment outcome, Rats

"

代码 组别 关节肿胀度（mL） 痛阈（s） β-EP (ng/g) IL-1β (ng/g)
S1 空白组 1.25±0.04 7.57±0.85 0.82±0.48 4.03±2.49
S2 模型组 1.69±0.06** 4.08±0.80** 4.10±2.62* 9.88±3.43**
S3 A1B1C1电针组 1.56±0.08**△△ 6.15±0.92**△△ 6.04±3.36** 6.07±3.58△
S4 A1B1C2电针组 1.52±0.06**△△ 5.46±1.20**△△ 5.37±2.65** 6.72±4.06△
S5 A1B2C1电针组 1.51±0.08**△△ 5.64±0.89**△△ 7.40±3.83** 7.80±3.66*
S6 A1B2C2电针组 1.48±0.12**△△ 4.96±0.49**△ 6.03±2.31** 7.26±2.92*
S7 A2B1C1电针组 1.61±0.10**△ 6.33±0.64**△△ 7.87±5.21**△ 6.32±4.28△
S8 A2B1C2电针组 1.45±0.06**△△ 6.00±0.59**△△ 6.95±3.99** 3.81±2.53△△
S9 A2B2C1电针组 1.56±0.18**△△ 6.67±0.63*△△ 8.81±4.99**△△ 4.79±3.41△△
S10 A2B2C2电针组 1.43±0.06**△△ 6.21±0.83**△△ 8.31±3.47**△ 5.33±3.61△△

"

代码 关节肿胀度 痛阈 β-EP IL-1β
S1 0.00 1.00 0.00 0.04
S2 1.00 0.00 0.41 1.00
S3 0.70 0.59 0.65 0.37
S4 0.61 0.40 0.57 0.48
S5 0.59 0.45 0.82 0.66
S6 0.52 0.25 0.65 0.57
S7 0.82 0.64 0.88 0.41
S8 0.45 0.55 0.77 0.00
S9 0.70 0.74 1.00 0.16
S10 0.41 0.61 0.94 0.25
[1] Kuai L, Yang HY, Jiang J, Chen H . Comparison of analgesic effects of electroacupuncture of multi-factor quantitative parameters on inflammatory pain in rats[J]. Zhongguo Zhen Jiu, 2008,28(11):829-832
蒯乐, 杨华元, 蒋洁, 陈颢 . 多因素量化参数电针对大鼠炎症痛镇痛作用的比较[J]. 中国针灸, 2008,28(11):829-832
[2] Kuai L, Jiang J, Yang HY . Electro-acupuncture parameters in treatment of adjuvant-induced arthritis in rats[J]. Shanghai Zhong Yi Yao Da Xue Xue Bao, 2008,22(3):73-75
蒯乐, 蒋洁, 杨华元 . 电针治疗大鼠佐剂性关节炎参数的研究[J]. 上海中医药大学学报, 2008,22(3):73-75
[3] Wu SJ . The realization of improved fuzzy clustering analysis method in MATLAB[J]. Hua Bei Ke Ji Xue Yuan Xue Bao, 2007,4(3):76-79
吴善杰 . 改进的模糊聚类分析方法在MATLAB中的实现[J]. 华北科技学院学报, 2007,4(3):76-79
[4] Wang J, He QY . Laws of syndrome element combination in stable angina pectoris: a study based on cluster analysis and corresponding-correlation analysis[J]. J Chin Integr Med, 2008,6(7):690-694
王阶, 何庆勇 . 基于聚类分析和对应分析的稳定型心绞痛证候要素组合规律的研究[J]. 中西医结合学报, 2008,6(7):690-694
[1] Na Wu , Lu Song , Xin-xin Yang, Jiang-lei Wei , Zhen-guo Liu. Effects of Chinese herbal medicine Tianqi Pingchan Granule on G protein-coupled receptor kinase 6 involved in the prevention of levodopa-induced dyskinesia in rats with Parkinson disease. Journal of Chinese Integrative Medicine, 2012, 10(9): 1018-1024.
[2] Qi-sheng Tang, Wen-jun Sun, Miao Qu, Dong-fang Guo. Analysis of syndrome discipline of generalized anxiety disorder using data mining techniques. Journal of Chinese Integrative Medicine, 2012, 10(9): 975-982.
[3] Lawrence A. Olatunji, Taofeek O. Usman, Joseph O. Adebayo, Victoria A. Olatunji . Effects of aqueous extract of Hibiscus sabdariffa on renal Na+-K+-ATPase and Ca2+-Mg2+-ATPase activities in Wistar rats. Journal of Chinese Integrative Medicine, 2012, 10(9): 1049-1055.
[4] Zhao-lan Liu, Qing Li , Yu-jie Mu , Ying Gao, Jian-ping Liu. Using nested case-control study to appraise the effectiveness of Chinese medicines in the treatment of diabetic nephropathy. Journal of Chinese Integrative Medicine, 2012, 10(9): 991-996.
[5] Dhirender Kaushik, Ajay Kumar, Pawan Kaushik, Avatar C. Rana. Anticonvulsant activity of alcoholic extract of bark of Pinus roxburghii Sarg. Journal of Chinese Integrative Medicine, 2012, 10(9): 1056-1060.
[6] Chan Chen, Chang-xun Chen, Xi-min Wu, Rui Wang, Yi-ming Li. Effects of extracts of Radix Scrophulariae on blood pressure in spontaneously hypertensive rats and the underlying mechanisms. Journal of Chinese Integrative Medicine, 2012, 10(9): 1009-1017.
[7] Jian-sheng Li, Ya Li, Su-yun Li, Yuan-yuan Wang, Li Deng, Yan-ge Tian, Su-li Jiang , Ying Wang. Long-term effects of Tiaobu Feishen therapies on systemic and local inflammation responses in rats with stable chronic obstructive pulmonary disease. Journal of Chinese Integrative Medicine, 2012, 10(9): 1039-1048.
[8] Karuna A. Talpate, Uma A. Bhosale, Mandar R. Zambare. Clitorea ternatea, a herb from Indian folklore, improves streptozotocin-induced diabetes and diabetes-induced cognitive decline in rats. Journal of Chinese Integrative Medicine, 2012, 10(8): 939-947.
[9] Samuel Joshua Pragasam, Vachana Murunikara, Evan Prince Sabina, Mahaboobkhan Rasool. Antiperoxidative potential of p-coumaric acid, a common dietary phenol, in adjuvant-induced arthritis in rats. Journal of Chinese Integrative Medicine, 2012, 10(8): 932-938.
[10] Zi-hui Li, Jian Wang, Rong-lin Cai, You-wen Wang, Jian-peng Hu. Establishment and evaluation of a rat model of ulcerative colitis with syndrome of dampness stagnancy due to spleen deficiency. Journal of Chinese Integrative Medicine, 2012, 10(8): 918-924.
[11] Meng Li, Ling Hu, Rong-lin Cai, Zi-jian Wu, Ke-ming Wang. Effects of electro-acupuncture at PC6 and BL15 on nerve electrical activity in spinal dorsal root and norepinephrine and dopamine contents in paraventricular nucleus of hypothalamus in rats with acute myocardial ischemia. Journal of Chinese Integrative Medicine, 2012, 10(8): 874-879.
[12] Xin-min Li, Hui Chen, Yan-yan Ren, Yan-li Lu. Effects of Chinese herbal medicine Xifeng Capsule on multidrug resistance-associated protein 1 expression in hippocampus and cortex of rats with lithium-pilocarpine-induced epilepsy. Journal of Chinese Integrative Medicine, 2012, 10(8): 911-917.
[13] Hong Wang , Jing-tian Ou , Xin Zhao , Ying Guoz , Hao-ping Mao. Vasodilator effect of oroxylin A on thoracic aorta isolated from rats. Journal of Chinese Integrative Medicine, 2012, 10(8): 880-885.
[14] C. Mouli Kalla, Vijaya Tartte, Dattatreya Rao Sirpurkar. Effectiveness of flavonoid-rich leaf extract of Acalypha indica in reversing experimental myocardial ischemia: biochemical and histopathological evidence. Journal of Chinese Integrative Medicine, 2012, 10(7): 784-792.
[15] Feng Xin-ying, Zhu Min, Zhang Qi-qi, Chen Yi-ping, Li Wen-wei. Selective protection of nigral dopaminergic neurons by echinacoside in a rat model of Parkinson disease induced by rotenone. Journal of Chinese Integrative Medicine, 2012, 10(7): 777-783.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
[1] Wei-xiong Liang. Problems-solving strategies in clinical treatment guideline for traditional Chinese medicine and integrative medicine. Journal of Chinese Integrative Medicine, 2008, 6(1): 1-4
[2] Zhao-guo Li. Discussion on English translation of commonly used sentences in traditional Chinese medicine: part one. Journal of Chinese Integrative Medicine, 2008, 6(1): 107-110
[3] Jun Hu, Jian-ping Liu. Non-invasive physical treatments for chronic/recurrent headache. Journal of Chinese Integrative Medicine, 2008, 6(1): 31
[4] Xue-mei Liu, Qi-fu Huang, Yun-ling Zhang, Jin-li Lou, Hong-sheng Liu, Hong Zheng. Effects of Tribulus terrestris L. saponion on apoptosis of cortical neurons induced by hypoxia-reoxygenation in rats. Journal of Chinese Integrative Medicine, 2008, 6(1): 45-50
[5] . Uniform requirements for manuscripts submitted to biomedical journals: Writing and editing for biomedical publication (Chinese version, part two). Journal of Chinese Integrative Medicine, 2010, 8(11): 1001-1005
[6] Daniel Weber, Janelle M Wheat, Geoffrey M Currie. Inflammation and cancer: Tumor initiation, progression and metastasis,and Chinese botanical medicines. Journal of Chinese Integrative Medicine, 2010, 8(11): 1006-1013
[7] Hong Liu , Guo-liang Zhang, Li Shen , Zhen Zeng, Bao-luo Zhou, Cheng-hai Liu, Guang Nie . Application and evaluation of a pseudotyped virus assay for screening herbs for anti-H5Nl avian influenza virus. Journal of Chinese Integrative Medicine, 2010, 8(11): 1036-1040
[8] Zhao-guo Li . A discussion of English translation of 1995 and 1997 Chinese National Standards of Traditional Chinese Medical Terminologies for Clinical Diagnosis and Treatment. Journal of Chinese Integrative Medicine, 2010, 8(11): 1090-1096
[9] Rui Jin, Bing Zhang. A complexity analysis of Chinese herbal property theory: the multiple formations of herbal property (Part 1). Journal of Chinese Integrative Medicine, 2012, 10(11): 1198-1205
[10] Hui-min Liu, Xian-bo Wang, Yu-juan Chang, Li-li Gu. Systematic review and meta-analysis of randomized controlled trials of integrative medicine therapy for treatment of chronic severe hepatitis. Journal of Chinese Integrative Medicine, 2012, 10(11): 1211-1228
[an error occurred while processing this directive]