SUBSCRIBE
Search JIM Advanced Search

Journal of Chinese Integrative Medicine ›› 2009, Vol. 7 ›› Issue (5): 478-481.doi: 10.3736/jcim20090515

Special Issue: Acupuncture & Moxibustion

• Medical Statistice • Previous Articles     Next Articles

Fuzzy cluster analysis of therapeutic effects of electro-acupuncture at different parameters

Le Kuaia,Ru-feng Jinb,Ming Gaoa,Hua-yuan Yanga   

  1. a Department of Traditional Chinese Engineering, College of Acupuncture-Moxibustion and Tuina, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
    b Department of Preventive Medicine,College of Basic Medical Sciences,Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
  • Received:2008-12-29 Accepted:2009-02-11 Online:2009-05-20 Published:2018-10-15

RichHTML

2

PDF (PC)

91

Cited

10

Like

Objective

To probe into the application of fuzzy cluster in analysis of therapeutic effects of electroacupuncture at different parameters on adjuvant-induced arthritis (AA) in rats.
Methods

One hundred Wistar rats were randomly divided into ten groups： normal control group, untreated group and eight electro-acupuncture groups at different parameters. There were ten rats in each group. AA rats were treated by electro-acupuncture at different frequencies (2 Hz or 100 Hz), waveforms (successive wave or intermittent wave) and current intensities (0.1 mA or 0.2 mA). Firstly, the anti-inflammatory and analgesic effects of electro-acupuncture at different parameters were compared with orthogonal experiment, and then with the application of fuzzy mathematics, the data of joint swelling, pain threshold and the contents of (3-endorphin ((3-EP) and interleukin-ip (IL-1(3) after the treatment in all groups were standardized by the method of data range normalization. Programming and solution were done by MATLAB. The methods of fuzzy similar matrix and the transitive closure were used in similarity evaluation of therapeutic effects of electroacupuncture at different parameters.
Results

Based on index determination and variance analysis, both the normal control group and untreated group were clustered to one category as A equaled to 0. 72. Electro-acupuncture at 100 Hz, successive wave, 0. 2 mA, electro-acupuncture at 100 Hz, intermittent wave, 0. 1 mA and electro-acupuncture at 100 Hz, intermittent wave, 0. 2 mA were clustered to one category and had similar good anti-inflammatory and analgesic effects. The therapeutic effects of the remaining electro-acupuncture types were similar.
Conclusion

Fuzzy cluster analysis provides a better method for evaluating the overall therapeutic effects of electro-acupuncture with multiple factors.

Key words: Fuzzy mathematics, Cluster analysis, Electroacupuncture, Treatment outcome, Rats

"

代码 组别 关节肿胀度（mL） 痛阈（s） β-EP (ng/g) IL-1β (ng/g)
S1 空白组 1.25±0.04 7.57±0.85 0.82±0.48 4.03±2.49
S2 模型组 1.69±0.06** 4.08±0.80** 4.10±2.62* 9.88±3.43**
S3 A1B1C1电针组 1.56±0.08**△△ 6.15±0.92**△△ 6.04±3.36** 6.07±3.58△
S4 A1B1C2电针组 1.52±0.06**△△ 5.46±1.20**△△ 5.37±2.65** 6.72±4.06△
S5 A1B2C1电针组 1.51±0.08**△△ 5.64±0.89**△△ 7.40±3.83** 7.80±3.66*
S6 A1B2C2电针组 1.48±0.12**△△ 4.96±0.49**△ 6.03±2.31** 7.26±2.92*
S7 A2B1C1电针组 1.61±0.10**△ 6.33±0.64**△△ 7.87±5.21**△ 6.32±4.28△
S8 A2B1C2电针组 1.45±0.06**△△ 6.00±0.59**△△ 6.95±3.99** 3.81±2.53△△
S9 A2B2C1电针组 1.56±0.18**△△ 6.67±0.63*△△ 8.81±4.99**△△ 4.79±3.41△△
S10 A2B2C2电针组 1.43±0.06**△△ 6.21±0.83**△△ 8.31±3.47**△ 5.33±3.61△△

"

代码 关节肿胀度 痛阈 β-EP IL-1β
S1 0.00 1.00 0.00 0.04
S2 1.00 0.00 0.41 1.00
S3 0.70 0.59 0.65 0.37
S4 0.61 0.40 0.57 0.48
S5 0.59 0.45 0.82 0.66
S6 0.52 0.25 0.65 0.57
S7 0.82 0.64 0.88 0.41
S8 0.45 0.55 0.77 0.00
S9 0.70 0.74 1.00 0.16
S10 0.41 0.61 0.94 0.25
[1] Kuai L, Yang HY, Jiang J, Chen H . Comparison of analgesic effects of electroacupuncture of multi-factor quantitative parameters on inflammatory pain in rats[J]. Zhongguo Zhen Jiu, 2008,28(11):829-832
蒯乐, 杨华元, 蒋洁, 陈颢 . 多因素量化参数电针对大鼠炎症痛镇痛作用的比较[J]. 中国针灸, 2008,28(11):829-832
[2] Kuai L, Jiang J, Yang HY . Electro-acupuncture parameters in treatment of adjuvant-induced arthritis in rats[J]. Shanghai Zhong Yi Yao Da Xue Xue Bao, 2008,22(3):73-75
蒯乐, 蒋洁, 杨华元 . 电针治疗大鼠佐剂性关节炎参数的研究[J]. 上海中医药大学学报, 2008,22(3):73-75
[3] Wu SJ . The realization of improved fuzzy clustering analysis method in MATLAB[J]. Hua Bei Ke Ji Xue Yuan Xue Bao, 2007,4(3):76-79
吴善杰 . 改进的模糊聚类分析方法在MATLAB中的实现[J]. 华北科技学院学报, 2007,4(3):76-79
[4] Wang J, He QY . Laws of syndrome element combination in stable angina pectoris: a study based on cluster analysis and corresponding-correlation analysis[J]. J Chin Integr Med, 2008,6(7):690-694
王阶, 何庆勇 . 基于聚类分析和对应分析的稳定型心绞痛证候要素组合规律的研究[J]. 中西医结合学报, 2008,6(7):690-694
[1] Xiang-yu Wei, Shi-lei Luo, HuiChen, Shan-shan Liu, Zhi-gang Gong, Song-huaZhan. Functional connectivity changes during migraine treatment with electroacupuncture at Shuaigu (GB8). Journal of Integrative Medicine, 2022, 20(3): 237-243.
[2] Liang Ding, Xin-you Zhang, Di-yao Wu, Meng-ling Liu. Application of an extreme learning machine network with particle swarm optimization in syndrome classification of primary liver cancer. Journal of Integrative Medicine, 2021, 19(5): 395-407.
[3] Bing-rong Li, Shi-yun Shao, Long Yuan, Ru Jia, Jian Sun, Qing Ji, Hua Sui, Li-hong Zhou, Yi Zhang, Hui Liu, Qi Li, Yan Wang, Bi-meng Zhang. Effects of mild moxibustion on intestinal microbiome and NLRP3 inflammasome in rats with 5-fluorouracil-induced intestinal mucositis. Journal of Integrative Medicine, 2021, 19(2): 144-157.
[4] Sitthichai Iamsaard, Supatcharee Arun, Jaturon Burawat, Supataechasit Yannasithinon, Saranya Tongpan, Sudtida Bunsueb, Natthapol Lapyuneyong, Pannawat Choowong-in, Nareelak Tangsrisakda, Chadaporn Chaimontri, Wannisa Sukhorum. Evaluation of antioxidant capacity and reproductive toxicity of aqueous extract of Thai Mucuna pruriens seeds. Journal of Integrative Medicine, 2020, 18(3): 265-273.
[5] Morufu Eyitayo Balogun, Elizabeth Enohnyaket Besong, Jacinta Nkechi Obimma, Ogochukwu Sophia Mbamalu, Fankou Serges Athanase Djobissie. Protective roles of Vigna subterranea (Bambara nut) in rats with aspirin-induced gastric mucosal injury. Journal of Integrative Medicine, 2018, 16(5): 342-349.
[6] Lucky Legbosi Nwidu, Raphael Ellis Teme. Hot aqueous leaf extract of Lasianthera africana (Icacinaceae) attenuates rifampicin-isoniazid-induced hepatotoxicity. Journal of Integrative Medicine, 2018, 16(4): 263-272.
[7] Kylie Connolly, Douglas Jackson, Candice Pullen, Andrew Fenning. Alpha-adrenoceptor antagonism by Crassostrea gigas oyster extract inhibits noradrenaline-induced vascular contraction in Wistar rats. Journal of Integrative Medicine, 2015, 13(3): 194-200.
[8] Udhaya Lavinya Baskaran, Sherry Joseph Martin, Rasool Mahaboobkhan, Sabina Evan Prince. Protective role of Triphala, an Indian traditional herbal formulation, against the nephrotoxic effects of bromobenzene in Wistar albino rats. Journal of Integrative Medicine, 2015, 13(2): 115-121.
[9] Hussein O. B. Oloyede, Matthew C. Adaja, Taofeek O. Ajiboye, Musa O. Salawu. Anti-ulcerogenic activity of aqueous extract of Carica papaya seed on indomethacin-induced peptic ulcer in male albino rats. Journal of Integrative Medicine, 2015, 13(2): 105-114.
[10] Anirudha A. Lande, Shirishkumar D. Ambavade, Uma S. Swami, Prafulla P. Adkara Prashant D. Ambavade, Arun B. Waghamare. Saponins isolated from roots of Chlorophytum borivilianum reduce acute and chronic inflammation and histone deacetylase. Journal of Integrative Medicine, 2015, 13(1): 25-33.
[11] Elizabeth Abidemi Balogun, Sylvia Orume Malomo, Joseph Oluwatope Adebayo, Ahmed Adebayo Ishola, Ayodele Olufemi Soladoye, Lawrence Aderemi Olatunji, Olatunji Matthew Kolawole, Stephen Olubunmi Oguntoye, Abiola Samuel Babatunde, Oluwole Busayo Akinola . In vivo antimalarial activity and toxicological effects of methanolic extract of Cocos nucifera (Dwarf red variety) husk fibre. Journal of Integrative Medicine, 2014, 12(6): 504-511.
[12] Meng-yue Liu, Cheng-wei Wang, Zhou-peng Wu, Ning Li. Electroacupuncture for the prevention of postoperative gastrointestinal dysfunction in patients undergoing vascular surgery under general anesthesia: Study protocol for a prospective practical randomized controlled trial. Journal of Integrative Medicine, 2014, 12(6): 512-519.
[13] Xin-fang Zhang, Ji Zhu, Wen-ye Geng, Shu-jun Zhao, Chuan-wei Jiang, Sheng-rong Cai, Miao Cheng, Chuan-yun Zhou, Zi-bing Liu. Electroacupuncture at Feishu (BL13) and Zusanli (ST36) down-regulates the expression of orexins and their receptors in rats with chronic obstructive pulmonary disease. Journal of Integrative Medicine, 2014, 12(5): 417-424.
[14] Benjamin Perry, Junzeng Zhang, Tarek Saleh, Yanwen Wang. Liuwei Dihuang, a traditional Chinese herbal formula, suppresses chronic inflammation and oxidative stress in obese rats. Journal of Integrative Medicine, 2014, 12(5): 447-454.
[15] Urmila Aswar, Mayuri Gurav, Ganesh More, Khaled Rashed, Manoj Aswar. Effect of aqueous extract of Solanum xanthocarpum Schrad. & Wendl. on postmenopausal syndrome in ovariectomized rats. Journal of Integrative Medicine, 2014, 12(5): 439-446.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
[1] Wei-xiong Liang. Problems-solving strategies in clinical treatment guideline for traditional Chinese medicine and integrative medicine. Journal of Chinese Integrative Medicine, 2008, 6(1): 1-4
[2] Zhao-guo Li. Discussion on English translation of commonly used sentences in traditional Chinese medicine: part one. Journal of Chinese Integrative Medicine, 2008, 6(1): 107-110
[3] Jun Hu, Jian-ping Liu. Non-invasive physical treatments for chronic/recurrent headache. Journal of Chinese Integrative Medicine, 2008, 6(1): 31
[4] Xue-mei Liu, Qi-fu Huang, Yun-ling Zhang, Jin-li Lou, Hong-sheng Liu, Hong Zheng. Effects of Tribulus terrestris L. saponion on apoptosis of cortical neurons induced by hypoxia-reoxygenation in rats. Journal of Chinese Integrative Medicine, 2008, 6(1): 45-50
[5] . Uniform requirements for manuscripts submitted to biomedical journals: Writing and editing for biomedical publication (Chinese version, part two). Journal of Chinese Integrative Medicine, 2010, 8(11): 1001-1005
[6] Daniel Weber, Janelle M Wheat, Geoffrey M Currie. Inflammation and cancer: Tumor initiation, progression and metastasis,and Chinese botanical medicines. Journal of Chinese Integrative Medicine, 2010, 8(11): 1006-1013
[7] Hong Liu , Guo-liang Zhang, Li Shen , Zhen Zeng, Bao-luo Zhou, Cheng-hai Liu, Guang Nie . Application and evaluation of a pseudotyped virus assay for screening herbs for anti-H5Nl avian influenza virus. Journal of Chinese Integrative Medicine, 2010, 8(11): 1036-1040
[8] Zhao-guo Li . A discussion of English translation of 1995 and 1997 Chinese National Standards of Traditional Chinese Medical Terminologies for Clinical Diagnosis and Treatment. Journal of Chinese Integrative Medicine, 2010, 8(11): 1090-1096
[9] Rui Jin, Bing Zhang. A complexity analysis of Chinese herbal property theory: the multiple formations of herbal property (Part 1). Journal of Chinese Integrative Medicine, 2012, 10(11): 1198-1205
[10] Hui-min Liu, Xian-bo Wang, Yu-juan Chang, Li-li Gu. Systematic review and meta-analysis of randomized controlled trials of integrative medicine therapy for treatment of chronic severe hepatitis. Journal of Chinese Integrative Medicine, 2012, 10(11): 1211-1228
Journal of Integrative Medicine, ISSN: 2095-4964 CN 31-2083/R
Copyright © Journal of Integrative Medicine
Powered by Beijing Magtech Co. Ltd
沪公网安备31010602003416号      沪ICP备18017633号-3