[an error occurred while processing this directive]

Journal of Chinese Integrative Medicine ›› 2009, Vol. 7 ›› Issue (6): 514-517.doi: 10.3736/jcim20090604

• Original Clinical Research • Previous Articles     Next Articles

Effects of Xuesaitong Injection on coagulation function of gastric cancer patients undergoing laparoscopic surgery: A randomized controlled trial

 Yu Wanga,Yan-ting Wanga,Ya-hua Linb,Zhong-dong Zoua   

  1. a Department of General Surgery,Fuzhou General Hospital of Nanjing Military Region, Fuzhou 350025, Fujian Province, China
    b Department of General Surgery, the Second Affiliated Hospital, Fuzhou General Hospital of Nanjing Military Region, Ningde 352100, Fujian Province, China
  • Received:2008-12-29 Accepted:2009-04-14 Online:2009-06-20 Published:2009-06-15

RichHTML

2

PDF (PC)

95

Cited

5

Like

Objective

To study the effects of Xuesaitong Injection, an extract from a Chinese herbal medicine, on coagulation function of gastric cancer patients undergoing laparoscopic surgery.
Methods

Fifty patients undergoing laparoscopic surgery for gastric cancer were randomly divided into control group and Xuesaitong group, with 25 patients in each group. Conventional anti-infection and transfusion treatment was given to the patients in the control group, and intravenous drip infusion of 400 mg Xuesaitong Injection added into 250 mL 5% glucose injection was administered once daily to the patients in the Xuesaitong group for 6 days from the first day after laparoscopic operation besides the conventional anti-infection and transfusion treatment. The values of prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen (FIB) and international normalized ratio (INR) were detected by using blood coagulation method, and the values of D-dimer (D-D) before operation, instantly and 3, 5, 7 days after operation were detected by using enzyme-linked immunosorbent assay in the two groups. Furthermore, the development of deep vein thrombosis on the day 7 after operation was observed by vein angiography.
Results

There were no significant differences in the values of PT, APTT, INR, FIB and D-D between the two groups before operation, and there were no significant changes in APTT and INR after operation in the two groups. The values of PT decreased in the two groups on day 3 after operation, while there was no significant difference between the two groups. The value of PT in the control group decreased gradually with the extension of postoperation time (P<0.05), while the PT value in the Xuesaitong group did not change significantly, and there was significant difference between the two groups (P<0.05). The values of FIB and D-D increased instantly after operation in the two groups as compared with those before operation (P<0.05), while there was no significant difference between the two groups. With the extension of postoperation time, the values of FIB and D-D increased gradually in the control group (P<0.05); the D-D value on day 3 after operation increased, but the D-D values on day 5 and day 7 after operation decreased gradually in the Xuesaitong group (P<0.05). The occurrence rate of deep vein thrombosis on day 7 after operation in the Xuesaitog group was lower than that in the control group.
Conclusion

Laparoscopic surgery for gastric cancer may cause high agglutination condition, which will increase the risk of deep vein thrombosis, and Xuesaitong Injection can improve this state.

Key words: Laparoscopic surgical procedures, Gastric cancer, Xuesaitong Injection, Coagulation factors, Randomized controlled trial

Table 1

Changes of coagulation and fibrolysis indexes in the patients before and after the operation (x±s)"

Group n Coagulation indexes Fibrolysis indexes
PT (s) APTT (s) INR FIB (g/L) D-D (mg/L)
Control
Before operation 25 12.84±0.68 29.42±4.76 1.04±0.12 2.82±0.51 0.18±0.07
Instantly after operation 25 12.51±0.62 29.21±4.74 1.04±0.11 3.66±0.72* 0.33±0.12*
Three days after operation 25 11.43±0.69*△ 28.96±4.83 0.96±0.11 4.12±0.76*△ 0.56±0.14*△
Five days after operation 25 11.26±0.68* 29.13±5.08 0.95±0.13 4.37±0.69*▲ 0.72±0.15*▲
Seven days after operation 25 10.63±0.64*□ 29.34±5.18 0.95±0.13 4.62±0.71*□ 1.17±0.18*□
Xuesaitong
Before operation 25 12.79±0.71 29.64±4.81 1.04±0.15 2.79±0.53 0.17±0.08
Instantly after operation 25 12.56±0.71 29.44±4.57 0.98±0.11 3.46±0.68* 0.34±0.13*
Three days after operation 25 11.47±0.63*△ 29.04±5.22 0.96±0.13 3.68±0.71*△■ 0.37±0.12*■■
Five days after operation 25 11.44±0.60* 28.76±5.11 0.91±0.12 3.84±0.58*■ 0.29±0.12*▲■
Seven days after operation 25 11.46±0.66*■ 29.06±5.02 0.95±0.15 3.37±0.56*□■ 0.23±0.10*□■■
[1] Japanese Gastric Cancer Association . Guidelines for the treatment of gastric cancer(2nd ed)[M]. Tokyo: Kanehara, 2004,( 2nd ed):12
[2] Holzheimer RG . Laparoscopic procedures as a risk factor of deep venous thrombosis, superficial ascending thrombophlebitis and pulmonary embolism — case report and review of the literature[J]. Eur J Med Res, 2004,9(9):417-422
[3] Schaepkens Van Riempst JT, Van Hee RH, Weyler JJ . Deep venous thrombosis after laparoscopic cholecystectomy and prevention with nadroparin[J]. Surg Endosc, 2002,16(1):184-187
doi: 10.1007/s004640090048
[4] Kuroiwa M, Arai M, Kinoshita S, Takenaka T, Okamoto H, Hoka S . Clinical characteristics of perioperative pulmonary thromboembolism: analysis of 18 patients in Kitasato University Hospital[J]. Masui, 2002,51(9):977-982
[5] Kinoshita H, Hara M, Maruyama Y, Matsuo H, Kawahara R, Nishimura K, Kodama T, Odo M, Shirouzu K, Aoyaqi S . A case of pulmonary embolism after abdominal angiography[J]. Kurume Med J, 2004,51(1):95-98
doi: 10.2739/kurumemedj.51.95
[6] Liu BB . Experimental study on anticoagulation function of Sanqi Tablets in rabbits[J]. Zhongguo Zhong Yi Yao Ke Ji, 2005,12(5):296
刘炳波 . 三七片对家兔凝血作用的实验研究[J]. 中国中医药科技, 2005,12(5):296
[7] Lensing AW, Buller HR, Prandoni P, Batchelor D, Molenaar AH, Coqo M, Huisman PM, Ten Cate JW . Contrast venography, the gold standard for the diagnosis of deep-vein thrombosis: improvement in observer agreement[J]. Thromb Haemost, 1992,67(1):8-12
doi: 10.1055/s-0038-1648130
[8] Wang MT, Yao XP, Li Q . Risk factor analysis of hospitalized patients with pulmonary thromboembolism and deep venous thrombosis[J]. Di Er Jun Yi Da Xue Xue Bao, 2004,25(7):740-742
王美堂, 姚小鹏, 李强 . 肺血栓栓塞症和深静脉血栓形成住院患者相关危险因素的分析[J]. 第二军医大学学报, 2004,25(7):740-742
[9] Zhang BG, Xue GH . Causes and risk factors of deep venous thrombosis[J]. Zhongguo Shi Yong Wai Ke Za Zhi, 2003,23(4):197-198
张柏根, 薛冠华 . 深静脉血栓形成的病因及高危因素[J]. 中国实用外科杂志, 2003,23(4):197-198
[10] Chen YH, Zhang SF, Sun JN, Wu JY, Jia ZH . Effect of Xuesaitong drop pills on experimerntal thrombosis and thrombolysis in rats[J]. Zhongguo Zhong Yao Za Zhi, 2007,32(3):253-256
陈云华, 张硕峰, 孙建宁, 吴金英, 贾占红 . 血塞通滴丸抗大鼠血栓形成及溶栓作用的实验研究[J]. 中国中药杂志, 2007,32(3):253-256
[1] Jing-lin Shi, Wan-hong Miao. Effects of acupuncture on lactoferrin content in tears and tear secretion in patients suffering from dry eyes: A randomized controlled trial. Journal of Chinese Integrative Medicine, 2012, 10(9): 1003-1008.
[2] Ming T. Tan , Jian-ping Liu , Lixing Lao. Adequate application of quantitative and qualitative statistic analytic methods in acupuncture clinical trials. Journal of Chinese Integrative Medicine, 2012, 10(8): 847-852.
[3] Lu Yu, Shui-miao Lin, Ru-qian Zhou, Wei-jun Tang, Pin-xian Huang, Ying Dong, Jian Wang, Zhi-hua Yu, Jiu-lin Chen, Li Wei, San-li Xing, Hui-juan Cao, Hong-bin Zhao. Chinese herbal medicine for patients with mild to moderate Alzheimer disease based on syndrome differentiation: A randomized controlled trial. Journal of Chinese Integrative Medicine, 2012, 10(7): 766-776.
[4] Peng Fu , Xue-qiang Huang, Ai-hong Yuan, Guang Yu, Xiao-bin Mei, Ruo-lan Cu. Effects of salvianolate combined with alprostadil and reduced glutathione on progression of chronic renal failure in patients with chronic kidney diseases: a long-term randomized controlled trial. Journal of Chinese Integrative Medicine, 2012, 10(6): 641-646.
[5] Hui Luo, Jian-ping Liu, Qing Li. Methodological issues and suggestions for improvement in randomized controlled trials of Chinese herbal medicine for recurrent miscarriage. Journal of Chinese Integrative Medicine, 2012, 10(6): 604-614.
[6] Shui-qiu Deng, Xue-nong Ouyang, Zong-yang Yu, Xi-hu Dai, Xi Chen, Fang-zheng Fang, Wen-wu Wang, Zhi-zhen Liu. Influence of Chinese herbal medicine Feitai Capsule on completion or delay of chemotherapy in patients with stage ⅢB/Ⅳ non-small-cell lung cancer: a Randomized controlled trial. Journal of Chinese Integrative Medicine, 2012, 10(6): 635-640.
[7] Ming-xing Zhao, Zhen-hua Dong, Zhong-hai Yu, Shi-yuan Xiao, Ya-ming Li . Effects of Ginkgo biloba extract in improving episodic memory of patients with mild cognitive impairment: A randomized controlled trial. Journal of Chinese Integrative Medicine, 2012, 10(6): 628-634.
[8] Ying-chun Miao , Jin-zhou Tian , Jing Shi , Min Mao. Effects of Chinese medicine for tonifying the kidney and resolving phlegm and blood stasis in treating patients with amnestic mild cognitive impairment: A randomized, double-blind and parallel-controlled trial. Journal of Chinese Integrative Medicine, 2012, 10(4): 390-397.
[9] Xiao-hui Sun, Sheng Liu . External Chinese medical therapy for pain associated with hyperplastic disease of the breast: Study protocol of a randomized, double-blind, multicenter, controlled trial. Journal of Chinese Integrative Medicine, 2012, 10(4): 384-389.
[10] Zhu Yan-feng, Luo Hai-ming, Deng Zhong-long, Fu De-yu, Yao Wang, Dai Jian. Effects of the Chinese patent medicine, Honghua Injection, on platelet glycoprotein Ⅱb/Ⅲa receptors in patients with acute coronary syndrome: a randomized controlled trial. Journal of Chinese Integrative Medicine, 2012, 10(3): 318-323.
[11] Li Min, Yang Ming-hui, Liu Yi. Effects of Chinese herbal medicine Bushen Huoxue Granule on quality of life of patients with Parkinson disease: a randomized, double-blinded and placebo-controlled trial. Journal of Chinese Integrative Medicine, 2012, 10(3): 310-317.
[12] Paula de Sousa Fragoso Ana, de Sá Ferreira Arthur. Evaluation of the immediate effects of manual acupuncture on brachial bicep muscle function in healthy individuals and poststroke patients: a study protocol of a parallel-group randomized clinical trial. Journal of Chinese Integrative Medicine, 2012, 10(3): 303-309.
[13] Li-xin Ma, Yu-yi Wang, Xin-xue Li, Jian-ping Liu . Systematic review on methodology of randomized controlled trials of post-marketing Chinese patent drugs for treatment of type 2 diabetes. Journal of Chinese Integrative Medicine, 2012, 10(3): 279-292.
[14] Wang Yun-fei, Que Hua-fa, Xu Jie-nan, Tang Han-jun, Xiang Huan-yu, Liu Xiao-dong, Zhang Zhen, Xing Jie, Shen Liang, Shan Wei, Liu An-min, Qiu Lian-yin, Deng Da-yi, Gao Dan. Assessment of external methods of traditional Chinese medicine in patients with chronic ulcer of the lower extremities: study protocol of a multicenter, randomized, parallel-group, prospective trial. Journal of Chinese Integrative Medicine, 2012, 10(2): 166-175.
[15] Liu Jian, Gao Ying, Kan Bao-hong, Zhou Li. Systematic review and meta-analysis of randomized controlled trials of Chinese herbal medicine in treatment of multiple sclerosis. Journal of Chinese Integrative Medicine, 2012, 10(2): 141-153.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
[1] Jin-rong Fu. Establishment of multivariate diagnosis and treatment system of modern gynecology of traditional Chinese medicine. Journal of Chinese Integrative Medicine, 2008, 6(1): 22-24
[2] Hao Li, Ming-jiang Yao, Wen-ming Zhao, Jie Guan, Lin-lin Cai, Ling Cui. A randomized, controlled, double-blind trial of Huannao Yicong capsule in senile patients with mild cognitive impairment. Journal of Chinese Integrative Medicine, 2008, 6(1): 25-31
[3] Zhi-chun Jin. Problems in establishing clinical guideline for integrated traditional Chinese and Western medicine. Journal of Chinese Integrative Medicine, 2008, 6(1): 5-8
[4] SUN Ming-yu, ZUO Jian, DUAN Ji-feng, HAN Jun, FAN Shi-ming, ZHANG Wei, ZHU Li-fang, YAO Ming-hui. Antitumor activities of kushen flavonoids in vivo and in vitro. Journal of Chinese Integrative Medicine, 2008, 6(1): 51-59
[5] Min Cheng, Qiong Feng, Shu-wen Qian, Hui Gao, Cui-qing Zhu. Preliminary assay of p-amyloid binding elements in heart-beneficial recipe. Journal of Chinese Integrative Medicine, 2008, 6(1): 68-72
[6] Ning-qun Wang, Liang-duo Jiang, Zong-xing Li. Research progress in asthma-related quality of life. Journal of Chinese Integrative Medicine, 2008, 6(1): 93-97
[7] Jing-yuan Mao, Chang-xiao Liu, Heng-he Wang, Guang-li Wei , Zhen-peng Zhang, Jie Xing, Wang Xian liang , Ying-fei Bi . Effects of Shenmai Injection on serum concentration and pharmacokinetics of digoxin in dogs with heart failure. Journal of Chinese Integrative Medicine, 2010, 8(11): 1070-1074
[8] Zhi-mei Wang, Bin Zhang. A study on translation of ellipses in Huangdi Neijing from perspective of hermeneutic theory. Journal of Chinese Integrative Medicine, 2010, 8(11): 1097-1100
[9] Gui Yu, Jie Wang. Thinking on building the network cardiovasology of Chinese medicine. Journal of Chinese Integrative Medicine, 2012, 10(11): 1206-1210
[10] Pedro Saganha João, Doenitz Christoph, Greten Tobias, Efferth Thomas, J. Greten Henry. Qigong therapy for physiotherapists suffering from burnout: a preliminary study. Journal of Chinese Integrative Medicine, 2012, 10(11): 1233-1239
[an error occurred while processing this directive]