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Journal of Chinese Integrative Medicine ›› 2009, Vol. 7 ›› Issue (6): 509-513.doi: 10.3736/jcim20090603

• Original Clinical Research • Previous Articles     Next Articles

Effects of Songling Xuemaikang Capsule on ambulatory blood pressure in treatment of essential hypertension: A single-blind randomized controlled trial

 Li Fu,Zhen-xing Mao, Jing Wang, Jing Zhang, Tai-rong Zheng, Sheng-lian Wang   

  1. Department of Cardiology, Chengdu First Peopled Hospital, Chengdu 610041, Sichuan Province, China
  • Received:2008-12-08 Accepted:2009-02-19 Online:2009-06-20 Published:2009-06-15

Objective

To explore the effects of Western medicine including Ca 2+ channel antagonist and angiotensin-receptor antagonist combined with Songling Xuemaikang Capsule (SXC), a compound traditional Chinese herbal medicine for calming liver and suppressing liver yang, on blood pressure indexes derived from 24-hour ambulatory blood pressure monitoring (ABPM), and to evaluate the effects and stability of SXC in lowering blood pressure.
Methods

Seventy patients with essential hypertension of grade 2 or grade 3 were randomly assigned to routine group and SXC group. There were 35 cases in each group. The patients in the routine group were administered with 2.5 mg levoamlodipine and 40 mg telmisartan once daily, and 1.5 g SXC was administered orally to the patients in the SXC group three times daily besides levoamlodipine and telmisartan treatment. They were all treated for two weeks. Twenty-four-hour ABPM, trough to peak ratio and smoothness index were measured before and after the treatment.
Results

Twenty-four-hour, day and night average systolic blood pressure (SBP) and 24-hour, day and night SBP load in the two groups were lowered as compared with before treatment (P<0.05). The effects of Western medicine combined with SXC on blood pressure depression were better than those of Western medicine (P<0.05). Western medicine combined with SXC had a significant influence on diastolic blood pressure (DBP) as compared with Western medicine (P<0.05). The heart rate in the SXC group was reduced as compared with before treatment and the routine group (P<0.05). Trough to peak ratio in SXC group was higher than that in the routine group, while there was no significant difference in smoothness index between the two groups. Morning surge in blood pressure in the two groups was improved as compared with before treatment (P<0.05), and there was a significant difference in morning surge in blood pressure between the two groups (P<0.05).
Conclusion

Western medicine combined with SXC has long-lasting effects in lowering heart rate and blood pressure, especially for SBP and SBP load. SXC plus Western medicine also has an inhibition effect on morning surge in blood pressure.

Key words: Hypertension, Blood pressure determination, Randomized controlled trial, Single-blind method

Table 1

Changes of ambulatory blood pressure in two groups (x±s, mmHg)"

Group n Twenty-four-hour
average SBP
Twenty-four-hour
average DBP
Day
average SBP
Day
average DBP
Night
average SBP
Night
average DBP
Routine
Before treatment 35 138.0±12.6 89.0±10.6 145.0±10.6 90.0±12.4 128.0±10.0 86.0±9.7
After treatment 35 119.0±8.5* 84.0±9.8 129.0±12.1* 88.0±10.3 110.0±10.6* 79.0±9.8*
SXC
Before treatment 35 145.0±12.3 88.0±11.1 147.0±11.4 91.0±9.9 132.0±11.1 84.0±11.4
After treatment 35 118.0±13.2* 77.0±8.4* 120.0±8.9* 83.0±11.4* 108.0±8.3* 73.0±8.8*

Table 2

Blood pressure load in two groups"

Group n Day SBP load
[M (Q25, Q75), %]
Day DBP load
[M (Q25, Q75),%]
Night SBP load
[M (Q25, Q75),%]
Night DBP load
(x±s, %)
Routine
Before treatment 35 70 (54,100) 58 (49,87) 70 (40,92) 50.2±13.7
After treatment 35 36 (20,70)* 45 (30,80) 39 (15, 68)* 33.5±11.3*
SXC
Before treatment 35 75 (52,100) 55 (21,71) 74 (32,88) 44.1±18.5
After treatment 35 15 (5,52)*△ 24 (7,49)* 20 (9,48)* 23.6±13.9*
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