[an error occurred while processing this directive]

Journal of Chinese Integrative Medicine ›› 2009, Vol. 7 ›› Issue (8): 706-716.doi: 10.3736/jcim20090802

• Systematic Review • Previous Articles     Next Articles

Chinese medicine for acute upper respiratory tract infection: A systematic review of randomized controlled trials

 Wen-bing Zhang,  Hong-li Jiang, Wei Zhou, Yun-qing Zhong, Hong-mei Yang, Juan-juan Fu, Bing Mao   

  1. Department of Integrated Traditional Chinese and Western Medicine» West China Hospital, Sichuan University,Chengdu 610041, Sichuan Province» China
  • Received:2009-03-03 Accepted:2009-05-14 Online:2009-08-20 Published:2009-08-15
  • Contact: Bing Mao E-mail:maobing@medmail.com.cn

RichHTML

7

PDF (PC)

102

Like

Objective

To evaluate the efficacy and safety of new drugs of traditional Chinese medicine (TCM) for acute upper respiratory tract infection (common cold).Methods: Reports regarding randomized controlled trials of Chinese medicine for common cold were reviewed. Related reports were selected and the methodological quality of the trials was assessed by the Jadad scale. Meanwhile, the stratified analysis was made according to different TCM syndrome types of common cold.
Results

Thirteen randomized controlled trials consistent with the inclusion criteria were selected and reviewed. As TCM treatment group was compared with control group, the meta analysis indicated that the relative risk (RR) for obviously effective rate was 1.10, and the 95% confidence interval (CI) was [1.05, 1.16]; the weighted mean difference (WMD) of the onset time of lowering body temperature was –1.70, and the 95% CI was [–2.76, –0.65]. There were significant differences in the above evaluation indexes between the two groups (P=0.000 2, P=0.002). The WMD of disappearing time of fever was –1.32, and the 95% CI was [–3.14, 0.49], while there was no significant difference between the two groups (P=0.15). As the common cold patients with wind-heat syndrome in the TCM treatment group were compared with those in the control group, the meta analysis indicated that the RR for obviously effective rate was 1.11, the 95% CI was [1.05, 1.19], and there was significant difference between the two groups (P=0.000 7). As the common cold patients with wind-cold syndrome in the TCM treatment group were compared with those in the control group, the meta analysis indicated that the RR for obviously effective rate was 1.07, the 95% CI was [0.99, 1.16], and there was no significant difference between the two groups (P=0.10). Serious adverse reactions had not been reported in the trials.
Conclusion

TCM new drugs developed in recent years for preventing and treating common cold have better therapeutic effects than the old ones. They can accelerate the onset time of lowering body temperature and improve the symptoms of common cold without any significant adverse reactions. Because of lacking of placebo-controlled and blank-controlled studies, further high-quality trials are still needed.

Key words: Traditional Chinese herbal drug, Acute upper respiratory tract infections, Randomized controlled trial, Systematic review, Meta analysis

Figure 1

Study selection process for randomized controlled trials"

Table 1

Clinical characteristics of enrolled trials"

Study Intervention Cases (male/female) Age ($\bar{x}$±s, yesrs)
Treatment Control Treatment Control Syndrome Treatment Control
Chang et al[7] Jinlian Qingre
capsule		 Jinlian Qingre granule 116 (47/69) 110 (36/74) Wind-heat 39.57±13.26 41.85±13.02
Chang et al[8] Chaige Qingre
granule		 Fufang Shuanghua granule 76 (36/40) 27 (11/16) Wind-heat 35.24±15.15 39.22±17.35
Chang et al[9] Andrographolide
drop-pill		 Andrographolide tablet 138 (67/71) 136 (62/74) Wind-heat 37.18±13.64 36.09±14.43
Guo[10] Yinma antivirus
granule		 Yingqiao Jiedu granule 40 (19/21) 40 (15/25) Wind-heat 31.23±8.04 28.63±6.08
Huang[11] Daqinglong
granule		 Ganmao Qingre granule 116 (47/69) 114 (51/63) Wind-cold 32.72±17.92 29.94±15.65
Ke[12] Shuanghuanglian
dispersible tablet		 Shuanghuanglian granule 118 (53/65) 119 (54/65) Wind-heat 28.92±8.19 29.02±8.04
Li[13] Shuangjinlian
oral liquid		 Shuanghuanglian oral liquid 119 (55/64) 119 (60/59) Wind-heat 37.31±12.60 38.72±13.90
Li et al[14] Rendong Ganmao
granule		 Antivirus granule 35 (9/26) 35 (11/24) Wind-heat 45.40±14.16 41.17±14.56
Lu[15] Gegen decoction Jinfang mixture 120 (60/60) 120 (57/63) Wind-cold Did not report
mean age		 Did not report
mean age
Mao et al[16] Lianpu
granule		 Shuanghuanglian oral liquid 60 (21/39) 20 (8/12) Wind-heat 31.20±12.92 30.00±12.04
Wang et al[17] Shuangjie capsule Chaihuang tablet 310(137/173) 101 (56/45) Wind-heat 37.60±12.90 38.20±13.20
Zhang et al[18] Mahuang Zhisou
capsule		 Mahuang Zhisou pill 114 (44/70) 116 (47/69) Wind-cold 38.37±11.82 38.16±11.98
Zuo[19] Jiuwei Qianghuo
capsule		 Jiuwei Qianghuo concentration 24 (13/11) 24 (15/9) Wind-cold 36.40±4.82 37.80±4.41

Table 2

Methodological quality of enrolled trials"

Study Randomization Allocation concealment Blinding Withdraw Jadad score ITT Baseline
Chang et al[7] Stratified random Yes Yes Yes 7 Yes P>0.05
Chang et al[8] Stratified random Yes Yes Yes 7 Yes P>0.05
Chang et al[9] Stratified random Yes Yes Yes 7 Yes P>0.05
Guo[10] Random number No Yes No 4 No P>0.05
Huang[11] Stratified random Yes Yes No 6 No P>0.05
Ke[12] No description No Yes Yes 4 Yes P>0.05
Li[13] Stratified random Yes Yes Yes 7 Yes P>0.05
Li et al[14] No description No Yes Yes 4 No P>0.05
Lu[15] No description No Yes Yes 4 No P>0.05
Mao et al[16] Random number No Yes Yes 6 Yes P>0.05
Wang et al[17] Stratified random Yes Yes Yes 7 Yes P>0.05
Zhang et al[18] Stratified random Yes Yes Yes 7 Yes P>0.05
Zuo[19] No description No Yes Yes 4 No PP>0.05

Figure 2

Total obviously effective rates in treatment group and control group"

Figure 3

Onset time of lowering body temperature in treatment group and control group"

Figure 4

Disappearing time of fever in treatment group and control group"

Figure 5

Total obviously effective rates in common cold patients with wind-cold syndrome and wind-heat syndrome"

Figure 6

Adverse reactions in treatment group and control group"

Figure 7

Funnel plot for total obviously effective rate"

[1] Kirkpatrick GL . The common cold[J]. Prim Care, 1996,23(4):657-675
doi: 10.1016/S0095-4543(05)70355-9
[2] Mao B, Li TQ, Ma JX . Adverse reactions of drugs for common cold and the countermeasures with traditional Chinese medicine[J]. Chengdu Zhong Yi Yao Da Xue Xue Bao, 2003,26(4):53-57
doi: 10.3969/j.issn.1004-0668.2003.04.024
毛兵, 李廷谦, 马建昕 . 抗感冒药的不良反应及中医药对策[J]. 成都中医药大学学报, 2003,26(4):53-57
doi: 10.3969/j.issn.1004-0668.2003.04.024
[3] Zheng XY. Guiding principles for clinical research on new drugs of traditional Chinese medicine(trial implementation)[M]. Beijing: China Medical-Pharmaceutical Science & Technology Publishing House, 2002: 58
郑筱萸 . 中药新药临床研究指导原则(试行)[M]. 北京: 中国医药科技出版社, 2002: 58
[4] Chen HZ. Practical internal medicine(11th ed)[M]. Beijing: People’s Medical Publishing House, 2001,( 11th ed)
陈灏珠 . 实用内科学(第11版)[M]. 北京: 人民卫生出版社, 2001,( 第11版)
[5] Mao B, Wang G, Fan T, Chen XD, Liu J, Wang L, Chang J, Ma JX, Guo J, Fu JJ, Li TQ . Assessing the quality of reporting of randomized controlled trials in traditional Chinese medicine[J]. Zhongguo Xun Zheng Yi Xue Za Zhi, 2007,7(12):880-887
毛兵, 王刚, 樊涛, 陈小东, 刘佳, 王蕾, 常静, 马建昕, 郭佳, 付娟娟, 李廷谦 . 中医药随机对照试验报告质量评价[J]. 中国循证医学杂志, 2007,7(12):880-887
[6] Jadad AR, Moore RA, Carroll D, Jenkinson C, Reynolds DJ, Gavaghan DJ , McQuay HJ.Assessing the quality of reports of randomized clinical trials: is blinding necessary?[J]. Control Clin Trials, 1996,17(1):1-12
doi: 10.1016/0197-2456(95)00134-4
[7] Chang J, Li TQ, Wan MH, Zhang RM, Zhang Y, Wang L, Zheng S, Jiang HW . A double-blind randomized controlled trial of Jinlianqingre Capsule in the treatment of acute upper respiratory tract infection(external wind-heat syndrome)[J]. Zhongguo Xun Zheng Yi Xue Za Zhi, 2005,5(8):593-598
常静, 李廷谦, 万美华, 张瑞明, 张颖, 王蕾, 郑甦, 蒋宏伟 . 金莲清热胶囊治疗急性上呼吸道感染(感冒风热证)的随机双盲对照试验[J]. 中国循证医学杂志, 2005,5(8):593-598
[8] Chang J, Zhang Y, Mao B, Wang L, Li TQ, Zhang RM . A double-blind, randomized controlled trial of Chaige Qingre Granule in treating acute upper respiratory tract infection of wind heat syndrome[J]. J Chin Integr Med, 2007,5(2):141-146
常静, 张颖, 毛兵, 王蕾, 李廷谦, 张瑞明 . 柴葛清热颗粒治疗急性上呼吸道感染风热证的双盲随机对照临床试验[J]. 中西医结合学报, 2007,5(2):141-146
[9] Chang J, Zhang RM, Zhang Y, Chen ZB, Zhang ZM, Xu Q, Yang YP, Long YY, Liu LL, Cai HY, Gao J, Lu N, Mao B, Wang L, Li TQ . Andrographolide drop-pill in treatment of acute upper respiratory tract infection with external wind-heat syndrome: a multicenter and randomized controlled trial[J]. J Chin Integr Med, 2008,6(12):1238-1245
常静, 张瑞明, 张颖, 陈志斌, 张宗铭, 徐强, 杨玉萍, 龙有余, 刘良丽, 蔡鸿彦, 高洁, 吕楠, 毛兵, 王蕾, 李廷谦 . 穿心莲内酯滴丸治疗急性上呼吸道感染外感风热证多中心随机对照临床试验[J]. 中西医结合学报, 2008,6(12):1238-1245
[10] Guo GH. Clinical observation of Yinma antivirus particles in treatment of common cold with external wind-heat syndrome. Wuhan: Hubei University of Chinese Medicine. 2008.
郭光辉 . 银马抗病毒颗粒治疗感冒(风热证)的临床观察. 武汉: 湖北中医学院. 2008
[11] Huang RD . Clinical research of Daqinglong Granule in treatment of upper respiratory tract infection with exterior cold and interior heat syndrome. Wuhan: University of Chinese Medicine. 2005.
黄瑞东 . 大青龙颗粒治疗感冒(表寒里热证)的临床研究. 武汉: 湖北中医学院. 2005
[12] Ke J. Used the standard of evidence-based medicine to appraise the validity of Shuanghuanglian dispersible piece in treating upper respiratory tract infection with exterior wind-heat syndrome. Wuhan: Hubei Univer-sity of Chinese Medicine. 2007.
柯佳 . 用循证医学方法评价双黄连分散片治疗感冒风热证的临床疗效. 武汉: 湖北中医学院. 2007
[13] Li J. Multi-center phase Ⅱ clinical research: the clinical efficacy security and side effects of Shuangjinlian oral liquid in treating common cold with wind-heat syndrome. Taiyuan: Shanxi Medical University. 2004.
doi: 10.7666/d.y602472
李晶 . 双金连口服液治疗感冒(风热证)临床安全性和有效性多中心Ⅱ期临床研究. 太原: 山西医科大学. 2004
doi: 10.7666/d.y602472
[14] Li MZ, Ji HW, Lei P, Fen W, Cao XJ, Luo Q, Wang HX . Rendong Ganmao Granule in treatment of common cold with wind-heat syndrome: clinical observation of 72 cases[J]. Xian Dai Zhong Yi Yao, 2008,28(4):8-9
李明珠, 吉海旺, 雷鹏, 冯伟, 曹小菊, 罗强, 王辉轩 . 忍冬感冒颗粒治疗风热感冒证72例临床观察[J]. 现代中医药, 2008,28(4):8-9
[15] Lu JN. Clinical research of Gegen decoction in treatment of common cold with wind-cold syndrome. Wuhan: Hubei University of Chinese Medicine. 2005.
吕婕宁 . 葛根汤治疗感冒(风寒证)的临床研究. 武汉: 湖北中医学院. 2005
[16] Mao B, Zhang RM, Wang L, Chang J, Li TQ . Randomized clinical trial of Lianpu Granule in the treatment of common cold(feng-re syndrome)[J]. Zhongguo Xun Zheng Yi Xue Za Zhi, 2004,4(10):677-684
毛兵, 张瑞明, 王蕾, 常静, 李廷谦 . 复方连蒲颗粒治疗感冒(风热证)的随机对照临床试验[J]. 中国循证医学杂志, 2004,4(10):677-684
[17] Wang L, Zhang RM, Zhao YL, Feng GX, Pan DJ, Huang XY, Mao B, Wang G, Chang J, Zhang Y, Wan MH, Guo J, Chen Y, Li TQ . A multiple center, randomized controlled, double-blinded and double-dummy trial of Shuangjie Capsule(Piece) in the treatment of the acute upper respiratory tract infection(the syndrome of heat attacking the lung and Weifen)[J]. Zhongguo Xun Zheng Yi Xue Za Zhi, 2006,6(3):162-170
doi: 10.3969/j.issn.1672-2531.2006.03.003
王蕾, 张瑞明, 赵艳玲, 冯国湘, 潘定举, 黄西园, 毛兵, 王刚, 常静, 张颖, 万美华, 郭佳, 陈雁, 李廷谦 .双解胶囊( 片剂 ) 治疗急性上呼吸道感染(风温病热在肺卫证)的多中心双盲双模拟随机对照临床试验[J]. 中国循证医学杂志, 2006,6(3):162-170
doi: 10.3969/j.issn.1672-2531.2006.03.003
[18] Zhang Y, Chang J, Zhang RM, Liu LL, Li FS, Jiang XY, Wang L, Mao B, Li TQ . Mahuang Zhisou Capsule in treatment of acute upper respiratory tract infection of external wind-cold syndrome: a multi-center, randomized controlled, and double-blind trial[J]. J Chin Integr Med, 2008,6(6):581-585
张颖, 常静, 张瑞明, 刘良丽, 李凤森, 江心悦, 王蕾, 毛兵, 李廷谦 . 麻黄止嗽胶囊治疗急性上呼吸道感染风寒证随机双盲多中心对照试验[J]. 中西医结合学报, 2008,6(6):581-585
[19] Zuo MY. Clinical observation of Jiuwei Qianghuo soft capsule in treatment of upper respiratory tract infection with wind-cold syndrome. Wuhan: Hubei University of Chinese Medicine. 2008.
左明晏 . 九味羌活软胶囊治疗上呼吸道感染(感冒风寒挟湿证)的临床观察. 武汉: 湖北中医学院. 2008
[20] Fu JJ, Wang G, Mao B . The assessment of scientificalness and ethic of placebo-controlled trials in traditional Chinese medicine[J]. Zhongguo Xun Zheng Yi Xue Za Zhi, 2008,8(9):781-785
付娟娟, 王刚, 毛兵 . 中医药随机对照试验中安慰剂应用科学性与伦理性评价[J]. 中国循证医学杂志, 2008,8(9):781-785
[21] Barrett BP, RL Brown , K Locken, R Maberry, JA Bobula, D’Alesslo D .Treatment of common cold with unrefined echinacea. A randomized, double-blind, placebo-controlled trial[J]. Ann Intern Med, 2002,137(12):939-946
doi: 10.7326/0003-4819-137-12-200212170-00006
[22] Goel V, Lovlin R, Barton R, Lyon MR, Bauer R, Lee TD, Basu TK . Efficacy of standardized echinacea preparation(Echinilin) for the treatment of the common cold: a randomized, double-blind, placebo-controlled trial[J]. J Clin Pharm Ther, 2004,29(1):75-83
doi: 10.1111/jcp.2004.29.issue-1
[23] Yale SH, Liu K . Echinacea purpurea therapy for the treatment of the common cold: a randomized, double-blind, placebo-controlled clinical trial[J]. Arch Inter Med, 2004,164(11):1237-1241
doi: 10.1001/archinte.164.11.1237
[24] Gabrielian ES, Shukarian AK, Goukasova GI, Chandanian GL, Panossian AG, Wikman G, Wagner H . A double-blind, placebo-controlled study of Andrographis paniculata fixed combination Kan Jang in the treatment of acute upper respiratory tract infections including sinusitis[J]. Phytomedicine, 2002,9(7):589-597
doi: 10.1078/094471102321616391
[25] Naser B, Lund B , Henneicke-von Zepelin HH, Köhler G, Lehmacher W, Scaglione F .A randomized, double-blind, placebo-controlled, clinical dose-response trial of an extract of Baptisia, Echinacea and Thuja for the treatment of patients with common cold[J]. Phytomedicine, 2005,12(10):715-722
doi: 10.1016/j.phymed.2005.03.002
[26] Lizogub VG, Riley DS, Heger M . Efficacy of pelargonium sidoides preparation in patients with the common cold: a randomized, double-blind, placebo-controlled clinical trial[J]. Explore, 2005,3(6):573-584
[1] Na Wu , Lu Song , Xin-xin Yang, Jiang-lei Wei , Zhen-guo Liu. Effects of Chinese herbal medicine Tianqi Pingchan Granule on G protein-coupled receptor kinase 6 involved in the prevention of levodopa-induced dyskinesia in rats with Parkinson disease. Journal of Chinese Integrative Medicine, 2012, 10(9): 1018-1024.
[2] Jing-lin Shi, Wan-hong Miao. Effects of acupuncture on lactoferrin content in tears and tear secretion in patients suffering from dry eyes: A randomized controlled trial. Journal of Chinese Integrative Medicine, 2012, 10(9): 1003-1008.
[3] Ming T. Tan , Jian-ping Liu , Lixing Lao. Adequate application of quantitative and qualitative statistic analytic methods in acupuncture clinical trials. Journal of Chinese Integrative Medicine, 2012, 10(8): 847-852.
[4] Xin-min Li, Hui Chen, Yan-yan Ren, Yan-li Lu. Effects of Chinese herbal medicine Xifeng Capsule on multidrug resistance-associated protein 1 expression in hippocampus and cortex of rats with lithium-pilocarpine-induced epilepsy. Journal of Chinese Integrative Medicine, 2012, 10(8): 911-917.
[5] Yong Zhang, Xiao-wen Sun, Jian-hua Xu, Hai Lu, Zhong-ze Fan, Jue Sun, Xiao-xiao Zhang. Effects of medicated serum prepared with Chinese herbal medicine Changweiqing on pharmacokinetics of oxaliplatin in colon cancer cells. Journal of Chinese Integrative Medicine, 2012, 10(8): 901-910.
[6] Wei-hua Xu, Ze-huai Wen, Wei-xiong Liang, Qi Wang. A review of research on the development of instruments for therapeutic efficacy evaluation of traditional Chinese medicine. Journal of Chinese Integrative Medicine, 2012, 10(7): 726-737.
[7] Lin Wang, Guan-liang Wang, Jia-han Liu, Di Li, De-zeng Zhu, Liang-neng Wu . Effects of ursolic acid in ameliorating insulin resistance in liver of KKAy mice via peroxisome proliferator-activated receptors α and γ. Journal of Chinese Integrative Medicine, 2012, 10(7): 793-799.
[8] Lu Yu, Shui-miao Lin, Ru-qian Zhou, Wei-jun Tang, Pin-xian Huang, Ying Dong, Jian Wang, Zhi-hua Yu, Jiu-lin Chen, Li Wei, San-li Xing, Hui-juan Cao, Hong-bin Zhao. Chinese herbal medicine for patients with mild to moderate Alzheimer disease based on syndrome differentiation: A randomized controlled trial. Journal of Chinese Integrative Medicine, 2012, 10(7): 766-776.
[9] Hui Luo, Jian-ping Liu, Qing Li. Methodological issues and suggestions for improvement in randomized controlled trials of Chinese herbal medicine for recurrent miscarriage. Journal of Chinese Integrative Medicine, 2012, 10(6): 604-614.
[10] Peng Fu , Xue-qiang Huang, Ai-hong Yuan, Guang Yu, Xiao-bin Mei, Ruo-lan Cu. Effects of salvianolate combined with alprostadil and reduced glutathione on progression of chronic renal failure in patients with chronic kidney diseases: a long-term randomized controlled trial. Journal of Chinese Integrative Medicine, 2012, 10(6): 641-646.
[11] Shui-qiu Deng, Xue-nong Ouyang, Zong-yang Yu, Xi-hu Dai, Xi Chen, Fang-zheng Fang, Wen-wu Wang, Zhi-zhen Liu. Influence of Chinese herbal medicine Feitai Capsule on completion or delay of chemotherapy in patients with stage ⅢB/Ⅳ non-small-cell lung cancer: a Randomized controlled trial. Journal of Chinese Integrative Medicine, 2012, 10(6): 635-640.
[12] Ming-xing Zhao, Zhen-hua Dong, Zhong-hai Yu, Shi-yuan Xiao, Ya-ming Li . Effects of Ginkgo biloba extract in improving episodic memory of patients with mild cognitive impairment: A randomized controlled trial. Journal of Chinese Integrative Medicine, 2012, 10(6): 628-634.
[13] Ying-chun Miao , Jin-zhou Tian , Jing Shi , Min Mao. Effects of Chinese medicine for tonifying the kidney and resolving phlegm and blood stasis in treating patients with amnestic mild cognitive impairment: A randomized, double-blind and parallel-controlled trial. Journal of Chinese Integrative Medicine, 2012, 10(4): 390-397.
[14] Xiao-hui Sun, Sheng Liu . External Chinese medical therapy for pain associated with hyperplastic disease of the breast: Study protocol of a randomized, double-blind, multicenter, controlled trial. Journal of Chinese Integrative Medicine, 2012, 10(4): 384-389.
[15] Zhu Yan-feng, Luo Hai-ming, Deng Zhong-long, Fu De-yu, Yao Wang, Dai Jian. Effects of the Chinese patent medicine, Honghua Injection, on platelet glycoprotein Ⅱb/Ⅲa receptors in patients with acute coronary syndrome: a randomized controlled trial. Journal of Chinese Integrative Medicine, 2012, 10(3): 318-323.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
[1] Jin-rong Fu. Establishment of multivariate diagnosis and treatment system of modern gynecology of traditional Chinese medicine. Journal of Chinese Integrative Medicine, 2008, 6(1): 22-24
[2] Hao Li, Ming-jiang Yao, Wen-ming Zhao, Jie Guan, Lin-lin Cai, Ling Cui. A randomized, controlled, double-blind trial of Huannao Yicong capsule in senile patients with mild cognitive impairment. Journal of Chinese Integrative Medicine, 2008, 6(1): 25-31
[3] Zhi-chun Jin. Problems in establishing clinical guideline for integrated traditional Chinese and Western medicine. Journal of Chinese Integrative Medicine, 2008, 6(1): 5-8
[4] SUN Ming-yu, ZUO Jian, DUAN Ji-feng, HAN Jun, FAN Shi-ming, ZHANG Wei, ZHU Li-fang, YAO Ming-hui. Antitumor activities of kushen flavonoids in vivo and in vitro. Journal of Chinese Integrative Medicine, 2008, 6(1): 51-59
[5] Min Cheng, Qiong Feng, Shu-wen Qian, Hui Gao, Cui-qing Zhu. Preliminary assay of p-amyloid binding elements in heart-beneficial recipe. Journal of Chinese Integrative Medicine, 2008, 6(1): 68-72
[6] Ning-qun Wang, Liang-duo Jiang, Zong-xing Li. Research progress in asthma-related quality of life. Journal of Chinese Integrative Medicine, 2008, 6(1): 93-97
[7] Jing-yuan Mao, Chang-xiao Liu, Heng-he Wang, Guang-li Wei , Zhen-peng Zhang, Jie Xing, Wang Xian liang , Ying-fei Bi . Effects of Shenmai Injection on serum concentration and pharmacokinetics of digoxin in dogs with heart failure. Journal of Chinese Integrative Medicine, 2010, 8(11): 1070-1074
[8] Zhi-mei Wang, Bin Zhang. A study on translation of ellipses in Huangdi Neijing from perspective of hermeneutic theory. Journal of Chinese Integrative Medicine, 2010, 8(11): 1097-1100
[9] Gui Yu, Jie Wang. Thinking on building the network cardiovasology of Chinese medicine. Journal of Chinese Integrative Medicine, 2012, 10(11): 1206-1210
[10] Pedro Saganha João, Doenitz Christoph, Greten Tobias, Efferth Thomas, J. Greten Henry. Qigong therapy for physiotherapists suffering from burnout: a preliminary study. Journal of Chinese Integrative Medicine, 2012, 10(11): 1233-1239
[an error occurred while processing this directive]