中医证本质研究与代谢组学技术：现状与思考

doi:10.3736/jcim20121001

Abstract

Syndromes constitute a core aspect in the study of Chinese medicine, and research on the concept of syndromes is important to the study of the process of modernization of traditional Chinese medicine. However, it is somewhat challenging to define a syndrome due to the complexity inherent in the subject, even with the assistance of the reductionism approach of modern medicine. Holistic and dynamic in nature and attaching much importance to functional changes, the newly emerging metabonomics is in many ways inline with the concepts of syndrome differentiation of pathological states in traditional Chinese medicine. Therefore, metabonomics has comparatively strong advantages in the very respect of revealing the natural laws of syndrome differentiation. By reviewing and analyzing the current research on the concept of syndromes and the application of metabonomic technology to exploring the essential core of syndrome differentiation, the authors illustrated the potential commonalities. This would also show the issues requiring attention between the study of syndromes and the metabonomic technology. In the meantime this study reflectd the core problems in detail and put forward suggestions with regard to reaching solutions.

Key words: syndrome, metabonomics, review

Jing Zhang , Long Liu , Xin Yan , Xiao-qiang Yue. Study of the syndromes of traditional Chinese medicine in terms of metabonomics technology: The current situation and considerations. Journal of Chinese Integrative Medicine, 2012, 10(10): 1069-1076.

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References 29

[1]	Zhang M . The influence of traditional culture on the formation of syndrome theories in traditional Chinese medicine[J]. Henan Zhong Yi, 2011,31(8):839-840
	张敏 . 传统文化对中医“证”理论形成的影响[J]. 河南中医, 2011,31(8):839-840
[2]	Wang YQ. Syndrome differentiation of traditional Chinese medicine[M]. Beijing: Peking Union Medical College Press, 2007,4
	王忆勤 . 中医辨证学[M]. 北京: 中国协和医科大学出版社, 2007,4
[3]	Shen ZY . My research course and thinking[J]. Zhong Yi Za Zhi, 2000,41(11):690-692
	沈自尹 . 我的科研历程和思考[J]. 中医杂志, 2000,41(11):690-692
[4]	Song JN . Discussion on basic research model and method of traditional Chinese medicine syndrome[J]. Zhongguo Zhong Yi Ji Chu Yi Xue Za Zhi, 2007,13(2):81-83 doi: 10.3969/j.issn.1006-3250.2007.02.001
	宋剑南 . 论中医证候基础研究的模式和方法[J]. 中国中医基础医学杂志, 2007,13(2):81-83 doi: 10.3969/j.issn.1006-3250.2007.02.001
[5]	Wang YY, Zhang QM, Zhang ZB . The induction of syndrome factor and affecting target[J]. Shandong Zhong Yi Yao Da Xue Xue Bao, 2006,30(1):6-7
	王永炎, 张启明, 张志斌 . 证候要素及其靶位的提取[J]. 山东中医药大学学报, 2006,30(1):6-7
[6]	Pan ZQ, Fang ZQ . Present study situation on the nature of traditional Chinese medicine syndrome and new trend of introducing the systematic biological technology[J]. Zhongguo Zhong Yi Yao Xin Xi Za Zhi, 2009,16(1):104-107
	潘志强, 方肇勤 . 中医证候本质研究现状及引入系统生物学技术新趋势[J]. 中国中医药信息杂志, 2009,16(1):104-107
[7]	Zheng HS, Jiang J, Jia W . Discussion on the application of metabonomics in research of traditional Chinese medicine syndrome nature[J]. Liaoning Zhong Yi Za Zhi, 2008,35(5):693-694
	郑海生, 蒋健, 贾伟 . 浅论代谢组学在中医证本质研究中的应用[J]. 辽宁中医杂志, 2008,35(5):693-694
[8]	Luo HG, Chen JX . Research on metabolomics technology and traditional Chinese medicine syndrome[J]. Zhongguo Zhong Yi Yao Xin Xi Za Zhi, 2007,14(5):3-5
	罗和古, 陈家旭 . 代谢组学技术与中医证候的研究[J]. 中国中医药信息杂志, 2007,14(5):3-5
[9]	Jian WX, Yuan ZK . Research on traditional Chinese medicine syndromes and metabonomics[J]. Zhonghua Zhong Yi Yao Xue Kan, 2009,27(2):351-352
	简维雄, 袁肇凯 . 中医“证候”与代谢组学研究[J]. 中华中医药学刊, 2009,27(2):351-352
[10]	Luo HG, Ding J, Yue GX, Chen JX . Metabonomic study of syndrome of liver qi stagnation and spleen deficiency in rats[J]. J Chin Integr Med, 2007,5(3):307-313
	罗和古, 丁杰, 岳广欣, 陈家旭 . 大鼠肝郁脾虚证的代谢组学研究[J]. 中西医结合学报, 2007,5(3):307-313
[11]	Xu S, Chen HB, Li H, Zhang Q, Cai HB, Yan XZ, Lü ZP . Establishment of rat model of syndrome of stagnation of liver qi and primary study using metabonomics[J]. Zhonghua Zhong Yi Yao Za Zhi, 2009,24(6):787-791
	徐舒, 陈合兵, 李洪, 张琪, 蔡红兵, 颜贤忠, 吕志平 . “肝郁证”大鼠模型的建立及代谢组学的初步研究[J]. 中华中医药杂志, 2009,24(6):787-791
[12]	Wang WM, Huang YH, Xiong ZF, Xu ZX, Sheng GG . Study on urine metabonomics for rat model with stagnation of liver-qi syndrome[J]. Zhong Xi Yi Jie He Gan Bing Za Zhi, 2010,20(2):102-105, 129
	王伟明, 黄育华, 熊振芳, 许朝霞, 盛国光 . 肝气郁结证大鼠尿液代谢组学研究[J]. 中西医结合肝病杂志, 2010,20(2):102-105, 129
[13]	Chen B, Wang WM, Huang YH . Effects of Caihushugan powder on urine metabonomics in model rats of stagnation with liver-qi syndrome[J]. Zhong Xi Yi Jie He Gan Bing Za Zhi, 2010,20(5):297-300
	陈斌, 王伟明, 黄育华 . 柴胡疏肝散对肝气郁结证大鼠尿液代谢组学的影响[J]. 中西医结合肝病杂志, 2010,20(5):297-300
[14]	Jian WX, Huang XP, Chen QH, Mo L, Zheng JH, Sun GX, Hu ZX, Yuan ZK . Research on metabolomics of heart blood stasis rat based on gas chromatography-mass spectrometry[J]. Zhonghua Zhong Yi Yao Xue Kan, 2009,27(4):796-798
	简维雄, 黄献平, 陈清华, 莫莉, 郑锦辉, 孙贵香, 胡志希, 袁肇凯 . 基于气相色谱-质谱的大鼠心血瘀阻证血浆代谢组学研究[J]. 中华中医药学刊, 2009,27(4):796-798
[15]	Li L, Wang JN, Ren JX, Xiang JF, Tang YL, Liu JX, Han D . Urine nuclear magnetic resonance spectroscopy metabolomics of rats with syndrome of blood stasis due to qi deficiency[J]. Ke Xue Tong Bao, 2007,52(15):1758-1762 doi: 10.1360/csb2007-52-15-1758
	李林, 王建农, 任建勋, 向俊锋, 唐亚林, 刘建勋, 韩丁 . 气虚血瘀证大鼠尿液的核磁共振谱代谢组学[J]. 科学通报, 2007,52(15):1758-1762 doi: 10.1360/csb2007-52-15-1758
[16]	Wang Y, Guo SZ, Li C, Chen JX, Chuo WJ, Dong F, Wang W, Wang YF . Analysis of plasma metabonomics of mini-swines with qi deficiency and blood stasis syndrome due to chronic myocardial ischemia[J]. J Chin Integr Med, 2011,9(2):158-164
	王勇, 郭淑贞, 李春, 陈建新, 啜文静, 董芳, 王伟, 王英锋 . 慢性心肌缺血模型小型猪血浆代谢组学分析[J]. 中西医结合学报, 2011,9(2):158-164
[17]	Chen M, Zhao L, Jia W . Metabonomic study on the biochemical profiles of a hydrocortisone-induced animal model[J]. J Proteome Res, 2005,4(6):2391-2396 doi: 10.1021/pr050158o pmid: 16335992
[18]	Lu J, Liu CF, Liu YD, Zu JX, Liu SM . Research on evaluation methods of the pyretic pulmonary syndrome model based on metabonomics[J]. Zhongguo Ji Ceng Yi Yao, 2010,17(1):1-3 doi: 10.3760/cma.j.issn.1008-6706.2010.01.001
	卢江, 柳长凤, 刘聿迪, 祖金祥, 刘树民 . 基于代谢组学技术的肺热证候模型评价方法研究[J]. 中国基层医药, 2010,17(1):1-3 doi: 10.3760/cma.j.issn.1008-6706.2010.01.001
[19]	Jiang HQ, Ma B, Nie L, Li YL . A nuclear magnetic resonance spectroscopic metabonomics analysis for serum samples of hypertension patients with hyperactivity of liver-yang[J]. Yao Xue Shi Jian Za Zhi, 2010,28(4):258-261 doi: 10.3969/j.issn.1006-0111.2010.04.006
	蒋海强, 马斌, 聂磊, 李运伦 . 高血压病肝阳上亢证患者血清样品的核磁共振谱代谢组学研究[J]. 药学实践杂志, 2010,28(4):258-261 doi: 10.3969/j.issn.1006-0111.2010.04.006
[20]	Lu YH, Hao HP, Wang GJ, Chen XH, Zhu XX, Xiang BR, Huang Q , A JY .Metabolomics approach to the biochemical differentiation of traditional Chinese medicine syndrome types of hypertension[J]. Zhongguo Lin Chuang Yao Li Xue Yu Zhi Liao Xue, 2007,12(10):1144-1150 doi: 10.3969/j.issn.1009-2501.2007.10.008
	陆益红, 郝海平, 王广基, 陈晓虎, 朱宣宣, 相秉仁, 黄青, 阿基业 . 高血压病中医分型的代谢组学研究[J]. 中国临床药理学与治疗学, 2007,12(10):1144-1150 doi: 10.3969/j.issn.1009-2501.2007.10.008
[21]	Jian WX, Yuan ZK, Huang XP, Chen QH, Zheng JH, Li YH, Wang LP . Detection and analysis on plasma metabolomics in patient with coronary heart disease of heart-blood stasis syndrome pattern[J]. Zhongguo Zhong Xi Yi Jie He Za Zhi, 2010,30(6):579-584
	简维雄, 袁肇凯, 黄献平, 陈清华, 郑景辉, 李勇华, 王丽萍 . 冠心病心血瘀阻证血浆代谢组学的检测分析[J]. 中国中西医结合杂志, 2010,30(6):579-584
[22]	Zhang HS, Jia YH, Hua HY, Wan ZY, Guan SY, Cao SP, Cui K, Wang XW . Plasma metabolomics research on phlegm and blood stasis syndromes of angina due to coronary heart disease[J]. Xin Zhong Yi, 2010,42(6):12-14
	张红栓, 贾钰华, 华何与, 万中原, 关山越, 曹世平, 崔凯, 王学文 . 冠心病心绞痛痰浊证、血瘀证的血浆代谢组学研究[J]. 新中医, 2010,42(6):12-14
[23]	Wang GJ , A JY,Yan B,Hao HP,Liu LS,Zhang Y,Gu SH,Zheng YT,Zhu XX .Metabonomic investigation on traditional Chinese medicine patterns of coronary artery disease[J]. Shi Jie Ke Xue Ji Shu Zhong Yi Yao Xian Dai Hua, 2009,11(1):127-133
	王广基, 阿基业, 严蓓, 郝海平, 刘林生, 张颖, 顾胜华, 郑媛婷, 朱萱萱 . 代谢组学研究冠心病中医分型的体内物质基础[J]. 世界科学技术中医药现代化, 2009,11(1):127-133
[24]	Hua HY, Jia YH, Zhang HS, Cao SP, Cui K, Guan SY, Wan ZY . Metabolomic study on plasma from patients with angina pectoris due to coronary heart disease with three kinds of blood-stasis syndrome[J]. Re Dai Yi Xue Za Zhi, 2010,10(3):258-279
	华何与, 贾钰华, 张红栓, 曹世平, 崔凯, 关山越, 万中原 . 冠心病心绞痛三种血瘀证的血浆代谢组学研究[J]. 热带医学杂志, 2010,10(3):258-279
[25]	Zhu XX, Wang GJ , A JY, Guan EZ, Yan B.Metabonomics approach to the biochemical differentiation of traditional Chinese medicine syndrome types of coronary heart disease[J]. Zhonghua Zhong Yi Yao Xue Kan, 2009,27(6):1267-1269
	朱萱萱, 王广基, 阿基业, 管恩泽, 严蓓 . 冠心病中医辨证分型的代谢组学研究[J]. 中华中医药学刊, 2009,27(6):1267-1269
[26]	Yan XH, Batur M, Li CY, Yang N, You LN, Hamurat U . Plasma metabonomics study on the asthma diagnosed as kidney-deficiency with phlegm-stasis syndrome in traditional Chinese medicine with nuclear magnetic resonance[J]. Xinjiang Yi Ke Da Xue Xue Bao, 2010,33(3):228-233
	严兴海 , 巴吐尔·买买提明 , 李春燕, 杨娜, 由丽娜, 哈木拉提·吾甫尔.基于核磁共振的肾虚痰瘀型哮喘患者血浆的代谢组学研究[J]. 新疆医科大学学报, 2010,33(3):228-233
[27]	Batur M, Halmurat U . Plasma metabonomics analysis of tumor patients with phlegm-stasis syndrome[J]. Zhongguo Zhong Xi Yi Jie He Za Zhi, 2011,31(4):492-495
	巴吐尔·买买提明, 哈木拉提·吾甫尔. 痰瘀证肿瘤患者血浆代谢组学研究[J]. 中国中西医结合杂志, 2011,31(4):492-495
[28]	Zhao XS, Yu KQ, Sun XM, Luo YJ, Yang HL, Nie XL, Li YP, Liu YY, Luo R . Metabonomics research of saliva in the physiopathological state of spleen diseases in TCM based on nuclear magnetic resonance[J]. Sichuan Zhong Yi, 2011,29(3):43-45
	赵晓山, 余克强, 孙晓敏, 罗云坚, 杨洪玲, 聂晓莉, 李玉萍, 刘艳艳, 罗仁 . 中医脾脏病理生理状态下唾液的代谢组研究[J]. 四川中医, 2011,29(3):43-45
[29]	Xu GY, Ge WH . Data analytical technique in metabolomic study and its applications[J]. Shizhen Guo Yi Guo Yao, 2011,22(7):1755-1758
	许广艳, 葛卫红 . 代谢组学的数据分析技术及其应用[J]. 时珍国医国药, 2011,22(7):1755-1758

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Study of the syndromes of traditional Chinese medicine in terms of metabonomics technology: The current situation and considerations

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