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Journal of Chinese Integrative Medicine ›› 2012, Vol. 10 ›› Issue (10): 1077-1083.doi: 10.3736/jcim20121002

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Facts about standardization of herbal medicine: A review

Garg Vandana1(),Ji Dhar Vir2,Sharma Anupam3,Dutt Rohit4   

  1. 1. Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak 124001, Haryana, India
    2. Swift School of Pharmacy Village Ghaggar Sarai, Tehsil Rajpura, Punjab 140401, India
    3. University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160014, India
    4. Guru Gobind Singh College of Pharmacy, Yamunanagar 135003, Haryana, India
  • Received:2012-03-29 Accepted:2012-04-19 Online:2012-10-20 Published:2018-10-15
  • Contact: Garg Vandana E-mail:vandugarg@rediffmail.com

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Natural products, either as pure compounds or as standardized plant extracts, provide extensive opportunities for new drug leads because of the unmatched availability of chemical diversity. In contrast to modern medicines, herbal medicines are frequently used to treat chronic diseases. Standardization guarantees the content of one or more active constituents and marker compounds. The plant environment and genetic factors could significantly affect the biochemical components of the plant extract, in which plants are still the most abundant and cost-effective resource for drug innovation. Production of botanical drugs requires genetically uniform monocultures of the source plant in fully standardized conditions, to assure the biochemical consistency and to optimize the safety and efficacy of every crop. The present review article illustrates about the methods for standardization of herbal medicine and how the goal of preparing herbal medicines of consistent quality and effects can be achieved.

Key words: genuine crude drugs, herbal drugs, plant extracts, review

[1] Cordell GA, Colvard MD . Natural products in a world out-of-balance. Arkivoc. 2007; ( Ⅶ):97-115.
[2] Manly SP, Padmanabha R, Lowe SE . Natural products or not? How to screen for natural products in the emerging HTS paradigm[J]. Methods Mol Biol, 2002, 190153-168
doi: 10.1385/1-59259-180-9:153 pmid: 12029820
[3] Nucbe NS, Afolayan AJ, Okoh AI . Assessment techniques of antimicrobial properties of natural compounds of plant origin: current methods and future trends[J]. Afr J Biotechnol, 2008,7(12):1797-1806
doi: 10.5897/AJB
[4] Galani VJ, Patel BG, Patel NB . Argyreia speciosa(Linn. f.) sweet: a comprehensive review[J]. Pharmacogn Rev, 2010,4(8):172-178
doi: 10.4103/0973-7847.70913 pmid: 3249918
[5] Calixto JB . Efficacy, safety, quality control, marketing and regulatory guidelines for herbal medicines(phytotherapeutic agents)[J]. Braz J Med Biol Res, 2000,33(2):179-189
doi: 10.1590/S0100-879X2000000200004
[6] Busse W . The significance of quality for efficacy and safety of herbal medicinal products[J]. Drug Inf J, 2000, 3415-23
doi: 10.1177/009286150003400102
[7] Bonati A . How and why should we standardize phytopharmaceutical drugs for clinical validation?[J] Ethnopharmacol. 1991; 32(1-3):195-197.
doi: 10.1016/0378-8741(91)90117-V pmid: 1881157
[8] Willard T . Edible and medicinal plants of the Rocky Mountains. Calgary: Wild Rose College of Natural Healing. 1996.
[9] Page LR . Whole herbs or standardized plant constituents? Total Health. 2001; 23(4):20.
[10] Bauer R . Quality criteria and standardization of phytopharmaceuticals: can acceptable drug standards be achieved? Drug Inf J. 1998; 32:101-110.
doi: 10.1177/009286159803200114
[11] Cos P, Vlietinck AJ, Berghe DV, Maes L . Anti-infective potential of natural products: how to develop a stronger in vitro ‘proof-of-concept’[J]. J Ethnopharmacol, 2006,106(3):290-302
doi: 10.1016/j.jep.2006.04.003
[12] Hildreth J, Hrabeta-Robinson E, Applequist W, Betz J, Miller J . Standard operating procedure for the collection and preparation of voucher plant specimens for use in the nutraceutical industry[J]. Anal Bioanal Chem, 2007,389(1):13-17
doi: 10.1007/s00216-007-1405-x
[13] Dubey NK, Tripathi P . Global promotion of herbal medicine: India’s opportunity[J]. Curr Sci, 2004,86(1):37-41
[14] Khatoon S, Mehrotra S, Shome U, Mehrotra BN . Analysis of commercial ‘Ratanjot’ by TLC fluorescence fingerprinting[J]. Int J Pharmacog, 1993,31(4):269-277
doi: 10.3109/13880209309082952
[15] Hylands PJ, Nicholson JK, Holmes EC, Elaine C, Dunn MJ. Process for quality control and standardization of medicinal plant products: US, 6806090 B1. (2004-10-19)[ 2012-02-13]. .
[16] de Barros Machado T, Leal IC, Kuster RM, Amaral AC, Kokis V, de Silva MG, dos Santos KR . Brazilian phytopharmaceuticals — evaluation against hospital bacteria[J]. Phytother Res, 2005,19(6):519-525
doi: 10.1002/ptr.1696 pmid: 16114081
[17] Plotnikoff GA, George J . Herbalism in Minnesota[J]. What should physicians know? Minn Med, 1999,82(5):12-26
[18] Hylands P . New approaches for the quality control and standardization of plant delivered pharmaceutical and neutraceutical products. Oxford: Oxford Natural Products Publications. 2002.
[19] World Health Organization . Guidelines for the assessment of herbal medicines. Programme on traditional medicines. Geneva: World Health Organization. 1991.
[20] Tierra M. Why standardized herbal extracts? An herbalist perspective.[ 2012-02-13]. .
[21] Evans WC . Techniques in microscopy: quantitative microscopy. A Text Book of Pharmacognosy.14 ed[M]. London: WB Saunders Company Ltd, 1996, 568-578
[22] Ministry of Health and Family Welfare of India.Indian pharmacopoeia, 1996, Volume Ⅱ[M]. New Delhi: Controller of Publications,1996,A50-A54, A96, A99
[23] Kokate C, Purohit A, Gokhale S . Text book of pharmacognosy.13th ed[M]. Pune: Nirali Prakashan, 1999, 74-84
[24] Wallis T . Textbook of pharmacognosy.5th ed[M]. New Delhi: CBS Publishers and Distributors, 1999,387, 558-562
[25] National Council Against Health Fraud. Consumer reports 1995: herbal roulette[M]. California: National Council Against Health Fraud, 1995, 678-705
[26] Barret S . St. John’s Wort 2004. [ 2012-02-13].
[27] Humberston CL, Akhtar J, Krenzelok EP . Acute hepatitis induced by kava kava[J]. J Toxicol Clin Toxicol, 2003,41(2):109-113
doi: 10.1081/CLT-120019123 pmid: 12733846
[28] Poon WT, Ho CH, Yip KL, Lai CK, Cheung KL, Sung RY, Chan AY, Mak TW . Grayanotoxin poisoning from Rhododendron simsii in an infant[J]. Hong Kong Med J, 2008,14(5):405-407
pmid: 18840915
[29] Ahn BM . Herbal preparation-induced liver injury[J]. Korean J Gastroenterol, 2004,44(3):113-125
pmid: 15385719
[30] Ho NK . Traditional Chinese medicine and treatment of neonatal jaundice[J]. Singapore Med J, 1996,37(6):645-651
pmid: 9104069
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