Search JIM Advanced Search

Journal of Chinese Integrative Medicine ›› 2005, Vol. 3 ›› Issue (2): 99-102.doi: 10.3736/jcim20050205

• Original Clinical Research • Previous Articles     Next Articles

Ginsenosides combined with dexamethasone in preventing and treating postembolization syndrome following transcatheter arterial chemoembolization: A randomized, controlled and double-blinded prospective trial

Ying-lu Feng,Chang-quan Ling,De-zeng Zhu,Chao-qin Yu,Zhe Chen,Bai Li   

  1. Department of Traditional Chinese Medicine, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
  • Received:2005-01-18 Online:2005-03-20 Published:2005-03-20
  • Contact: Chang-quan Ling


To observe the effect of ginsenosides (GS) and low dose glucocorticoid in preventing and treating the postembolization syndrome following transcatheter arterial chemoembolization (TACE).


Eighty patients with primary liver carcinoma were randomly divided into 4 double-blinded groups, with 20 patients in each group. Patients in groups A, B, C, D were treated with placebo, dexamethasone (Dex), GS, Dex and GS, respectively. The changes of clinical symptoms and laboratory tests after TACE were observed.


Dex combined with GS markedly decreased the occurrence ratio and lasting time of the symptoms such as nausea, vomiting, fever and pain, and protected the function of liver as compared with the placebo (P<0.05). Single use of Dex or GS improved some symptoms as compared with the placebo, but it was not as good as the combination of Dex and GS.


ex combined with GS can effectively prevent and treat the postembolization syndrome following TACE.

Key words: Liver cancer, Transcatheter arterial chemoembolization, Dexamethasone, Ginsenosides

CLC Number: 

  • R735.1

Tab 1

General information of patients in each group"

Group n Gender (cases) Age (years) Stage [Cases (%)]
Male Female Stage Ⅱ Stage Ⅲ
Group A 20 15 5 54.4±11.4 14(70.0) 6(30.0)
Group B 20 12 8 50.4±12.7 17(85.0) 3(15.0)
Group C 20 14 6 52.1±11.1 15(75.0) 5(25.0)
Group D 20 14 6 58.3±9.9 14(70.0) 6(30.0)

Tab 2

Degrees of side effects after TACE in each group (Cases)"

Group n Nausea and vomiting degree Fever degree Pain degree
0 I 0 I 0 I
Group A 20 4 10 2 4 6 1 13 0 3 15 1 1
Group B 20 12 4 2 2 15 4 1 0 12 8 0 0
Group C 20 15 4 1 0 6 4 10 0 15 5 0 0
Group D 20 17 3 0 0 17 2 1 0 16 4 0 0

Tab 3

Lasting time of side effects after TACE in each group ($\bar{x}$±s, d)"

*P<0.05, vs group A

Group n Lasting time
Nausea and vomiting Fever Pain
Group A 20 2.61±1.42 4.38±2.31 5.16±2.77
Group B 20 1.78±1.23 1.75±1.16* 1.58±0.99*
Group C 20 1.28±0.94* 3.65±1.93 1.82±1.41*
Group D 20 1.02±0.76* 1.11±0.68* 1.34±0.89*

Tab 4

Stages of Child-Pugh before and after TACE in each group (Cases)"

Group n Stages of Child-Pugh
Group A
Before TACE 20 16 4 0
After TACE 20 8 9 3
Group B
Before TACE 20 17 3 0
After TACE 20 13 6 1
Group C
Before TACE 20 17 3 0
After TACE 20 12 7 1
Group D
Before TACE 20 15 5 0
After TACE 20 17 3 0
[1] Attele AS, Wu JA, Yuan CS . Ginseng pharmacology: multiple constituents and multiple actions[J]. Biochem Pharmacol, 1999,58(11):1685-1693
doi: 10.1016/S0006-2952(99)00212-9
[2] Kong X, Hu Y, Rui R , et al. Effects of Chinese herbal medicinal ingredients on peripheral lymphocyte proliferation and serum antibody titer after vaccination in chicken[J]. Int Immunopharmacol, 2004,4(7):975-982
doi: 10.1016/j.intimp.2004.03.008
[3] 中国抗癌协会肝癌专业委员会. 原发性肝癌的临床诊断与分期标准[J]. 中华肝脏病杂志, 2001,9(6):324
[4] 王建华, 周康荣 . 肝癌综合性介入治疗规范化方案(草案)[J]. 临床放射学杂志, 2002,21(7):497-500
doi: 10.3969/j.issn.1001-9324.2002.07.004
[5] 周际昌 . 实用肿瘤内科学(第1版)[M]. 北京: 人民卫生出版社, 2003,( 第1版):424
[6] 权启镇 . 新肝脏病学(第1版)[M]. 济南: 山东科学技术出版社, 2003,( 第1版):111
[7] 吴一萍, 张毅 . 糖皮质激素在肿瘤并发症中的应用[J]. 临床肿瘤学杂志, 2001,6(4):387-388
[8] 陈颖, 陈燕茹 . 防治肝癌介入术后迟发性恶心呕吐的观察[J]. 护士进修杂志, 2003,18(4):374-375
[9] Yun TK .Experimental and epidemiological evidence on non-organ specific cancer preventive effect of Korean ginseng and identification of active compounds[J].Mutat Res, 2003, 523-524: 63-74
[10] Lee EJ, Ko E, Lee J , et al. Ginsenoside Rg1 enhances CD4+ T-cell activities and modulates Th1/Th2 differentiation[J]. Int Immunopharmacol, 2004,4(2):235-244
doi: 10.1016/j.intimp.2003.12.007 pmid: 14996415
[11] 窦德强, 靳玲, 陈英杰 . 人参的化学成分及药理活性的研究进展与展望[J]. 沈阳药科大学学报, 1999,16(2):151-155
[1] Chang-quan Ling, Jia Fan, Hong-sheng Lin, Feng Shen, Zhen-ye Xu, Li-zhu Lin, Shu-kui Qin, Wei-ping Zhou, Xiao-feng Zhai, Bai Li, Qing-hui Zhou, on behalf of the Chinese Integrative Therapy of Primary Liver Cancer Working Group. Clinical practice guidelines for the treatment of primary liver cancer with integrative traditional Chinese and Western medicine. Journal of Integrative Medicine, 2018, 16(4): 236-248.
[2] Lin Jia, Wan-yin Wang, Li-mei Zhou, Feng-feng Mo, Min Li. Antimotion sickness effects of ginsenosides combined with dexamethasone in rats. Journal of Chinese Integrative Medicine, 2010, 8(4): 358-362.
[3] Huo-jun Zhang, Ji-jin Yang, Wei-xing Wang, Xu Jiang, Yan-jun Mao, Chao-ai Yang, Ji-xiang Guo. Effects of Jinlong Capsule on expressions of interleukin-2 and soluble interleukin-2 receptor in patients with primary liver cancer after transarterial chemoembolization therapy. Journal of Chinese Integrative Medicine, 2008, 6(9): 907-910.
[4] Zhi-jun Dai, Xi-jing Wang, Qian Xue, Zong-zheng Ji, Xiao-xu Liu, Hua-feng Kang, Hai-tao Guan, Xiao-bin Ma, Hong-tao Ren. Effects of Scutellaria Barbata drug-containing serum on apoptosis and mitochondrial transmembrane potential of hepatoma H22 cells. Journal of Chinese Integrative Medicine, 2008, 6(8): 821-826.
[5] Zhi-qiang Pan, Zhao-qin Fang, Wen-li Lu, Chao Liang, Zhong-hua Wu, Xiao-mei Liu, Li Hou, Hui Zhang, Shao-yuan Zhuo, Ming-juan Liao, Bi-feng Gao. Differentially expressed genes in adrenal gland of H22 liver cancer mice with different syndromes and in different stages. Journal of Chinese Integrative Medicine, 2008, 6(8): 843-851.
[6] Zhi-jun Dai, Xi-jing Wang, Zong-zheng Ji, Zong-fang Li, Wei Tang, Hua-feng Kang, Xiao-bin Ma, Lei Liu. Scutellaria barbata extract enhances efficacy and reduces toxicity of chemotherapy in hepatoma H22-bearing mice. Journal of Chinese Integrative Medicine, 2008, 6(7): 720-724.
[7] Hong-yun Chen, Zhe Chen. Transcatheter arterial chemoembolization combined with other therapies for the treatment of primary hepatic carcinoma: a review. Journal of Chinese Integrative Medicine, 2008, 6(4): 422-426.
[8] Hai-bo Yu, Cheng-en Pan, Wu-jun Wu, Si-hai Zhao, Hui-feng Zhang. Effects of resveratrol on matrix metalloproteinase-9 expression in hepatoma cells. Journal of Chinese Integrative Medicine, 2008, 6(3): 270-273.
[9] Yu Hao, Ping Wang, Jun Wu, Quan-ying Qiu. Effects of ginsenoside and berberine on secretion of immunosuppressive cytokines in lung carcinoma cell line PG. Journal of Chinese Integrative Medicine, 2008, 6(3): 278-282.
[10] Zhen Sun, Yong-hua Su, Xiao-qiang Yue. Professor Ling Changquan's experience in treating primary liver cancer: an analysis of herbal medication. Journal of Chinese Integrative Medicine, 2008, 6(12): 1221-1225.
[11] A-gao Zhou, Yong Zhang, Gang Kui, De-Yun Kong, Hai-liang Ge, Qiu-hua Ren, Jia-rong Dong, Sheng Hong, Xu-ming Mao, Yin Wang, Hui-zheng Zhang, Shu-jun Wang. Influence of traditional Chinese compound recipes with different efficacy on body weight, tumor weight and immune function in H22 cancer-bearing mice. Journal of Chinese Integrative Medicine, 2008, 6(1): 77-82.
[12] Chen Zhang, Bai Li, Shu-qin Lu, Yong Li, Yong-hua Su, Chang-quan Ling. Effects of melittin on expressions of mitochondria membrane protein 7A6, cell apoptosis-related gene products Fas and Fas Ligand in hepatocarcinoma cells. Journal of Chinese Integrative Medicine, 2007, 5(5): 559-563.
[13] Xiao-yan Mu, Ai-guang Zhao. Progress in research of traditional Chinese medicine in inducing differentiation of human hepatoma cells. Journal of Chinese Integrative Medicine, 2007, 5(1): 92-96.
[14] Min Li​, Chang-quan Ling​, Xue-qiang Huang​, Zhi-lei Shen. Effects of ginsenosides extracted from ginseng stem and leaves on glucocorticoid receptor in different viscera in heat-damaged rats. Journal of Chinese Integrative Medicine, 2006, 4(2): 156-159.
[15] Chang-quan Ling, Qing Liu, Dong-tao Li, Xiao-qiang Yue, Feng-gang Hou, De-zeng Zhu, Chao-qin Yu, Zhe Chen, Xiao-feng Zhai, Yang Yu. Study of a qualitative diagnostic criterion for basic syndromes of traditional Chinese medicine in patients with primary liver cancer. Journal of Chinese Integrative Medicine, 2005, 3(2): 95-98.
Full text



[1] Yi-ting He, Qing-lin Zha, Jian-ping Yu, Yong Tan, Cheng Lu, Ai-ping Lv. Principal factor analysis of symptoms of rheumatoid arthritis and their correlations with efficacy of traditional Chinese medicine and Western medicine. Journal of Chinese Integrative Medicine, 2008, 6(1): 32-36
[2] Zhi-chun Jin. Problems in establishing clinical guideline for integrated traditional Chinese and Western medicine. Journal of Chinese Integrative Medicine, 2008, 6(1): 5-8
[3] Xi Lin, Jian-ping Liu. Tai chi for treating rheumatoid arthritis. Journal of Chinese Integrative Medicine, 2008, 6(1): 82
[4] Daniel Weber, Janelle M Wheat, Geoffrey M Currie. Inflammation and cancer: Tumor initiation, progression and metastasis,and Chinese botanical medicines. Journal of Chinese Integrative Medicine, 2010, 8(11): 1006-1013
[5] Hong Liu , Guo-liang Zhang, Li Shen , Zhen Zeng, Bao-luo Zhou, Cheng-hai Liu, Guang Nie . Application and evaluation of a pseudotyped virus assay for screening herbs for anti-H5Nl avian influenza virus. Journal of Chinese Integrative Medicine, 2010, 8(11): 1036-1040
[6] Zhi-mei Wang, Bin Zhang. A study on translation of ellipses in Huangdi Neijing from perspective of hermeneutic theory. Journal of Chinese Integrative Medicine, 2010, 8(11): 1097-1100
[7] You-hua Wang , Shang Li , Bin-rui Yang , Lun-qing Zhang , Xin Zhou , Bei-wen Xu, Ming-yuan Li . Use of zebrafish models for the research of traditional Chinese medicine. Journal of Chinese Integrative Medicine, 2012, 10(11): 1189-1197
[8] Hui-min Liu, Xian-bo Wang, Yu-juan Chang, Li-li Gu. Systematic review and meta-analysis of randomized controlled trials of integrative medicine therapy for treatment of chronic severe hepatitis. Journal of Chinese Integrative Medicine, 2012, 10(11): 1211-1228
[9] Pedro Saganha João, Doenitz Christoph, Greten Tobias, Efferth Thomas, J. Greten Henry. Qigong therapy for physiotherapists suffering from burnout: a preliminary study. Journal of Chinese Integrative Medicine, 2012, 10(11): 1233-1239
[10] Dong-tao Li, Jian Wang , Hong-yang Jiang , Feng-lei Shi , Fu-yu Li , Ji-hong Liu , Yong-mei Cheng , Nan Yan , Ai-hua Hu, Mei-zeng Zhang , Jie Li, Ling-bo Wei , Rong-qin Jiang. Quantitative evaluation of the degrees of traditional Chinese medicine qualitative syndromes of osteoporosis. Journal of Chinese Integrative Medicine, 2012, 10(11): 1254-1262