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Journal of Chinese Integrative Medicine ›› 2005, Vol. 3 ›› Issue (5): 366-369.doi: 10.3736/jcim20050509

• Original Clinical Research • Previous Articles     Next Articles

Clinical observation on treatment of IgA nephropathy with Huobahuagen Tablets and irbesartan

Xiao-dong Guan1,Yu-fang Wu2,Wen Zhao1   

  1. 1. Department of Nephrology, Donghua Hospital, Sun Yat-sen University, Dongguan, Guangdong Province 523010, China
    2. Clinical Laboratory, Donghua Hospital, Sun Yat-sen University, Dongguan, Guangdong Province 523010, China
  • Received:2005-02-28 Online:2005-09-20 Published:2005-09-20
  • Contact: Xiao-dong Guan


To observe the effects of Huobahuagen Tablets combined with irbesartan on the risk factors of IgA nephropathy.


Sixty-two patients diagnosed as IgA nephropathy were randomly divided into control group and treatment group. Thirty patients in the control group were treated with Huobahuagen Tablets (5 tablets po t.i.d.), and 32 patients in the treatment group were treated with irbesartan (150 to 300 mg po q.d.), besides the same treatment as the control group. After 3 months of treatment, the levels of blood pressure (BP), 24 h urine protein (Upr), urinary red blood cells (URBC), blood triglycerides (TG), total cholesterol (TC), albumin (Alb), alanine transaminase (ALT), white blood cells (WBC) and serum creatinine (Scr) were observed.


After treatment, the levels of Upr, URBC and Scr in both groups were decreased, as compared with those before treatment (P<0.05 or P<0.01), and the levels of BP, Upr, URBC and Scr in the treatment group were lower than those in the control group (P<0.01). The levels of Alb in both groups were increased, as compared with those before treatment (P<0.05 or P<0.01), and the level of Alb in the treatment group was higher than that in the control group (P<0.05).


Huobahuagen Tablets, when used together with irbesartan, may improve the renal function of the patients with IgA nephropathy and slow the deterioration of the disease by reducing BP, Upr, URBC and Scr.

Key words: Huobahuagen Tablets, Irbesartan, Glomerulonephritis, IgA, Risk factors

CLC Number: 

  • R692.31

Tab 1

Changes of blood pressure in 2 groups ($\bar{x}$±s, mm Hg)"

Group n Systolic pressure Diastolic pressure
Control group
Before treatment 30 150.0±22.6 96.8±12.2
After treatment 30 148.6±21.8 96.4±12.6
Treatment group
Before treatment 32 152.0±22.8 98.5±11.6
After treatment 32 128.8±13.4**△△ 84.7±7.9**△△

Tab 2

Changes of laboratory indexes in 2 groups ($\bar{x}$±s )"

Group n Upr
(g/24 h)
Control group
Before treatment 30 2.24±1.32 37.5±17.5 212.8±60.4 31.6±5.8 2.59±1.35 6.98±2.74 37.92±4.56 6.32±1.62
After treatment 30 0.98±0.42** 16.5±9.5** 182.4±36.2* 35.2±6.8* 2.52±1.27 6.86±2.65 39.86±9.26 5.52±1.48
Treatment group
Before treatment 32 2.26±1.27 38.5±16.5 216.4±56.2 31.4±5.6 2.65±1.32 6.63±2.65 37.10±4.62 6.20±1.60
After treatment 32 0.46±0.22**△△ 9.5±6.5**△△ 128.6±36.4**△△ 38.8±7.3** 2.58±1.24 6.23±2.83 40.13±9.31 5.46±1.52
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