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Journal of Integrative Medicine ›› 2014, Vol. 12 ›› Issue (2): 86-93.doi: 10.1016/S2095-4964(14)60018-2

• Review • Previous Articles     Next Articles

Pharmacological effects and active phytoconstituents of Swietenia mahagoni: A review

Yelaware Puttaswamy Naveena, Gunashekar Divya Rupinia, Faiyaz Ahmedb, Asna Urooja   

  1. Department of Studies in Food Science and Nutrition, University of Mysore, Manasagangothri, Mysore-570006, India
    Indian Institute of Crop Processing Technology, Ministry of Food Processing Industries, Government of India, Thanjavur-613005, India
  • Received:2013-11-30 Accepted:2014-02-21 Online:2014-03-10 Published:2014-03-15

The usage of Swietenia mahagoni, a popular medicinal plant in India and some African countries, dates back to ancient times for its curative properties in diseases like malaria, diabetes, and diarrhea. It is also used as an anti-pyretic, bitter tonic and astringent. Its pharmacological activities are being widely explored. Although many important groups of phytochemicals have been identified and isolated from various parts of the plant, most of these researches have been focused on seeds. Toxicological studies have established the safety of many of these plant extracts, and found insignificant side effects. Here we present a comprehensive review of all the pharmacological effects and constituent phytochemicals of the plant.

Key words: Swietenia, Plant extracts, Medicine, Oriental traditional, Reviews

Figure 1

Images of the tree, fruit and leaves of Swietenia mahagoni"

Figure 2


Figure 3


Figure 4


Figure 5


Figure 6

Swiemahogin A"

Figure 7

Swiemahogin B"

[1] Elbert L . Atlas of United States trees.Washington, D[M]. C.: U.S. Dept. of Agriculture, Forest Service, 1978: 3-5
[2] Britton L, Millspaugh CF. The Bahama flora. New York: Ulan Press. 1920.
[3] Francis JK. Swietenia mahagoni Jacq, West Indies Mahogany: Meliaceae, Mahogany family. Washington, D.C.: U.S. Department of Agriculture, Forest Service, Southern Forest Experiment Station, Institute ofTropical Forestry. 1991.
[4] Bacsal K, Chavez L, Diaz I, Espina S, Javillo J, Manzanilla H, Motalban J, Panganiba C, Rodriguez A, Sumpaico C, Talip B, Yap S . The effect of Swietenia mahogani(Mahogany) seed extract on indomethacin-inducd gastric ulcers in female sprague-dawley rats[J]. Acta Med Philipp, 1997,33:127-139
[5] Grandtner MM . Elsevier’s dictionary of trees[M]. London: Elsevier Science, 2005: 1-381
[6] Sanyal M, Datta PC . Pharmacognosy of Swietenia mahagoni bark drug[J]. Anc Sci Life, 1986,5(3):172-181
[7] Howes FN . Vegetable tanning materials[M]. London: Butterworth’s Scientific Publications, 1953: 287
[8] . Watt G.A dictionary of the economic products of India. New Delhi: Periodical Experts. 1889.
doi: 10.1038/051150a0
[9] Watt JM, Breyer-Brandwijk MG. The medicinal and poisonous plants of southern and eastern Africa. 2nd ed. Edinburgh: E & SLivingston. 1962.
[10] Krishnan Marg KS . The wealth of India — an encyclopedia of Indian raw material resources[M]. New Delhi: CSIR, 1976: 84-87
[11] Burkill IH, Birtwistle W, Foxworthy FW, Scrivenor JB, Watson JG. A dictionary of the economic products of Malay Peninsula. 2nd ed.. Kuala Lumpur: Governments of Malaysia and Singapore by the Ministry of Agriculture and Co-operatives. 1966.
[12] Chakraborty DP, Basak SP . Cyclomahogenol, a new tetracyclic triterpene from Swietenia mahagoni[J]. Phytochemistry, 1971,10(6):1367-1372
doi: 10.1016/S0031-9422(00)84344-7
[13] Hajra S, Mehta A, Pandey P . Phenolic compounds and antioxidant activity of Swietenia mahagoni seeds[J]. Int J Pharm Pharm Sci, 2011,3(Suppl 5):431-434
[14] Sahgal G, Ramanathan S, Sasidharan S, Mordi MN, Ismail S, Mansor SM . Phytochemical and antimicrobial activity of Swietenia mahagoni crude methanolic seed extract[J]. Trop Biomed, 2009,26(3):274-279
doi: 10.1016/j.trstmh.2009.02.009 pmid: 20237441
[15] Rahman AK, Chowdhury AK, Ali HA, Raihan SZ, Ali MS, Nahar L, Sarker SD . Antibacterial activity of two limonoids from Swietenia mahagoni against multiple-drug-resistant(MDR) bacterial strains[J]. J Nat Med, 2009,63(1):41-45
doi: 10.1007/s11418-008-0287-3
[16] Ekimoto H, Irie Y, Araki Y, Han GQ, Kadota S, Kikuchi T . Platelet aggregation inhibitors from the seeds of Swietenia mahagoni: inhibition of in vitro and in vivo platelet-activating factor-induced effects of tetranortriterpenoids related to swietenine and swietenolide[J]. Planta Med, 1991,57(1):56-58
doi: 10.1055/s-2006-960018
[17] Kadota S, Marpaung L, Kikuchi T, Ekimoto H . Constituents of the seeds of Swietenia mahagoni JACQ. III. structures of mahonin and secomahoganin[J]. Chem Pharm Bull, 1990,38(6):1495-1500
doi: 10.1248/cpb.38.1495
[18] Lin BD, Yuan T, Zhang CR, Dong L, Zhang B, Wu Y, Yue JM . Structurally diverse limonoids from the fruits of Swietenia mahagoni[J]. J Nat Prod, 2009,72(12):2084-2090
doi: 10.1021/np900522h pmid: 19902967
[19] Chen YY, Wang XN, Fan CQ, Yin S, Yue JM . Swiemahogins A and B, two novel limonoids from Swietenia mahogany[J]. Tetrahedron Lett, 2007,48(42):7480-7484
doi: 10.1016/j.tetlet.2007.08.066
[20] Sahgal G, Ramanathan S, Sasidharan S, Mordi MN, Ismail S, Mansor SM . Phytochemical and antimicrobial activity of Swietenia mahagoni crude methanolic seed extract[J]. Trop Biomed, 2009,26(3):274-279
doi: 10.1016/j.trstmh.2009.02.009 pmid: 20237441
[21] Goun E, Cunningham G, Chu D, Nguyen C, Miles D . Antibacterial and antifungal activity of Indonesian ethnomedical plants[J]. Fitoterapia, 2003,76(4):592-596
[22] Sahgal G, Ramanathan S, Sasidharan S, Mordi MN, Ismail S, Mansor SM . In vitro and in vivo anticandidal activity of Swietenia mahogani methanolic seed extract[J]. Trop Biomed, 2011,28(1):132-137
doi: 10.1371/journal.pntd.0001034 pmid: 21602779
[23] Shipar MAH, Chowdhury R, Majid MA, Uddin MH, Rahman IMM . Physico-chemical characterization, antimicrobial activity and toxicity analysis of Swietenia mahagoni seed oil[J]. Int J Agric Biol, 2004,6(2):350-354
[24] Sharma M, Mohan V, Abraham M, Joshy PJ, Reghuvaran DK . Antimicrobial screening of different extracts of South Indian medicinal plants of Meliaceae[J]. J Med Plants Res, 2011,5(5):688-695
[25] Ghosh S, Besra SE, Roy K, Gupta JK, Vedasiromoni JR . Pharmacological effects of methanolic extract of Swietenia mahagoni Jacq(Meliaceae) seeds[J]. Int Green Pharm, 2009,3(3):206-210
doi: 10.4103/0973-8258.56275
[26] Haldar PK, Adhikari S, Bera S, Bhattacharya S, Panda SP, Kandar CC . Hepatoprotective efficacy of Swietenia mahagoni L. Jacq.(Meliaceae) bark against paracetamol induced hepatic damage in rats[J]. Indian J Pharm Educ Res, 2011,45(2):108-113
[27] Udem S, Nwaogu I, Onyejekwe O . Evaluation of hepatoprotective activity of aqeous leaf extract of Swietenia mahogani(Maliaceae) in chronic alcohol-induced liver injury in rats[J]. Maced J Med Sci, 2011,4(1):31-36
[28] Hajra S, Mehta A, Pandey P . Evaluation of the antidiarrhoeal activity of Swietenia mahagoni seed extracts[J]. Int J Pharm, 2012,8(5):416-421
doi: 10.3923/ijp.2012.416.421
[29] Sahga G, Ramanathan S, Sasidharan S, Mordi MN, Ismail S, Mansor SM . In vitro antioxidant and xanthine oxidase inhibitory activities of methanolic Swietenia mahagoni seed extracts[J]. Molecules, 2009,14(11):4476-4485
doi: 10.3390/molecules14114476
[30] Alrdahe SS, Abdulla MA, Razak SA, Kadir FA, Hassandarvish P . Gastroprotective activity of Swietenia mahagoni seed extract on ethanol-induced gastric mucosal injury in rats[J]. World Acad Sci Eng Technol, 2010,43:883-887
[31] Panda SP, Bera S, Naskar S, Adhikary S, Kandar CC, Haldar PK . Depressant and anticonvulsant effect of methanol extract of Swietenia mahagoni in mice[J]. Indian J Pharm Educ Res, 2010,44(3):283-287
[32] Rahman MA, Akther P, Roy D, Das AK . Antinociceptive and neuropharmacological activities of Swietenia mahagoni(L.) Jacq[J]. Pharmacologyonline, 2010,3:225-234
[33] De D, Chatterjee K, Ali KM, Bera TK, Ghosh D . Antidiabetic potentiality of the aqueous-methanolic extract of seed of Swietenia mahagoni(L.) Jacq. in streptozotocin-induced diabetic male albino rat: a correlative and evidence-based approach with antioxidative and antihyperlipidemic activities[J]. Evid Based Complement Alternat Med, 2011,2011:892807
[34] Hajra S, Mehta A, Pandey P, Vyas SP . Antioxidant and antidiabetic potential of ethanolic extract of Swietenia mahagoni(Linn.) seeds[J]. Int J Pharm Res Dev, 2011,3(3):180-186
[35] Li DD, Chen JH, Chen Q, Li GW, Chen J, Yue JM, Chen ML, Wang XP, Shen JH, Shen X, Jiang HL . Swietenia mahagony extract shows agonistic activity to PPARγ and gives ameliorative effects on diabetic db/db mice[J]. Acta Pharmacol Sin, 2005,26(2):220-222
doi: 10.1111/aphs.2005.26.issue-2
[36] Otake T, Mori H, Morimoto M, Ueba N, Sutardjo S, Kusumoto IT, Hattori M, Namba T . Screening of indonesian plant extracts for anti-human immunodeficiency virus — type 1(HIV-1) activity[J]. Phytother Res, 1995,9(1):6-10
doi: 10.1002/(ISSN)1099-1573
[37] Hajra S, Mehta A, Pandey P . Immunostimulating activity of methanolic extract of Swietenia mahagoni seeds[J]. Int J Pharm Pharm Sci, 2012,4(1):442-445
[38] Adhikari U, Singha S, Chandra G . In vitro repellent and larvicidal efficacy of Swietenia mahagoni against the larval forms of Culex quinquefasciatus Say[J]. Asian Pac J Trop Biomed, 2012,2(1):260-264
doi: 10.1016/S2222-1808(12)60057-7
[39] Mostafa M, Hemayet H, Hossain MA, Biswas PK, Haque MZ . Insecticidal activity of plant extracts against Tribolium castaneum Herbst[J]. J Adv Sci Res, 2012,3(3):80-84
[40] Sahgal G, Ramanathan S, Sasidharan S, Mordi MN, Ismail S, Mansor SM . Brine shrimp lethality and acute oral toxicity studies on Swietenia mahagoni(Linn.) Jacq. seed methanolic extract[J]. Pharmacognosy Res, 2010,2(4):215-220
doi: 10.4103/0974-8490.69107
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