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Journal of Integrative Medicine ›› 2016, Vol. 14 ›› Issue (5): 359-373.doi: 10.1016/S2095-4964(16)60274-1

• Review • Previous Articles     Next Articles

Phytochemical profile and biological activity of Juglans regia

Nisha Pantha, Keshav Raj Paudelb, Rajendra Karkib   

  1. a College of Pharmacy and Natural Medicine Research Institute, Mokpo National University, Muan-gun 58554, South Korea 
    b Department of Oriental Medicine Resource, Mokpo National University, Muan-gun 534-729, South Korea
  • Received:2016-06-25 Accepted:2016-08-01 Online:2016-09-15 Published:2016-09-15
  • Contact: Rajendra Karki, PhD; E-mail:

Juglans regia Linn. (Juglandaceae), popularly known as English or Persian walnut, is a valuable medicinal plant with a potency to cure various diseases in traditional medicine. Since ancient time, different local ethnic groups have used various part of J. regia for a wide array of ailments including helminthiasis, diarrhea, sinusitis, stomach ache, arthritis, asthma, eczema, scrofula, skin disorders, diabetes mellitus, anorexia, thyroid dysfunction, cancer and infectious diseases. Biological activities of J. regia have been reported in several peer review journals and scientific attention is increasing. The present review attempts to provide comprehensive information on plant description, ethnobotanical use, toxicity, phytochemical profile, pharmacology, clinical studies and current research prospective of the J. regia. Currently, there is an immense interest on isolation/identification of active constituents from walnut and screening those active compounds for pharmacological activities. In addition, researchers are performing clinical trials as well as screening various solvent extracts or fractions of J. regia in several animal diseases models to identify promising therapeutic benefits. In the present work, we review the latest information based on published scientific investigations of J. regia.

Key words: Plant extracts, Juglans regia, Medicine, Traditional, Phytochemicals, Pharmacology

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