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Journal of Integrative Medicine ›› 2017, Vol. 15 ›› Issue (2): 88-94.doi: 10.1016/S2095-4964(17)60311-X

• Review • Previous Articles     Next Articles

Ayurvedic concept of Shatkriyakala: A traditional knowledge of cancer pathogenesis and therapy

Ashutosh Chauhana, Deepak Kumar Semwalb, Satyendra Prasad Mishrac, Ruchi Badoni Semwald   

  1. a Department of Biotechnology, Faculty of Biomedical Sciences, Uttarakhand Ayurved University,Harrawala, Dehradun 248001, India 
    b Department of Phytochemistry, Faculty of Biomedical Sciences, Uttarakhand Ayurved University,Harrawala, Dehradun 248001, India 
    c Uttarakhand Ayurved University, Harrawala, Dehradun 248001, India 
    d Department of Pharmaceutical Sciences, Tshwane University of Technology, Pretoria 0001, South Africa
  • Received:2016-07-19 Accepted:2016-10-26 Online:2017-03-15 Published:2017-03-15
  • Contact: Deepak Kumar Semwal; E-mail:

The term Kriyakala refers to the recognition of the stage of a disease's progress, which helps to determine appropriate measure to correct the imbalance in Doshas (biological factors). It is a compound expression, comprised of Kriya and Kala, where Kriya means the choice to treatment (medicine, food and daily-routine) used to improve the disturbance in Doshas, and Kala refers to the stage of progress of a disease. Sushruta, an ancient Indian surgeon, has described the concept of Kriyakala in Varnaprashnadhyaya, an ancient Vedic Sanskrit text, which seeks to explain the incidence of Varnas in terms of Doshic disturbances. Varna, in modern parlance, may be described as an inflammatory process that may lead ulceration and chronic inflammation, promoting all stages of carcinogenesis. Abnormal interactions between Prakriti (genotype) and environmental factors vitiate the Doshas and impair immunity, which can lead to aberrant cell growth and cancer. Moreover, the interaction between vitiated Doshas and weak Dhatus (body tissues) manifests as cancers of a specific organ. Shatkriyakala (six stages of progress of a disease), on the other hand, provides a framework to assess the cancer and its pathogenesis in different stages. According to Ayurvedic concepts, all cancer therapies treat the affected tissues indirectly by eliminating vitiated Doshas, rejuvenating Dhatus and restoring immunity in cancer patients. The present review describes the six stages of Shatkriyakala in detail, with an emphasis on research areas to validate the concept of Shatkriyakala. This traditional knowledge can be utilized with modern technologies to detect predisposition for cancer or diagnose cancer in its early stages.

Key words: Medicine, Ayurvedic, Shatkriyakala, Tumors, Malignant

1 Semwal DK, Mishra SP, Chauhan A, Semwal RB.Adverse health effects of tobacco and role of Ayurveda in their reduction.J Med Sci. 2015; 15: 139-146.
2 Sumantran VN, Tillu G.Cancer, infl ammation, and insights from Ayurveda.Evid Based Complement Alternat Med. 2012; 2012: 306346.
3 Stewart BW, Wild CP.World Cancer Report 2014. Geneva: World Health Organization. 2014.
4 The development and causes of cancer. In: Cooper GM. The cell: a molecular approach. 2nd ed. Sunderland: Sinauer Associates. 2000.
5 Valastyan S, Weinberg RA.Tumor metastasis: molecular insights and evolving paradigms.Cell. 2011; 147(2): 275-292.
6 Dwarakanatha C.Introduction to Kayachikitsa. Varanasi: Chaukhambha Orientalia. 1996: 83-109.
7 Lad VD.Textbook of Ayurveda: a complete guide to clinical assessment. Vol II. Albuquerque: The Ayurvedic Press. 2006: 190, 199-202.
8 Aggarwal BB, Prasad S, Reuter S, Kannappan R, Yadev VR, Park B, Kim JH, Gupta SC, Phromnoi K, Sundaram C, Prasad S, Chaturvedi MM, Sung B.Identification of novel anti-inflammatory agents from Ayurvedic medicine for prevention of chronic diseases: “reverse pharmacology” and “bedside to bench” approach.Curr Drug Targets. 2011; 12(11): 1595-653.
9 Svoboda RE.A yurveda: life, health and longevity. Albuquerque: The Ayurvedic Press. 2004.
10 Balachandran P, Govindarajan R.Cancer—an Ayurvedic perspective.Pharmacol Res. 2005; 51(1): 19-30.
11 Bhishagratna KL. S ushruta Samhita. Varanasi: Choukhamba Orientalia.1991: Vol. 3. Hindi.
12 Singh RH.An assessment of the Ayurvedic concept of cancer and a new paradigm of anticancer treatment in Ayurveda.J Altern Complement Med. 2002; 8(5): 609-614.
13 Samal J.Public health importance ofShatkriyakala in relation to natural history of disease. Int J Res Ayurveda Pharm. 2013; 4(30): 468-471.
14 Hankare S, Mulla M.A study ofShatakriyakala and its importance in manifestation of diseases. Ayurlog Nat J Res Ayurved Sci. 2014: 3: 1-7.
15 Joshi LG, Ade JS, Deore SS, Shendage RG, Gavane NA.A literary review ofShatkriyakala. UJAHM. 2015; 3(3): 60-62.
16 Bhosgikar A.A review onShatkriyakala. Int Ayurved Med J. 2014; 2: 318-324.
17 17 Yadav S. Concept of Shat Kriya Kala. (2015-08-16) [2016- 06-13]. . Concept of Shat Kriya Kala. (2015-08-16) [2016- 06-13]. =Articles&ArticleID=48760.
18 Gupta KA. Astanga Hridayam, Hindi Commentary. Varanasi: Choukhamba Prakashan. 2007: 91. Hindi.
19 Jadavaji TA. Sushruta Samhita of Sushruta with Nibandhasamgraha Commentary. 9th ed. Varanasi: Choukhamba Orientalia.2007: 104. Hindi.
20 Ghanekar BG. Sushruta Samhita Sutrasthan. New Delhi: Meharchand Lacchmandas Publications.1998: 137. Hindi.
21 Shirke PR, Deshmukhe PN, Patil RB, Kirte MC, Sawant DP.Study ofDhatupradoshaja Vikar w.s.r.t. Raktadhatupradoshaja Vikara: a literery review. Int J Ayu Alt Med. 2016; 4: 116-122.
22 Kumar B, Paliwal M.Concept ofShatkriyakala as mentioned in Sushruta Samhita. J Adv Res Ayur Yoga Unani Sidd Homeo. 2014; 1: 10-12.
23 23 Kriyakala. (2001) [2016-06-17]. 2001) [2016-06-17]. http://
24 Prasher B, Negi S, Aggarwal S, Mandal AK, Sethi TP, Deshmukh SR, Purohit SG, Sengupta S, Khanna S, Mohammad F, Garg G, Brahmachari SK, Mukerji M.Whole genome expression and biochemical correlates of extreme constitutional types defi ned in Ayurveda.J Transl Med. 2008; 6: 48-60.
25 Bhushan P, Kalpana J, Arvind C.Classification of human population based on HLA gene polymorphism and the concept ofPrakriti in Ayurveda. J Altern Complement Med. 2005; 11(2): 349-353.
26 Hanash S, Taguchi A.Application of proteomics to cancer early detection.Cancer J. 2011; 17: 423-428.
27 Lu M, Faull KF, Whitelegge JP, He JB, Shen DJ, Saxton RE, Chang HR.Proteomics and mass spectrometry for cancer biomarker discovery.Biomark Insights. 2007; 2: 347-360.
28 Shukla HD, Mahmood J, Vujaskovic Z.Integrated proteogenomic approach for early diagnosis and prognosis of cancer. Cancer Lett.2015; 369(1): 28-36.
29 Ziegler A, Koch A, Krockenberger K, Grosshennig A.Personalized medicine using DNA biomarkers: a review.Hum Genet. 2012; 131(10): 1627-1638.
30 Duracková Z.Some current insights into oxidative stress.Physiol Res. 2010; 59(4): 459-469.
31 Fang J. Seki T, Maeda H.Therapeutic strategies by modulating oxygen stress in cancer and infl ammation. Adv Drug Deliv Rev.2009; 61(4): 290-302.
32 Khandrika L, Kumar B, Koul S, Maroni P, Koul HK.Role of oxidative stress in prostate cancer.Cancer Lett. 2009; 282(2): 125-136.
33 Visconti R, Grieco D.New insights on oxidative stress in cancer.Curr Opin Drug Discov Devel. 2009; 12(2): 240-245.
34 Reuter S, Gupta SC, Chaturvedi MM, Aggarwal BB.Oxidative stress, inflammation, and cancer: how are they linked? Free Radic Biol Med. 2010; 49(11): 1603-1616.
35 Mishra A, Shiozawa Y, Pienta KJ, Taichman RS.Homing of cancer cells to the bone. Cancer Microenviron.2011; 4(3): 221-235.
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